|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.989
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.984
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.956
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.913
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.910
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.909
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.905
|
|
|
|
regulation of protein oligomerization
|
GO:0032459 |
26 |
0.895
|
|
|
|
regulation of release of cytochrome c from mitochondria
|
GO:0090199 |
29 |
0.879
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.872
|
|
|
|
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
|
GO:1901030 |
3 |
0.871
|
|
|
|
negative regulation of phosphatase activity
|
GO:0010923 |
61 |
0.866
|
|
|
|
positive regulation of release of cytochrome c from mitochondria
|
GO:0090200 |
18 |
0.855
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.852
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.845
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.841
|
|
|
|
positive regulation of mitochondrion organization
|
GO:0010822 |
30 |
0.834
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.823
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.822
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.774
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.769
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.768
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.763
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.699
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.687
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.686
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.680
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.668
|
|
|
|
positive regulation of protein oligomerization
|
GO:0032461 |
17 |
0.641
|
|
|
|
regulation of mitochondrion organization
|
GO:0010821 |
54 |
0.587
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.584
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.581
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.574
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.549
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.545
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.533
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.529
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.516
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.504
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.494
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.481
|
Fly |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.481
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.478
|
Mouse |
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.451
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.443
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.418
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.413
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.408
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.401
|
|
|
|
negative regulation of endoplasmic reticulum calcium ion concentration
|
GO:0032471 |
6 |
0.395
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.388
|
Mouse |
|
|
positive regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway
|
GO:1903378 |
2 |
0.387
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.387
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.380
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.374
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.363
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.362
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.361
|
|
|
|
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
|
GO:0001844 |
2 |
0.360
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.351
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.351
|
|
|
|
positive regulation of fibroblast apoptotic process
|
GO:2000271 |
6 |
0.345
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.341
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.338
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.336
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.335
|
|
|
|
apoptotic process involved in morphogenesis
|
GO:0060561 |
3 |
0.332
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.330
|
Mouse |
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.330
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.328
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.327
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.327
|
|
|
|
nephron tubule epithelial cell differentiation
|
GO:0072160 |
3 |
0.319
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.319
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.318
|
|
|
|
positive regulation of protein homooligomerization
|
GO:0032464 |
7 |
0.317
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.287
|
|
|
|
growth
|
GO:0040007 |
202 |
0.286
|
|
|
|
modulation of programmed cell death in other organism
|
GO:0044531 |
1 |
0.285
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.277
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.270
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c
|
GO:0008635 |
2 |
0.265
|
|
|
|
negative regulation of catenin import into nucleus
|
GO:0035414 |
7 |
0.260
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.259
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.259
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.258
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.254
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.245
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
23 |
0.242
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.242
|
Mouse |
|
|
positive regulation of endoplasmic reticulum unfolded protein response
|
GO:1900103 |
4 |
0.239
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.238
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.238
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.238
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.234
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.232
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.231
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.226
|
|
|
|
establishment of protein localization to mitochondrion
|
GO:0072655 |
22 |
0.223
|
|
|
|
system process
|
GO:0003008 |
349 |
0.217
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.209
|
|
|
|
regulation of apoptotic dna fragmentation
|
GO:1902510 |
3 |
0.209
|
|
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.202
|
|
|
|
behavioral defense response
|
GO:0002209 |
0 |
0.201
|
|
|
|
insemination
|
GO:0007320 |
1 |
0.201
|
|
|
|
modulation of programmed cell death in other organism involved in symbiotic interaction
|
GO:0052248 |
1 |
0.201
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.198
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.197
|
Mouse |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.197
|
Mouse |
|
|
positive regulation of apoptotic process involved in mammary gland involution
|
GO:0060058 |
1 |
0.195
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.193
|
|
|
|
modulation by symbiont of host programmed cell death
|
GO:0052040 |
1 |
0.192
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.190
|
|
|
|
metanephric nephron epithelium development
|
GO:0072243 |
4 |
0.189
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.189
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.188
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.179
|
Fly |
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.177
|
|
|
|
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway
|
GO:1902177 |
4 |
0.176
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.175
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.173
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.172
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.170
|
|
|
|
copulation
|
GO:0007620 |
1 |
0.170
|
|
|
|
er nucleus signaling pathway
|
GO:0006984 |
23 |
0.170
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.170
|
|
|
|
regulation of membrane permeability
|
GO:0090559 |
25 |
0.169
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.169
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.168
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.166
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.166
|
Fly |
|
|
modulation of apoptotic process in other organism
|
GO:0044532 |
1 |
0.163
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.161
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.153
|
|
|
|
response to gamma radiation
|
GO:0010332 |
14 |
0.153
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.150
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.147
|
|
|
|
positive regulation of apoptotic process involved in morphogenesis
|
GO:1902339 |
1 |
0.145
|
|
|
|
modulation by organism of apoptotic process in other organism involved in symbiotic interaction
|
GO:0052433 |
1 |
0.145
|
|
|
|
regulation of cardiac muscle cell proliferation
|
GO:0060043 |
4 |
0.144
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.144
|
|
|
|
modulation by symbiont of host cellular process
|
GO:0044068 |
3 |
0.143
|
|
|
|
regulation of mitochondrial membrane permeability
|
GO:0046902 |
25 |
0.143
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.141
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.140
|
|
|
|
sensory organ development
|
GO:0007423 |
52 |
0.139
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.136
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.134
|
|
|
|
hippo signaling
|
GO:0035329 |
20 |
0.132
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.131
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.131
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.130
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.129
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.128
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.125
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.124
|
|
|
|
modulation by symbiont of host apoptotic process
|
GO:0052150 |
1 |
0.123
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.122
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.121
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
51 |
0.121
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.120
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.120
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.120
|
|
|
|
positive regulation of b cell apoptotic process
|
GO:0002904 |
1 |
0.119
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.119
|
|
|
|
positive regulation of myeloid cell apoptotic process
|
GO:0033034 |
2 |
0.118
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.117
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.115
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.114
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.113
|
|
|
|
regulation of carbohydrate metabolic process
|
GO:0006109 |
54 |
0.112
|
|
|
|
negative regulation of dephosphorylation
|
GO:0035305 |
63 |
0.112
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.111
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.110
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.110
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.109
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.107
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.107
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.106
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.105
|
|
|
|
cell differentiation involved in metanephros development
|
GO:0072202 |
3 |
0.103
|
|
|
|
positive regulation of oxidative stress induced cell death
|
GO:1903209 |
5 |
0.103
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.103
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.103
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.102
|
|
|
|
kidney morphogenesis
|
GO:0060993 |
19 |
0.102
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.101
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.101
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.100
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.098
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.098
|
|
|
|
regulation of symbiosis encompassing mutualism through parasitism
|
GO:0043903 |
109 |
0.097
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.097
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.097
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.097
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.095
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.094
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.093
|
|
|
|
positive regulation of mitochondrial membrane permeability
|
GO:0035794 |
17 |
0.093
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.092
|
|
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.092
|
|
|
|
regulation of cellular ph reduction
|
GO:0032847 |
1 |
0.092
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.090
|
|
|
|
protein insertion into mitochondrial membrane
|
GO:0051204 |
3 |
0.089
|
|
|
|
neural tube patterning
|
GO:0021532 |
2 |
0.088
|
|
|
|
mitochondrial membrane organization
|
GO:0007006 |
40 |
0.088
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.087
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.087
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.086
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.086
|
Fly |
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.086
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.085
|
|
|
|
mitochondrial outer membrane permeabilization
|
GO:0097345 |
15 |
0.084
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.084
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.083
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.082
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.082
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.081
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.081
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.081
|
|
|
|
modulation by virus of host process
|
GO:0019054 |
2 |
0.080
|
|
|
|
regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902108 |
18 |
0.080
|
|
|
|
eye morphogenesis
|
GO:0048592 |
16 |
0.077
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.077
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.077
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.077
|
|
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
2 |
0.076
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.076
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.076
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.076
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.075
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.075
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.074
|
|
|
|
male meiosis
|
GO:0007140 |
1 |
0.074
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.073
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.073
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.073
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.073
|
|
|
|
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
GO:0070059 |
12 |
0.072
|
|
|
|
metanephros development
|
GO:0001656 |
16 |
0.072
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.071
|
Fly |
|
|
response to virus
|
GO:0009615 |
126 |
0.071
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.071
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.071
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.070
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.070
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.070
|
|
|
|
liposaccharide metabolic process
|
GO:1903509 |
27 |
0.069
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.068
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.068
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.067
|
|
|
|
organ growth
|
GO:0035265 |
12 |
0.067
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.067
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.067
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.066
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.066
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.066
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.065
|
|
|
|
establishment or maintenance of transmembrane electrochemical gradient
|
GO:0010248 |
2 |
0.065
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.063
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.063
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.062
|
|
|
|
histone lysine methylation
|
GO:0034968 |
50 |
0.062
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.062
|
Mouse |
|
|
apoptotic process in bone marrow
|
GO:0071839 |
1 |
0.062
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.062
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.061
|
|
|
|
positive regulation of neuron apoptotic process
|
GO:0043525 |
8 |
0.061
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.060
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.060
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.060
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.059
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.059
|
|
|
|
epidermis morphogenesis
|
GO:0048730 |
3 |
0.059
|
|
|
|
negative regulation of hippo signaling
|
GO:0035331 |
6 |
0.059
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.059
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.058
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.058
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.057
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.057
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.057
|
|
|
|
response to electrical stimulus
|
GO:0051602 |
1 |
0.056
|
|
|
|
oocyte maturation
|
GO:0001556 |
1 |
0.056
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.055
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
|
GO:0042771 |
23 |
0.055
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.054
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.054
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.054
|
|
|
|
regulation of striated muscle tissue development
|
GO:0016202 |
26 |
0.054
|
|
|
|
regulation of protein homooligomerization
|
GO:0032462 |
11 |
0.054
|
|
|
|
asymmetric stem cell division
|
GO:0098722 |
1 |
0.054
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.054
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.054
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.053
|
Fly |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.053
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.053
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.052
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.052
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.052
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.052
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
41 |
0.051
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.050
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.050
|
|
|
|
regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902041 |
24 |
0.050
|
|
|
|
dna damage response signal transduction resulting in transcription
|
GO:0042772 |
12 |
0.050
|
|
|
|
negative regulation of calcium ion transport into cytosol
|
GO:0010523 |
3 |
0.050
|
|
|
|
positive regulation of dna catabolic process
|
GO:1903626 |
2 |
0.050
|
|
|
|
fibroblast apoptotic process
|
GO:0044346 |
8 |
0.049
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.049
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.049
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.049
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.049
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.049
|
|
|
|
macromolecule methylation
|
GO:0043414 |
97 |
0.049
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.048
|
|
|
|
eye development
|
GO:0001654 |
42 |
0.048
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.047
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.047
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.046
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.046
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.046
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.045
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.045
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.045
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
40 |
0.044
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.044
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.044
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.044
|
Fly |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.043
|
|
|
|
regulation of protein dephosphorylation
|
GO:0035304 |
18 |
0.043
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.043
|
|
|
|
regulation of metanephric nephron tubule epithelial cell differentiation
|
GO:0072307 |
1 |
0.043
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.043
|
|
|
|
positive regulation of developmental pigmentation
|
GO:0048087 |
2 |
0.043
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.043
|
|
|
|
negative regulation of canonical wnt signaling pathway
|
GO:0090090 |
55 |
0.042
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.042
|
|
|
|
mitochondrial outer membrane permeabilization involved in programmed cell death
|
GO:1902686 |
16 |
0.042
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.042
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.042
|
|
|
|
positive regulation of response to dna damage stimulus
|
GO:2001022 |
43 |
0.041
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.041
|
|
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.040
|
|
|
|
negative regulation by symbiont of host apoptotic process
|
GO:0033668 |
1 |
0.040
|
|
|
|
release of matrix enzymes from mitochondria
|
GO:0032976 |
1 |
0.039
|
|
|
|
regulation of apoptotic process involved in morphogenesis
|
GO:1902337 |
1 |
0.039
|
|
|
|
fear response
|
GO:0042596 |
0 |
0.039
|
|
|
|
renal tubule development
|
GO:0061326 |
19 |
0.039
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.039
|
|
|
|
embryonic eye morphogenesis
|
GO:0048048 |
2 |
0.039
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
34 |
0.039
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.039
|
|
|
|
positive regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902110 |
16 |
0.039
|
|
|
|
negative regulation by symbiont of host programmed cell death
|
GO:0052041 |
1 |
0.039
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.038
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.038
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.038
|
|
|
|
negative regulation of response to dna damage stimulus
|
GO:2001021 |
33 |
0.038
|
|
|
|
protein localization to mitochondrion
|
GO:0070585 |
25 |
0.038
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.038
|
|
|
|
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway
|
GO:1903376 |
7 |
0.037
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.037
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
38 |
0.037
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.037
|
|
|
|
regulation of epithelial cell differentiation involved in kidney development
|
GO:2000696 |
4 |
0.037
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.036
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.036
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.036
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.036
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.036
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.036
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.036
|
|
|
|
response to starvation
|
GO:0042594 |
59 |
0.036
|
|
|
|
embryonic digestive tract morphogenesis
|
GO:0048557 |
2 |
0.035
|
|
|
|
patterning of blood vessels
|
GO:0001569 |
2 |
0.035
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.035
|
|
|
|
cd8 positive alpha beta t cell differentiation
|
GO:0043374 |
1 |
0.035
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.035
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.035
|
|
|
|
response to hydrogen peroxide
|
GO:0042542 |
40 |
0.035
|
|
|
|
fibroblast proliferation
|
GO:0048144 |
33 |
0.034
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.034
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.034
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.034
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.034
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.034
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.034
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.034
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.034
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.034
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.034
|
|
|
|
neuroblast division
|
GO:0055057 |
1 |
0.034
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.033
|
|
|
|
positive regulation of autophagy
|
GO:0010508 |
24 |
0.033
|
|
|
|
regulation of histone modification
|
GO:0031056 |
47 |
0.033
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.033
|
|
|
|
negative regulation of protein binding
|
GO:0032091 |
35 |
0.033
|
|
|
|
positive regulation of apoptotic dna fragmentation
|
GO:1902512 |
1 |
0.033
|
|
|
|
peptide metabolic process
|
GO:0006518 |
51 |
0.033
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.033
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.032
|
|
|
|
negative regulation of cardiac muscle cell proliferation
|
GO:0060044 |
2 |
0.032
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.032
|
|
|
|
protein deacylation
|
GO:0035601 |
39 |
0.032
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.032
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.032
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.032
|
|
|
|
protein glycosylation
|
GO:0006486 |
62 |
0.032
|
|
|
|
positive regulation of cell growth
|
GO:0030307 |
48 |
0.032
|
|
|
|
regulation of execution phase of apoptosis
|
GO:1900117 |
11 |
0.031
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.031
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.031
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.031
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.031
|
|
|
|
nucleus localization
|
GO:0051647 |
1 |
0.031
|
|
|
|
microvillus organization
|
GO:0032528 |
2 |
0.031
|
|
|
|
centrosome separation
|
GO:0051299 |
3 |
0.031
|
|
|
|
regulation of oxidative stress induced intrinsic apoptotic signaling pathway
|
GO:1902175 |
16 |
0.031
|
|
|
|
regulation of stem cell maintenance
|
GO:2000036 |
4 |
0.031
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.030
|
|
|
|
convergent extension
|
GO:0060026 |
1 |
0.030
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.030
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.030
|
|
|
|
response to caffeine
|
GO:0031000 |
3 |
0.030
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.030
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
44 |
0.030
|
|
|
|
camera type eye development
|
GO:0043010 |
25 |
0.030
|
|
|
|
embryonic camera type eye development
|
GO:0031076 |
2 |
0.030
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.029
|
|
|
|
embryonic heart tube morphogenesis
|
GO:0003143 |
8 |
0.029
|
|
|
|
nucleic acid phosphodiester bond hydrolysis
|
GO:0090305 |
102 |
0.029
|
|
|
|
negative regulation of execution phase of apoptosis
|
GO:1900118 |
6 |
0.029
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.029
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.029
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.029
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.029
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.029
|
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.029
|
|
|
|
neuron death in response to oxidative stress
|
GO:0036475 |
9 |
0.028
|
|
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
91 |
0.028
|
|
|
|
glial cell apoptotic process
|
GO:0034349 |
7 |
0.028
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.028
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.028
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.028
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.028
|
|
|
|
embryonic camera type eye morphogenesis
|
GO:0048596 |
2 |
0.028
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.028
|
|
|
|
negative regulation of axonogenesis
|
GO:0050771 |
4 |
0.028
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.028
|
|
|
|
negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction
|
GO:0052490 |
1 |
0.028
|
|
|
|
regulation of cardiac muscle tissue growth
|
GO:0055021 |
4 |
0.028
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.028
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.028
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.028
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.028
|
|
|
|
axis elongation
|
GO:0003401 |
4 |
0.027
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.027
|
|
|
|
positive regulation of cell cycle arrest
|
GO:0071158 |
23 |
0.027
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.027
|
|
|
|
regulation of oxidative stress induced neuron death
|
GO:1903203 |
9 |
0.027
|
|
|
|
macromolecule glycosylation
|
GO:0043413 |
63 |
0.027
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.027
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
56 |
0.027
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.027
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.027
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.026
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.026
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.026
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.026
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.026
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.026
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.026
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.026
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.026
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.026
|
|
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.026
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.026
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.026
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.026
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.025
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.025
|
|
|
|
glycosylation
|
GO:0070085 |
71 |
0.025
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.025
|
|
|
|
regulation of glial cell proliferation
|
GO:0060251 |
4 |
0.025
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.025
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.025
|
|
