Homo sapiens

19 known processes

USP25

ubiquitin specific peptidase 25

(Aliases: USP21)

USP25 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein deubiquitination GO:0016579 79 0.657
locomotory behavior GO:0007626 1 0.229
cellular macromolecule catabolic process GO:0044265 380 0.201
protein modification by small protein removal GO:0070646 92 0.200
protein k63 linked deubiquitination GO:0070536 21 0.137
ras protein signal transduction GO:0007265 73 0.114
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.113
modification dependent macromolecule catabolic process GO:0043632 212 0.095
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.093
cellular response to endogenous stimulus GO:0071495 336 0.093
adult locomotory behavior GO:0008344 1 0.084
small gtpase mediated signal transduction GO:0007264 78 0.084
post embryonic development GO:0009791 2 0.082
modification dependent protein catabolic process GO:0019941 209 0.081
protein polyubiquitination GO:0000209 110 0.075
cytoplasmic transport GO:0016482 379 0.075
protein catabolic process GO:0030163 325 0.073
regulation of cellular component biogenesis GO:0044087 281 0.073
positive regulation of wnt signaling pathway GO:0030177 54 0.072
protein ubiquitination GO:0016567 314 0.068
cellular response to abiotic stimulus GO:0071214 117 0.067
Human
endomembrane system organization GO:0010256 196 0.065
regulation of cellular amine metabolic process GO:0033238 11 0.064
negative regulation of cellular protein metabolic process GO:0032269 353 0.062
protein modification by small protein conjugation GO:0032446 342 0.060
apoptotic signaling pathway GO:0097190 268 0.060
Human
memory GO:0007613 3 0.055
ubiquitin dependent protein catabolic process GO:0006511 206 0.055
protein k48 linked deubiquitination GO:0071108 19 0.054
intracellular protein transport GO:0006886 270 0.053
female gamete generation GO:0007292 2 0.051
nervous system development GO:0007399 293 0.049
cellular protein catabolic process GO:0044257 261 0.047
cellular response to growth factor stimulus GO:0071363 197 0.045
actin filament based process GO:0030029 224 0.045
posttranscriptional regulation of gene expression GO:0010608 213 0.044
cellular amino acid metabolic process GO:0006520 116 0.043
circadian behavior GO:0048512 2 0.043
peptidyl serine phosphorylation GO:0018105 101 0.042
rhythmic behavior GO:0007622 2 0.042
vesicle mediated transport GO:0016192 371 0.042
regulation of cell cycle GO:0051726 393 0.041
purine nucleoside triphosphate catabolic process GO:0009146 392 0.041
response to transforming growth factor beta GO:0071559 94 0.041
negative regulation of protein metabolic process GO:0051248 391 0.040
multicellular organismal aging GO:0010259 3 0.039
response to abiotic stimulus GO:0009628 336 0.039
Human
microtubule based process GO:0007017 210 0.039
proteasomal protein catabolic process GO:0010498 176 0.038
cytokinesis GO:0000910 96 0.037
negative regulation of catalytic activity GO:0043086 335 0.037
anion transport GO:0006820 161 0.037
single organism cellular localization GO:1902580 332 0.036
enzyme linked receptor protein signaling pathway GO:0007167 303 0.036
organic anion transport GO:0015711 103 0.035
lipid localization GO:0010876 106 0.035
chemical homeostasis GO:0048878 306 0.034
cellular response to radiation GO:0071478 65 0.034
Human
oogenesis GO:0048477 2 0.034
intrinsic apoptotic signaling pathway GO:0097193 127 0.034
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.033
regulation of protein stability GO:0031647 87 0.032
endosomal transport GO:0016197 129 0.032
metal ion homeostasis GO:0055065 169 0.032
immune response GO:0006955 307 0.032
carbohydrate metabolic process GO:0005975 207 0.031
response to uv GO:0009411 73 0.031
Human
regulation of synaptic plasticity GO:0048167 3 0.031
regulation of small gtpase mediated signal transduction GO:0051056 156 0.031
regulation of locomotion GO:0040012 329 0.030
behavior GO:0007610 112 0.030
peptidyl threonine modification GO:0018210 45 0.030
positive regulation of cellular amine metabolic process GO:0033240 7 0.030
positive regulation of cell differentiation GO:0045597 211 0.030
rho protein signal transduction GO:0007266 26 0.030
single organism membrane organization GO:0044802 268 0.030
synaptic vesicle recycling GO:0036465 3 0.029
positive regulation of organelle organization GO:0010638 195 0.029
cellular protein complex assembly GO:0043623 188 0.029
sleep GO:0030431 2 0.029
response to growth factor GO:0070848 205 0.029
amine metabolic process GO:0009308 44 0.029
positive regulation of catabolic process GO:0009896 310 0.028
regulation of protein complex assembly GO:0043254 147 0.028
cellular response to glucocorticoid stimulus GO:0071385 4 0.028
peptidyl threonine phosphorylation GO:0018107 41 0.027
wnt signaling pathway GO:0016055 156 0.027
protein glycosylation GO:0006486 62 0.027
nucleoside triphosphate metabolic process GO:0009141 422 0.027
cell morphogenesis GO:0000902 296 0.027
protein localization to organelle GO:0033365 280 0.026
synaptic vesicle endocytosis GO:0048488 2 0.026
response to ionizing radiation GO:0010212 65 0.026
Human
dna replication GO:0006260 116 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
regulation of ras protein signal transduction GO:0046578 155 0.026
regulation of wnt signaling pathway GO:0030111 123 0.026
long term memory GO:0007616 2 0.026
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.026
cellular macromolecular complex assembly GO:0034622 324 0.026
neuromuscular junction development GO:0007528 3 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
signal transduction by phosphorylation GO:0023014 297 0.026
cellular component morphogenesis GO:0032989 314 0.026
regulation of cellular amino acid metabolic process GO:0006521 6 0.025
single organism carbohydrate metabolic process GO:0044723 193 0.025
protein processing GO:0016485 226 0.025
regulation of purine nucleotide catabolic process GO:0033121 205 0.024
positive regulation of nucleotide metabolic process GO:0045981 230 0.024
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.024
protein localization to membrane GO:0072657 160 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
cell type specific apoptotic process GO:0097285 125 0.024
regulation of intracellular transport GO:0032386 195 0.024
positive regulation of gtpase activity GO:0043547 166 0.024
purine nucleoside catabolic process GO:0006152 398 0.024
positive regulation of transport GO:0051050 336 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.024
negative regulation of proteolysis GO:0045861 132 0.024
regulation of homeostatic process GO:0032844 121 0.023
regulation of protein localization GO:0032880 296 0.023
circadian sleep wake cycle process GO:0022410 2 0.023
positive regulation of developmental process GO:0051094 314 0.023
negative regulation of binding GO:0051100 57 0.023
generation of neurons GO:0048699 152 0.023
indole containing compound metabolic process GO:0042430 4 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.022
hindbrain development GO:0030902 3 0.022
regulation of cellular response to stress GO:0080135 244 0.022
regulation of cellular component movement GO:0051270 334 0.022
dephosphorylation GO:0016311 209 0.022
microtubule cytoskeleton organization GO:0000226 176 0.022
protein maturation GO:0051604 233 0.022
regulation of proteolysis GO:0030162 293 0.022
embryo development GO:0009790 123 0.022
cation homeostasis GO:0055080 189 0.022
maintenance of location GO:0051235 112 0.021
organophosphate catabolic process GO:0046434 430 0.021
cell division GO:0051301 168 0.021
cellular amine metabolic process GO:0044106 41 0.021
organelle assembly GO:0070925 176 0.021
positive regulation of transferase activity GO:0051347 227 0.021
mitotic cell cycle GO:0000278 326 0.021
system process GO:0003008 349 0.021
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.021
regulation of secretion GO:0051046 194 0.021
signal transduction by p53 class mediator GO:0072331 72 0.021
Human
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.021
Human
epithelial cell differentiation GO:0030855 141 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
ion homeostasis GO:0050801 230 0.020
neuron differentiation GO:0030182 138 0.020
regulation of stress activated mapk cascade GO:0032872 84 0.020
regulation of establishment of protein localization GO:0070201 242 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
ribonucleotide catabolic process GO:0009261 405 0.020
positive regulation of protein phosphorylation GO:0001934 313 0.020
purine ribonucleoside metabolic process GO:0046128 437 0.020
cell projection organization GO:0030030 252 0.020
nitrogen compound transport GO:0071705 191 0.020
regulation of nucleoside metabolic process GO:0009118 209 0.020
regulation of nucleotide catabolic process GO:0030811 205 0.019
growth GO:0040007 202 0.019
hair cell differentiation GO:0035315 2 0.019
determination of adult lifespan GO:0008340 2 0.019
stress activated mapk cascade GO:0051403 93 0.019
regulation of protein processing GO:0070613 150 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
lipid transport GO:0006869 90 0.019
negative regulation of protein processing GO:0010955 142 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
protein targeting GO:0006605 187 0.019
regulation of synaptic vesicle transport GO:1902803 3 0.019
nucleoside catabolic process GO:0009164 408 0.019
positive regulation of cellular component organization GO:0051130 376 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
positive regulation of hydrolase activity GO:0051345 331 0.018
cation transport GO:0006812 331 0.018
compound eye development GO:0048749 1 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
cardiovascular system development GO:0072358 262 0.018
regulation of circadian sleep wake cycle sleep GO:0045187 2 0.018
rna splicing GO:0008380 131 0.018
glycoprotein biosynthetic process GO:0009101 91 0.018
blood vessel morphogenesis GO:0048514 162 0.018
membrane organization GO:0061024 292 0.018
mapk cascade GO:0000165 288 0.018
canonical wnt signaling pathway GO:0060070 116 0.018
regulation of cytoplasmic transport GO:1903649 149 0.018
nucleoside monophosphate metabolic process GO:0009123 191 0.017
rab protein signal transduction GO:0032482 4 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
synaptic transmission GO:0007268 61 0.017
purine containing compound catabolic process GO:0072523 411 0.017
regulation of mitotic cell cycle GO:0007346 189 0.017
positive regulation of intracellular transport GO:0032388 104 0.017
circadian sleep wake cycle sleep GO:0050802 2 0.017
peptidyl serine modification GO:0018209 106 0.017
purine ribonucleotide catabolic process GO:0009154 404 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
endosome to lysosome transport GO:0008333 21 0.017
glycosylation GO:0070085 71 0.017
photoreceptor cell differentiation GO:0046530 2 0.017
actin filament organization GO:0007015 128 0.017
vasculature development GO:0001944 181 0.017
neuroblast proliferation GO:0007405 4 0.017
sequestering of metal ion GO:0051238 24 0.017
oocyte differentiation GO:0009994 2 0.017
regulation of peptidase activity GO:0052547 180 0.016
response to other organism GO:0051707 261 0.016
developmental growth GO:0048589 48 0.016
inner ear morphogenesis GO:0042472 4 0.016
neurogenesis GO:0022008 169 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
neuron projection development GO:0031175 106 0.016
blastocyst development GO:0001824 3 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.016
organic acid transport GO:0015849 65 0.016
establishment of protein localization to organelle GO:0072594 172 0.016
regulation of dna metabolic process GO:0051052 153 0.016
jnk cascade GO:0007254 80 0.016
anterior posterior axis specification GO:0009948 2 0.015
metencephalon development GO:0022037 2 0.015
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
positive regulation of nucleotide catabolic process GO:0030813 185 0.015
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.015
cell part morphogenesis GO:0032990 137 0.015
mrna processing GO:0006397 133 0.015
nucleoside triphosphate catabolic process GO:0009143 394 0.015
organic hydroxy compound transport GO:0015850 63 0.015
regulation of protein transport GO:0051223 213 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
stem cell division GO:0017145 2 0.015
regulation of vesicle mediated transport GO:0060627 130 0.015
regeneration GO:0031099 4 0.015
cell cycle checkpoint GO:0000075 117 0.015
Human
dna repair GO:0006281 198 0.015
macromolecule glycosylation GO:0043413 63 0.015
extrinsic apoptotic signaling pathway GO:0097191 119 0.015
immune effector process GO:0002252 159 0.015
protein localization to plasma membrane GO:0072659 93 0.015
nucleotide catabolic process GO:0009166 408 0.014
carboxylic acid transport GO:0046942 63 0.014
regulation of binding GO:0051098 111 0.014
ribonucleoside triphosphate catabolic process GO:0009203 391 0.014
secretion by cell GO:0032940 226 0.014
covalent chromatin modification GO:0016569 254 0.014
rna processing GO:0006396 255 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
cellular response to hormone stimulus GO:0032870 125 0.014
chromatin organization GO:0006325 351 0.014
cellular response to decreased oxygen levels GO:0036294 51 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
ventricular cardiac muscle cell differentiation GO:0055012 1 0.014
glycoprotein metabolic process GO:0009100 110 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
positive regulation of kinase activity GO:0033674 204 0.014
regulation of transferase activity GO:0051338 355 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
response to decreased oxygen levels GO:0036293 96 0.014
secretion GO:0046903 254 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
tripartite regional subdivision GO:0007351 2 0.014
regulation of protein maturation GO:1903317 150 0.014
central nervous system development GO:0007417 123 0.014
cellular ketone metabolic process GO:0042180 80 0.013
regulation of circadian sleep wake cycle GO:0042749 2 0.013
response to hypoxia GO:0001666 96 0.013
actin cytoskeleton organization GO:0030036 207 0.013
cell morphogenesis involved in differentiation GO:0000904 144 0.013
response to external biotic stimulus GO:0043207 261 0.013
cellular response to uv GO:0034644 32 0.013
Human
amino acid transport GO:0006865 28 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
protein localization to synapse GO:0035418 2 0.013
skin development GO:0043588 76 0.013
sequestering of calcium ion GO:0051208 17 0.013
ribonucleoprotein complex subunit organization GO:0071826 81 0.013
response to biotic stimulus GO:0009607 276 0.013
circulatory system development GO:0072359 262 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
anatomical structure homeostasis GO:0060249 100 0.013
positive regulation of phosphorylation GO:0042327 394 0.013
tissue regeneration GO:0042246 3 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
innate immune response GO:0045087 178 0.013
positive regulation of protein transport GO:0051222 135 0.013
regulation of cell cycle process GO:0010564 266 0.013
regulation of immune response GO:0050776 201 0.013
multicellular organismal iron ion homeostasis GO:0060586 1 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
transition metal ion homeostasis GO:0055076 31 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
neurological system process GO:0050877 163 0.013
cytokine mediated signaling pathway GO:0019221 109 0.013
positive regulation of cellular component movement GO:0051272 181 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
protein stabilization GO:0050821 64 0.012
organ morphogenesis GO:0009887 147 0.012
protein oligomerization GO:0051259 173 0.012
thalamus development GO:0021794 2 0.012
stress activated protein kinase signaling cascade GO:0031098 94 0.012
cell cycle phase transition GO:0044770 173 0.012
mating GO:0007618 1 0.012
response to electrical stimulus GO:0051602 1 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
regulation of chromosome organization GO:0033044 103 0.012
organelle localization GO:0051640 84 0.012
protein dephosphorylation GO:0006470 81 0.012
regulation of dephosphorylation GO:0035303 96 0.012
negative regulation of protein modification process GO:0031400 200 0.012
lipid metabolic process GO:0006629 381 0.012
regulation of vasculature development GO:1901342 97 0.012
nuclear division GO:0000280 128 0.012
regulation of protein catabolic process GO:0042176 155 0.012
response to hormone GO:0009725 175 0.012
ribonucleoprotein complex assembly GO:0022618 78 0.012
regulation of cell adhesion GO:0030155 166 0.012
lipid biosynthetic process GO:0008610 177 0.012
positive regulation of gtp catabolic process GO:0033126 166 0.012
cellular response to hypoxia GO:0071456 51 0.012
organelle fission GO:0048285 149 0.012
sterol homeostasis GO:0055092 28 0.011
segmentation GO:0035282 4 0.011
cellular response to dna damage stimulus GO:0006974 379 0.011
Human
positive regulation of myeloid cell apoptotic process GO:0033034 2 0.011
negative regulation of protein maturation GO:1903318 142 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
sensory organ development GO:0007423 52 0.011
endocytosis GO:0006897 159 0.011
regulation of protein ubiquitination GO:0031396 95 0.011
cellular response to light stimulus GO:0071482 34 0.011
Human
gtp catabolic process GO:0006184 237 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.011
neuron projection morphogenesis GO:0048812 50 0.011
regulation of ion transport GO:0043269 189 0.011
protein localization to nucleus GO:0034504 136 0.011
cerebellum development GO:0021549 2 0.011
positive regulation of growth GO:0045927 58 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
negative regulation of extracellular matrix disassembly GO:0010716 3 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
response to oxygen containing compound GO:1901700 369 0.011
regulation of kinase activity GO:0043549 314 0.011
positive regulation of cell motility GO:2000147 177 0.011
response to radiation GO:0009314 151 0.011
Human
mitotic nuclear division GO:0007067 119 0.011
pathway restricted smad protein phosphorylation GO:0060389 38 0.011
positive regulation of secretion GO:0051047 116 0.011
response to virus GO:0009615 126 0.011
mrna metabolic process GO:0016071 175 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
golgi vesicle transport GO:0048193 80 0.011
negative regulation of peptidase activity GO:0010466 91 0.011
positive regulation of homeostatic process GO:0032846 47 0.011
gtp metabolic process GO:0046039 239 0.011
regulation of canonical wnt signaling pathway GO:0060828 88 0.011
neural tube formation GO:0001841 3 0.011
regulation of cell motility GO:2000145 299 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
cell development GO:0048468 328 0.010
bmp signaling pathway GO:0030509 49 0.010
calcium ion homeostasis GO:0055074 122 0.010
epithelium development GO:0060429 227 0.010
regulation of growth GO:0040008 165 0.010
nucleoside phosphate catabolic process GO:1901292 412 0.010
regulation of dna replication GO:0006275 68 0.010
cell adhesion GO:0007155 325 0.010
regulation of synaptic vesicle endocytosis GO:1900242 1 0.010
response to light stimulus GO:0009416 87 0.010
Human
sterol transport GO:0015918 39 0.010
blastoderm segmentation GO:0007350 2 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
negative regulation of cell death GO:0060548 345 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.010
reactive oxygen species biosynthetic process GO:1903409 4 0.010
mitotic cell cycle process GO:1903047 286 0.010
regulation of rab protein signal transduction GO:0032483 39 0.010
negative regulation of transport GO:0051051 176 0.010

USP25 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.027
disease of cellular proliferation DOID:14566 174 0.027
organ system cancer DOID:0050686 164 0.022
sensory system disease DOID:0050155 203 0.016
nervous system disease DOID:863 431 0.016
auditory system disease DOID:2742 53 0.015
nonsyndromic deafness DOID:0050563 50 0.015
autosomal recessive nonsyndromic deafness DOID:0050565 33 0.014
central nervous system disease DOID:331 186 0.013
skin disease DOID:37 33 0.012
integumentary system disease DOID:16 43 0.012
muscular disease DOID:0080000 114 0.011
musculoskeletal system disease DOID:17 223 0.011
muscle tissue disease DOID:66 113 0.011