Homo sapiens

67 known processes

PARP1

poly (ADP-ribose) polymerase 1

(Aliases: PPOL,ADPRT,PARP-1,ADPRT 1,PARP,ADPRT1,pADPRT-1)

PARP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 1.000
chromatin modification GO:0016568 298 1.000
cellular response to dna damage stimulus GO:0006974 379 1.000
chromatin organization GO:0006325 351 1.000
dna conformation change GO:0071103 113 0.999
double strand break repair GO:0006302 101 0.999
base excision repair GO:0006284 21 0.995
Mouse
regulation of dna metabolic process GO:0051052 153 0.978
covalent chromatin modification GO:0016569 254 0.977
response to abiotic stimulus GO:0009628 336 0.976
mitotic cell cycle GO:0000278 326 0.973
dna ligation GO:0006266 10 0.968
atp metabolic process GO:0046034 176 0.961
chromatin assembly or disassembly GO:0006333 78 0.961
nucleoside monophosphate metabolic process GO:0009123 191 0.957
dna packaging GO:0006323 77 0.956
single strand break repair GO:0000012 6 0.941
double strand break repair via nonhomologous end joining GO:0006303 10 0.941
response to ionizing radiation GO:0010212 65 0.941
histone modification GO:0016570 251 0.940
dna replication GO:0006260 116 0.940
g2 dna damage checkpoint GO:0031572 26 0.934
purine nucleoside monophosphate catabolic process GO:0009128 158 0.933
determination of adult lifespan GO:0008340 2 0.927
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.922
immune system development GO:0002520 195 0.915
positive regulation of programmed cell death GO:0043068 249 0.901
dna dependent dna replication GO:0006261 44 0.891
microtubule based process GO:0007017 210 0.887
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.876
purine ribonucleoside metabolic process GO:0046128 437 0.861
gene silencing GO:0016458 49 0.850
mitotic dna damage checkpoint GO:0044773 28 0.836
viral process GO:0016032 146 0.834
nucleoside triphosphate metabolic process GO:0009141 422 0.824
purine nucleoside triphosphate metabolic process GO:0009144 412 0.822
regulation of chromatin organization GO:1902275 56 0.821
nucleoside monophosphate catabolic process GO:0009125 159 0.809
positive regulation of developmental process GO:0051094 314 0.808
mitotic g2 dna damage checkpoint GO:0007095 7 0.803
mitotic dna integrity checkpoint GO:0044774 30 0.802
regulation of cell cycle GO:0051726 393 0.798
response to radiation GO:0009314 151 0.789
chromatin silencing GO:0006342 12 0.786
microtubule cytoskeleton organization GO:0000226 176 0.784
protein modification by small protein conjugation GO:0032446 342 0.783
response to oxygen containing compound GO:1901700 369 0.775
regulation of chromatin modification GO:1903308 51 0.773
non recombinational repair GO:0000726 14 0.769
circulatory system development GO:0072359 262 0.747
post embryonic development GO:0009791 2 0.745
ribonucleoside monophosphate metabolic process GO:0009161 187 0.741
cellular macromolecule catabolic process GO:0044265 380 0.733
cellular amino acid metabolic process GO:0006520 116 0.724
macromolecule methylation GO:0043414 97 0.719
nucleoside catabolic process GO:0009164 408 0.704
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.689
ribonucleoside triphosphate metabolic process GO:0009199 412 0.689
protein localization to chromosome GO:0034502 30 0.685
cell type specific apoptotic process GO:0097285 125 0.659
response to hypoxia GO:0001666 96 0.649
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.649
protein ubiquitination GO:0016567 314 0.635
dna ligation involved in dna repair GO:0051103 4 0.621
dna duplex unwinding GO:0032508 30 0.615
dna recombination GO:0006310 77 0.599
histone h3 k9 modification GO:0061647 11 0.589
negative regulation of cellular protein metabolic process GO:0032269 353 0.578
positive regulation of dna metabolic process GO:0051054 73 0.574
establishment of organelle localization GO:0051656 59 0.567
viral life cycle GO:0019058 132 0.558
regulation of chromosome organization GO:0033044 103 0.555
dna geometric change GO:0032392 32 0.548
apoptotic signaling pathway GO:0097190 268 0.547
purine nucleoside monophosphate metabolic process GO:0009126 186 0.546
nucleoside triphosphate catabolic process GO:0009143 394 0.532
response to nitrogen compound GO:1901698 184 0.526
chromosome condensation GO:0030261 15 0.522
positive regulation of viral process GO:0048524 37 0.511
dna synthesis involved in dna repair GO:0000731 6 0.509
generation of neurons GO:0048699 152 0.507
methylation GO:0032259 106 0.502
nucleotide catabolic process GO:0009166 408 0.501
negative regulation of cell cycle GO:0045786 193 0.501
dna strand elongation involved in dna replication GO:0006271 3 0.500
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.495
hematopoietic or lymphoid organ development GO:0048534 186 0.484
chromatin assembly GO:0031497 61 0.468
negative regulation of protein metabolic process GO:0051248 391 0.458
oogenesis GO:0048477 2 0.451
establishment of nucleus localization GO:0040023 1 0.449
response to gamma radiation GO:0010332 14 0.448
negative regulation of cell cycle process GO:0010948 121 0.446
mitotic nuclear division GO:0007067 119 0.443
mitotic cell cycle checkpoint GO:0007093 68 0.441
embryo development ending in birth or egg hatching GO:0009792 34 0.441
Worm
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.438
histone methylation GO:0016571 60 0.422
regulation of mitotic cell cycle GO:0007346 189 0.417
posttranscriptional regulation of gene expression GO:0010608 213 0.417
dna catabolic process GO:0006308 49 0.416
aging GO:0007568 66 0.414
mitotic cell cycle phase transition GO:0044772 162 0.411
chromatin remodeling GO:0006338 55 0.404
cellular response to organic cyclic compound GO:0071407 127 0.402
cellular protein catabolic process GO:0044257 261 0.400
dna strand elongation GO:0022616 5 0.385
purine nucleoside triphosphate catabolic process GO:0009146 392 0.383
growth GO:0040007 202 0.379
Mouse
protein alkylation GO:0008213 74 0.372
organophosphate catabolic process GO:0046434 430 0.371
cellular response to abiotic stimulus GO:0071214 117 0.369
response to decreased oxygen levels GO:0036293 96 0.362
cell cycle checkpoint GO:0000075 117 0.358
protein localization to organelle GO:0033365 280 0.357
Rat
purine containing compound catabolic process GO:0072523 411 0.357
regulation of gene expression epigenetic GO:0040029 73 0.357
regulation of proteolysis GO:0030162 293 0.356
hematopoietic stem cell differentiation GO:0060218 4 0.355
dna damage checkpoint GO:0000077 68 0.355
atp catabolic process GO:0006200 157 0.351
mitotic cell cycle process GO:1903047 286 0.346
response to organic cyclic compound GO:0014070 204 0.345
regulation of cell cycle phase transition GO:1901987 126 0.338
regulation of histone modification GO:0031056 47 0.329
sulfur compound metabolic process GO:0006790 101 0.326
regulation of cellular response to stress GO:0080135 244 0.318
signal transduction in response to dna damage GO:0042770 57 0.317
histone lysine methylation GO:0034968 50 0.314
cellular response to organonitrogen compound GO:0071417 124 0.309
glycosyl compound catabolic process GO:1901658 413 0.307
secretion GO:0046903 254 0.305
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.291
generation of precursor metabolites and energy GO:0006091 68 0.287
regulation of response to dna damage stimulus GO:2001020 94 0.284
ribonucleoside monophosphate catabolic process GO:0009158 158 0.282
negative regulation of mitotic cell cycle GO:0045930 102 0.281
multicellular organismal aging GO:0010259 3 0.281
protein processing GO:0016485 226 0.278
Rat
nucleosome assembly GO:0006334 50 0.276
endomembrane system organization GO:0010256 196 0.271
negative regulation of cell cycle phase transition GO:1901988 89 0.270
response to other organism GO:0051707 261 0.268
protein methylation GO:0006479 74 0.265
negative regulation of cellular component organization GO:0051129 235 0.262
response to hormone GO:0009725 175 0.257
negative regulation of dna metabolic process GO:0051053 57 0.248
positive regulation of apoptotic process GO:0043065 246 0.247
neurogenesis GO:0022008 169 0.242
dna modification GO:0006304 27 0.230
positive regulation of chromatin modification GO:1903310 30 0.225
modification dependent protein catabolic process GO:0019941 209 0.224
cellular response to endogenous stimulus GO:0071495 336 0.224
histone h3 k4 methylation GO:0051568 27 0.220
positive regulation of immune system process GO:0002684 283 0.218
interspecies interaction between organisms GO:0044419 156 0.217
single organism reproductive process GO:0044702 98 0.216
regulation of endopeptidase activity GO:0052548 170 0.214
signal transduction by p53 class mediator GO:0072331 72 0.214
regulation of dna methylation GO:0044030 2 0.212
cell aging GO:0007569 52 0.209
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.208
intrinsic apoptotic signaling pathway GO:0097193 127 0.201
ribonucleotide catabolic process GO:0009261 405 0.199
multi organism cellular process GO:0044764 156 0.194
negative regulation of apoptotic process GO:0043066 316 0.194
protein catabolic process GO:0030163 325 0.194
negative regulation of protein modification process GO:0031400 200 0.192
regulation of double strand break repair GO:2000779 22 0.191
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.187
segmentation GO:0035282 4 0.187
purine ribonucleoside catabolic process GO:0046130 398 0.185
response to oxidative stress GO:0006979 121 0.180
Mouse
response to inorganic substance GO:0010035 127 0.177
Mouse
response to external biotic stimulus GO:0043207 261 0.176
cellular response to oxygen containing compound GO:1901701 276 0.174
response to oxygen levels GO:0070482 100 0.173
mitotic recombination GO:0006312 8 0.172
dna methylation or demethylation GO:0044728 19 0.169
regulation of cellular amino acid metabolic process GO:0006521 6 0.162
membrane organization GO:0061024 292 0.160
negative regulation of cell death GO:0060548 345 0.159
Worm
response to lipid GO:0033993 206 0.159
b cell activation GO:0042113 33 0.157
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.157
telencephalon development GO:0021537 17 0.156
regulation of mitotic cell cycle phase transition GO:1901990 118 0.152
histone h3 k27 acetylation GO:0043974 2 0.148
positive regulation of immune response GO:0050778 159 0.147
cell cycle phase transition GO:0044770 173 0.145
oxidation reduction process GO:0055114 396 0.144
ribonucleoside triphosphate catabolic process GO:0009203 391 0.141
negative regulation of gene expression epigenetic GO:0045814 19 0.139
negative regulation of protein maturation GO:1903318 142 0.138
hemopoiesis GO:0030097 180 0.136
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.136
metaphase plate congression GO:0051310 18 0.136
negative regulation of catabolic process GO:0009895 104 0.134
proteasomal protein catabolic process GO:0010498 176 0.131
ribonucleoside catabolic process GO:0042454 406 0.128
neuron differentiation GO:0030182 138 0.128
protein acylation GO:0043543 138 0.127
tricarboxylic acid metabolic process GO:0072350 4 0.126
positive regulation of cellular component organization GO:0051130 376 0.124
regulation of protein processing GO:0070613 150 0.123
embryo development GO:0009790 123 0.123
Worm
organelle localization GO:0051640 84 0.122
positive regulation of organelle organization GO:0010638 195 0.122
regulation of proteasomal protein catabolic process GO:0061136 87 0.120
meiosis i GO:0007127 4 0.118
cellular response to oxygen levels GO:0071453 55 0.117
rna interference GO:0016246 4 0.117
response to alcohol GO:0097305 64 0.116
cell development GO:0048468 328 0.114
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.112
positive regulation of hydrolase activity GO:0051345 331 0.112
spindle organization GO:0007051 53 0.111
regulation of neuron apoptotic process GO:0043523 35 0.110
negative regulation of proteolysis GO:0045861 132 0.109
chromosome segregation GO:0007059 114 0.107
cell projection organization GO:0030030 252 0.107
regulation of cell cycle process GO:0010564 266 0.106
cellular response to hormone stimulus GO:0032870 125 0.106
nucleosome organization GO:0034728 66 0.106
reciprocal dna recombination GO:0035825 4 0.105
regulation of cell development GO:0060284 161 0.105
meiotic chromosome segregation GO:0045132 4 0.105
cellular component morphogenesis GO:0032989 314 0.104
cell cycle arrest GO:0007050 71 0.103
response to uv GO:0009411 73 0.103
dna unwinding involved in dna replication GO:0006268 2 0.103
regulation of viral process GO:0050792 103 0.102
response to steroid hormone GO:0048545 80 0.100
cellular response to nitrogen compound GO:1901699 144 0.100
cell cycle g2 m phase transition GO:0044839 43 0.100
negative regulation of catalytic activity GO:0043086 335 0.100
negative regulation of organelle organization GO:0010639 126 0.099
regulation of cell growth GO:0001558 135 0.099
response to drug GO:0042493 81 0.099
regulation of nucleoside metabolic process GO:0009118 209 0.097
regulation of protein acetylation GO:1901983 25 0.096
nucleotide excision repair GO:0006289 31 0.095
mitotic g2 m transition checkpoint GO:0044818 9 0.095
vesicle mediated transport GO:0016192 371 0.095
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.094
pharynx development GO:0060465 1 0.093
regulation of cellular amine metabolic process GO:0033238 11 0.092
amine metabolic process GO:0009308 44 0.091
developmental programmed cell death GO:0010623 3 0.091
immune response GO:0006955 307 0.090
regulation of multi organism process GO:0043900 157 0.089
response to caffeine GO:0031000 3 0.089
cardiovascular system development GO:0072358 262 0.088
positive regulation of histone modification GO:0031058 29 0.088
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.088
hematopoietic progenitor cell differentiation GO:0002244 38 0.087
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.086
meiotic cell cycle process GO:1903046 8 0.081
nervous system development GO:0007399 293 0.081
regulation of growth GO:0040008 165 0.080
Mouse
response to virus GO:0009615 126 0.080
regulation of angiogenesis GO:0045765 92 0.079
negative regulation of programmed cell death GO:0043069 321 0.079
Worm
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.079
regulation of defense response GO:0031347 154 0.077
positive regulation of helicase activity GO:0051096 6 0.074
osteoblast differentiation GO:0001649 92 0.074
cell activation GO:0001775 213 0.074
regulation of protein ubiquitination GO:0031396 95 0.073
cellular response to hypoxia GO:0071456 51 0.071
positive regulation of proteolysis GO:0045862 142 0.070
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.069
response to organonitrogen compound GO:0010243 156 0.069
regulation of protein localization GO:0032880 296 0.068
Rat
dna demethylation GO:0080111 12 0.068
neuron development GO:0048666 113 0.067
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.067
response to light stimulus GO:0009416 87 0.066
cellular response to ionizing radiation GO:0071479 32 0.065
negative regulation of phosphorus metabolic process GO:0010563 267 0.063
retina layer formation GO:0010842 3 0.063
regulation of dna recombination GO:0000018 23 0.063
regulation of cell differentiation GO:0045595 393 0.063
regulation of dna repair GO:0006282 47 0.061
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.059
purine nucleotide catabolic process GO:0006195 405 0.059
positive regulation of cell death GO:0010942 263 0.056
regulation of viral transcription GO:0046782 34 0.056
modification dependent macromolecule catabolic process GO:0043632 212 0.056
nuclear division GO:0000280 128 0.055
replicative cell aging GO:0001302 3 0.055
nucleotide biosynthetic process GO:0009165 109 0.054
extrinsic apoptotic signaling pathway GO:0097191 119 0.054
regulation of gene silencing GO:0060968 24 0.053
developmental process involved in reproduction GO:0003006 66 0.053
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.053
nucleoside phosphate catabolic process GO:1901292 412 0.053
ossification GO:0001503 121 0.053
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.053
regulation of protein maturation GO:1903317 150 0.052
regulation of peptidase activity GO:0052547 180 0.052
nuclear migration GO:0007097 1 0.052
dna integrity checkpoint GO:0031570 71 0.051
cellular response to lipid GO:0071396 127 0.051
nucleoside phosphate biosynthetic process GO:1901293 109 0.048
organelle fission GO:0048285 149 0.048
lymphocyte activation GO:0046649 133 0.047
cellular amine metabolic process GO:0044106 41 0.047
cellular ketone metabolic process GO:0042180 80 0.046
chromatin remodeling at centromere GO:0031055 2 0.045
positive regulation of transport GO:0051050 336 0.045
Rat
positive regulation of catabolic process GO:0009896 310 0.045
regulation of protein catabolic process GO:0042176 155 0.044
multi organism reproductive process GO:0044703 54 0.044
cellular component disassembly involved in execution phase of apoptosis GO:0006921 13 0.044
secretion by cell GO:0032940 226 0.043
chemical homeostasis GO:0048878 306 0.042
positive regulation of cellular catabolic process GO:0031331 284 0.042
response to bacterium GO:0009617 144 0.041
centrosome organization GO:0051297 58 0.041
reproduction GO:0000003 63 0.041
regulation of cellular protein catabolic process GO:1903362 96 0.041
apoptotic nuclear changes GO:0030262 13 0.041
response to temperature stimulus GO:0009266 22 0.041
regulation of kinase activity GO:0043549 314 0.040
endocytosis GO:0006897 159 0.040
alpha amino acid metabolic process GO:1901605 72 0.040
tissue homeostasis GO:0001894 63 0.039
histone deacetylation GO:0016575 32 0.039
reproductive structure development GO:0048608 55 0.038
dna biosynthetic process GO:0071897 40 0.038
maintenance of dna repeat elements GO:0043570 4 0.038
response to metal ion GO:0010038 84 0.037
ubiquitin dependent protein catabolic process GO:0006511 206 0.036
negative regulation of hydrolase activity GO:0051346 182 0.035
positive regulation of cellular amine metabolic process GO:0033240 7 0.035
cell activation involved in immune response GO:0002263 30 0.035
regulation of viral genome replication GO:0045069 48 0.033
positive regulation of growth GO:0045927 58 0.033
dna alkylation GO:0006305 7 0.033
development of primary sexual characteristics GO:0045137 35 0.033
positive regulation of response to dna damage stimulus GO:2001022 43 0.033
regulation of protein complex assembly GO:0043254 147 0.033
brain development GO:0007420 97 0.033
telomere organization GO:0032200 33 0.033
Mouse
dna hypermethylation GO:0044026 1 0.033
androgen receptor signaling pathway GO:0030521 34 0.033
mitotic chromosome condensation GO:0007076 11 0.033
positive regulation of multi organism process GO:0043902 56 0.033
tube development GO:0035295 125 0.033
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.031
regulation of binding GO:0051098 111 0.031
Rat
leukocyte activation GO:0045321 164 0.031
purine ribonucleotide catabolic process GO:0009154 404 0.031
negative regulation of chromosome organization GO:2001251 48 0.030
cytoplasmic transport GO:0016482 379 0.030
Rat
multicellular organismal homeostasis GO:0048871 67 0.030
positive regulation of chromatin silencing GO:0031937 3 0.030
reproductive process GO:0022414 106 0.029
blood circulation GO:0008015 113 0.029
cellular response to decreased oxygen levels GO:0036294 51 0.029
oocyte development GO:0048599 1 0.028
purine nucleoside catabolic process GO:0006152 398 0.028
response to heat GO:0009408 21 0.028
mitotic sister chromatid segregation GO:0000070 53 0.028
regulation of immune effector process GO:0002697 91 0.028
telomere maintenance GO:0000723 32 0.027
Mouse
protein import into nucleus GO:0006606 104 0.026
Rat
protein maturation GO:0051604 233 0.026
Rat
negative regulation of phosphate metabolic process GO:0045936 267 0.026
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.026
genetic imprinting GO:0071514 1 0.026
single organism cellular localization GO:1902580 332 0.026
Rat
positive regulation of histone methylation GO:0031062 12 0.026
positive regulation of leukocyte activation GO:0002696 80 0.025
posttranscriptional gene silencing GO:0016441 25 0.025
negative regulation of intracellular signal transduction GO:1902532 183 0.024
single fertilization GO:0007338 11 0.024
forebrain development GO:0030900 26 0.024
anatomical structure formation involved in morphogenesis GO:0048646 284 0.023
receptor mediated endocytosis GO:0006898 84 0.023
replication fork processing GO:0031297 13 0.023
mitotic sister chromatid separation GO:0051306 18 0.023
ribosome assembly GO:0042255 9 0.023
lipid homeostasis GO:0055088 39 0.023
central nervous system development GO:0007417 123 0.023
defense response GO:0006952 315 0.022
cellular response to insulin stimulus GO:0032869 41 0.022
immune effector process GO:0002252 159 0.022
head development GO:0060322 108 0.022
positive regulation of cell proliferation GO:0008284 301 0.022
positive regulation of cell development GO:0010720 92 0.022
positive regulation of lymphocyte activation GO:0051251 73 0.022
somatic diversification of immune receptors GO:0002200 8 0.021
reciprocal meiotic recombination GO:0007131 4 0.021
reproductive system development GO:0061458 56 0.021
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.021
regulation of histone acetylation GO:0035065 19 0.021
limbic system development GO:0021761 3 0.021
protein localization to chromosome centromeric region GO:0071459 12 0.021
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.020
adaptive immune response GO:0002250 49 0.020
lens development in camera type eye GO:0002088 2 0.020
regulation of keratinocyte apoptotic process GO:1902172 1 0.020
regulation of microtubule based process GO:0032886 74 0.020
negative regulation of transferase activity GO:0051348 124 0.019
regulation of cysteine type endopeptidase activity GO:2000116 127 0.019
cell morphogenesis GO:0000902 296 0.019
mismatch repair GO:0006298 15 0.019
intracellular receptor signaling pathway GO:0030522 104 0.018
nuclear transport GO:0051169 179 0.018
Rat
cell projection morphogenesis GO:0048858 129 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.018
response to wounding GO:0009611 168 0.018
regulation of transferase activity GO:0051338 355 0.018
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.018
protein sumoylation GO:0016925 25 0.018
positive regulation of chromosome organization GO:2001252 41 0.017
response to ethanol GO:0045471 11 0.017
epithelium development GO:0060429 227 0.017
regulation of lymphocyte activation GO:0051249 103 0.017
regulation of transcription by chromatin organization GO:0034401 1 0.017
regulation of nucleocytoplasmic transport GO:0046822 98 0.017
Rat
cell division GO:0051301 168 0.017
adult locomotory behavior GO:0008344 1 0.017
peptidyl lysine modification GO:0018205 144 0.017
positive regulation of defense response GO:0031349 87 0.017
regulation of protein kinase activity GO:0045859 289 0.017
g2 m transition of mitotic cell cycle GO:0000086 41 0.017
regulation of chromatin silencing GO:0031935 8 0.017
digestive system development GO:0055123 75 0.016
response to peptide GO:1901652 65 0.016
multicellular organism reproduction GO:0032504 42 0.016
response to biotic stimulus GO:0009607 276 0.016
hippocampus development GO:0021766 1 0.016
skin development GO:0043588 76 0.016
anatomical structure homeostasis GO:0060249 100 0.016
Mouse
negative regulation of protein processing GO:0010955 142 0.016
regulation of histone methylation GO:0031060 16 0.016
nuclear export GO:0051168 69 0.016
positive regulation of protein ubiquitination GO:0031398 53 0.016
regulation of nuclear division GO:0051783 65 0.016
multi multicellular organism process GO:0044706 18 0.016
regulation of dna replication GO:0006275 68 0.016
negative regulation of multi organism process GO:0043901 92 0.016
cellular modified amino acid metabolic process GO:0006575 64 0.015
meiotic chromosome separation GO:0051307 3 0.015
nuclear import GO:0051170 106 0.015
Rat
ribonucleoside biosynthetic process GO:0042455 25 0.015
leukocyte activation involved in immune response GO:0002366 30 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
histone phosphorylation GO:0016572 16 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
Rat
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.015
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.015
response to alkaloid GO:0043279 20 0.015
vascular smooth muscle cell differentiation GO:0035886 3 0.014
intracellular mrna localization GO:0008298 1 0.014
positive regulation of protein transport GO:0051222 135 0.014
Rat
negative regulation of phosphorylation GO:0042326 174 0.014
coenzyme metabolic process GO:0006732 65 0.014
sensory organ development GO:0007423 52 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
rna catabolic process GO:0006401 71 0.014
positive regulation of histone h3 k4 methylation GO:0051571 8 0.014
cell growth GO:0016049 160 0.014
establishment of chromosome localization GO:0051303 20 0.014
dna double strand break processing GO:0000729 10 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.014
sex differentiation GO:0007548 45 0.014
ras protein signal transduction GO:0007265 73 0.013
response to estrogen GO:0043627 47 0.013
regulation of chromatin assembly or disassembly GO:0001672 6 0.013
negative regulation of histone h3 k9 methylation GO:0051573 3 0.013
cellular amide metabolic process GO:0043603 69 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.013
pharyngeal system development GO:0060037 2 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
positive regulation of developmental growth GO:0048639 16 0.013
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.013
citrate metabolic process GO:0006101 2 0.013
response to acid chemical GO:0001101 66 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
Rat
sexual reproduction GO:0019953 37 0.012
regulation of cell motility GO:2000145 299 0.012
mitotic spindle assembly checkpoint GO:0007094 14 0.012
cell morphogenesis involved in differentiation GO:0000904 144 0.012

PARP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.115
nervous system disease DOID:863 431 0.052
neuropathy DOID:870 52 0.052
organ system cancer DOID:0050686 164 0.033
cancer DOID:162 167 0.033
central nervous system disease DOID:331 186 0.013