Homo sapiens

642 known processes

TNF

tumor necrosis factor

(Aliases: TNFSF2,DIF,TNF-alpha,TNFA)

TNF biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular amine metabolic process GO:0033240 7 0.953
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.952
cytokine mediated signaling pathway GO:0019221 109 0.945
positive regulation of cytokine production GO:0001819 167 0.937
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.926
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.921
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.921
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.915
response to biotic stimulus GO:0009607 276 0.894
myeloid dendritic cell chemotaxis GO:0002408 3 0.886
i kappab kinase nf kappab signaling GO:0007249 166 0.884
cytokine production GO:0001816 247 0.863
jak stat cascade GO:0007259 46 0.846
cellular amino acid metabolic process GO:0006520 116 0.843
immune system development GO:0002520 195 0.840
regulation of cellular amino acid metabolic process GO:0006521 6 0.835
mature natural killer cell chemotaxis GO:0035782 1 0.835
peptidyl tyrosine phosphorylation GO:0018108 170 0.828
regulation of response to external stimulus GO:0032101 222 0.822
hemopoiesis GO:0030097 180 0.816
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.814
response to molecule of bacterial origin GO:0002237 82 0.797
cell type specific apoptotic process GO:0097285 125 0.796
cellular response to biotic stimulus GO:0071216 71 0.785
apoptotic signaling pathway GO:0097190 268 0.779
positive regulation of jak stat cascade GO:0046427 35 0.777
positive regulation of cell proliferation GO:0008284 301 0.776
positive regulation of mapk cascade GO:0043410 190 0.776
cellular ketone metabolic process GO:0042180 80 0.775
defense response GO:0006952 315 0.760
response to other organism GO:0051707 261 0.755
positive regulation of immune system process GO:0002684 283 0.752
extrinsic apoptotic signaling pathway GO:0097191 119 0.751
positive regulation of phosphorylation GO:0042327 394 0.748
cellular response to cytokine stimulus GO:0071345 181 0.748
erk1 and erk2 cascade GO:0070371 104 0.747
negative regulation of apoptotic process GO:0043066 316 0.744
regulation of defense response GO:0031347 154 0.735
regulation of transferase activity GO:0051338 355 0.733
positive regulation of protein transport GO:0051222 135 0.726
response to bacterium GO:0009617 144 0.724
cellular ion homeostasis GO:0006873 168 0.718
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.706
amine metabolic process GO:0009308 44 0.700
adaptive immune response GO:0002250 49 0.699
positive regulation of jnk cascade GO:0046330 52 0.697
cellular response to oxygen containing compound GO:1901701 276 0.692
osteoclast differentiation GO:0030316 21 0.683
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.678
response to lipopolysaccharide GO:0032496 70 0.677
positive regulation of protein import into nucleus GO:0042307 46 0.675
positive regulation of cell death GO:0010942 263 0.674
regulation of cellular ketone metabolic process GO:0010565 50 0.670
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.668
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.647
regulation of stress activated mapk cascade GO:0032872 84 0.642
positive regulation of protein phosphorylation GO:0001934 313 0.639
eosinophil activation involved in immune response GO:0002278 2 0.638
response to nitric oxide GO:0071731 4 0.636
negative regulation of programmed cell death GO:0043069 321 0.635
response to lipid GO:0033993 206 0.631
positive regulation of map kinase activity GO:0043406 80 0.628
positive regulation of kinase activity GO:0033674 204 0.625
rho protein signal transduction GO:0007266 26 0.622
cellular response to molecule of bacterial origin GO:0071219 62 0.612
positive regulation of epithelial cell proliferation GO:0050679 65 0.606
immune response GO:0006955 307 0.601
peptidyl tyrosine modification GO:0018212 170 0.598
cation homeostasis GO:0055080 189 0.594
regulation of cellular amine metabolic process GO:0033238 11 0.590
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.584
positive regulation of programmed cell death GO:0043068 249 0.581
cellular response to tumor necrosis factor GO:0071356 63 0.579
cellular metal ion homeostasis GO:0006875 146 0.579
regulation of inflammatory response GO:0050727 46 0.578
small gtpase mediated signal transduction GO:0007264 78 0.578
response to oxygen containing compound GO:1901700 369 0.578
negative regulation of multicellular organismal process GO:0051241 317 0.573
metal ion homeostasis GO:0055065 169 0.567
regulation of protein localization GO:0032880 296 0.565
negative regulation of t cell cytokine production GO:0002725 4 0.555
negative regulation of response to wounding GO:1903035 47 0.553
regulation of apoptotic signaling pathway GO:2001233 175 0.549
regulation of cell differentiation GO:0045595 393 0.544
single organism nuclear import GO:1902593 104 0.537
positive regulation of cd8 positive alpha beta t cell proliferation GO:2000566 1 0.528
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.528
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.528
calcium ion homeostasis GO:0055074 122 0.527
signal transduction by phosphorylation GO:0023014 297 0.522
cellular cation homeostasis GO:0030003 163 0.520
eosinophil degranulation GO:0043308 2 0.505
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.502
regulation of leukocyte differentiation GO:1902105 61 0.499
response to wounding GO:0009611 168 0.499
regulation of jnk cascade GO:0046328 73 0.495
positive regulation of gtp catabolic process GO:0033126 166 0.490
regulation of response to wounding GO:1903034 101 0.488
regulation of leukocyte migration GO:0002685 63 0.485
ras protein signal transduction GO:0007265 73 0.479
negative regulation of cell death GO:0060548 345 0.477
jnk cascade GO:0007254 80 0.474
regulation of small gtpase mediated signal transduction GO:0051056 156 0.471
divalent inorganic cation homeostasis GO:0072507 136 0.467
tumor necrosis factor production GO:0032640 43 0.463
mapk cascade GO:0000165 288 0.455
response to growth factor GO:0070848 205 0.448
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.447
cellular response to organic cyclic compound GO:0071407 127 0.440
positive regulation of cytoplasmic transport GO:1903651 82 0.440
regulation of map kinase activity GO:0043405 108 0.439
response to cytokine GO:0034097 232 0.439
cytoplasmic transport GO:0016482 379 0.439
regulation of protein serine threonine kinase activity GO:0071900 179 0.435
ion homeostasis GO:0050801 230 0.433
immune response activating signal transduction GO:0002757 90 0.433
positive regulation of intracellular protein transport GO:0090316 76 0.431
positive regulation of immune response GO:0050778 159 0.431
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.422
negative regulation of alpha beta t cell proliferation GO:0046642 1 0.421
regulation of cytoplasmic transport GO:1903649 149 0.420
intracellular protein transport GO:0006886 270 0.420
regulation of mapk cascade GO:0043408 262 0.419
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.417
regulation of adaptive immune response GO:0002819 33 0.417
positive regulation of defense response GO:0031349 87 0.416
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.410
regulation of erk1 and erk2 cascade GO:0070372 99 0.407
positive regulation of apoptotic process GO:0043065 246 0.400
regulation of cytokine production GO:0001817 232 0.400
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.399
cellular calcium ion homeostasis GO:0006874 117 0.397
leukocyte differentiation GO:0002521 98 0.396
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.395
regulation of kinase activity GO:0043549 314 0.392
regulation of protein transport GO:0051223 213 0.390
myeloid cell differentiation GO:0030099 117 0.381
positive regulation of cellular catabolic process GO:0031331 284 0.379
regulation of granzyme a production GO:2000511 1 0.377
regulation of tumor necrosis factor production GO:0032680 43 0.366
eosinophil mediated immunity GO:0002447 2 0.362
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.355
establishment of lymphocyte polarity GO:0001767 2 0.352
positive regulation of nucleotide metabolic process GO:0045981 230 0.350
regulation of leukocyte activation GO:0002694 115 0.349
cellular response to lipopolysaccharide GO:0071222 57 0.345
regulation of rho protein signal transduction GO:0035023 79 0.345
regulation of immune response GO:0050776 201 0.338
guanosine containing compound metabolic process GO:1901068 244 0.336
positive regulation of response to external stimulus GO:0032103 88 0.335
regulation of nucleotide metabolic process GO:0006140 269 0.335
negative regulation of natural killer cell chemotaxis GO:2000502 1 0.334
establishment of protein localization to organelle GO:0072594 172 0.333
positive regulation of proteolysis GO:0045862 142 0.328
hematopoietic or lymphoid organ development GO:0048534 186 0.326
positive regulation of cell activation GO:0050867 81 0.324
positive regulation of cell differentiation GO:0045597 211 0.319
ribonucleoside triphosphate metabolic process GO:0009199 412 0.318
leukocyte mediated immunity GO:0002443 59 0.314
interleukin 2 production GO:0032623 20 0.313
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.311
cellular chemical homeostasis GO:0055082 180 0.310
response to tumor necrosis factor GO:0034612 76 0.310
purine nucleotide catabolic process GO:0006195 405 0.309
positive regulation of transport GO:0051050 336 0.309
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.308
positive regulation of nf kappab import into nucleus GO:0042346 13 0.307
nucleotide catabolic process GO:0009166 408 0.305
response to external biotic stimulus GO:0043207 261 0.305
negative regulation of t helper 1 cell activation GO:2000518 1 0.302
regulation of locomotion GO:0040012 329 0.295
nucleoside triphosphate catabolic process GO:0009143 394 0.293
regulation of anatomical structure morphogenesis GO:0022603 286 0.293
regulation of ras gtpase activity GO:0032318 128 0.291
chemical homeostasis GO:0048878 306 0.288
divalent inorganic cation transport GO:0072511 158 0.287
regulation of cellular response to stress GO:0080135 244 0.286
cellular homeostasis GO:0019725 196 0.284
activation of immune response GO:0002253 114 0.282
positive regulation of transferase activity GO:0051347 227 0.281
cell cell signaling GO:0007267 155 0.280
amide transport GO:0042886 76 0.278
cellular response to growth factor stimulus GO:0071363 197 0.277
lymphocyte activation GO:0046649 133 0.277
protein import GO:0017038 130 0.274
negative regulation of neurological system process GO:0031645 2 0.273
gtp metabolic process GO:0046039 239 0.270
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.270
positive regulation of rho gtpase activity GO:0032321 56 0.268
negative regulation of c c chemokine binding GO:2001264 1 0.267
negative regulation of defense response GO:0031348 47 0.266
inflammatory response GO:0006954 79 0.265
gtp catabolic process GO:0006184 237 0.263
purine ribonucleoside catabolic process GO:0046130 398 0.262
cellular amine metabolic process GO:0044106 41 0.261
regulation of protein kinase activity GO:0045859 289 0.260
regulation of c c chemokine binding GO:2001263 1 0.259
cation transport GO:0006812 331 0.259
regulation of macrophage chemotaxis GO:0010758 4 0.258
secretion GO:0046903 254 0.258
negative regulation of lymphocyte chemotaxis GO:1901624 2 0.258
negative regulation of developmental process GO:0051093 247 0.256
regulation of system process GO:0044057 101 0.255
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.255
negative regulation of cytokine production GO:0001818 82 0.249
regulation of chemotaxis GO:0050920 74 0.249
positive regulation of intracellular transport GO:0032388 104 0.246
regulation of secretion GO:0051046 194 0.246
positive regulation of cell migration GO:0030335 172 0.245
positive regulation of hydrolase activity GO:0051345 331 0.243
regulation of gtp catabolic process GO:0033124 180 0.241
leukocyte apoptotic process GO:0071887 31 0.241
regulation of t cell proliferation GO:0042129 42 0.238
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.238
positive regulation of cell motility GO:2000147 177 0.237
positive regulation of macrophage chemotaxis GO:0010759 3 0.237
nucleoside triphosphate metabolic process GO:0009141 422 0.236
cell activation GO:0001775 213 0.235
g protein coupled receptor signaling pathway GO:0007186 207 0.230
purine ribonucleotide catabolic process GO:0009154 404 0.230
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.228
nuclear transport GO:0051169 179 0.226
secretion by cell GO:0032940 226 0.224
cytosolic calcium ion homeostasis GO:0051480 89 0.224
positive regulation of apoptotic signaling pathway GO:2001235 70 0.223
protein modification by small protein conjugation GO:0032446 342 0.222
regulation of neutrophil migration GO:1902622 10 0.221
negative regulation of cell proliferation GO:0008285 228 0.221
regulation of endothelial cell apoptotic process GO:2000351 24 0.219
protein import into nucleus GO:0006606 104 0.219
cdc42 protein signal transduction GO:0032488 4 0.219
positive regulation of leukocyte migration GO:0002687 46 0.217
immune response regulating signaling pathway GO:0002764 97 0.217
response to virus GO:0009615 126 0.214
regulation of cellular component movement GO:0051270 334 0.213
regulation of lymphocyte activation GO:0051249 103 0.212
regulation of protein targeting GO:1903533 91 0.210
protein localization to nucleus GO:0034504 136 0.210
regulation of protein import into nucleus GO:0042306 78 0.210
positive regulation of nucleotide catabolic process GO:0030813 185 0.210
positive regulation of rac gtpase activity GO:0032855 31 0.207
positive regulation of leukocyte chemotaxis GO:0002690 38 0.206
granzyme a production GO:0035746 1 0.202
innate immune response GO:0045087 178 0.201
positive regulation of catabolic process GO:0009896 310 0.199
regulation of nucleotide catabolic process GO:0030811 205 0.198
regulation of myeloid cell differentiation GO:0045637 81 0.197
regulation of calcium ion transport into cytosol GO:0010522 33 0.196
regulation of nucleoside metabolic process GO:0009118 209 0.195
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.193
cellular response to endogenous stimulus GO:0071495 336 0.189
regulation of rho gtpase activity GO:0032319 66 0.188
t cell migration GO:0072678 16 0.188
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.187
cyclic nucleotide metabolic process GO:0009187 82 0.186
regulation of neutrophil chemotaxis GO:0090022 10 0.185
positive regulation of leukocyte proliferation GO:0070665 48 0.184
regulation of reactive oxygen species metabolic process GO:2000377 41 0.184
regulation of proteolysis GO:0030162 293 0.183
granulocyte migration GO:0097530 40 0.183
glial cell migration GO:0008347 4 0.181
glycosyl compound catabolic process GO:1901658 413 0.180
positive regulation of response to wounding GO:1903036 28 0.179
purine containing compound catabolic process GO:0072523 411 0.179
ion transmembrane transport GO:0034220 338 0.178
regulation of intracellular transport GO:0032386 195 0.178
response to nitrogen compound GO:1901698 184 0.178
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.175
negative regulation of immune system process GO:0002683 136 0.174
regulation of ras protein signal transduction GO:0046578 155 0.173
positive regulation of chemotaxis GO:0050921 57 0.173
cellular divalent inorganic cation homeostasis GO:0072503 128 0.172
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.171
chemotaxis GO:0006935 157 0.171
negative regulation of cd4 positive alpha beta t cell proliferation GO:2000562 1 0.170
purine nucleoside triphosphate catabolic process GO:0009146 392 0.169
regulation of establishment of protein localization GO:0070201 242 0.166
blood vessel development GO:0001568 172 0.166
positive regulation of osteoclast differentiation GO:0045672 9 0.165
establishment of t cell polarity GO:0001768 2 0.165
intrinsic apoptotic signaling pathway GO:0097193 127 0.163
regulation of jak stat cascade GO:0046425 44 0.160
organophosphate catabolic process GO:0046434 430 0.160
response to alcohol GO:0097305 64 0.159
nucleocytoplasmic transport GO:0006913 176 0.159
protein targeting GO:0006605 187 0.159
positive regulation of lymphocyte activation GO:0051251 73 0.158
regulation of purine nucleotide catabolic process GO:0033121 205 0.157
positive regulation of locomotion GO:0040017 186 0.157
muscle cell proliferation GO:0033002 35 0.156
positive regulation of calcium ion transport GO:0051928 51 0.155
regulation of protein localization to nucleus GO:1900180 85 0.152
taxis GO:0042330 157 0.150
blood vessel morphogenesis GO:0048514 162 0.149
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.149
positive regulation of release of sequestered calcium ion into cytosol GO:0051281 16 0.148
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.148
regulation of cell activation GO:0050865 125 0.146
programmed necrotic cell death GO:0097300 18 0.146
positive regulation of innate immune response GO:0045089 79 0.144
negative regulation of response to external stimulus GO:0032102 83 0.144
metal ion transport GO:0030001 272 0.143
regulation of hormone levels GO:0010817 125 0.143
positive regulation of nucleoside metabolic process GO:0045979 186 0.143
negative regulation of myeloid cell differentiation GO:0045638 42 0.143
purine nucleoside catabolic process GO:0006152 398 0.143
peptide transport GO:0015833 74 0.143
regulation of epithelial cell proliferation GO:0050678 113 0.142
granzyme b production GO:0071613 1 0.142
stress activated mapk cascade GO:0051403 93 0.141
cellular response to dna damage stimulus GO:0006974 379 0.139
calcium ion transport GO:0006816 147 0.139
cellular response to lipid GO:0071396 127 0.139
natural killer cell chemotaxis GO:0035747 6 0.138
divalent metal ion transport GO:0070838 152 0.137
regulation of leukocyte chemotaxis GO:0002688 46 0.136
positive regulation of protein kinase activity GO:0045860 190 0.135
action potential GO:0001508 34 0.135
vasculature development GO:0001944 181 0.135
guanosine containing compound catabolic process GO:1901069 239 0.135
cd8 positive alpha beta t cell activation GO:0036037 3 0.134
regulation of ion homeostasis GO:2000021 73 0.134
regulation of multi organism process GO:0043900 157 0.134
cellular response to external stimulus GO:0071496 111 0.133
response to abiotic stimulus GO:0009628 336 0.133
negative regulation of leukocyte apoptotic process GO:2000107 16 0.133
interleukin 6 production GO:0032635 37 0.132
regulation of transcription factor import into nucleus GO:0042990 39 0.131
regulation of cell migration GO:0030334 289 0.131
nitrogen compound transport GO:0071705 191 0.130
positive regulation of leukocyte activation GO:0002696 80 0.130
ribonucleoside catabolic process GO:0042454 406 0.130
negative regulation of alpha beta t cell activation GO:0046636 3 0.130
single organism cellular localization GO:1902580 332 0.130
regulation of behavior GO:0050795 82 0.129
sequestering of calcium ion GO:0051208 17 0.129
neurological system process GO:0050877 163 0.129
regulation of lymphocyte proliferation GO:0050670 64 0.129
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.128
regulation of camp metabolic process GO:0030814 52 0.126
bone mineralization GO:0030282 34 0.125
negative regulation of lymphocyte migration GO:2000402 4 0.125
positive regulation of behavior GO:0048520 60 0.124
viral life cycle GO:0019058 132 0.123
leukocyte activation GO:0045321 164 0.123
regulation of sensory perception GO:0051931 3 0.121
response to mechanical stimulus GO:0009612 51 0.121
regulation of intracellular protein transport GO:0033157 123 0.121
purine nucleoside triphosphate metabolic process GO:0009144 412 0.120
purine ribonucleoside metabolic process GO:0046128 437 0.120
regulation of calcium ion transport GO:0051924 79 0.120
sequestering of metal ion GO:0051238 24 0.120
ribonucleoside triphosphate catabolic process GO:0009203 391 0.118
lymphocyte mediated immunity GO:0002449 48 0.116
regulation of gtpase activity GO:0043087 180 0.116
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.115
positive regulation of cellular component organization GO:0051130 376 0.115
positive regulation of cd8 positive alpha beta t cell activation GO:2001187 1 0.115
system process GO:0003008 349 0.115
regulation of cell motility GO:2000145 299 0.114
positive regulation of t cell apoptotic process GO:0070234 4 0.114
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.114
positive regulation of neutrophil chemotaxis GO:0090023 7 0.113
calcium ion transport into cytosol GO:0060402 48 0.113
negative regulation of inflammatory response GO:0050728 22 0.112
eosinophil activation GO:0043307 3 0.112
positive regulation of leukocyte mediated immunity GO:0002705 24 0.112
epithelial cell proliferation GO:0050673 128 0.111
defense response to other organism GO:0098542 129 0.111
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.109
cyclic nucleotide mediated signaling GO:0019935 26 0.109
regulation of interleukin 2 production GO:0032663 19 0.109
positive regulation of cdc42 gtpase activity GO:0043089 6 0.109
regulation of secretion by cell GO:1903530 177 0.109
second messenger mediated signaling GO:0019932 78 0.108
calcium mediated signaling GO:0019722 44 0.108
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.108
response to organic cyclic compound GO:0014070 204 0.107
membrane protein ectodomain proteolysis GO:0006509 33 0.107
regulation of ion transport GO:0043269 189 0.106
lymphocyte proliferation GO:0046651 70 0.105
response to interleukin 1 GO:0070555 47 0.104
posttranscriptional regulation of gene expression GO:0010608 213 0.103
rna destabilization GO:0050779 1 0.103
cell chemotaxis GO:0060326 112 0.103
endothelial cell apoptotic process GO:0072577 26 0.102
regulation of t helper 1 cell activation GO:2000517 1 0.102
macrophage chemotaxis GO:0048246 10 0.102
tyrosine phosphorylation of stat protein GO:0007260 33 0.100
angiogenesis GO:0001525 147 0.099
positive regulation of adaptive immune response GO:0002821 21 0.099
positive regulation of leukocyte differentiation GO:1902107 37 0.098
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.098
regulation of cdc42 protein signal transduction GO:0032489 14 0.098
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.097
regulation of cell cycle GO:0051726 393 0.097
transmission of nerve impulse GO:0019226 11 0.096
negative regulation of apoptotic signaling pathway GO:2001234 97 0.096
positive regulation of jun kinase activity GO:0043507 23 0.096
maintenance of location GO:0051235 112 0.095
regulation of hormone secretion GO:0046883 57 0.095
transmembrane transport GO:0055085 399 0.094
neuronal action potential GO:0019228 9 0.093
protein catabolic process GO:0030163 325 0.093
regulation of osteoclast differentiation GO:0045670 18 0.093
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.093
cytosolic calcium ion transport GO:0060401 48 0.092
regulation of cellular component biogenesis GO:0044087 281 0.092
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.092
protein processing GO:0016485 226 0.091
positive regulation of transcription factor import into nucleus GO:0042993 25 0.091
positive regulation of cellular component movement GO:0051272 181 0.091
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.091
endothelial cell proliferation GO:0001935 65 0.090
lymphocyte chemotaxis GO:0048247 17 0.088
peptide hormone secretion GO:0030072 50 0.088
t helper 1 cell activation GO:0035711 1 0.087
regulation of leukocyte mediated immunity GO:0002703 38 0.086
positive regulation of stress activated mapk cascade GO:0032874 60 0.086
interleukin 8 mediated signaling pathway GO:0038112 2 0.085
regulation of metal ion transport GO:0010959 120 0.085
protein localization to organelle GO:0033365 280 0.085
regulation of granzyme b production GO:0071661 1 0.084
hormone secretion GO:0046879 65 0.083
cellular response to mechanical stimulus GO:0071260 39 0.083
nf kappab import into nucleus GO:0042348 22 0.081
cytokine production involved in immune response GO:0002367 27 0.081
myeloid leukocyte differentiation GO:0002573 60 0.081
interspecies interaction between organisms GO:0044419 156 0.081
sensory perception of pain GO:0019233 4 0.081
protein oligomerization GO:0051259 173 0.081
lymphocyte apoptotic process GO:0070227 20 0.081
regulation of protein binding GO:0043393 66 0.080
interferon gamma production GO:0032609 39 0.080
negative regulation of immune response GO:0050777 40 0.080
positive regulation of granzyme b production GO:0071663 1 0.080
response to oxidative stress GO:0006979 121 0.079
pattern recognition receptor signaling pathway GO:0002221 48 0.079
positive regulation of ion transport GO:0043270 87 0.079
nervous system development GO:0007399 293 0.078
positive regulation of myeloid cell differentiation GO:0045639 39 0.078
cell adhesion GO:0007155 325 0.077
regulation of cell morphogenesis GO:0022604 153 0.077
lipid metabolic process GO:0006629 381 0.077
protein targeting to nucleus GO:0044744 104 0.076
positive regulation of ras gtpase activity GO:0032320 117 0.075
regulation of membrane potential GO:0042391 95 0.073
myeloid leukocyte activation GO:0002274 34 0.073
regulation of lymphocyte chemotaxis GO:1901623 12 0.073
negative regulation of adaptive immune response GO:0002820 9 0.073
activation of innate immune response GO:0002218 55 0.073
positive regulation of t cell proliferation GO:0042102 33 0.072
ribonucleotide catabolic process GO:0009261 405 0.072
regulation of purine nucleotide metabolic process GO:1900542 264 0.072
negative regulation of t cell apoptotic process GO:0070233 4 0.071
positive regulation of homotypic cell cell adhesion GO:0034112 4 0.070
regulation of innate immune response GO:0045088 97 0.070
regulation of sensory perception of pain GO:0051930 3 0.069
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.069
regulation of leukocyte apoptotic process GO:2000106 25 0.068
cellular component morphogenesis GO:0032989 314 0.068
organ morphogenesis GO:0009887 147 0.067
regulation of endothelial cell proliferation GO:0001936 56 0.067
regulation of neurological system process GO:0031644 6 0.066
monocyte chemotaxis GO:0002548 20 0.066
exocytosis GO:0006887 71 0.066
reactive nitrogen species metabolic process GO:2001057 3 0.066
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 1 0.065
regulation of peptide secretion GO:0002791 42 0.065
modification of morphology or physiology of other organism GO:0035821 43 0.065
regulation of ion transmembrane transport GO:0034765 132 0.065
cell morphogenesis GO:0000902 296 0.064
positive regulation of protein localization to nucleus GO:1900182 48 0.063
regulation of nf kappab import into nucleus GO:0042345 22 0.062
sarcoplasmic reticulum calcium ion transport GO:0070296 13 0.062
hormone transport GO:0009914 68 0.062
negative regulation of secretion GO:0051048 58 0.061
cellular macromolecular complex assembly GO:0034622 324 0.061
regulation of cell adhesion GO:0030155 166 0.061
positive regulation of natural killer cell chemotaxis GO:2000503 5 0.061
cardiovascular system development GO:0072358 262 0.061
response to inorganic substance GO:0010035 127 0.060
myeloid leukocyte migration GO:0097529 62 0.059
chemokine c c motif ligand 11 production GO:0071954 1 0.059
positive regulation of astrocyte chemotaxis GO:2000464 1 0.059
viral process GO:0016032 146 0.059
positive regulation of lipid metabolic process GO:0045834 50 0.059
positive regulation of acute inflammatory response GO:0002675 2 0.058
regulation of t cell mediated immunity GO:0002709 18 0.058
regulation of peptide transport GO:0090087 62 0.058
single organism cell adhesion GO:0098602 179 0.058
regulation of interferon gamma production GO:0032649 36 0.057
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 11 0.057
regulation of t cell chemotaxis GO:0010819 7 0.057
innate immune response activating signal transduction GO:0002758 48 0.056
positive regulation of developmental process GO:0051094 314 0.056

TNF disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.096
disease of cellular proliferation DOID:14566 174 0.096
organ system cancer DOID:0050686 164 0.096