Homo sapiens

67 known processes

CASC5

cancer susceptibility candidate 5

(Aliases: KIAA1570,hSpc105,CT29,hKNL-1,KNL1,D40,AF15Q14)

CASC5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
spindle assembly checkpoint GO:0071173 17 0.773
negative regulation of mitotic sister chromatid segregation GO:0033048 17 0.674
chromosome segregation GO:0007059 114 0.657
negative regulation of phosphatase activity GO:0010923 61 0.546
sister chromatid cohesion GO:0007062 24 0.512
attachment of spindle microtubules to kinetochore GO:0008608 17 0.355
sister chromatid segregation GO:0000819 54 0.348
negative regulation of catalytic activity GO:0043086 335 0.346
protein localization to chromosome centromeric region GO:0071459 12 0.314
dephosphorylation GO:0016311 209 0.313
regulation of dephosphorylation GO:0035303 96 0.304
mitotic spindle assembly checkpoint GO:0007094 14 0.278
regulation of cell cycle GO:0051726 393 0.260
regulation of mitotic sister chromatid segregation GO:0033047 27 0.243
intrinsic apoptotic signaling pathway GO:0097193 127 0.234
negative regulation of phosphate metabolic process GO:0045936 267 0.228
centromeric sister chromatid cohesion GO:0070601 3 0.224
regulation of protein processing GO:0070613 150 0.224
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.207
negative regulation of chromosome segregation GO:0051985 18 0.187
regulation of phosphatase activity GO:0010921 81 0.174
cell cycle phase transition GO:0044770 173 0.172
post embryonic development GO:0009791 2 0.158
negative regulation of cellular component organization GO:0051129 235 0.156
cell cycle checkpoint GO:0000075 117 0.154
negative regulation of protein processing GO:0010955 142 0.153
mitotic cell cycle GO:0000278 326 0.147
protein localization to organelle GO:0033365 280 0.144
negative regulation of chromosome organization GO:2001251 48 0.143
protein localization to kinetochore GO:0034501 10 0.142
regulation of apoptotic signaling pathway GO:2001233 175 0.140
circulatory system development GO:0072359 262 0.138
chromosome separation GO:0051304 23 0.134
negative regulation of protein maturation GO:1903318 142 0.129
mitotic sister chromatid segregation GO:0000070 53 0.127
regulation of proteolysis GO:0030162 293 0.119
organelle assembly GO:0070925 176 0.117
negative regulation of sister chromatid segregation GO:0033046 17 0.116
regulation of cell cycle process GO:0010564 266 0.112
maintenance of protein location GO:0045185 57 0.111
regulation of protein maturation GO:1903317 150 0.108
regulation of mitotic cell cycle GO:0007346 189 0.106
negative regulation of cell cycle phase transition GO:1901988 89 0.102
cellular macromolecule catabolic process GO:0044265 380 0.101
regulation of chromosome segregation GO:0051983 44 0.100
apoptotic signaling pathway GO:0097190 268 0.100
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.099
regulation of cellular ketone metabolic process GO:0010565 50 0.099
regulation of cell cycle phase transition GO:1901987 126 0.098
negative regulation of cell death GO:0060548 345 0.098
negative regulation of cell cycle GO:0045786 193 0.095
proteasomal protein catabolic process GO:0010498 176 0.094
regulation of sister chromatid cohesion GO:0007063 9 0.092
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.091
regulation of mitotic cell cycle phase transition GO:1901990 118 0.091
protein maturation GO:0051604 233 0.090
protein processing GO:0016485 226 0.086
protein catabolic process GO:0030163 325 0.086
negative regulation of phosphorus metabolic process GO:0010563 267 0.085
negative regulation of cellular protein catabolic process GO:1903363 38 0.080
organelle fission GO:0048285 149 0.080
negative regulation of protein metabolic process GO:0051248 391 0.079
mitotic cell cycle checkpoint GO:0007093 68 0.079
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.078
negative regulation of cellular protein metabolic process GO:0032269 353 0.069
regulation of cellular amine metabolic process GO:0033238 11 0.068
mitotic spindle checkpoint GO:0071174 18 0.066
protein dephosphorylation GO:0006470 81 0.065
regulation of mitosis GO:0007088 63 0.065
single organism membrane organization GO:0044802 268 0.065
regulation of cell division GO:0051302 116 0.063
positive regulation of cell death GO:0010942 263 0.062
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.062
regulation of proteasomal protein catabolic process GO:0061136 87 0.062
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.061
multi organism cellular process GO:0044764 156 0.060
cellular amino acid metabolic process GO:0006520 116 0.060
maintenance of location in cell GO:0051651 62 0.059
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.059
regulation of cellular amino acid metabolic process GO:0006521 6 0.058
microtubule anchoring GO:0034453 24 0.056
metaphase anaphase transition of cell cycle GO:0044784 21 0.053
regulation of protein catabolic process GO:0042176 155 0.053
negative regulation of mitotic cell cycle GO:0045930 102 0.053
amine metabolic process GO:0009308 44 0.052
negative regulation of hydrolase activity GO:0051346 182 0.052
cellular protein catabolic process GO:0044257 261 0.051
cellular ketone metabolic process GO:0042180 80 0.051
negative regulation of proteolysis GO:0045861 132 0.051
regulation of sister chromatid segregation GO:0033045 27 0.049
negative regulation of catabolic process GO:0009895 104 0.049
histone modification GO:0016570 251 0.049
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.048
ubiquitin dependent protein catabolic process GO:0006511 206 0.046
regulation of mitotic sister chromatid separation GO:0010965 27 0.046
modification dependent protein catabolic process GO:0019941 209 0.046
negative regulation of cellular catabolic process GO:0031330 83 0.046
mitotic sister chromatid separation GO:0051306 18 0.046
negative regulation of protein catabolic process GO:0042177 59 0.043
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.043
positive regulation of cell proliferation GO:0008284 301 0.042
regulation of nuclear division GO:0051783 65 0.042
negative regulation of protein modification process GO:0031400 200 0.040
negative regulation of dephosphorylation GO:0035305 63 0.039
cellular amine metabolic process GO:0044106 41 0.039
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.039
negative regulation of intracellular signal transduction GO:1902532 183 0.039
cell projection organization GO:0030030 252 0.038
male meiosis GO:0007140 1 0.038
regulation of protein dephosphorylation GO:0035304 18 0.037
protein dna complex subunit organization GO:0071824 80 0.037
oogenesis GO:0048477 2 0.037
positive regulation of protein phosphorylation GO:0001934 313 0.037
peptidyl tyrosine phosphorylation GO:0018108 170 0.036
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.035
regulation of cellular protein catabolic process GO:1903362 96 0.035
positive regulation of apoptotic process GO:0043065 246 0.035
negative regulation of cell cycle process GO:0010948 121 0.034
mitotic cell cycle process GO:1903047 286 0.034
chemical homeostasis GO:0048878 306 0.033
negative regulation of organelle organization GO:0010639 126 0.033
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.033
regulation of chromosome organization GO:0033044 103 0.033
membrane organization GO:0061024 292 0.033
regulation of protein kinase activity GO:0045859 289 0.032
negative regulation of programmed cell death GO:0043069 321 0.031
regulation of cellular component movement GO:0051270 334 0.031
single organism cellular localization GO:1902580 332 0.031
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.030
positive regulation of organelle organization GO:0010638 195 0.030
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.030
modification dependent macromolecule catabolic process GO:0043632 212 0.029
positive regulation of chromosome segregation GO:0051984 9 0.029
negative regulation of cell division GO:0051782 31 0.029
mitotic nuclear division GO:0007067 119 0.028
maintenance of location GO:0051235 112 0.027
cardiovascular system development GO:0072358 262 0.027
regulation of protein localization GO:0032880 296 0.027
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.026
female gamete generation GO:0007292 2 0.026
heart development GO:0007507 95 0.026
protein acetylation GO:0006473 116 0.026
limbic system development GO:0021761 3 0.025
metaphase plate congression GO:0051310 18 0.025
multicellular organismal aging GO:0010259 3 0.025
negative regulation of apoptotic signaling pathway GO:2001234 97 0.025
positive regulation of cellular component organization GO:0051130 376 0.025
microtubule based process GO:0007017 210 0.025
regulation of transferase activity GO:0051338 355 0.024
positive regulation of programmed cell death GO:0043068 249 0.024
interspecies interaction between organisms GO:0044419 156 0.024
intracellular protein transport GO:0006886 270 0.024
cytoplasmic transport GO:0016482 379 0.024
metal ion transport GO:0030001 272 0.023
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.023
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.023
mitotic cell cycle phase transition GO:0044772 162 0.023
system process GO:0003008 349 0.023
cell growth GO:0016049 160 0.022
actin filament based movement GO:0030048 17 0.022
positive regulation of cellular amine metabolic process GO:0033240 7 0.022
tissue regeneration GO:0042246 3 0.022
vesicle mediated transport GO:0016192 371 0.021
positive regulation of cytoskeleton organization GO:0051495 83 0.021
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.021
response to abiotic stimulus GO:0009628 336 0.020
positive regulation of transferase activity GO:0051347 227 0.020
photoreceptor cell differentiation GO:0046530 2 0.020
viral life cycle GO:0019058 132 0.020
adult locomotory behavior GO:0008344 1 0.019
organelle localization GO:0051640 84 0.019
cellular component morphogenesis GO:0032989 314 0.019
plasma membrane organization GO:0007009 115 0.019
positive regulation of meiotic cell cycle GO:0051446 2 0.019
regulation of cell motility GO:2000145 299 0.018
maintenance of protein location in cell GO:0032507 56 0.018
determination of adult lifespan GO:0008340 2 0.018
regulation of cellular component biogenesis GO:0044087 281 0.018
regulation of locomotion GO:0040012 329 0.018
regulation of kinase activity GO:0043549 314 0.018
secretion GO:0046903 254 0.018
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.018
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.018
regulation of cell migration GO:0030334 289 0.018
regulation of viral process GO:0050792 103 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.017
actin filament based process GO:0030029 224 0.017
actin mediated cell contraction GO:0070252 12 0.017
negative regulation of apoptotic process GO:0043066 316 0.017
cation transport GO:0006812 331 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
response to radiation GO:0009314 151 0.017
defense response GO:0006952 315 0.017
organic hydroxy compound metabolic process GO:1901615 147 0.016
viral process GO:0016032 146 0.016
regulation of gene expression epigenetic GO:0040029 73 0.016
blastocyst development GO:0001824 3 0.016
divalent inorganic cation transport GO:0072511 158 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
calcium ion transport GO:0006816 147 0.016
cell projection assembly GO:0030031 126 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.016
positive regulation of proteolysis GO:0045862 142 0.015
positive regulation of protein kinase activity GO:0045860 190 0.015
positive regulation of apoptotic signaling pathway GO:2001235 70 0.015
actin polymerization or depolymerization GO:0008154 56 0.015
regulation of cytoplasmic transport GO:1903649 149 0.014
reproductive structure development GO:0048608 55 0.014
endosomal transport GO:0016197 129 0.014
regulation of meiotic cell cycle GO:0051445 4 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
reproductive system development GO:0061458 56 0.014
neurological system process GO:0050877 163 0.014
meiotic chromosome segregation GO:0045132 4 0.014
locomotory behavior GO:0007626 1 0.014
regulation of multi organism process GO:0043900 157 0.013
negative regulation of cellular amine metabolic process GO:0033239 3 0.013
neuron development GO:0048666 113 0.013
spindle checkpoint GO:0031577 26 0.013
growth GO:0040007 202 0.013
protein localization to nucleus GO:0034504 136 0.013
cellular response to ammonium ion GO:0071242 4 0.013
negative regulation of cell growth GO:0030308 83 0.013
regulation of cell projection organization GO:0031344 107 0.013
protein acylation GO:0043543 138 0.013
positive regulation of protein transport GO:0051222 135 0.013
cell part morphogenesis GO:0032990 137 0.013
positive regulation of transport GO:0051050 336 0.012
actin cytoskeleton organization GO:0030036 207 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
regulation of peptidase activity GO:0052547 180 0.012
cell morphogenesis GO:0000902 296 0.012
hindbrain development GO:0030902 3 0.012
epithelium development GO:0060429 227 0.012
regulation of anatomical structure morphogenesis GO:0022603 286 0.012
regulation of intracellular transport GO:0032386 195 0.012
peptidyl threonine modification GO:0018210 45 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
oocyte development GO:0048599 1 0.012
positive regulation of mitotic cell cycle GO:0045931 60 0.012
chromatin modification GO:0016568 298 0.012
immune system development GO:0002520 195 0.012
regulation of protein complex assembly GO:0043254 147 0.012
neurogenesis GO:0022008 169 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
protein autophosphorylation GO:0046777 123 0.012
cellular response to cytokine stimulus GO:0071345 181 0.011
embryonic placenta development GO:0001892 1 0.011
cell substrate adhesion GO:0031589 132 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.011
rna processing GO:0006396 255 0.011
cation homeostasis GO:0055080 189 0.011
protein targeting GO:0006605 187 0.011
sequestering of metal ion GO:0051238 24 0.011
ossification GO:0001503 121 0.010
peptidyl tyrosine modification GO:0018212 170 0.010
regulation of dna replication GO:0006275 68 0.010
regeneration GO:0031099 4 0.010
regulation of protein transport GO:0051223 213 0.010
signal transduction by phosphorylation GO:0023014 297 0.010
ras protein signal transduction GO:0007265 73 0.010
negative regulation of mitosis GO:0045839 24 0.010
divalent metal ion transport GO:0070838 152 0.010
dna replication GO:0006260 116 0.010

CASC5 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.074
cancer DOID:162 167 0.045
organ system cancer DOID:0050686 164 0.045
large intestine cancer DOID:5672 29 0.014
colon cancer DOID:219 25 0.014
gastrointestinal system cancer DOID:3119 52 0.014
intestinal cancer DOID:10155 29 0.014
colorectal cancer DOID:9256 29 0.014
physical disorder DOID:0080015 41 0.003
congenital nervous system abnormality DOID:2490 21 0.003
microcephaly DOID:10907 6 0.000