Homo sapiens

12 known processes

EME1

essential meiotic endonuclease 1 homolog 1 (S. pombe)

(Aliases: MMS4L,FLJ31364,SLX2A)

EME1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via single strand annealing GO:0045002 4 0.925
dna catabolic process GO:0006308 49 0.916
g2 dna damage checkpoint GO:0031572 26 0.772
double strand break repair via homologous recombination GO:0000724 50 0.678
dna repair GO:0006281 198 0.635
dna catabolic process endonucleolytic GO:0000737 37 0.586
response to intra s dna damage checkpoint signaling GO:0072429 4 0.570
dna catabolic process exonucleolytic GO:0000738 17 0.530
double strand break repair GO:0006302 101 0.510
mitotic cell cycle checkpoint GO:0007093 68 0.506
mitotic dna damage checkpoint GO:0044773 28 0.505
response to dna damage checkpoint signaling GO:0072423 4 0.501
dna recombination GO:0006310 77 0.489
cellular response to biotic stimulus GO:0071216 71 0.443
telomere maintenance GO:0000723 32 0.436
cell cycle checkpoint GO:0000075 117 0.433
cellular response to dna damage stimulus GO:0006974 379 0.432
cellular macromolecule catabolic process GO:0044265 380 0.430
recombinational repair GO:0000725 50 0.424
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.399
cell cycle phase transition GO:0044770 173 0.306
nucleotide excision repair GO:0006289 31 0.305
cellular response to endogenous stimulus GO:0071495 336 0.296
dna damage checkpoint GO:0000077 68 0.296
regulation of mitotic cell cycle phase transition GO:1901990 118 0.295
dna integrity checkpoint GO:0031570 71 0.294
response to dna integrity checkpoint signaling GO:0072402 4 0.276
response to biotic stimulus GO:0009607 276 0.262
mitotic cell cycle phase transition GO:0044772 162 0.258
nucleoside phosphate catabolic process GO:1901292 412 0.231
negative regulation of cell cycle phase transition GO:1901988 89 0.230
negative regulation of mitotic cell cycle GO:0045930 102 0.227
regulation of cell cycle GO:0051726 393 0.216
nucleotide excision repair dna incision GO:0033683 7 0.215
regulation of cell cycle phase transition GO:1901987 126 0.210
regulation of mitotic cell cycle GO:0007346 189 0.206
negative regulation of cell cycle process GO:0010948 121 0.187
mitotic g2 dna damage checkpoint GO:0007095 7 0.185
non recombinational repair GO:0000726 14 0.161
response to cell cycle checkpoint signaling GO:0072396 4 0.160
mitotic dna integrity checkpoint GO:0044774 30 0.151
nucleoside triphosphate metabolic process GO:0009141 422 0.142
post embryonic development GO:0009791 2 0.132
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.126
dna double strand break processing GO:0000729 10 0.124
mitotic cell cycle GO:0000278 326 0.124
mitotic cell cycle process GO:1903047 286 0.117
sex determination GO:0007530 3 0.110
ribonucleoside monophosphate metabolic process GO:0009161 187 0.102
negative regulation of cell cycle GO:0045786 193 0.097
regulation of cell cycle process GO:0010564 266 0.095
atp catabolic process GO:0006200 157 0.086
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.083
nucleotide catabolic process GO:0009166 408 0.081
positive regulation of hydrolase activity GO:0051345 331 0.076
purine ribonucleotide catabolic process GO:0009154 404 0.074
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.072
ribonucleotide catabolic process GO:0009261 405 0.067
purine ribonucleoside metabolic process GO:0046128 437 0.065
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.064
organophosphate catabolic process GO:0046434 430 0.062
ribonucleoside triphosphate metabolic process GO:0009199 412 0.059
ribonucleoside catabolic process GO:0042454 406 0.059
purine nucleoside monophosphate metabolic process GO:0009126 186 0.055
gene conversion GO:0035822 1 0.055
regulation of dna metabolic process GO:0051052 153 0.054
purine containing compound catabolic process GO:0072523 411 0.052
nucleoside monophosphate catabolic process GO:0009125 159 0.051
purine nucleoside monophosphate catabolic process GO:0009128 158 0.051
purine nucleoside catabolic process GO:0006152 398 0.048
nucleoside catabolic process GO:0009164 408 0.047
glycosyl compound catabolic process GO:1901658 413 0.042
ribonucleoside triphosphate catabolic process GO:0009203 391 0.041
purine ribonucleoside catabolic process GO:0046130 398 0.038
mitotic g2 m transition checkpoint GO:0044818 9 0.036
ribonucleoside monophosphate catabolic process GO:0009158 158 0.036
purine nucleotide catabolic process GO:0006195 405 0.033
positive regulation of catabolic process GO:0009896 310 0.033
amine metabolic process GO:0009308 44 0.033
response to radiation GO:0009314 151 0.033
regulation of cellular ketone metabolic process GO:0010565 50 0.032
cellular amino acid metabolic process GO:0006520 116 0.032
meiosis i GO:0007127 4 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
positive regulation of cellular catabolic process GO:0031331 284 0.031
determination of adult lifespan GO:0008340 2 0.030
purine nucleoside triphosphate catabolic process GO:0009146 392 0.029
female gamete generation GO:0007292 2 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
nucleoside monophosphate metabolic process GO:0009123 191 0.028
atp metabolic process GO:0046034 176 0.027
cellular amine metabolic process GO:0044106 41 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.025
actin filament based process GO:0030029 224 0.025
cellular protein complex assembly GO:0043623 188 0.024
replicative cell aging GO:0001302 3 0.023
cellular ketone metabolic process GO:0042180 80 0.022
regulation of purine nucleotide metabolic process GO:1900542 264 0.022
morphogenesis of embryonic epithelium GO:0016331 4 0.022
multicellular organismal aging GO:0010259 3 0.022
meiotic chromosome segregation GO:0045132 4 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.022
negative regulation of catalytic activity GO:0043086 335 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.020
regeneration GO:0031099 4 0.020
negative regulation of organelle organization GO:0010639 126 0.020
vesicle mediated transport GO:0016192 371 0.019
immune response GO:0006955 307 0.019
negative regulation of programmed cell death GO:0043069 321 0.019
dephosphorylation GO:0016311 209 0.018
cellular component disassembly GO:0022411 92 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
negative regulation of protein metabolic process GO:0051248 391 0.017
actin filament based movement GO:0030048 17 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
regulation of nucleoside metabolic process GO:0009118 209 0.016
response to abiotic stimulus GO:0009628 336 0.016
microtubule based process GO:0007017 210 0.016
positive regulation of nucleotide metabolic process GO:0045981 230 0.016
anatomical structure homeostasis GO:0060249 100 0.016
nervous system development GO:0007399 293 0.015
cellular component morphogenesis GO:0032989 314 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
protein maturation GO:0051604 233 0.015
maintenance of location GO:0051235 112 0.015
epithelium development GO:0060429 227 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
neuromuscular junction development GO:0007528 3 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
negative regulation of protein processing GO:0010955 142 0.014
oxidation reduction process GO:0055114 396 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
membrane organization GO:0061024 292 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
cell division GO:0051301 168 0.014
negative regulation of cellular protein metabolic process GO:0032269 353 0.014
regulation of protein kinase activity GO:0045859 289 0.014
response to ionizing radiation GO:0010212 65 0.014
cell morphogenesis GO:0000902 296 0.014
reciprocal meiotic recombination GO:0007131 4 0.014
negative regulation of cell death GO:0060548 345 0.013
response to wounding GO:0009611 168 0.013
protein catabolic process GO:0030163 325 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
gtp metabolic process GO:0046039 239 0.013
single organism cellular localization GO:1902580 332 0.013
protein localization to organelle GO:0033365 280 0.013
cellular protein catabolic process GO:0044257 261 0.013
cell projection assembly GO:0030031 126 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
intracellular protein transport GO:0006886 270 0.013
spermatid development GO:0007286 4 0.013
regulation of protein processing GO:0070613 150 0.013
cytoplasmic transport GO:0016482 379 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
transmembrane transport GO:0055085 399 0.013
g2 m transition of mitotic cell cycle GO:0000086 41 0.012
oogenesis GO:0048477 2 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
spermatid differentiation GO:0048515 4 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
hindbrain development GO:0030902 3 0.012
hemopoiesis GO:0030097 180 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
response to oxygen containing compound GO:1901700 369 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
myosin filament assembly GO:0031034 2 0.012
base excision repair GO:0006284 21 0.012
chemical homeostasis GO:0048878 306 0.011
dna geometric change GO:0032392 32 0.011
defense response GO:0006952 315 0.011
endocytosis GO:0006897 159 0.011
positive regulation of transport GO:0051050 336 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
nitrogen compound transport GO:0071705 191 0.011
regulation of kinase activity GO:0043549 314 0.011
gtp catabolic process GO:0006184 237 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
single organism membrane organization GO:0044802 268 0.011
cell type specific apoptotic process GO:0097285 125 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
execution phase of apoptosis GO:0097194 32 0.011
cell part morphogenesis GO:0032990 137 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
mapk cascade GO:0000165 288 0.010
carbohydrate derivative biosynthetic process GO:1901137 207 0.010
apoptotic signaling pathway GO:0097190 268 0.010
regulation of meiosis GO:0040020 3 0.010
protein oligomerization GO:0051259 173 0.010
negative regulation of catabolic process GO:0009895 104 0.010
mitochondrion organization GO:0007005 156 0.010
ion transmembrane transport GO:0034220 338 0.010

EME1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.430
bone marrow disease DOID:4961 31 0.430
hematopoietic system disease DOID:74 100 0.430
aplastic anemia DOID:12449 30 0.250
anemia DOID:2355 55 0.250
congenital hypoplastic anemia DOID:1342 26 0.112
fanconi s anemia DOID:13636 16 0.112
cancer DOID:162 167 0.056
disease of cellular proliferation DOID:14566 174 0.056
organ system cancer DOID:0050686 164 0.056
musculoskeletal system disease DOID:17 223 0.020
connective tissue disease DOID:65 109 0.020
xeroderma pigmentosum DOID:0050427 8 0.014
disease of metabolism DOID:0014667 295 0.011
inherited metabolic disorder DOID:655 242 0.011