Homo sapiens

0 known processes

DIABLO

diablo, IAP-binding mitochondrial protein

(Aliases: SMAC,FLJ10537,FLJ25049,SMAC3,DIABLO-S)

DIABLO biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of peptidase activity GO:0052547 180 0.514
cellular macromolecule catabolic process GO:0044265 380 0.403
positive regulation of apoptotic signaling pathway GO:2001235 70 0.384
protein modification by small protein conjugation GO:0032446 342 0.277
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.275
negative regulation of cell death GO:0060548 345 0.254
post embryonic development GO:0009791 2 0.198
regulation of cysteine type endopeptidase activity GO:2000116 127 0.196
adult locomotory behavior GO:0008344 1 0.190
positive regulation of apoptotic process GO:0043065 246 0.183
positive regulation of programmed cell death GO:0043068 249 0.183
cellular protein catabolic process GO:0044257 261 0.178
regulation of endopeptidase activity GO:0052548 170 0.168
extrinsic apoptotic signaling pathway GO:0097191 119 0.163
negative regulation of apoptotic process GO:0043066 316 0.155
regulation of cell differentiation GO:0045595 393 0.152
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.136
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.136
negative regulation of cellular protein metabolic process GO:0032269 353 0.126
mitochondrion organization GO:0007005 156 0.126
cellular response to dna damage stimulus GO:0006974 379 0.124
cellular response to muramyl dipeptide GO:0071225 3 0.119
positive regulation of developmental process GO:0051094 314 0.118
cellular response to external stimulus GO:0071496 111 0.116
locomotory behavior GO:0007626 1 0.115
regulation of proteolysis GO:0030162 293 0.111
i kappab kinase nf kappab signaling GO:0007249 166 0.111
protein processing GO:0016485 226 0.106
regulation of cell cycle GO:0051726 393 0.099
negative regulation of programmed cell death GO:0043069 321 0.091
modification dependent protein catabolic process GO:0019941 209 0.091
protein catabolic process GO:0030163 325 0.090
positive regulation of kinase activity GO:0033674 204 0.090
response to cytokine GO:0034097 232 0.088
cellular amine metabolic process GO:0044106 41 0.087
regulation of protein kinase activity GO:0045859 289 0.087
protein ubiquitination GO:0016567 314 0.085
regulation of apoptotic signaling pathway GO:2001233 175 0.080
positive regulation of cell differentiation GO:0045597 211 0.079
regulation of macrophage differentiation GO:0045649 9 0.079
lipid metabolic process GO:0006629 381 0.076
negative regulation of protein metabolic process GO:0051248 391 0.075
protein maturation GO:0051604 233 0.075
regulation of kinase activity GO:0043549 314 0.074
positive regulation of macrophage differentiation GO:0045651 7 0.070
nitrogen compound transport GO:0071705 191 0.068
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.068
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.068
mitotic cell cycle phase transition GO:0044772 162 0.066
positive regulation of myeloid cell differentiation GO:0045639 39 0.066
regulation of cellular amine metabolic process GO:0033238 11 0.065
negative regulation of peptidase activity GO:0010466 91 0.064
positive regulation of hydrolase activity GO:0051345 331 0.064
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.062
cellular response to cytokine stimulus GO:0071345 181 0.062
negative regulation of apoptotic signaling pathway GO:2001234 97 0.062
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.062
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.062
myeloid cell differentiation GO:0030099 117 0.061
positive regulation of proteolysis GO:0045862 142 0.059
response to abiotic stimulus GO:0009628 336 0.059
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.057
regulation of leukocyte activation GO:0002694 115 0.057
g1 s transition of mitotic cell cycle GO:0000082 78 0.056
cellular response to oxygen containing compound GO:1901701 276 0.056
positive regulation of cell cycle process GO:0090068 106 0.056
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.055
regulation of canonical wnt signaling pathway GO:0060828 88 0.055
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.054
ubiquitin dependent protein catabolic process GO:0006511 206 0.053
apoptotic signaling pathway GO:0097190 268 0.053
negative regulation of catalytic activity GO:0043086 335 0.053
response to oxygen containing compound GO:1901700 369 0.053
intrinsic apoptotic signaling pathway GO:0097193 127 0.052
regulation of wnt signaling pathway GO:0030111 123 0.051
negative regulation of endopeptidase activity GO:0010951 84 0.051
amine metabolic process GO:0009308 44 0.050
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.050
trail activated apoptotic signaling pathway GO:0036462 4 0.050
wnt signaling pathway GO:0016055 156 0.049
substantia nigra development GO:0021762 45 0.046
regulation of leukocyte differentiation GO:1902105 61 0.046
positive regulation of peptidase activity GO:0010952 88 0.045
regulation of cellular amino acid metabolic process GO:0006521 6 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
response to biotic stimulus GO:0009607 276 0.044
cellular amino acid metabolic process GO:0006520 116 0.044
cellular lipid metabolic process GO:0044255 303 0.043
regulation of protein maturation GO:1903317 150 0.042
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.041
positive regulation of cell death GO:0010942 263 0.041
embryo development GO:0009790 123 0.041
positive regulation of immune system process GO:0002684 283 0.041
regulation of cell cycle process GO:0010564 266 0.041
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.041
positive regulation of cellular amine metabolic process GO:0033240 7 0.040
regulation of myeloid cell differentiation GO:0045637 81 0.040
protein polyubiquitination GO:0000209 110 0.040
cardiac ventricle formation GO:0003211 2 0.039
negative regulation of hydrolase activity GO:0051346 182 0.038
regulation of response to dna damage stimulus GO:2001020 94 0.036
cellular response to endogenous stimulus GO:0071495 336 0.036
cellular response to abiotic stimulus GO:0071214 117 0.036
cellular response to lipid GO:0071396 127 0.036
neuromuscular junction development GO:0007528 3 0.035
regulation of mitotic cell cycle phase transition GO:1901990 118 0.035
female gamete generation GO:0007292 2 0.034
signal transduction in absence of ligand GO:0038034 22 0.033
nucleobase containing compound transport GO:0015931 51 0.033
regulation of transmembrane transporter activity GO:0022898 74 0.032
regulation of transferase activity GO:0051338 355 0.032
canonical wnt signaling pathway GO:0060070 116 0.031
transmembrane transport GO:0055085 399 0.031
regulation of neuron death GO:1901214 56 0.031
regulation of cellular response to stress GO:0080135 244 0.031
immune effector process GO:0002252 159 0.031
neuron death GO:0070997 65 0.031
negative regulation of proteolysis GO:0045861 132 0.031
determination of adult lifespan GO:0008340 2 0.030
positive regulation of protein ubiquitination GO:0031398 53 0.030
proteasomal protein catabolic process GO:0010498 176 0.029
cell type specific apoptotic process GO:0097285 125 0.029
oogenesis GO:0048477 2 0.029
startle response GO:0001964 3 0.028
cardiac right ventricle morphogenesis GO:0003215 3 0.028
vesicle mediated transport GO:0016192 371 0.028
regulation of t cell proliferation GO:0042129 42 0.027
system process GO:0003008 349 0.026
regulation of protein processing GO:0070613 150 0.026
cell cycle arrest GO:0007050 71 0.026
zymogen activation GO:0031638 70 0.026
ion transmembrane transport GO:0034220 338 0.026
aortic valve development GO:0003176 3 0.026
positive regulation of neuron death GO:1901216 14 0.026
growth GO:0040007 202 0.026
cardiac right ventricle formation GO:0003219 1 0.026
epithelial cell differentiation GO:0030855 141 0.025
secretion GO:0046903 254 0.025
cell cycle phase transition GO:0044770 173 0.025
regulation of cell cycle g1 s phase transition GO:1902806 42 0.025
dna damage checkpoint GO:0000077 68 0.025
photoreceptor cell differentiation GO:0046530 2 0.025
regulation of mitotic cell cycle GO:0007346 189 0.024
membrane organization GO:0061024 292 0.024
regulation of necroptotic process GO:0060544 7 0.024
multicellular organismal aging GO:0010259 3 0.024
response to hormone GO:0009725 175 0.024
regulation of cytoskeleton organization GO:0051493 177 0.024
regulation of cell cycle phase transition GO:1901987 126 0.024
membrane lipid metabolic process GO:0006643 53 0.024
negative regulation of cell cycle GO:0045786 193 0.024
response to decreased oxygen levels GO:0036293 96 0.024
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.024
innate immune response GO:0045087 178 0.023
limbic system development GO:0021761 3 0.023
release of cytochrome c from mitochondria GO:0001836 35 0.023
negative regulation of protein processing GO:0010955 142 0.023
regulation of protein ubiquitination GO:0031396 95 0.023
programmed necrotic cell death GO:0097300 18 0.023
negative regulation of intracellular signal transduction GO:1902532 183 0.023
multicellular organismal reproductive process GO:0048609 40 0.023
defense response GO:0006952 315 0.023
negative regulation of cellular component organization GO:0051129 235 0.023
cytokine mediated signaling pathway GO:0019221 109 0.022
positive regulation of phosphorylation GO:0042327 394 0.022
negative regulation of cell cycle process GO:0010948 121 0.022
activation of cysteine type endopeptidase activity GO:0097202 57 0.022
negative regulation of developmental process GO:0051093 247 0.022
regulation of cell division GO:0051302 116 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.022
regulation of reactive oxygen species metabolic process GO:2000377 41 0.022
peptidyl serine autophosphorylation GO:0036289 2 0.022
negative regulation of cell proliferation GO:0008285 228 0.022
negative regulation of cell cycle phase transition GO:1901988 89 0.022
lymphocyte activation GO:0046649 133 0.021
signal transduction involved in dna integrity checkpoint GO:0072401 15 0.021
negative regulation of protein maturation GO:1903318 142 0.021
cellular response to uv GO:0034644 32 0.021
cell activation GO:0001775 213 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.021
central nervous system development GO:0007417 123 0.021
regulation of growth GO:0040008 165 0.020
regulation of t cell activation GO:0050863 77 0.020
response to wounding GO:0009611 168 0.020
forebrain neuron differentiation GO:0021879 3 0.020
leukocyte differentiation GO:0002521 98 0.020
negative regulation of protein modification process GO:0031400 200 0.020
positive regulation of protein polyubiquitination GO:1902916 3 0.020
apoptotic mitochondrial changes GO:0008637 57 0.020
regulation of cell cycle arrest GO:0071156 36 0.020
regulation of hormone levels GO:0010817 125 0.020
negative regulation of transport GO:0051051 176 0.020
positive regulation of immune response GO:0050778 159 0.020
mitotic cell cycle GO:0000278 326 0.019
wound healing GO:0042060 115 0.019
positive regulation of transferase activity GO:0051347 227 0.019
regulation of lymphocyte apoptotic process GO:0070228 15 0.019
immune system development GO:0002520 195 0.019
cardiac chamber formation GO:0003207 2 0.019
regulation of cellular ketone metabolic process GO:0010565 50 0.019
regeneration GO:0031099 4 0.019
tissue regeneration GO:0042246 3 0.019
myeloid leukocyte differentiation GO:0002573 60 0.019
cellular ketone metabolic process GO:0042180 80 0.019
mitotic cell cycle process GO:1903047 286 0.019
macrophage differentiation GO:0030225 11 0.019
cell adhesion GO:0007155 325 0.018
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.018
stress activated protein kinase signaling cascade GO:0031098 94 0.018
cell projection assembly GO:0030031 126 0.018
receptor mediated endocytosis GO:0006898 84 0.018
cellular response to acid chemical GO:0071229 44 0.018
positive regulation of gtp catabolic process GO:0033126 166 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
positive regulation of protein phosphorylation GO:0001934 313 0.018
cell projection organization GO:0030030 252 0.018
small gtpase mediated signal transduction GO:0007264 78 0.018
response to oxygen levels GO:0070482 100 0.018
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.018
sensory perception GO:0007600 103 0.018
positive regulation of cellular component organization GO:0051130 376 0.018
leukocyte activation GO:0045321 164 0.017
oocyte development GO:0048599 1 0.017
regulation of cell activation GO:0050865 125 0.017
gtp catabolic process GO:0006184 237 0.017
reproductive process GO:0022414 106 0.017
regulation of meiotic cell cycle GO:0051445 4 0.017
regulation of protein linear polyubiquitination GO:1902528 2 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.017
protein localization to organelle GO:0033365 280 0.017
negative regulation of multicellular organismal process GO:0051241 317 0.017
regulation of cell projection organization GO:0031344 107 0.017
mitotic g1 s transition checkpoint GO:0044819 17 0.017
regulation of cellular component movement GO:0051270 334 0.017
cell cycle g1 s phase transition GO:0044843 80 0.017
cellular response to organic cyclic compound GO:0071407 127 0.017
signal transduction involved in cell cycle checkpoint GO:0072395 16 0.017
inner ear morphogenesis GO:0042472 4 0.016
response to tumor necrosis factor GO:0034612 76 0.016
single organism membrane fusion GO:0044801 37 0.016
biological adhesion GO:0022610 331 0.016
dephosphorylation GO:0016311 209 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
positive regulation of cell motility GO:2000147 177 0.016
developmental programmed cell death GO:0010623 3 0.016
cell division GO:0051301 168 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
regulation of actin filament based process GO:0032970 141 0.016
regulation of cell motility GO:2000145 299 0.016
response to mechanical stimulus GO:0009612 51 0.016
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.016
regulation of myeloid leukocyte differentiation GO:0002761 39 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.015
endocytosis GO:0006897 159 0.015
cation homeostasis GO:0055080 189 0.015
rho protein signal transduction GO:0007266 26 0.015
regulation of microtubule cytoskeleton organization GO:0070507 61 0.015
lymphocyte proliferation GO:0046651 70 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
chemical homeostasis GO:0048878 306 0.015
secretion by cell GO:0032940 226 0.015
regulation of jnk cascade GO:0046328 73 0.015
regulation of cell adhesion GO:0030155 166 0.015
response to retinoic acid GO:0032526 33 0.015
regulation of cell morphogenesis GO:0022604 153 0.015
response to nitrogen compound GO:1901698 184 0.015
regulation of anion transport GO:0044070 25 0.015
regulation of nucleotide catabolic process GO:0030811 205 0.015
hindbrain development GO:0030902 3 0.015
positive regulation of leukocyte differentiation GO:1902107 37 0.014
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.014
embryonic hindlimb morphogenesis GO:0035116 2 0.014
autophagy GO:0006914 88 0.014
small molecule biosynthetic process GO:0044283 157 0.014
neuron development GO:0048666 113 0.014
cell growth GO:0016049 160 0.014
actin filament based process GO:0030029 224 0.014
regulation of neuron apoptotic process GO:0043523 35 0.014
brain development GO:0007420 97 0.014
signal transduction in response to dna damage GO:0042770 57 0.014
response to radiation GO:0009314 151 0.014
cellular response to retinoic acid GO:0071300 19 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
cellular response to light stimulus GO:0071482 34 0.014
positive regulation of mapk cascade GO:0043410 190 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
purine nucleoside catabolic process GO:0006152 398 0.014
posttranscriptional regulation of gene expression GO:0010608 213 0.014
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.014
motor neuron axon guidance GO:0008045 2 0.014
cellular response to radiation GO:0071478 65 0.014
neurological system process GO:0050877 163 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
positive regulation of protein linear polyubiquitination GO:1902530 2 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
mating GO:0007618 1 0.013
t cell activation GO:0042110 99 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
regulation of microtubule based process GO:0032886 74 0.013
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.013
mrna metabolic process GO:0016071 175 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
neuron apoptotic process GO:0051402 39 0.013
epithelium development GO:0060429 227 0.013
regulation of defense response GO:0031347 154 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
t cell homeostasis GO:0043029 3 0.013
negative regulation of kinase activity GO:0033673 106 0.013
regulation of mononuclear cell proliferation GO:0032944 65 0.013
lymphocyte apoptotic process GO:0070227 20 0.013
mitotic cell cycle checkpoint GO:0007093 68 0.013
leukocyte proliferation GO:0070661 74 0.013
response to organonitrogen compound GO:0010243 156 0.013
anion transport GO:0006820 161 0.013
actin mediated cell contraction GO:0070252 12 0.013
protein polymerization GO:0051258 71 0.013
cell morphogenesis GO:0000902 296 0.013
peptide hormone secretion GO:0030072 50 0.013
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.013
cellular response to dexamethasone stimulus GO:0071549 1 0.013
protein k63 linked ubiquitination GO:0070534 31 0.013
regulation of cellular protein catabolic process GO:1903362 96 0.013
organophosphate catabolic process GO:0046434 430 0.013
regulation of innate immune response GO:0045088 97 0.013
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.013
positive regulation of neuron apoptotic process GO:0043525 8 0.012
exocytosis GO:0006887 71 0.012
spermatid development GO:0007286 4 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
cell part morphogenesis GO:0032990 137 0.012
amide transport GO:0042886 76 0.012
leukocyte apoptotic process GO:0071887 31 0.012
peripheral nervous system development GO:0007422 2 0.012
negative regulation of transferase activity GO:0051348 124 0.012
protein homooligomerization GO:0051260 100 0.012
stress activated mapk cascade GO:0051403 93 0.012
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.012
response to uv GO:0009411 73 0.012
b cell homeostasis GO:0001782 1 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
response to metal ion GO:0010038 84 0.012
cell substrate adhesion GO:0031589 132 0.012
neurogenesis GO:0022008 169 0.012
regulation of peptidyl serine phosphorylation GO:0033135 50 0.012
purine ribonucleoside metabolic process GO:0046128 437 0.012
single organism membrane organization GO:0044802 268 0.012
actin filament organization GO:0007015 128 0.012
regulation of lymphocyte proliferation GO:0050670 64 0.012
positive regulation of organelle organization GO:0010638 195 0.012
macromolecule methylation GO:0043414 97 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
regulation of mapk cascade GO:0043408 262 0.012
regulation of endothelial cell differentiation GO:0045601 4 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.011
organelle localization GO:0051640 84 0.011
negative regulation of immune system process GO:0002683 136 0.011
sensory perception of sound GO:0007605 37 0.011
midbrain development GO:0030901 45 0.011
hippocampus development GO:0021766 1 0.011
associative learning GO:0008306 1 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
rna processing GO:0006396 255 0.011
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.011
necrotic cell death GO:0070265 21 0.011
negative regulation of myotube differentiation GO:0010832 4 0.011
positive regulation of cardiac muscle tissue growth GO:0055023 2 0.011
keratinocyte differentiation GO:0030216 36 0.011
hemopoiesis GO:0030097 180 0.011
regulation of transmembrane transport GO:0034762 139 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.011
cochlea development GO:0090102 1 0.011
positive regulation of locomotion GO:0040017 186 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
regulation of immune effector process GO:0002697 91 0.011
head development GO:0060322 108 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
dna integrity checkpoint GO:0031570 71 0.011
response to bacterium GO:0009617 144 0.011
cytoplasmic transport GO:0016482 379 0.011
positive regulation of cell cycle GO:0045787 140 0.011
neural nucleus development GO:0048857 47 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
regulation of multi organism process GO:0043900 157 0.011
response to muramyl dipeptide GO:0032495 4 0.011
response to hypoxia GO:0001666 96 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.010
dna catabolic process GO:0006308 49 0.010
response to acid chemical GO:0001101 66 0.010
organ formation GO:0048645 3 0.010
t cell proliferation GO:0042098 45 0.010
ceramide metabolic process GO:0006672 25 0.010
transmission of nerve impulse GO:0019226 11 0.010
rna splicing GO:0008380 131 0.010
atp synthesis coupled electron transport GO:0042773 4 0.010
phospholipid metabolic process GO:0006644 99 0.010
mapk cascade GO:0000165 288 0.010
cell matrix adhesion GO:0007160 85 0.010
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.010

DIABLO disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.054
disease of cellular proliferation DOID:14566 174 0.054
central nervous system disease DOID:331 186 0.038
nervous system disease DOID:863 431 0.038
organ system cancer DOID:0050686 164 0.023
parkinson s disease DOID:14330 18 0.019
synucleinopathy DOID:0050890 22 0.019
neurodegenerative disease DOID:1289 102 0.019
sensory system disease DOID:0050155 203 0.016
eye and adnexa disease DOID:1492 150 0.016
eye disease DOID:5614 149 0.016
retinal disease DOID:5679 118 0.012
retinal degeneration DOID:8466 89 0.011
retinitis pigmentosa DOID:10584 51 0.011