Homo sapiens

124 known processes

HTRA2

HtrA serine peptidase 2

(Aliases: PRSS25,OMI,PARK13)

HTRA2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein catabolic process GO:0030163 325 0.170
protein modification by small protein conjugation GO:0032446 342 0.165
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.132
protein ubiquitination GO:0016567 314 0.128
negative regulation of cell death GO:0060548 345 0.124
Rat
positive regulation of apoptotic process GO:0043065 246 0.116
negative regulation of programmed cell death GO:0043069 321 0.115
positive regulation of cell death GO:0010942 263 0.109
negative regulation of cellular protein metabolic process GO:0032269 353 0.107
negative regulation of protein metabolic process GO:0051248 391 0.098
cellular response to dna damage stimulus GO:0006974 379 0.096
negative regulation of intracellular signal transduction GO:1902532 183 0.094
modification dependent protein catabolic process GO:0019941 209 0.092
negative regulation of apoptotic process GO:0043066 316 0.091
cellular protein catabolic process GO:0044257 261 0.088
protein processing GO:0016485 226 0.083
protein maturation GO:0051604 233 0.080
negative regulation of proteolysis GO:0045861 132 0.078
cellular amino acid metabolic process GO:0006520 116 0.075
response to abiotic stimulus GO:0009628 336 0.075
negative regulation of protein maturation GO:1903318 142 0.072
regulation of protein maturation GO:1903317 150 0.071
negative regulation of protein processing GO:0010955 142 0.071
regulation of cell differentiation GO:0045595 393 0.063
positive regulation of cellular amine metabolic process GO:0033240 7 0.062
positive regulation of programmed cell death GO:0043068 249 0.059
regulation of proteolysis GO:0030162 293 0.058
negative regulation of developmental process GO:0051093 247 0.058
negative regulation of catalytic activity GO:0043086 335 0.057
regulation of cellular amine metabolic process GO:0033238 11 0.055
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.055
regulation of cellular ketone metabolic process GO:0010565 50 0.049
small gtpase mediated signal transduction GO:0007264 78 0.049
regulation of cellular response to stress GO:0080135 244 0.049
regulation of transferase activity GO:0051338 355 0.048
cellular amine metabolic process GO:0044106 41 0.047
response to oxygen containing compound GO:1901700 369 0.047
positive regulation of transferase activity GO:0051347 227 0.047
ubiquitin dependent protein catabolic process GO:0006511 206 0.044
response to cytokine GO:0034097 232 0.044
response to light stimulus GO:0009416 87 0.044
positive regulation of response to dna damage stimulus GO:2001022 43 0.042
response to radiation GO:0009314 151 0.042
amine metabolic process GO:0009308 44 0.042
negative regulation of apoptotic signaling pathway GO:2001234 97 0.040
positive regulation of developmental process GO:0051094 314 0.040
cellular response to cytokine stimulus GO:0071345 181 0.037
regulation of protein catabolic process GO:0042176 155 0.037
i kappab kinase nf kappab signaling GO:0007249 166 0.037
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.037
regulation of protein processing GO:0070613 150 0.036
positive regulation of cell differentiation GO:0045597 211 0.036
regulation of cellular amino acid metabolic process GO:0006521 6 0.035
regulation of cell cycle process GO:0010564 266 0.034
dna repair GO:0006281 198 0.034
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.033
regulation of dna metabolic process GO:0051052 153 0.032
cellular ketone metabolic process GO:0042180 80 0.032
cellular response to endogenous stimulus GO:0071495 336 0.032
apoptotic signaling pathway GO:0097190 268 0.031
immune response GO:0006955 307 0.031
post embryonic development GO:0009791 2 0.030
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.030
protein oligomerization GO:0051259 173 0.029
modification dependent macromolecule catabolic process GO:0043632 212 0.029
system process GO:0003008 349 0.028
locomotory behavior GO:0007626 1 0.028
Mouse
protein homooligomerization GO:0051260 100 0.028
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.027
positive regulation of immune system process GO:0002684 283 0.027
establishment of protein localization to organelle GO:0072594 172 0.027
positive regulation of protein phosphorylation GO:0001934 313 0.027
defense response GO:0006952 315 0.027
multicellular organismal aging GO:0010259 3 0.027
regulation of cysteine type endopeptidase activity GO:2000116 127 0.027
pharynx development GO:0060465 1 0.026
cell cycle arrest GO:0007050 71 0.026
cellular response to lipid GO:0071396 127 0.025
hemopoiesis GO:0030097 180 0.025
regulation of cellular protein catabolic process GO:1903362 96 0.025
epithelium development GO:0060429 227 0.025
response to uv GO:0009411 73 0.025
ras protein signal transduction GO:0007265 73 0.024
proteasomal protein catabolic process GO:0010498 176 0.024
oogenesis GO:0048477 2 0.024
dna demethylation GO:0080111 12 0.023
coenzyme metabolic process GO:0006732 65 0.023
positive regulation of cell cycle process GO:0090068 106 0.023
monocarboxylic acid metabolic process GO:0032787 185 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.023
regulation of protein ubiquitination GO:0031396 95 0.023
oocyte development GO:0048599 1 0.023
nervous system development GO:0007399 293 0.022
Mouse
response to biotic stimulus GO:0009607 276 0.022
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.022
regulation of peptidase activity GO:0052547 180 0.022
regulation of response to dna damage stimulus GO:2001020 94 0.022
positive regulation of apoptotic signaling pathway GO:2001235 70 0.022
cell division GO:0051301 168 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
negative regulation of cellular catabolic process GO:0031330 83 0.022
protein acetylation GO:0006473 116 0.022
chromatin modification GO:0016568 298 0.022
negative regulation of catabolic process GO:0009895 104 0.022
intracellular protein transport GO:0006886 270 0.021
positive regulation of cell cycle GO:0045787 140 0.021
positive regulation of protein ubiquitination GO:0031398 53 0.021
regulation of leukocyte activation GO:0002694 115 0.021
cellular response to growth factor stimulus GO:0071363 197 0.021
extrinsic apoptotic signaling pathway GO:0097191 119 0.021
positive regulation of hydrolase activity GO:0051345 331 0.021
cellular lipid metabolic process GO:0044255 303 0.021
Rat
growth GO:0040007 202 0.021
Mouse
immune effector process GO:0002252 159 0.020
intrinsic apoptotic signaling pathway GO:0097193 127 0.020
cell growth GO:0016049 160 0.020
regulation of cell cycle GO:0051726 393 0.020
negative regulation of protein modification process GO:0031400 200 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.020
regulation of leukocyte differentiation GO:1902105 61 0.020
neurogenesis GO:0022008 169 0.020
Mouse
protein polyubiquitination GO:0000209 110 0.020
demethylation GO:0070988 37 0.020
regulation of protein kinase activity GO:0045859 289 0.020
protein acylation GO:0043543 138 0.020
response to inorganic substance GO:0010035 127 0.020
positive regulation of myeloid cell differentiation GO:0045639 39 0.019
regulation of kinase activity GO:0043549 314 0.019
protein localization to organelle GO:0033365 280 0.019
determination of adult lifespan GO:0008340 2 0.019
negative regulation of peptidase activity GO:0010466 91 0.019
positive regulation of phosphorylation GO:0042327 394 0.019
dephosphorylation GO:0016311 209 0.018
regulation of transcription during mitosis GO:0045896 2 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.018
transmembrane transport GO:0055085 399 0.018
regulation of viral process GO:0050792 103 0.018
methylation GO:0032259 106 0.018
covalent chromatin modification GO:0016569 254 0.018
actin mediated cell contraction GO:0070252 12 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
secretion by cell GO:0032940 226 0.018
sulfur compound metabolic process GO:0006790 101 0.018
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.017
negative regulation of cell cycle GO:0045786 193 0.017
positive regulation of binding GO:0051099 45 0.017
positive regulation of organelle organization GO:0010638 195 0.017
positive regulation of cytokine production GO:0001819 167 0.017
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.017
female gamete generation GO:0007292 2 0.017
neurological system process GO:0050877 163 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.017
cranial nerve development GO:0021545 4 0.016
protein polymerization GO:0051258 71 0.016
innate immune response GO:0045087 178 0.016
cellular response to abiotic stimulus GO:0071214 117 0.016
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.016
urogenital system development GO:0001655 65 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
organophosphate catabolic process GO:0046434 430 0.016
response to wounding GO:0009611 168 0.016
response to metal ion GO:0010038 84 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
response to organic cyclic compound GO:0014070 204 0.016
atp metabolic process GO:0046034 176 0.016
cellular protein complex assembly GO:0043623 188 0.016
protein autophosphorylation GO:0046777 123 0.016
regulation of binding GO:0051098 111 0.016
response to other organism GO:0051707 261 0.016
histone modification GO:0016570 251 0.016
negative regulation of cell differentiation GO:0045596 171 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.015
cell cycle phase transition GO:0044770 173 0.015
cell cycle checkpoint GO:0000075 117 0.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.015
dna integrity checkpoint GO:0031570 71 0.015
macromolecule methylation GO:0043414 97 0.015
response to growth factor GO:0070848 205 0.015
cofactor metabolic process GO:0051186 87 0.015
peptidyl serine phosphorylation GO:0018105 101 0.015
response to lipid GO:0033993 206 0.015
negative regulation of hydrolase activity GO:0051346 182 0.015
apoptotic mitochondrial changes GO:0008637 57 0.015
cellular response to external stimulus GO:0071496 111 0.015
regulation of proteasomal protein catabolic process GO:0061136 87 0.015
response to nitric oxide GO:0071731 4 0.015
peptidyl serine modification GO:0018209 106 0.015
negative regulation of endopeptidase activity GO:0010951 84 0.015
hematopoietic or lymphoid organ development GO:0048534 186 0.014
positive regulation of leukocyte differentiation GO:1902107 37 0.014
organelle fission GO:0048285 149 0.014
response to virus GO:0009615 126 0.014
regulation of protein transport GO:0051223 213 0.014
positive regulation of kinase activity GO:0033674 204 0.014
rho protein signal transduction GO:0007266 26 0.014
nerve development GO:0021675 4 0.014
maintenance of location GO:0051235 112 0.014
dna replication GO:0006260 116 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
nucleoside catabolic process GO:0009164 408 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
meiosis i GO:0007127 4 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
regulation of myeloid cell differentiation GO:0045637 81 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
cytoplasmic transport GO:0016482 379 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
regulation of protein localization GO:0032880 296 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
dna damage checkpoint GO:0000077 68 0.013
regulation of synaptic plasticity GO:0048167 3 0.013
regulation of protein complex assembly GO:0043254 147 0.013
protein import GO:0017038 130 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
regulation of response to external stimulus GO:0032101 222 0.013
chromatin organization GO:0006325 351 0.013
ribonucleoside triphosphate catabolic process GO:0009203 391 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
cell morphogenesis GO:0000902 296 0.013
peptidyl tyrosine phosphorylation GO:0018108 170 0.013
regulation of multi organism process GO:0043900 157 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
regulation of immune response GO:0050776 201 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
cell aging GO:0007569 52 0.012
hindbrain development GO:0030902 3 0.012
response to external biotic stimulus GO:0043207 261 0.012
negative regulation of protein catabolic process GO:0042177 59 0.012
regulation of canonical wnt signaling pathway GO:0060828 88 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
single organism membrane organization GO:0044802 268 0.012
rna splicing GO:0008380 131 0.012
regulation of chromosome organization GO:0033044 103 0.012
lipid metabolic process GO:0006629 381 0.012
Rat
secretion GO:0046903 254 0.012
mitotic cell cycle GO:0000278 326 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
regulation of secretion by cell GO:1903530 177 0.012
myeloid cell differentiation GO:0030099 117 0.012
positive regulation of transport GO:0051050 336 0.012
anatomical structure homeostasis GO:0060249 100 0.012
segmentation GO:0035282 4 0.012
negative regulation of multi organism process GO:0043901 92 0.012
nucleoside phosphate catabolic process GO:1901292 412 0.012
purine nucleoside catabolic process GO:0006152 398 0.012
fatty acid metabolic process GO:0006631 115 0.012
purine containing compound catabolic process GO:0072523 411 0.011
actin filament based movement GO:0030048 17 0.011
cranial nerve morphogenesis GO:0021602 1 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
protein localization to nucleus GO:0034504 136 0.011
viral process GO:0016032 146 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
immune system development GO:0002520 195 0.011
positive regulation of dna metabolic process GO:0051054 73 0.011
regulation of secretion GO:0051046 194 0.011
negative regulation of dna metabolic process GO:0051053 57 0.011
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.011
interspecies interaction between organisms GO:0044419 156 0.011
response to lipopolysaccharide GO:0032496 70 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
optic nerve development GO:0021554 2 0.011
viral life cycle GO:0019058 132 0.011
leukocyte differentiation GO:0002521 98 0.011
compound eye development GO:0048749 1 0.011
associative learning GO:0008306 1 0.011
defense response to other organism GO:0098542 129 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.011
multi organism cellular process GO:0044764 156 0.011
positive regulation of catabolic process GO:0009896 310 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.011
ion transmembrane transport GO:0034220 338 0.011
endosomal transport GO:0016197 129 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
viral release from host cell GO:0019076 21 0.010
axis elongation GO:0003401 4 0.010
positive regulation of immune response GO:0050778 159 0.010
regulation of ras protein signal transduction GO:0046578 155 0.010
cell part morphogenesis GO:0032990 137 0.010
negative regulation of cellular protein catabolic process GO:1903363 38 0.010
cellular homeostasis GO:0019725 196 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
neuromuscular junction development GO:0007528 3 0.010
single organismal cell cell adhesion GO:0016337 148 0.010

HTRA2 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.026
nervous system disease DOID:863 431 0.026
cancer DOID:162 167 0.016
disease of cellular proliferation DOID:14566 174 0.016
organ system cancer DOID:0050686 164 0.016
sensory system disease DOID:0050155 203 0.014
Human
neurodegenerative disease DOID:1289 102 0.014
musculoskeletal system disease DOID:17 223 0.013
disease of metabolism DOID:0014667 295 0.012
parkinson s disease DOID:14330 18 0.005
synucleinopathy DOID:0050890 22 0.005