Homo sapiens

0 known processes

MTHFD1

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

(Aliases: MTHFC,MTHFD)

MTHFD1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.534
sensory perception of pain GO:0019233 4 0.470
cellular response to uv GO:0034644 32 0.324
oogenesis GO:0048477 2 0.243
hormone catabolic process GO:0042447 4 0.219
response to cytokine GO:0034097 232 0.161
regulation of hormone levels GO:0010817 125 0.138
cellular response to cytokine stimulus GO:0071345 181 0.132
embryo development GO:0009790 123 0.110
dna replication GO:0006260 116 0.110
response to abiotic stimulus GO:0009628 336 0.106
ras protein signal transduction GO:0007265 73 0.102
mitotic cell cycle process GO:1903047 286 0.100
protein processing GO:0016485 226 0.099
dna dependent dna replication GO:0006261 44 0.099
rna processing GO:0006396 255 0.097
positive regulation of cell proliferation GO:0008284 301 0.088
organonitrogen compound biosynthetic process GO:1901566 200 0.086
g1 s transition of mitotic cell cycle GO:0000082 78 0.084
circulatory system process GO:0003013 113 0.084
lipid metabolic process GO:0006629 381 0.081
mitotic cell cycle phase transition GO:0044772 162 0.079
regulation of meiotic cell cycle GO:0051445 4 0.076
nucleoside phosphate biosynthetic process GO:1901293 109 0.073
hormone metabolic process GO:0042445 61 0.071
response to uv GO:0009411 73 0.070
mitotic cell cycle GO:0000278 326 0.068
response to oxygen containing compound GO:1901700 369 0.066
negative regulation of mitotic cell cycle GO:0045930 102 0.065
endocrine process GO:0050886 25 0.065
positive regulation of meiotic cell cycle GO:0051446 2 0.065
renal system development GO:0072001 63 0.064
response to decreased oxygen levels GO:0036293 96 0.064
ribonucleoside triphosphate metabolic process GO:0009199 412 0.062
small molecule biosynthetic process GO:0044283 157 0.061
determination of adult lifespan GO:0008340 2 0.059
organic acid biosynthetic process GO:0016053 97 0.058
protein catabolic process GO:0030163 325 0.058
oocyte maturation GO:0001556 1 0.057
protein maturation GO:0051604 233 0.056
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 12 0.056
small gtpase mediated signal transduction GO:0007264 78 0.056
cell morphogenesis GO:0000902 296 0.054
carboxylic acid biosynthetic process GO:0046394 97 0.053
circulatory system development GO:0072359 262 0.053
receptor metabolic process GO:0043112 81 0.052
purine containing compound biosynthetic process GO:0072522 88 0.051
response to light stimulus GO:0009416 87 0.050
regeneration GO:0031099 4 0.049
organophosphate biosynthetic process GO:0090407 163 0.048
cellular response to light stimulus GO:0071482 34 0.048
purine ribonucleoside metabolic process GO:0046128 437 0.047
regulation of mitotic cell cycle GO:0007346 189 0.045
cellular hormone metabolic process GO:0034754 41 0.045
covalent chromatin modification GO:0016569 254 0.044
neurological system process GO:0050877 163 0.044
nucleotide biosynthetic process GO:0009165 109 0.042
cellular response to oxygen containing compound GO:1901701 276 0.040
response to radiation GO:0009314 151 0.040
peripheral nervous system development GO:0007422 2 0.040
cell fate determination GO:0001709 3 0.040
hematopoietic or lymphoid organ development GO:0048534 186 0.040
carbohydrate derivative biosynthetic process GO:1901137 207 0.040
female gamete generation GO:0007292 2 0.039
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.039
system process GO:0003008 349 0.038
cellular lipid metabolic process GO:0044255 303 0.038
oocyte development GO:0048599 1 0.038
nervous system development GO:0007399 293 0.037
vesicle mediated transport GO:0016192 371 0.037
sensory perception GO:0007600 103 0.037
response to hypoxia GO:0001666 96 0.037
negative regulation of cell cycle phase transition GO:1901988 89 0.037
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.036
negative regulation of cell cycle GO:0045786 193 0.036
regulation of protein kinase activity GO:0045859 289 0.036
cellular amino acid metabolic process GO:0006520 116 0.036
Human
endocytosis GO:0006897 159 0.035
cellular response to radiation GO:0071478 65 0.035
negative regulation of programmed cell death GO:0043069 321 0.035
brain development GO:0007420 97 0.035
lipid biosynthetic process GO:0008610 177 0.034
oxidation reduction process GO:0055114 396 0.034
positive regulation of immune system process GO:0002684 283 0.033
generation of neurons GO:0048699 152 0.032
cell cycle g1 s phase transition GO:0044843 80 0.032
cell cycle checkpoint GO:0000075 117 0.032
mononuclear cell proliferation GO:0032943 71 0.031
multicellular organismal aging GO:0010259 3 0.031
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.031
nucleoside monophosphate metabolic process GO:0009123 191 0.031
regulation of cell cycle phase transition GO:1901987 126 0.031
growth GO:0040007 202 0.030
lymphocyte activation GO:0046649 133 0.030
cardiovascular system development GO:0072358 262 0.030
immune system development GO:0002520 195 0.030
cell cycle phase transition GO:0044770 173 0.030
chemical homeostasis GO:0048878 306 0.029
ribonucleoside monophosphate metabolic process GO:0009161 187 0.029
small molecule catabolic process GO:0044282 92 0.029
negative regulation of cell cycle process GO:0010948 121 0.029
ribose phosphate biosynthetic process GO:0046390 82 0.028
cell aging GO:0007569 52 0.028
cellular response to abiotic stimulus GO:0071214 117 0.028
cellular lipid catabolic process GO:0044242 65 0.028
peptide metabolic process GO:0006518 51 0.028
cellular component morphogenesis GO:0032989 314 0.028
microtubule based process GO:0007017 210 0.028
calcitonin catabolic process GO:0010816 1 0.027
response to organonitrogen compound GO:0010243 156 0.027
leukocyte activation GO:0045321 164 0.027
cell projection organization GO:0030030 252 0.027
regulation of dna replication GO:0006275 68 0.026
monovalent inorganic cation transport GO:0015672 128 0.026
receptor mediated endocytosis GO:0006898 84 0.026
regulation of ras protein signal transduction GO:0046578 155 0.026
chromatin modification GO:0016568 298 0.026
head development GO:0060322 108 0.025
purine nucleotide biosynthetic process GO:0006164 84 0.025
mitotic cell cycle checkpoint GO:0007093 68 0.025
mitochondrion organization GO:0007005 156 0.025
t cell activation GO:0042110 99 0.025
amine metabolic process GO:0009308 44 0.025
embryo development ending in birth or egg hatching GO:0009792 34 0.025
regulation of kinase activity GO:0043549 314 0.024
cellular response to oxidative stress GO:0034599 85 0.024
cation transport GO:0006812 331 0.024
neuropeptide catabolic process GO:0010813 2 0.023
mitotic nuclear division GO:0007067 119 0.023
regulation of cellular amine metabolic process GO:0033238 11 0.023
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.023
meiosis i GO:0007127 4 0.023
cell adhesion GO:0007155 325 0.023
inorganic ion transmembrane transport GO:0098660 231 0.022
lymphocyte proliferation GO:0046651 70 0.022
histone modification GO:0016570 251 0.022
substance p catabolic process GO:0010814 1 0.022
cellular response to dna damage stimulus GO:0006974 379 0.022
oocyte differentiation GO:0009994 2 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.022
regulation of proteolysis GO:0030162 293 0.021
metencephalon development GO:0022037 2 0.021
regulation of transferase activity GO:0051338 355 0.021
segmentation GO:0035282 4 0.021
negative regulation of cell proliferation GO:0008285 228 0.021
neurogenesis GO:0022008 169 0.021
multicellular organismal homeostasis GO:0048871 67 0.021
cellular chemical homeostasis GO:0055082 180 0.021
cell type specific apoptotic process GO:0097285 125 0.021
response to hormone GO:0009725 175 0.021
blood circulation GO:0008015 113 0.021
reproduction GO:0000003 63 0.021
aging GO:0007568 66 0.021
glycosyl compound catabolic process GO:1901658 413 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
spindle organization GO:0007051 53 0.020
regulation of cell differentiation GO:0045595 393 0.020
regulation of binding GO:0051098 111 0.020
response to other organism GO:0051707 261 0.020
response to oxidative stress GO:0006979 121 0.020
regulation of feeding behavior GO:0060259 3 0.020
lipid localization GO:0010876 106 0.020
ncrna processing GO:0034470 83 0.020
reproductive structure development GO:0048608 55 0.020
kidney development GO:0001822 53 0.019
regulation of microtubule based process GO:0032886 74 0.019
mitotic spindle elongation GO:0000022 4 0.019
monocarboxylic acid metabolic process GO:0032787 185 0.019
Human
mitochondrial membrane organization GO:0007006 40 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
skin development GO:0043588 76 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.018
response to extracellular stimulus GO:0009991 85 0.018
hindbrain development GO:0030902 3 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.018
lymphocyte homeostasis GO:0002260 4 0.018
regulation of protein localization GO:0032880 296 0.018
cerebellum development GO:0021549 2 0.018
negative regulation of cell death GO:0060548 345 0.018
tube development GO:0035295 125 0.018
glycerophospholipid metabolic process GO:0006650 84 0.018
lipid catabolic process GO:0016042 84 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
cell projection morphogenesis GO:0048858 129 0.018
cell part morphogenesis GO:0032990 137 0.018
protein folding GO:0006457 38 0.018
atp metabolic process GO:0046034 176 0.018
cellular amide metabolic process GO:0043603 69 0.018
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.017
single organism carbohydrate metabolic process GO:0044723 193 0.017
heart development GO:0007507 95 0.017
multi organism reproductive process GO:0044703 54 0.017
cell projection assembly GO:0030031 126 0.017
modification dependent protein catabolic process GO:0019941 209 0.017
developmental process involved in reproduction GO:0003006 66 0.017
cell development GO:0048468 328 0.017
regulation of mitotic cell cycle phase transition GO:1901990 118 0.017
positive regulation of developmental process GO:0051094 314 0.017
regulation of cell morphogenesis GO:0022604 153 0.017
ion homeostasis GO:0050801 230 0.017
positive regulation of organelle organization GO:0010638 195 0.016
negative regulation of cellular protein metabolic process GO:0032269 353 0.016
positive regulation of proteolysis GO:0045862 142 0.016
purine containing compound catabolic process GO:0072523 411 0.016
negative regulation of catalytic activity GO:0043086 335 0.016
glycerolipid metabolic process GO:0046486 107 0.016
dicarboxylic acid metabolic process GO:0043648 29 0.016
positive regulation of dna replication GO:0045740 35 0.016
positive regulation of immune response GO:0050778 159 0.016
regulation of cell cycle GO:0051726 393 0.016
response to endoplasmic reticulum stress GO:0034976 49 0.016
cell cell signaling GO:0007267 155 0.016
regulation of cell cycle process GO:0010564 266 0.015
response to lipid GO:0033993 206 0.015
response to uv b GO:0010224 10 0.015
response to nitrogen compound GO:1901698 184 0.015
immune response GO:0006955 307 0.015
ribonucleotide biosynthetic process GO:0009260 81 0.015
cellular amine metabolic process GO:0044106 41 0.015
carboxylic acid catabolic process GO:0046395 71 0.015
spermatid differentiation GO:0048515 4 0.015
cellular protein catabolic process GO:0044257 261 0.015
positive regulation of cellular component movement GO:0051272 181 0.015
peptidyl serine modification GO:0018209 106 0.015
tissue homeostasis GO:0001894 63 0.015
dna recombination GO:0006310 77 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
nuclear division GO:0000280 128 0.015
positive regulation of leukocyte activation GO:0002696 80 0.015
g2 dna damage checkpoint GO:0031572 26 0.015
calcium ion transport GO:0006816 147 0.015
blastoderm segmentation GO:0007350 2 0.014
regulation of small gtpase mediated signal transduction GO:0051056 156 0.014
intracellular mrna localization GO:0008298 1 0.014
t cell homeostasis GO:0043029 3 0.014
establishment of organelle localization GO:0051656 59 0.014
peptidyl tyrosine dephosphorylation GO:0035335 36 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
cell division GO:0051301 168 0.014
cellular response to hypoxia GO:0071456 51 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
reproductive process GO:0022414 106 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
protein ubiquitination GO:0016567 314 0.014
cellular ion homeostasis GO:0006873 168 0.014
central nervous system development GO:0007417 123 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.013
maintenance of location GO:0051235 112 0.013
phospholipid metabolic process GO:0006644 99 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
associative learning GO:0008306 1 0.013
regulation of cell cycle g1 s phase transition GO:1902806 42 0.013
cellular response to decreased oxygen levels GO:0036294 51 0.013
cellular cation homeostasis GO:0030003 163 0.013
dna conformation change GO:0071103 113 0.013
response to oxygen levels GO:0070482 100 0.013
leukocyte proliferation GO:0070661 74 0.013
ubiquitin dependent protein catabolic process GO:0006511 206 0.013
single organism cellular localization GO:1902580 332 0.013
jak stat cascade GO:0007259 46 0.013
protein oligomerization GO:0051259 173 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
regulation of cellular amino acid metabolic process GO:0006521 6 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
regulation of secretion GO:0051046 194 0.013
digestive tract development GO:0048565 75 0.013
response to peptide GO:1901652 65 0.013
cellular metal ion homeostasis GO:0006875 146 0.012
epithelial cell differentiation GO:0030855 141 0.012
negative regulation of organelle organization GO:0010639 126 0.012
regulation of reactive oxygen species metabolic process GO:2000377 41 0.012
cellular response to organic cyclic compound GO:0071407 127 0.012
response to inorganic substance GO:0010035 127 0.012
secretion by cell GO:0032940 226 0.012
erythrocyte development GO:0048821 3 0.012
sensory organ development GO:0007423 52 0.012
innate immune response GO:0045087 178 0.012
response to drug GO:0042493 81 0.012
metal ion transport GO:0030001 272 0.012
ncrna metabolic process GO:0034660 108 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
double strand break repair via homologous recombination GO:0000724 50 0.012
bradykinin catabolic process GO:0010815 4 0.012
ribonucleoprotein complex biogenesis GO:0022613 116 0.012
sleep GO:0030431 2 0.012
single organism cell adhesion GO:0098602 179 0.012
organelle localization GO:0051640 84 0.012
regulation of lipid catabolic process GO:0050994 23 0.012
wound healing GO:0042060 115 0.012
dna strand elongation involved in dna replication GO:0006271 3 0.012
positive regulation of cell cycle GO:0045787 140 0.011
apoptotic signaling pathway GO:0097190 268 0.011
cellular amino acid catabolic process GO:0009063 31 0.011
organic acid catabolic process GO:0016054 71 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
dephosphorylation GO:0016311 209 0.011
cellular amino acid biosynthetic process GO:0008652 30 0.011
regulation of chromosome organization GO:0033044 103 0.011
negative regulation of proteolysis GO:0045861 132 0.011
translation GO:0006412 132 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
histone methylation GO:0016571 60 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
regulation of protein catabolic process GO:0042176 155 0.011
positive regulation of cell death GO:0010942 263 0.011
cellular homeostasis GO:0019725 196 0.011
cell cycle arrest GO:0007050 71 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
neuron death GO:0070997 65 0.011
positive regulation of lipid metabolic process GO:0045834 50 0.011
regulation of dna metabolic process GO:0051052 153 0.011
activation of immune response GO:0002253 114 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
regulation of t cell activation GO:0050863 77 0.011
mitotic dna damage checkpoint GO:0044773 28 0.011
positive regulation of peptidase activity GO:0010952 88 0.011
cellular response to peptide hormone stimulus GO:0071375 56 0.011
dna damage checkpoint GO:0000077 68 0.010
tripartite regional subdivision GO:0007351 2 0.010
negative regulation of t cell apoptotic process GO:0070233 4 0.010
cellular response to oxygen levels GO:0071453 55 0.010
chromatin organization GO:0006325 351 0.010
regulation of lipid metabolic process GO:0019216 96 0.010
cation transmembrane transport GO:0098655 238 0.010
regulation of systemic arterial blood pressure GO:0003073 19 0.010
response to bacterium GO:0009617 144 0.010
leukocyte apoptotic process GO:0071887 31 0.010
nucleoside triphosphate metabolic process GO:0009141 422 0.010
negative regulation of kinase activity GO:0033673 106 0.010

MTHFD1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.116
inherited metabolic disorder DOID:655 242 0.116
disease of cellular proliferation DOID:14566 174 0.066
cancer DOID:162 167 0.053
organ system cancer DOID:0050686 164 0.053
amino acid metabolic disorder DOID:9252 50 0.034
sensory system disease DOID:0050155 203 0.027
nervous system disease DOID:863 431 0.027
auditory system disease DOID:2742 53 0.016
nonsyndromic deafness DOID:0050563 50 0.016