Homo sapiens

50 known processes

POLA1

polymerase (DNA directed), alpha 1, catalytic subunit

(Aliases: DKFZp686K1672,POLA,p180)

POLA1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication GO:0006260 116 1.000
dna dependent dna replication GO:0006261 44 0.999
double strand break repair GO:0006302 101 0.991
post embryonic development GO:0009791 2 0.959
vesicle mediated transport GO:0016192 371 0.947
cellular response to dna damage stimulus GO:0006974 379 0.832
meiosis i GO:0007127 4 0.711
regulation of cell cycle phase transition GO:1901987 126 0.618
cell division GO:0051301 168 0.597
dna replication initiation GO:0006270 6 0.577
endocytosis GO:0006897 159 0.573
double strand break repair via homologous recombination GO:0000724 50 0.573
meiotic chromosome segregation GO:0045132 4 0.519
dna strand elongation involved in dna replication GO:0006271 3 0.492
meiotic nuclear division GO:0007126 10 0.484
gonad development GO:0008406 34 0.469
mitotic cell cycle process GO:1903047 286 0.441
mitotic cell cycle GO:0000278 326 0.433
sex differentiation GO:0007548 45 0.415
regulation of cell cycle GO:0051726 393 0.377
receptor mediated endocytosis GO:0006898 84 0.374
histone lysine methylation GO:0034968 50 0.343
negative regulation of cell cycle process GO:0010948 121 0.335
reproductive process GO:0022414 106 0.307
Worm
g2 dna damage checkpoint GO:0031572 26 0.304
reproductive structure development GO:0048608 55 0.294
embryo development GO:0009790 123 0.273
Worm
single organism reproductive process GO:0044702 98 0.257
Worm
dna damage checkpoint GO:0000077 68 0.255
nuclear division GO:0000280 128 0.255
determination of adult lifespan GO:0008340 2 0.252
Worm
membrane organization GO:0061024 292 0.249
non recombinational repair GO:0000726 14 0.216
embryo development ending in birth or egg hatching GO:0009792 34 0.210
Worm
organelle fission GO:0048285 149 0.187
dna repair GO:0006281 198 0.181
developmental process involved in reproduction GO:0003006 66 0.179
reproductive system development GO:0061458 56 0.163
histone methylation GO:0016571 60 0.160
nucleus organization GO:0006997 28 0.159
regulation of mitotic cell cycle GO:0007346 189 0.159
protein alkylation GO:0008213 74 0.157
nucleoside monophosphate catabolic process GO:0009125 159 0.153
blastocyst development GO:0001824 3 0.153
microtubule based process GO:0007017 210 0.152
regulation of meiotic cell cycle GO:0051445 4 0.152
development of primary sexual characteristics GO:0045137 35 0.146
dna conformation change GO:0071103 113 0.142
mitotic nuclear division GO:0007067 119 0.140
protein localization to chromosome centromeric region GO:0071459 12 0.134
single organism carbohydrate metabolic process GO:0044723 193 0.132
negative regulation of cell cycle GO:0045786 193 0.130
regulation of cell cycle process GO:0010564 266 0.127
negative regulation of mitotic cell cycle GO:0045930 102 0.126
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.122
microtubule cytoskeleton organization GO:0000226 176 0.120
ribonucleoside monophosphate catabolic process GO:0009158 158 0.115
positive regulation of cell proliferation GO:0008284 301 0.109
telomere maintenance GO:0000723 32 0.108
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.105
mitotic dna integrity checkpoint GO:0044774 30 0.104
base excision repair GO:0006284 21 0.101
engulfment of apoptotic cell GO:0043652 2 0.101
mitotic dna damage checkpoint GO:0044773 28 0.097
sister chromatid cohesion GO:0007062 24 0.095
reciprocal meiotic recombination GO:0007131 4 0.094
chromosome segregation GO:0007059 114 0.093
g1 s transition of mitotic cell cycle GO:0000082 78 0.092
cellular response to endogenous stimulus GO:0071495 336 0.091
dna packaging GO:0006323 77 0.088
male meiosis GO:0007140 1 0.088
regulation of dna replication GO:0006275 68 0.086
cellular response to nitrogen compound GO:1901699 144 0.086
cell cycle checkpoint GO:0000075 117 0.086
regulation of double strand break repair GO:2000779 22 0.084
purine nucleoside triphosphate catabolic process GO:0009146 392 0.082
covalent chromatin modification GO:0016569 254 0.081
regulation of mitotic cell cycle phase transition GO:1901990 118 0.080
growth GO:0040007 202 0.079
dna strand elongation GO:0022616 5 0.079
histone h3 k4 methylation GO:0051568 27 0.078
protein localization to organelle GO:0033365 280 0.075
chordate embryonic development GO:0043009 34 0.074
cellular amino acid metabolic process GO:0006520 116 0.072
positive regulation of cellular component organization GO:0051130 376 0.071
cell cycle g1 s phase transition GO:0044843 80 0.070
nucleotide excision repair GO:0006289 31 0.067
mitotic sister chromatid cohesion GO:0007064 12 0.066
leading strand elongation GO:0006272 1 0.064
regulation of dna metabolic process GO:0051052 153 0.059
cellular ketone metabolic process GO:0042180 80 0.057
meiotic cell cycle GO:0051321 13 0.056
Yeast
negative regulation of cell cycle phase transition GO:1901988 89 0.055
dna geometric change GO:0032392 32 0.052
mitotic cell cycle phase transition GO:0044772 162 0.052
double strand break repair via nonhomologous end joining GO:0006303 10 0.050
g2 m transition of mitotic cell cycle GO:0000086 41 0.049
generation of neurons GO:0048699 152 0.049
lagging strand elongation GO:0006273 3 0.047
purine nucleotide catabolic process GO:0006195 405 0.047
cell cycle phase transition GO:0044770 173 0.045
anatomical structure homeostasis GO:0060249 100 0.044
regulation of cellular ketone metabolic process GO:0010565 50 0.044
positive regulation of hydrolase activity GO:0051345 331 0.043
negative regulation of meiotic cell cycle GO:0051447 2 0.042
protein dna complex subunit organization GO:0071824 80 0.042
methylation GO:0032259 106 0.042
negative regulation of cell death GO:0060548 345 0.042
carbohydrate metabolic process GO:0005975 207 0.041
response to purine containing compound GO:0014074 40 0.040
intracellular protein transport GO:0006886 270 0.039
genitalia development GO:0048806 10 0.039
tube development GO:0035295 125 0.039
regulation of cellular amine metabolic process GO:0033238 11 0.039
histone modification GO:0016570 251 0.039
regulation of cell cycle g1 s phase transition GO:1902806 42 0.039
cell activation GO:0001775 213 0.039
sensory organ development GO:0007423 52 0.038
regulation of cellular amino acid metabolic process GO:0006521 6 0.037
carbohydrate derivative biosynthetic process GO:1901137 207 0.037
dna synthesis involved in dna repair GO:0000731 6 0.036
Yeast
response to organic cyclic compound GO:0014070 204 0.036
response to oxygen containing compound GO:1901700 369 0.036
reproduction GO:0000003 63 0.035
Yeast Worm
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.035
nucleoside triphosphate metabolic process GO:0009141 422 0.035
cellular amine metabolic process GO:0044106 41 0.035
response to inorganic substance GO:0010035 127 0.034
dna integrity checkpoint GO:0031570 71 0.034
regulation of nucleocytoplasmic transport GO:0046822 98 0.034
regulation of protein localization GO:0032880 296 0.034
mitotic cell cycle checkpoint GO:0007093 68 0.034
resolution of meiotic recombination intermediates GO:0000712 3 0.033
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.033
ribonucleoside triphosphate catabolic process GO:0009203 391 0.033
cell projection morphogenesis GO:0048858 129 0.033
ribonucleoside monophosphate metabolic process GO:0009161 187 0.033
purine nucleoside monophosphate catabolic process GO:0009128 158 0.032
telomere organization GO:0032200 33 0.032
female gamete generation GO:0007292 2 0.031
regulation of meiosis GO:0040020 3 0.030
protein ubiquitination GO:0016567 314 0.030
apoptotic cell clearance GO:0043277 12 0.030
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.029
nucleoside triphosphate catabolic process GO:0009143 394 0.029
negative regulation of dna metabolic process GO:0051053 57 0.029
purine ribonucleoside metabolic process GO:0046128 437 0.029
cellular response to organic cyclic compound GO:0071407 127 0.029
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.028
positive regulation of meiotic cell cycle GO:0051446 2 0.028
amine metabolic process GO:0009308 44 0.028
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.028
negative regulation of apoptotic process GO:0043066 316 0.028
nuclear transport GO:0051169 179 0.028
rna dependent dna replication GO:0006278 16 0.027
Yeast
positive regulation of protein complex assembly GO:0031334 86 0.027
regulation of double strand break repair via homologous recombination GO:0010569 11 0.026
purine ribonucleoside catabolic process GO:0046130 398 0.026
b cell activation GO:0042113 33 0.026
purine containing compound catabolic process GO:0072523 411 0.025
anatomical structure formation involved in morphogenesis GO:0048646 284 0.025
epithelium development GO:0060429 227 0.025
multi organism reproductive process GO:0044703 54 0.024
Worm
response to nitrogen compound GO:1901698 184 0.024
regulation of cellular response to stress GO:0080135 244 0.024
circulatory system development GO:0072359 262 0.023
regeneration GO:0031099 4 0.023
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.023
cytoplasmic transport GO:0016482 379 0.023
nucleoside catabolic process GO:0009164 408 0.023
protein targeting GO:0006605 187 0.023
cellular response to oxygen containing compound GO:1901701 276 0.023
cellular component disassembly GO:0022411 92 0.022
dna unwinding involved in dna replication GO:0006268 2 0.022
intrinsic apoptotic signaling pathway GO:0097193 127 0.022
mitotic g2 m transition checkpoint GO:0044818 9 0.022
purine nucleoside monophosphate metabolic process GO:0009126 186 0.021
chromatin modification GO:0016568 298 0.021
regulation of dna methylation GO:0044030 2 0.021
cardiovascular system development GO:0072358 262 0.021
defense response to bacterium GO:0042742 63 0.021
wound healing GO:0042060 115 0.021
maintenance of dna repeat elements GO:0043570 4 0.021
positive regulation of transport GO:0051050 336 0.021
cell cycle g2 m phase transition GO:0044839 43 0.020
lymphocyte activation GO:0046649 133 0.020
maintenance of location GO:0051235 112 0.020
chromatin organization GO:0006325 351 0.020
sister chromatid segregation GO:0000819 54 0.019
positive regulation of dna replication GO:0045740 35 0.019
regulation of locomotion GO:0040012 329 0.019
double strand break repair via single strand annealing GO:0045002 4 0.019
dna double strand break processing GO:0000729 10 0.019
chromatin assembly or disassembly GO:0006333 78 0.019
regulation of intracellular transport GO:0032386 195 0.019
cell type specific apoptotic process GO:0097285 125 0.019
regulation of protein kinase activity GO:0045859 289 0.019
macromolecule methylation GO:0043414 97 0.018
regulation of kinase activity GO:0043549 314 0.018
gene silencing GO:0016458 49 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
positive regulation of cell cycle GO:0045787 140 0.018
protein catabolic process GO:0030163 325 0.017
dna modification GO:0006304 27 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
regulation of cell activation GO:0050865 125 0.017
positive regulation of cell cycle process GO:0090068 106 0.017
positive regulation of protein transport GO:0051222 135 0.017
positive regulation of intracellular protein transport GO:0090316 76 0.016
dna recombination GO:0006310 77 0.016
positive regulation of intracellular transport GO:0032388 104 0.016
hematopoietic or lymphoid organ development GO:0048534 186 0.016
leukocyte activation GO:0045321 164 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.016
regulation of intracellular protein transport GO:0033157 123 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
protein dna complex assembly GO:0065004 64 0.015
protein modification by small protein conjugation GO:0032446 342 0.015
nervous system development GO:0007399 293 0.015
multicellular organismal aging GO:0010259 3 0.015
Worm
organ morphogenesis GO:0009887 147 0.015
response to extracellular stimulus GO:0009991 85 0.015
phagocytosis GO:0006909 42 0.015
regulation of peptidase activity GO:0052547 180 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.015
chromosome condensation GO:0030261 15 0.015
microtubule anchoring GO:0034453 24 0.014
response to ionizing radiation GO:0010212 65 0.014
protein localization to chromosome GO:0034502 30 0.014
nucleotide catabolic process GO:0009166 408 0.014
negative regulation of catalytic activity GO:0043086 335 0.014
endomembrane system organization GO:0010256 196 0.014
mrna metabolic process GO:0016071 175 0.014
peptide metabolic process GO:0006518 51 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
oocyte maturation GO:0001556 1 0.014
response to external biotic stimulus GO:0043207 261 0.014
organophosphate catabolic process GO:0046434 430 0.014
oogenesis GO:0048477 2 0.013
nuclear export GO:0051168 69 0.013
single organism cellular localization GO:1902580 332 0.013
segmentation GO:0035282 4 0.013
regulation of growth GO:0040008 165 0.013
positive regulation of cytoskeleton organization GO:0051495 83 0.013
rna splicing GO:0008380 131 0.013
positive regulation of dna metabolic process GO:0051054 73 0.013
response to other organism GO:0051707 261 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
macromolecular complex disassembly GO:0032984 60 0.013
nitrogen compound transport GO:0071705 191 0.013
dna duplex unwinding GO:0032508 30 0.013
meiotic chromosome separation GO:0051307 3 0.013
neurogenesis GO:0022008 169 0.013
response to organonitrogen compound GO:0010243 156 0.013
signal transduction by p53 class mediator GO:0072331 72 0.013
negative regulation of cellular protein metabolic process GO:0032269 353 0.013
microtubule based movement GO:0007018 32 0.013
regulation of dna dependent dna replication GO:0090329 19 0.013
isotype switching GO:0045190 3 0.013
meiotic cell cycle process GO:1903046 8 0.013
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.013
regulation of lymphocyte activation GO:0051249 103 0.013
positive regulation of cytoplasmic transport GO:1903651 82 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
response to reactive oxygen species GO:0000302 61 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
positive regulation of leukocyte activation GO:0002696 80 0.012
cell projection organization GO:0030030 252 0.012
cellular response to ionizing radiation GO:0071479 32 0.012
regulation of cytoplasmic transport GO:1903649 149 0.012
telomere maintenance via recombination GO:0000722 4 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
head development GO:0060322 108 0.012
nucleoside phosphate biosynthetic process GO:1901293 109 0.012
protein methylation GO:0006479 74 0.012
positive regulation of lymphocyte activation GO:0051251 73 0.012
cell cell signaling GO:0007267 155 0.011
regulation of leukocyte activation GO:0002694 115 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
maintenance of protein location in cell GO:0032507 56 0.011
attachment of spindle microtubules to kinetochore GO:0008608 17 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
internal protein amino acid acetylation GO:0006475 101 0.011
regulation of chromosome organization GO:0033044 103 0.011
cell part morphogenesis GO:0032990 137 0.011
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.011
glycosylation GO:0070085 71 0.011
purine ribonucleotide catabolic process GO:0009154 404 0.010
negative regulation of organelle organization GO:0010639 126 0.010
negative regulation of phosphorus metabolic process GO:0010563 267 0.010
response to nutrient levels GO:0031667 81 0.010

POLA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.028
cancer DOID:162 167 0.019
disease of metabolism DOID:0014667 295 0.014
immune system disease DOID:2914 155 0.012