Homo sapiens

28 known processes

MELK

maternal embryonic leucine zipper kinase

(Aliases: HPK38,KIAA0175)

MELK biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic cell cycle process GO:1903047 286 0.308
nucleoside phosphate catabolic process GO:1901292 412 0.289
purine nucleoside triphosphate catabolic process GO:0009146 392 0.250
nuclear division GO:0000280 128 0.241
chromosome segregation GO:0007059 114 0.240
ribonucleotide catabolic process GO:0009261 405 0.221
regulation of chromosome segregation GO:0051983 44 0.214
mitotic cell cycle GO:0000278 326 0.212
regulation of mitotic cell cycle GO:0007346 189 0.195
microtubule based process GO:0007017 210 0.191
purine ribonucleoside metabolic process GO:0046128 437 0.190
mitotic nuclear division GO:0007067 119 0.172
regulation of cell cycle GO:0051726 393 0.169
single organism cellular localization GO:1902580 332 0.151
nucleoside triphosphate metabolic process GO:0009141 422 0.148
post embryonic development GO:0009791 2 0.131
Worm
nucleoside monophosphate metabolic process GO:0009123 191 0.127
nucleoside triphosphate catabolic process GO:0009143 394 0.127
purine nucleoside catabolic process GO:0006152 398 0.115
ribonucleoside triphosphate catabolic process GO:0009203 391 0.115
organophosphate catabolic process GO:0046434 430 0.113
meiotic chromosome segregation GO:0045132 4 0.113
nucleoside monophosphate catabolic process GO:0009125 159 0.110
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.106
ribonucleoside triphosphate metabolic process GO:0009199 412 0.102
regulation of cell cycle process GO:0010564 266 0.099
nucleotide catabolic process GO:0009166 408 0.098
purine nucleotide catabolic process GO:0006195 405 0.097
regulation of cellular response to stress GO:0080135 244 0.091
centrosome organization GO:0051297 58 0.090
purine ribonucleoside catabolic process GO:0046130 398 0.089
microtubule cytoskeleton organization GO:0000226 176 0.088
ribonucleoside catabolic process GO:0042454 406 0.086
cytokinesis GO:0000910 96 0.083
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.074
sister chromatid segregation GO:0000819 54 0.073
atp catabolic process GO:0006200 157 0.071
purine nucleoside triphosphate metabolic process GO:0009144 412 0.069
nucleoside catabolic process GO:0009164 408 0.069
purine nucleoside monophosphate metabolic process GO:0009126 186 0.069
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.068
purine containing compound catabolic process GO:0072523 411 0.067
glycosyl compound catabolic process GO:1901658 413 0.067
maintenance of location GO:0051235 112 0.066
organelle assembly GO:0070925 176 0.066
cellular protein complex assembly GO:0043623 188 0.065
mitotic cell cycle phase transition GO:0044772 162 0.063
small gtpase mediated signal transduction GO:0007264 78 0.063
organelle fission GO:0048285 149 0.062
microtubule organizing center organization GO:0031023 62 0.060
ribonucleoside monophosphate metabolic process GO:0009161 187 0.059
ribonucleoside monophosphate catabolic process GO:0009158 158 0.057
mitotic sister chromatid segregation GO:0000070 53 0.056
ras protein signal transduction GO:0007265 73 0.054
positive regulation of cell cycle process GO:0090068 106 0.053
purine ribonucleotide catabolic process GO:0009154 404 0.051
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.051
vesicle mediated transport GO:0016192 371 0.049
endomembrane system organization GO:0010256 196 0.049
response to abiotic stimulus GO:0009628 336 0.049
maintenance of location in cell GO:0051651 62 0.048
cell fate determination GO:0001709 3 0.047
multicellular organismal aging GO:0010259 3 0.047
blastocyst development GO:0001824 3 0.046
regulation of dna metabolic process GO:0051052 153 0.046
embryo development GO:0009790 123 0.046
regulation of purine nucleotide metabolic process GO:1900542 264 0.045
positive regulation of cell cycle GO:0045787 140 0.044
negative regulation of cell cycle GO:0045786 193 0.042
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.042
positive regulation of phosphorylation GO:0042327 394 0.041
protein catabolic process GO:0030163 325 0.041
dna recombination GO:0006310 77 0.040
cellular macromolecular complex assembly GO:0034622 324 0.040
atp metabolic process GO:0046034 176 0.040
oxidation reduction process GO:0055114 396 0.040
protein localization to nucleus GO:0034504 136 0.039
dna repair GO:0006281 198 0.039
nervous system development GO:0007399 293 0.038
Worm
regulation of protein localization GO:0032880 296 0.037
meiosis i GO:0007127 4 0.037
regulation of nucleotide metabolic process GO:0006140 269 0.037
immune system development GO:0002520 195 0.037
Zebrafish
spindle assembly GO:0051225 29 0.036
regulation of mitotic sister chromatid segregation GO:0033047 27 0.035
purine nucleoside monophosphate catabolic process GO:0009128 158 0.035
regulation of kinase activity GO:0043549 314 0.034
nucleus localization GO:0051647 1 0.033
positive regulation of nucleotide metabolic process GO:0045981 230 0.033
anatomical structure formation involved in morphogenesis GO:0048646 284 0.032
positive regulation of catabolic process GO:0009896 310 0.032
cellular component morphogenesis GO:0032989 314 0.032
dna packaging GO:0006323 77 0.032
cell cell signaling GO:0007267 155 0.031
regulation of small gtpase mediated signal transduction GO:0051056 156 0.031
signal transduction by phosphorylation GO:0023014 297 0.030
maintenance of protein location GO:0045185 57 0.030
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.030
regulation of nucleoside metabolic process GO:0009118 209 0.030
positive regulation of hydrolase activity GO:0051345 331 0.029
regulation of transferase activity GO:0051338 355 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
guanosine containing compound metabolic process GO:1901068 244 0.029
dephosphorylation GO:0016311 209 0.029
regulation of mitotic cell cycle phase transition GO:1901990 118 0.029
cell division GO:0051301 168 0.028
Worm
regulation of response to dna damage stimulus GO:2001020 94 0.028
protein processing GO:0016485 226 0.028
cell cycle phase transition GO:0044770 173 0.028
recombinational repair GO:0000725 50 0.028
female gamete generation GO:0007292 2 0.028
positive regulation of protein kinase activity GO:0045860 190 0.027
cellular component disassembly GO:0022411 92 0.027
spindle elongation GO:0051231 4 0.027
response to radiation GO:0009314 151 0.027
cellular response to dna damage stimulus GO:0006974 379 0.027
regulation of microtubule based process GO:0032886 74 0.027
protein localization to organelle GO:0033365 280 0.027
regeneration GO:0031099 4 0.027
negative regulation of cellular protein metabolic process GO:0032269 353 0.027
ubiquitin dependent protein catabolic process GO:0006511 206 0.026
cellular macromolecule catabolic process GO:0044265 380 0.026
regulation of nucleotide catabolic process GO:0030811 205 0.026
positive regulation of nucleotide catabolic process GO:0030813 185 0.026
endocytosis GO:0006897 159 0.026
regulation of cell cycle phase transition GO:1901987 126 0.025
circulatory system development GO:0072359 262 0.025
negative regulation of programmed cell death GO:0043069 321 0.024
organ morphogenesis GO:0009887 147 0.024
positive regulation of cell differentiation GO:0045597 211 0.024
interspecies interaction between organisms GO:0044419 156 0.024
determination of adult lifespan GO:0008340 2 0.024
organophosphate biosynthetic process GO:0090407 163 0.024
establishment of nucleus localization GO:0040023 1 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
cellular amine metabolic process GO:0044106 41 0.024
negative regulation of mitotic cell cycle GO:0045930 102 0.024
clearance of foreign intracellular dna by conversion of dna cytidine to uridine GO:0044356 1 0.024
negative regulation of protein metabolic process GO:0051248 391 0.024
oogenesis GO:0048477 2 0.024
positive regulation of developmental process GO:0051094 314 0.023
negative regulation of catalytic activity GO:0043086 335 0.023
establishment of organelle localization GO:0051656 59 0.023
modification dependent macromolecule catabolic process GO:0043632 212 0.022
positive regulation of kinase activity GO:0033674 204 0.022
mitotic cell cycle checkpoint GO:0007093 68 0.022
regulation of mitosis GO:0007088 63 0.022
central nervous system development GO:0007417 123 0.022
positive regulation of nucleoside metabolic process GO:0045979 186 0.022
cell activation GO:0001775 213 0.022
regulation of proteolysis GO:0030162 293 0.021
positive regulation of protein phosphorylation GO:0001934 313 0.021
nuclear migration GO:0007097 1 0.021
positive regulation of gtpase activity GO:0043547 166 0.021
neurogenesis GO:0022008 169 0.021
Worm
nucleotide biosynthetic process GO:0009165 109 0.021
cardiovascular system development GO:0072358 262 0.020
protein oligomerization GO:0051259 173 0.020
chromatin modification GO:0016568 298 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
positive regulation of dna metabolic process GO:0051054 73 0.020
epithelium development GO:0060429 227 0.020
regulation of purine nucleotide catabolic process GO:0033121 205 0.020
regulation of dna repair GO:0006282 47 0.020
regulation of mapk cascade GO:0043408 262 0.020
negative regulation of cell cycle phase transition GO:1901988 89 0.020
single organism reproductive process GO:0044702 98 0.020
positive regulation of gtp catabolic process GO:0033126 166 0.020
enzyme linked receptor protein signaling pathway GO:0007167 303 0.020
regulation of cell differentiation GO:0045595 393 0.020
response to oxygen containing compound GO:1901700 369 0.019
response to decreased oxygen levels GO:0036293 96 0.019
cellular amino acid metabolic process GO:0006520 116 0.019
gtp catabolic process GO:0006184 237 0.019
spermatid differentiation GO:0048515 4 0.019
cellular lipid metabolic process GO:0044255 303 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
single organism membrane organization GO:0044802 268 0.019
regulation of cytoplasmic transport GO:1903649 149 0.019
cellular ketone metabolic process GO:0042180 80 0.019
positive regulation of cell proliferation GO:0008284 301 0.018
regulation of protein processing GO:0070613 150 0.018
negative regulation of cellular component organization GO:0051129 235 0.018
regulation of cellular amino acid metabolic process GO:0006521 6 0.018
regulation of cell division GO:0051302 116 0.018
developmental process involved in reproduction GO:0003006 66 0.018
cellular component assembly involved in morphogenesis GO:0010927 73 0.018
immune response GO:0006955 307 0.018
cell development GO:0048468 328 0.017
Zebrafish
positive regulation of programmed cell death GO:0043068 249 0.017
Mouse
neuroblast division GO:0055057 1 0.017
Worm
reproduction GO:0000003 63 0.017
negative regulation of apoptotic process GO:0043066 316 0.017
regulation of cellular ketone metabolic process GO:0010565 50 0.017
gtp metabolic process GO:0046039 239 0.017
protein targeting GO:0006605 187 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
double strand break repair via homologous recombination GO:0000724 50 0.016
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.016
negative regulation of proteolysis GO:0045861 132 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.016
intracellular protein transport GO:0006886 270 0.016
double strand break repair GO:0006302 101 0.016
dna conformation change GO:0071103 113 0.016
negative regulation of protein processing GO:0010955 142 0.016
cellular response to endogenous stimulus GO:0071495 336 0.015
response to hypoxia GO:0001666 96 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
cellular response to oxidative stress GO:0034599 85 0.015
Mouse
cofactor metabolic process GO:0051186 87 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
epithelial cell differentiation GO:0030855 141 0.015
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.015
cytoplasmic transport GO:0016482 379 0.015
regulation of protein transport GO:0051223 213 0.015
protein autophosphorylation GO:0046777 123 0.015
reproductive structure development GO:0048608 55 0.014
regulation of gtpase activity GO:0043087 180 0.014
oocyte differentiation GO:0009994 2 0.014
meiotic nuclear division GO:0007126 10 0.014
wnt signaling pathway GO:0016055 156 0.014
negative regulation of protein modification process GO:0031400 200 0.014
negative regulation of cell cycle process GO:0010948 121 0.014
negative regulation of cell death GO:0060548 345 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
positive regulation of organelle organization GO:0010638 195 0.014
positive regulation of protein transport GO:0051222 135 0.014
positive regulation of transferase activity GO:0051347 227 0.014
spindle organization GO:0007051 53 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
tissue regeneration GO:0042246 3 0.014
protein maturation GO:0051604 233 0.014
adult locomotory behavior GO:0008344 1 0.013
digestive system development GO:0055123 75 0.013
cell cycle checkpoint GO:0000075 117 0.013
regulation of cellular component biogenesis GO:0044087 281 0.013
regulation of protein catabolic process GO:0042176 155 0.013
spindle assembly involved in mitosis GO:0090307 12 0.013
reproductive process GO:0022414 106 0.013
heart development GO:0007507 95 0.013
protein homooligomerization GO:0051260 100 0.013
cell morphogenesis GO:0000902 296 0.013
cytoskeleton dependent cytokinesis GO:0061640 22 0.013
oocyte development GO:0048599 1 0.013
actin filament based process GO:0030029 224 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
regulation of protein kinase activity GO:0045859 289 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
cilium morphogenesis GO:0060271 75 0.013
regulation of dna replication GO:0006275 68 0.013
sex differentiation GO:0007548 45 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
mitotic cytokinesis GO:0000281 19 0.013
regulation of nucleocytoplasmic transport GO:0046822 98 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
mrna processing GO:0006397 133 0.013
regulation of intracellular protein transport GO:0033157 123 0.012
attachment of spindle microtubules to kinetochore GO:0008608 17 0.012
hemopoiesis GO:0030097 180 0.012
Zebrafish
head development GO:0060322 108 0.012
response to oxidative stress GO:0006979 121 0.012
Mouse
blood vessel morphogenesis GO:0048514 162 0.012
negative regulation of protein maturation GO:1903318 142 0.012
response to light stimulus GO:0009416 87 0.012
growth GO:0040007 202 0.012
somatic muscle development GO:0007525 1 0.012
microtubule based movement GO:0007018 32 0.012
cellular response to radiation GO:0071478 65 0.012
nucleoside phosphate biosynthetic process GO:1901293 109 0.012
locomotory behavior GO:0007626 1 0.012
regulation of protein maturation GO:1903317 150 0.012
reproductive system development GO:0061458 56 0.012
cell cycle g1 s phase transition GO:0044843 80 0.012
positive regulation of mitotic cell cycle GO:0045931 60 0.012
regulation of protein ubiquitination GO:0031396 95 0.012
cell projection organization GO:0030030 252 0.012
mitochondrial genome maintenance GO:0000002 8 0.012
regulation of proteasomal protein catabolic process GO:0061136 87 0.012
cell cycle g2 m phase transition GO:0044839 43 0.012
regulation of protein targeting GO:1903533 91 0.012
chromatin remodeling GO:0006338 55 0.011
positive regulation of cellular component organization GO:0051130 376 0.011
regulation of chromosome organization GO:0033044 103 0.011
positive regulation of cell death GO:0010942 263 0.011
Mouse
regulation of intracellular transport GO:0032386 195 0.011
peptidyl serine phosphorylation GO:0018105 101 0.011
regulation of peptidase activity GO:0052547 180 0.011
organelle localization GO:0051640 84 0.011
negative regulation of organelle organization GO:0010639 126 0.011
sex determination GO:0007530 3 0.011
biological adhesion GO:0022610 331 0.011
dna replication GO:0006260 116 0.011
cell part morphogenesis GO:0032990 137 0.011
myosin filament assembly GO:0031034 2 0.011
centromere complex assembly GO:0034508 10 0.011
regulation of protein complex assembly GO:0043254 147 0.011
maintenance of protein location in cell GO:0032507 56 0.011
tube development GO:0035295 125 0.011
oocyte maturation GO:0001556 1 0.011
immune effector process GO:0002252 159 0.011
striated muscle myosin thick filament assembly GO:0071688 2 0.011
lymphocyte activation GO:0046649 133 0.010
cellular response to oxygen containing compound GO:1901701 276 0.010
positive regulation of transport GO:0051050 336 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
amine metabolic process GO:0009308 44 0.010
regulation of protein import into nucleus GO:0042306 78 0.010

MELK disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.023
disease of cellular proliferation DOID:14566 174 0.015