Homo sapiens

11 known processes

HTRA1

HtrA serine peptidase 1

(Aliases: ARMD7,PRSS11,ORF480,L56,HtrA)

HTRA1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
circulatory system development GO:0072359 262 0.292
cardiovascular system development GO:0072358 262 0.279
cell adhesion GO:0007155 325 0.262
regulation of cell migration GO:0030334 289 0.242
regulation of cellular component movement GO:0051270 334 0.229
negative regulation of protein metabolic process GO:0051248 391 0.213
regulation of locomotion GO:0040012 329 0.207
protein processing GO:0016485 226 0.191
regulation of response to external stimulus GO:0032101 222 0.186
Rat
regulation of proteolysis GO:0030162 293 0.181
Human Fly
angiogenesis GO:0001525 147 0.176
negative regulation of developmental process GO:0051093 247 0.164
regulation of cell differentiation GO:0045595 393 0.159
cell substrate adhesion GO:0031589 132 0.157
response to wounding GO:0009611 168 0.157
biological adhesion GO:0022610 331 0.157
taxis GO:0042330 157 0.138
negative regulation of multicellular organismal process GO:0051241 317 0.132
response to oxygen containing compound GO:1901700 369 0.125
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.124
negative regulation of cell migration GO:0030336 102 0.119
cell chemotaxis GO:0060326 112 0.112
negative regulation of cellular protein metabolic process GO:0032269 353 0.106
ameboidal type cell migration GO:0001667 135 0.102
regulation of secretion GO:0051046 194 0.101
anatomical structure formation involved in morphogenesis GO:0048646 284 0.100
post embryonic development GO:0009791 2 0.099
cellular amino acid metabolic process GO:0006520 116 0.099
positive regulation of cell proliferation GO:0008284 301 0.099
Rat
positive regulation of cellular component organization GO:0051130 376 0.098
regulation of peptidase activity GO:0052547 180 0.095
Human Fly
regulation of body fluid levels GO:0050878 99 0.093
blood vessel morphogenesis GO:0048514 162 0.092
cell development GO:0048468 328 0.092
Fly
protein maturation GO:0051604 233 0.092
vasculature development GO:0001944 181 0.089
positive regulation of developmental process GO:0051094 314 0.088
negative regulation of cellular component movement GO:0051271 106 0.086
regulation of epithelial cell migration GO:0010632 93 0.083
nervous system development GO:0007399 293 0.083
enzyme linked receptor protein signaling pathway GO:0007167 303 0.082
Zebrafish Mouse
determination of adult lifespan GO:0008340 2 0.082
blood coagulation GO:0007596 76 0.082
cellular ketone metabolic process GO:0042180 80 0.081
negative regulation of peptidase activity GO:0010466 91 0.079
regulation of cell motility GO:2000145 299 0.078
regulation of cellular amine metabolic process GO:0033238 11 0.078
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.076
Zebrafish
negative regulation of locomotion GO:0040013 118 0.076
epithelium migration GO:0090132 119 0.073
positive regulation of locomotion GO:0040017 186 0.069
protein catabolic process GO:0030163 325 0.068
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.068
cell matrix adhesion GO:0007160 85 0.065
positive regulation of programmed cell death GO:0043068 249 0.065
Human Fly
response to abiotic stimulus GO:0009628 336 0.064
Human
retina vasculature morphogenesis in camera type eye GO:0061299 3 0.064
endothelial cell migration GO:0043542 86 0.064
hemostasis GO:0007599 76 0.064
cellular component morphogenesis GO:0032989 314 0.064
regulation of leukocyte chemotaxis GO:0002688 46 0.062
intracellular protein transport GO:0006886 270 0.061
regulation of cell adhesion GO:0030155 166 0.061
wound healing GO:0042060 115 0.060
system process GO:0003008 349 0.060
regulation of protein maturation GO:1903317 150 0.060
regulation of establishment of protein localization GO:0070201 242 0.059
single organism cellular localization GO:1902580 332 0.059
generation of neurons GO:0048699 152 0.058
regulation of blood coagulation GO:0030193 42 0.058
negative regulation of protein processing GO:0010955 142 0.058
cell projection organization GO:0030030 252 0.058
multicellular organismal aging GO:0010259 3 0.058
cell morphogenesis involved in differentiation GO:0000904 144 0.056
negative regulation of cell differentiation GO:0045596 171 0.056
vesicle mediated transport GO:0016192 371 0.056
cellular response to growth factor stimulus GO:0071363 197 0.056
Human Zebrafish Mouse
positive regulation of immune system process GO:0002684 283 0.055
extracellular matrix organization GO:0030198 41 0.055
positive regulation of cellular amine metabolic process GO:0033240 7 0.054
skeletal system development GO:0001501 79 0.052
coagulation GO:0050817 78 0.052
positive regulation of transferase activity GO:0051347 227 0.051
positive regulation of transport GO:0051050 336 0.051
negative regulation of proteolysis GO:0045861 132 0.050
regulation of mapk cascade GO:0043408 262 0.050
regulation of protein processing GO:0070613 150 0.050
regulation of transferase activity GO:0051338 355 0.050
amine metabolic process GO:0009308 44 0.050
negative regulation of transport GO:0051051 176 0.049
secretion GO:0046903 254 0.047
regulation of cellular ketone metabolic process GO:0010565 50 0.047
positive regulation of phosphorylation GO:0042327 394 0.047
cytoplasmic transport GO:0016482 379 0.046
single organismal cell cell adhesion GO:0016337 148 0.045
response to cytokine GO:0034097 232 0.045
Human
single organism membrane organization GO:0044802 268 0.045
negative regulation of protein maturation GO:1903318 142 0.045
cytokine production GO:0001816 247 0.044
response to lipid GO:0033993 206 0.043
Human
negative regulation of epithelial cell proliferation GO:0050680 48 0.043
chemotaxis GO:0006935 157 0.043
regulation of growth GO:0040008 165 0.043
epithelial cell migration GO:0010631 119 0.042
cell morphogenesis GO:0000902 296 0.042
immune response GO:0006955 307 0.042
regulation of protein kinase activity GO:0045859 289 0.041
mapk cascade GO:0000165 288 0.041
positive regulation of protein kinase activity GO:0045860 190 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.041
blood vessel development GO:0001568 172 0.040
regulation of mesenchymal stem cell proliferation GO:1902460 1 0.040
regulation of secretion by cell GO:1903530 177 0.039
positive regulation of cell differentiation GO:0045597 211 0.039
negative regulation of catalytic activity GO:0043086 335 0.039
positive regulation of apoptotic process GO:0043065 246 0.039
Human Fly
regulation of vasculature development GO:1901342 97 0.038
peptidyl tyrosine phosphorylation GO:0018108 170 0.037
regulation of protein localization GO:0032880 296 0.037
protein secretion GO:0009306 98 0.037
negative regulation of endopeptidase activity GO:0010951 84 0.037
negative regulation of cell adhesion GO:0007162 64 0.036
negative regulation of cell motility GO:2000146 104 0.036
cellular response to oxygen containing compound GO:1901701 276 0.036
Human
membrane organization GO:0061024 292 0.036
regulation of angiogenesis GO:0045765 92 0.035
regulation of protein transport GO:0051223 213 0.035
regulation of kinase activity GO:0043549 314 0.035
regulation of cellular response to growth factor stimulus GO:0090287 76 0.035
Zebrafish Mouse
neuron projection development GO:0031175 106 0.035
cell projection morphogenesis GO:0048858 129 0.035
regeneration GO:0031099 4 0.035
carbohydrate derivative biosynthetic process GO:1901137 207 0.034
positive regulation of protein phosphorylation GO:0001934 313 0.034
carboxylic acid biosynthetic process GO:0046394 97 0.034
negative regulation of cell proliferation GO:0008285 228 0.034
neuron differentiation GO:0030182 138 0.034
positive regulation of cell motility GO:2000147 177 0.033
single organism cell adhesion GO:0098602 179 0.033
blastoderm segmentation GO:0007350 2 0.033
negative regulation of cell death GO:0060548 345 0.033
positive regulation of kinase activity GO:0033674 204 0.033
organonitrogen compound biosynthetic process GO:1901566 200 0.032
cellular amine metabolic process GO:0044106 41 0.032
positive regulation of secretion GO:0051047 116 0.032
protein targeting GO:0006605 187 0.032
posttranscriptional regulation of gene expression GO:0010608 213 0.031
positive regulation of cell death GO:0010942 263 0.031
Human Fly
nuclear transport GO:0051169 179 0.031
regulation of canonical wnt signaling pathway GO:0060828 88 0.031
positive regulation of cell migration GO:0030335 172 0.031
regulation of behavior GO:0050795 82 0.030
cell growth GO:0016049 160 0.030
growth GO:0040007 202 0.030
neurogenesis GO:0022008 169 0.030
regulation of cell growth GO:0001558 135 0.030
regulation of renal albumin absorption GO:2000532 1 0.030
positive regulation of mesenchymal stem cell differentiation GO:2000741 4 0.029
regulation of blood volume by renin angiotensin GO:0002016 1 0.029
negative regulation of programmed cell death GO:0043069 321 0.029
regulation of endopeptidase activity GO:0052548 170 0.029
Human Fly
basement membrane organization GO:0071711 3 0.029
response to organonitrogen compound GO:0010243 156 0.028
secretion by cell GO:0032940 226 0.028
digestive system development GO:0055123 75 0.028
establishment of protein localization to organelle GO:0072594 172 0.028
negative regulation of intracellular signal transduction GO:1902532 183 0.028
plasma membrane organization GO:0007009 115 0.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.028
Mouse
wnt signaling pathway GO:0016055 156 0.028
negative regulation of blood vessel morphogenesis GO:2000181 41 0.028
endocytosis GO:0006897 159 0.027
regulation of cytoplasmic transport GO:1903649 149 0.027
regulation of chemotaxis GO:0050920 74 0.027
female gamete generation GO:0007292 2 0.027
negative regulation of protein modification process GO:0031400 200 0.027
organic acid biosynthetic process GO:0016053 97 0.027
regulation of coagulation GO:0050818 44 0.026
protein localization to membrane GO:0072657 160 0.026
extracellular structure organization GO:0043062 41 0.026
negative regulation of hydrolase activity GO:0051346 182 0.026
lipid metabolic process GO:0006629 381 0.026
cellular response to cytokine stimulus GO:0071345 181 0.026
Human
regulation of endothelial cell migration GO:0010594 67 0.026
blood circulation GO:0008015 113 0.026
oogenesis GO:0048477 2 0.025
epithelium development GO:0060429 227 0.025
cellular response to organic cyclic compound GO:0071407 127 0.025
monocarboxylic acid metabolic process GO:0032787 185 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
response to nitrogen compound GO:1901698 184 0.025
segmentation GO:0035282 4 0.025
positive regulation of hydrolase activity GO:0051345 331 0.025
Human Fly
positive regulation of cell adhesion GO:0045785 84 0.025
regulation of leukocyte migration GO:0002685 63 0.025
neuromuscular junction development GO:0007528 3 0.025
regulation of protein secretion GO:0050708 86 0.024
chemical homeostasis GO:0048878 306 0.024
negative regulation of cell growth GO:0030308 83 0.024
negative regulation of phosphorus metabolic process GO:0010563 267 0.024
regulation of cell development GO:0060284 161 0.024
sensory organ development GO:0007423 52 0.024
negative regulation of growth GO:0045926 97 0.024
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.023
Human
renal system process involved in regulation of blood volume GO:0001977 4 0.023
cell type specific apoptotic process GO:0097285 125 0.023
regulation of wnt signaling pathway GO:0030111 123 0.023
regulation of cell activation GO:0050865 125 0.023
protein import GO:0017038 130 0.023
protein localization to organelle GO:0033365 280 0.023
endothelial cell proliferation GO:0001935 65 0.023
leukocyte migration GO:0050900 107 0.023
cellular macromolecule catabolic process GO:0044265 380 0.023
Human
small molecule biosynthetic process GO:0044283 157 0.022
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.022
regulation of cell projection organization GO:0031344 107 0.022
regulation of nucleocytoplasmic transport GO:0046822 98 0.022
hindbrain development GO:0030902 3 0.022
regulation of intracellular transport GO:0032386 195 0.022
regulation of nervous system development GO:0051960 88 0.022
regulation of cell substrate adhesion GO:0010810 68 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.021
negative regulation of epithelial cell migration GO:0010633 38 0.021
innate immune response GO:0045087 178 0.021
response to biotic stimulus GO:0009607 276 0.021
Rat
tissue morphogenesis GO:0048729 96 0.021
organelle assembly GO:0070925 176 0.021
circadian behavior GO:0048512 2 0.021
cyclic nucleotide metabolic process GO:0009187 82 0.021
cellular lipid metabolic process GO:0044255 303 0.021
response to radiation GO:0009314 151 0.021
single organism carbohydrate metabolic process GO:0044723 193 0.021
negative regulation of secretion GO:0051048 58 0.020
regulation of cysteine type endopeptidase activity GO:2000116 127 0.020
Human Fly
signal transduction by phosphorylation GO:0023014 297 0.020
oxidation reduction process GO:0055114 396 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
regulation of intracellular protein transport GO:0033157 123 0.020
regulation of neuron differentiation GO:0045664 70 0.020
negative regulation of protein transport GO:0051224 75 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
protein oligomerization GO:0051259 173 0.020
regulation of axon guidance GO:1902667 3 0.020
response to external biotic stimulus GO:0043207 261 0.020
Rat
reactive oxygen species metabolic process GO:0072593 75 0.020
translation GO:0006412 132 0.020
regulation of protein catabolic process GO:0042176 155 0.020
negative regulation of vasculature development GO:1901343 43 0.019
circulatory system process GO:0003013 113 0.019
regulation of immune response GO:0050776 201 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.019
negative regulation of cell cycle GO:0045786 193 0.019
monosaccharide metabolic process GO:0005996 74 0.019
negative regulation of immune system process GO:0002683 136 0.019
Rat
ossification GO:0001503 121 0.019
negative regulation of protein activation cascade GO:2000258 7 0.019
regulation of axon extension involved in axon guidance GO:0048841 2 0.019
cell fate determination GO:0001709 3 0.019
reactive oxygen species biosynthetic process GO:1903409 4 0.019
motor neuron axon guidance GO:0008045 2 0.018
actin filament based process GO:0030029 224 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
Human
activation of protein kinase activity GO:0032147 90 0.018
regulation of cellular component biogenesis GO:0044087 281 0.018
synaptic transmission cholinergic GO:0007271 2 0.018
cellular response to dna damage stimulus GO:0006974 379 0.018
Human
mesenchymal cell differentiation GO:0048762 52 0.018
unsaturated fatty acid metabolic process GO:0033559 37 0.018
response to axon injury GO:0048678 1 0.018
regulation of anatomical structure size GO:0090066 101 0.018
defense response GO:0006952 315 0.018
Rat
cell projection assembly GO:0030031 126 0.018
anterior posterior axis specification GO:0009948 2 0.018
cell part morphogenesis GO:0032990 137 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
reproductive process GO:0022414 106 0.018
Fly
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.017
Mouse
glycoprotein metabolic process GO:0009100 110 0.017
leukocyte chemotaxis GO:0030595 76 0.017
cellular protein catabolic process GO:0044257 261 0.017
Human
monocarboxylic acid biosynthetic process GO:0072330 67 0.017
nucleoside phosphate biosynthetic process GO:1901293 109 0.017
neuron development GO:0048666 113 0.017
actin filament based movement GO:0030048 17 0.017
positive regulation of cellular component biogenesis GO:0044089 158 0.017
regulation of cellular response to stress GO:0080135 244 0.017
forebrain generation of neurons GO:0021872 3 0.017
lipid localization GO:0010876 106 0.017
protein ubiquitination GO:0016567 314 0.017
purine nucleotide biosynthetic process GO:0006164 84 0.017
sulfur compound metabolic process GO:0006790 101 0.017
protein targeting to nucleus GO:0044744 104 0.016
urogenital system development GO:0001655 65 0.016
retina vasculature development in camera type eye GO:0061298 3 0.016
protein o linked glycosylation via serine GO:0018242 3 0.016
positive regulation of secretion by cell GO:1903532 108 0.016
response to steroid hormone GO:0048545 80 0.016
positive regulation of mapk cascade GO:0043410 190 0.016
regulation of defense response GO:0031347 154 0.016
Rat
carbohydrate metabolic process GO:0005975 207 0.016
tissue migration GO:0090130 119 0.016
establishment of protein localization to plasma membrane GO:0090002 68 0.016
canonical wnt signaling pathway GO:0060070 116 0.016
epithelial cell proliferation GO:0050673 128 0.016
Rat
rhythmic behavior GO:0007622 2 0.016
morphogenesis of a polarized epithelium GO:0001738 3 0.016
cerebellum development GO:0021549 2 0.016
positive regulation of cytokine production GO:0001819 167 0.016
purine ribonucleotide catabolic process GO:0009154 404 0.016
cellular response to nitrogen compound GO:1901699 144 0.016
positive regulation of cell development GO:0010720 92 0.016
digestive tract morphogenesis GO:0048546 56 0.015
apoptotic signaling pathway GO:0097190 268 0.015
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
negative regulation of response to external stimulus GO:0032102 83 0.015
Rat
peptidyl tyrosine modification GO:0018212 170 0.015
regulation of hemostasis GO:1900046 42 0.015
response to other organism GO:0051707 261 0.015
Rat
negative regulation of neuron differentiation GO:0045665 21 0.015
nucleotide biosynthetic process GO:0009165 109 0.015
mitotic cell cycle process GO:1903047 286 0.015
ribonucleotide biosynthetic process GO:0009260 81 0.015
regulation of cell cycle process GO:0010564 266 0.015
regulation of protein targeting GO:1903533 91 0.015
tissue regeneration GO:0042246 3 0.015
positive regulation of stem cell differentiation GO:2000738 29 0.015
regulation of innate immune response GO:0045088 97 0.015
response to purine containing compound GO:0014074 40 0.015
regulation of cytokine production GO:0001817 232 0.015
establishment of protein localization to membrane GO:0090150 121 0.015
glycoprotein biosynthetic process GO:0009101 91 0.015
neuron projection regeneration GO:0031102 1 0.015
epidermis morphogenesis GO:0048730 3 0.015
prostate gland development GO:0030850 3 0.015
patterning of blood vessels GO:0001569 2 0.015
regulation of wound healing GO:0061041 56 0.015
organophosphate catabolic process GO:0046434 430 0.015
organ morphogenesis GO:0009887 147 0.015
Rat
endomembrane system organization GO:0010256 196 0.015
negative regulation of trophoblast cell migration GO:1901164 3 0.015
positive regulation of lymphocyte activation GO:0051251 73 0.015
locomotory behavior GO:0007626 1 0.014
zymogen activation GO:0031638 70 0.014
positive regulation of protein transport GO:0051222 135 0.014
peripheral nervous system development GO:0007422 2 0.014
regulation of blood pressure GO:0008217 30 0.014
photoreceptor cell differentiation GO:0046530 2 0.014
purine nucleoside catabolic process GO:0006152 398 0.014
regulation of leukocyte activation GO:0002694 115 0.014
mitotic cell cycle GO:0000278 326 0.014
compound eye development GO:0048749 1 0.014
positive regulation of cell activation GO:0050867 81 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.014
peptidyl serine modification GO:0018209 106 0.014
positive regulation of immune response GO:0050778 159 0.014
actin mediated cell contraction GO:0070252 12 0.014
purine nucleoside triphosphate metabolic process GO:0009144 412 0.014
regulation of complement activation lectin pathway GO:0001868 2 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
aging GO:0007568 66 0.014
nuclear import GO:0051170 106 0.014
purine nucleotide catabolic process GO:0006195 405 0.014
lipid biosynthetic process GO:0008610 177 0.014
osteoblast differentiation GO:0001649 92 0.014
rho protein signal transduction GO:0007266 26 0.014
positive regulation of catabolic process GO:0009896 310 0.014
response to acid chemical GO:0001101 66 0.014
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.014
protein modification by small protein conjugation GO:0032446 342 0.014
regulation of protein localization to nucleus GO:1900180 85 0.014
regulation of neurogenesis GO:0050767 82 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
single organism nuclear import GO:1902593 104 0.013
viral process GO:0016032 146 0.013
neural crest cell migration GO:0001755 2 0.013
response to hypoxia GO:0001666 96 0.013
muscle cell differentiation GO:0042692 63 0.013
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.013
spermatid differentiation GO:0048515 4 0.013
ribonucleoside triphosphate metabolic process GO:0009199 412 0.013
response to bacterium GO:0009617 144 0.013
mesenchymal cell development GO:0014031 50 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.013
positive regulation of leukocyte activation GO:0002696 80 0.013
regulation of reactive oxygen species metabolic process GO:2000377 41 0.013
activation of immune response GO:0002253 114 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
regulation of protein import into nucleus GO:0042306 78 0.013
negative regulation of insulin like growth factor receptor signaling pathway GO:0043569 4 0.013
cellular response to abiotic stimulus GO:0071214 117 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
regulation of ras protein signal transduction GO:0046578 155 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
interspecies interaction between organisms GO:0044419 156 0.013
regulation of vasculogenesis GO:2001212 3 0.013
response to organic cyclic compound GO:0014070 204 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
nucleoside phosphate catabolic process GO:1901292 412 0.013
protein localization to nucleus GO:0034504 136 0.013
kidney development GO:0001822 53 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
embryonic camera type eye morphogenesis GO:0048596 2 0.013
endoderm formation GO:0001706 33 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
leukocyte activation GO:0045321 164 0.013
positive regulation of organelle organization GO:0010638 195 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
negative regulation of interleukin 1 secretion GO:0050711 4 0.013
collagen metabolic process GO:0032963 28 0.013
response to inorganic substance GO:0010035 127 0.013
cell cell signaling GO:0007267 155 0.013
retinal ganglion cell axon guidance GO:0031290 2 0.013
cellular response to hormone stimulus GO:0032870 125 0.013
negative regulation of apoptotic signaling pathway GO:2001234 97 0.013
limbic system development GO:0021761 3 0.013
maintenance of location GO:0051235 112 0.013
embryonic morphogenesis GO:0048598 85 0.013
connective tissue development GO:0061448 39 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
inner ear morphogenesis GO:0042472 4 0.012
cell activation GO:0001775 213 0.012
regulation of cell cycle GO:0051726 393 0.012
tripartite regional subdivision GO:0007351 2 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.012
neural crest cell development GO:0014032 3 0.012
behavior GO:0007610 112 0.012
protein localization to plasma membrane GO:0072659 93 0.012
purine containing compound biosynthetic process GO:0072522 88 0.012
cellular amide metabolic process GO:0043603 69 0.012
purine containing compound catabolic process GO:0072523 411 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
vasodilation GO:0042311 4 0.012
heart development GO:0007507 95 0.012
signal transduction by p53 class mediator GO:0072331 72 0.012
myoblast fusion GO:0007520 1 0.012
hexose metabolic process GO:0019318 55 0.012
positive regulation of endothelial cell migration GO:0010595 39 0.012
nitrogen compound transport GO:0071705 191 0.012
regulation of neural precursor cell proliferation GO:2000177 4 0.012
fatty acid metabolic process GO:0006631 115 0.012
response to light stimulus GO:0009416 87 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
metencephalon development GO:0022037 2 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.012
Mouse
cytokine mediated signaling pathway GO:0019221 109 0.012
muscle cell development GO:0055001 29 0.012
central nervous system development GO:0007417 123 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
Human
nucleotide catabolic process GO:0009166 408 0.012
regulation of cartilage development GO:0061035 12 0.012
ribonucleotide catabolic process GO:0009261 405 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
oocyte development GO:0048599 1 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
regulation of protein stability GO:0031647 87 0.012
determination of dorsal ventral asymmetry GO:0048262 4 0.011
protein import into nucleus GO:0006606 104 0.011
morphogenesis of an epithelium GO:0002009 60 0.011
oocyte differentiation GO:0009994 2 0.011
integrin mediated signaling pathway GO:0007229 32 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
regulation of epithelial cell proliferation GO:0050678 113 0.011
Rat
negative regulation of protein kinase activity GO:0006469 98 0.011
head development GO:0060322 108 0.011
regulation of neuron projection development GO:0010975 57 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
positive regulation of nervous system development GO:0051962 54 0.011
inflammatory response GO:0006954 79 0.011
negative regulation of angiogenesis GO:0016525 39 0.011
gastrulation GO:0007369 51 0.011
response to organophosphorus GO:0046683 41 0.011
response to growth factor GO:0070848 205 0.011
Human Zebrafish Mouse

HTRA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.068
nervous system disease DOID:863 431 0.068
eye and adnexa disease DOID:1492 150 0.064
eye disease DOID:5614 149 0.064
musculoskeletal system disease DOID:17 223 0.053
immune system disease DOID:2914 155 0.046
disease of metabolism DOID:0014667 295 0.033
inherited metabolic disorder DOID:655 242 0.033
connective tissue disease DOID:65 109 0.032
retinal disease DOID:5679 118 0.027
bone development disease DOID:0080006 55 0.024
bone disease DOID:0080001 88 0.024
central nervous system disease DOID:331 186 0.023
Human
retinal degeneration DOID:8466 89 0.013
vascular disease DOID:178 25 0.013
cardiovascular system disease DOID:1287 106 0.013
disease of mental health DOID:150 70 0.012
neurodegenerative disease DOID:1289 102 0.012
Human
osteochondrodysplasia DOID:2256 35 0.011