Homo sapiens

0 known processes

MANF

mesencephalic astrocyte-derived neurotrophic factor

(Aliases: ARP,ARMET,MGC142150,MGC142148)

MANF biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of developmental process GO:0051094 314 0.434
glycosylation GO:0070085 71 0.314
post embryonic development GO:0009791 2 0.192
response to unfolded protein GO:0006986 24 0.131
cellular response to unfolded protein GO:0034620 16 0.117
regulation of cell motility GO:2000145 299 0.108
purine nucleoside catabolic process GO:0006152 398 0.104
response to abiotic stimulus GO:0009628 336 0.101
ribonucleotide catabolic process GO:0009261 405 0.091
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.088
modification dependent macromolecule catabolic process GO:0043632 212 0.083
response to oxygen containing compound GO:1901700 369 0.083
organonitrogen compound biosynthetic process GO:1901566 200 0.083
protein catabolic process GO:0030163 325 0.081
negative regulation of apoptotic process GO:0043066 316 0.081
purine containing compound catabolic process GO:0072523 411 0.076
ubiquitin dependent protein catabolic process GO:0006511 206 0.069
negative regulation of programmed cell death GO:0043069 321 0.065
single organism cellular localization GO:1902580 332 0.063
vesicle mediated transport GO:0016192 371 0.062
hindbrain development GO:0030902 3 0.061
modification dependent protein catabolic process GO:0019941 209 0.061
cellular protein catabolic process GO:0044257 261 0.061
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.060
purine ribonucleoside metabolic process GO:0046128 437 0.058
response to hypoxia GO:0001666 96 0.057
glycoprotein biosynthetic process GO:0009101 91 0.056
establishment of protein localization to organelle GO:0072594 172 0.053
positive regulation of hydrolase activity GO:0051345 331 0.051
er nucleus signaling pathway GO:0006984 23 0.049
posttranscriptional regulation of gene expression GO:0010608 213 0.048
negative regulation of cell death GO:0060548 345 0.048
purine ribonucleoside catabolic process GO:0046130 398 0.045
cellular macromolecule catabolic process GO:0044265 380 0.045
oogenesis GO:0048477 2 0.044
locomotory behavior GO:0007626 1 0.044
proteasomal protein catabolic process GO:0010498 176 0.041
protein import GO:0017038 130 0.040
positive regulation of cellular component organization GO:0051130 376 0.040
positive regulation of immune system process GO:0002684 283 0.040
regulation of protein stability GO:0031647 87 0.040
regulation of cellular response to stress GO:0080135 244 0.039
negative regulation of t cell apoptotic process GO:0070233 4 0.039
metencephalon development GO:0022037 2 0.038
regulation of cell differentiation GO:0045595 393 0.038
protein glycosylation GO:0006486 62 0.038
mitotic cytokinetic process GO:1902410 2 0.038
protein localization to organelle GO:0033365 280 0.038
positive regulation of nucleotide catabolic process GO:0030813 185 0.038
nucleoside phosphate catabolic process GO:1901292 412 0.037
intracellular protein transport GO:0006886 270 0.037
positive regulation of growth GO:0045927 58 0.036
enzyme linked receptor protein signaling pathway GO:0007167 303 0.036
regulation of locomotion GO:0040012 329 0.035
growth GO:0040007 202 0.035
single organism carbohydrate metabolic process GO:0044723 193 0.035
regulation of behavior GO:0050795 82 0.035
positive regulation of transport GO:0051050 336 0.034
maintenance of location in cell GO:0051651 62 0.034
transmembrane transport GO:0055085 399 0.033
cellular response to organonitrogen compound GO:0071417 124 0.033
guanosine containing compound catabolic process GO:1901069 239 0.032
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.031
actin filament organization GO:0007015 128 0.031
maintenance of location GO:0051235 112 0.031
regulation of proteolysis GO:0030162 293 0.031
response to external biotic stimulus GO:0043207 261 0.030
purine ribonucleotide catabolic process GO:0009154 404 0.030
chaperone mediated protein folding GO:0061077 13 0.029
ribonucleoside triphosphate metabolic process GO:0009199 412 0.029
lipid localization GO:0010876 106 0.029
ribonucleoside catabolic process GO:0042454 406 0.028
regulation of purine nucleotide catabolic process GO:0033121 205 0.028
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.028
cellular response to oxidative stress GO:0034599 85 0.028
determination of adult lifespan GO:0008340 2 0.028
organophosphate catabolic process GO:0046434 430 0.028
cytoplasmic transport GO:0016482 379 0.028
cellular response to external stimulus GO:0071496 111 0.027
nervous system development GO:0007399 293 0.027
Zebrafish
regulation of t cell activation GO:0050863 77 0.027
positive regulation of cellular catabolic process GO:0031331 284 0.027
nucleoside triphosphate metabolic process GO:0009141 422 0.026
nucleocytoplasmic transport GO:0006913 176 0.026
positive regulation of phosphorylation GO:0042327 394 0.026
cellular response to endogenous stimulus GO:0071495 336 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.026
response to endoplasmic reticulum stress GO:0034976 49 0.025
guanosine containing compound metabolic process GO:1901068 244 0.024
regulation of establishment of protein localization GO:0070201 242 0.024
positive regulation of nucleotide metabolic process GO:0045981 230 0.024
membrane organization GO:0061024 292 0.024
cytokinesis GO:0000910 96 0.024
positive regulation of dna metabolic process GO:0051054 73 0.024
positive regulation of nucleoside metabolic process GO:0045979 186 0.024
rna interference GO:0016246 4 0.023
gtp catabolic process GO:0006184 237 0.023
positive regulation of catabolic process GO:0009896 310 0.023
reactive nitrogen species metabolic process GO:2001057 3 0.023
interleukin 2 secretion GO:0070970 3 0.023
female gamete generation GO:0007292 2 0.023
regulation of multi organism process GO:0043900 157 0.023
regulation of growth GO:0040008 165 0.023
skeletal system development GO:0001501 79 0.022
purine nucleoside triphosphate metabolic process GO:0009144 412 0.022
receptor mediated endocytosis GO:0006898 84 0.022
endocytosis GO:0006897 159 0.022
cellular amine metabolic process GO:0044106 41 0.022
cellular response to oxygen containing compound GO:1901701 276 0.022
positive regulation of immune response GO:0050778 159 0.022
regulation of cellular component movement GO:0051270 334 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.022
secretion GO:0046903 254 0.022
cofactor metabolic process GO:0051186 87 0.021
protein localization to nucleus GO:0034504 136 0.021
actin cytoskeleton organization GO:0030036 207 0.021
regulation of protein localization GO:0032880 296 0.021
cofactor biosynthetic process GO:0051188 31 0.021
response to biotic stimulus GO:0009607 276 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
negative regulation of acute inflammatory response GO:0002674 3 0.021
intrinsic apoptotic signaling pathway GO:0097193 127 0.021
regulation of cell activation GO:0050865 125 0.021
cellular response to dna damage stimulus GO:0006974 379 0.021
response to lipid GO:0033993 206 0.021
response to other organism GO:0051707 261 0.020
protein transmembrane transport GO:0071806 25 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
mitotic cell cycle process GO:1903047 286 0.020
response to nitrogen compound GO:1901698 184 0.020
response to growth factor GO:0070848 205 0.020
positive regulation of t cell activation GO:0050870 54 0.020
regulation of reactive oxygen species metabolic process GO:2000377 41 0.020
positive regulation of cell differentiation GO:0045597 211 0.020
cell division GO:0051301 168 0.020
regulation of wnt protein secretion GO:0061356 1 0.019
cellular response to toxic substance GO:0097237 4 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.019
embryo development GO:0009790 123 0.019
cellular response to starvation GO:0009267 58 0.019
positive regulation of protein phosphorylation GO:0001934 313 0.019
coenzyme metabolic process GO:0006732 65 0.019
organophosphate biosynthetic process GO:0090407 163 0.019
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.019
cellular response to growth factor stimulus GO:0071363 197 0.019
response to transforming growth factor beta GO:0071559 94 0.018
nitrogen compound transport GO:0071705 191 0.018
regulation of cellular component biogenesis GO:0044087 281 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.018
regulation of cell cycle GO:0051726 393 0.018
glycoprotein metabolic process GO:0009100 110 0.018
regulation of peptidase activity GO:0052547 180 0.018
cellular response to biotic stimulus GO:0071216 71 0.018
macromolecule glycosylation GO:0043413 63 0.017
response to bacterium GO:0009617 144 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.017
positive regulation of intracellular transport GO:0032388 104 0.017
regulation of leukocyte apoptotic process GO:2000106 25 0.017
protein targeting GO:0006605 187 0.017
protein import into nucleus GO:0006606 104 0.017
regulation of protein transport GO:0051223 213 0.017
autophagy GO:0006914 88 0.017
protein folding GO:0006457 38 0.017
lipid metabolic process GO:0006629 381 0.017
cellular response to lipopolysaccharide GO:0071222 57 0.016
regulation of nucleoside metabolic process GO:0009118 209 0.016
dorsal ventral pattern formation GO:0009953 15 0.016
protein stabilization GO:0050821 64 0.016
negative regulation of cellular protein metabolic process GO:0032269 353 0.016
positive regulation of multicellular organism growth GO:0040018 6 0.016
negative regulation of apoptotic signaling pathway GO:2001234 97 0.016
secretion by cell GO:0032940 226 0.016
sleep GO:0030431 2 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.016
gene silencing by rna GO:0031047 26 0.016
membrane budding GO:0006900 28 0.016
positive regulation of cell cycle GO:0045787 140 0.016
regulation of protein kinase activity GO:0045859 289 0.016
negative regulation of retinoic acid receptor signaling pathway GO:0048387 4 0.016
regulation of b cell differentiation GO:0045577 2 0.016
regulation of cellular amino acid metabolic process GO:0006521 6 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
single organism cell adhesion GO:0098602 179 0.015
immune response GO:0006955 307 0.015
multicellular organismal aging GO:0010259 3 0.015
cytokine secretion GO:0050663 64 0.015
regulation of phosphatase activity GO:0010921 81 0.015
reproductive process GO:0022414 106 0.015
cell type specific apoptotic process GO:0097285 125 0.015
cytokine production GO:0001816 247 0.015
regulation of transferase activity GO:0051338 355 0.015
positive regulation of cell migration GO:0030335 172 0.015
immune system development GO:0002520 195 0.015
compound eye development GO:0048749 1 0.015
mitotic cell cycle GO:0000278 326 0.015
positive regulation of cell division GO:0051781 59 0.015
regulation of gene expression epigenetic GO:0040029 73 0.015
response to inorganic substance GO:0010035 127 0.015
t cell activation GO:0042110 99 0.015
regulation of meiosis GO:0040020 3 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.014
endoplasmic reticulum unfolded protein response GO:0030968 16 0.014
posttranslational protein targeting to membrane GO:0006620 5 0.014
microtubule cytoskeleton organization GO:0000226 176 0.014
ribonucleoside triphosphate catabolic process GO:0009203 391 0.014
negative regulation of cell cycle GO:0045786 193 0.014
positive regulation of leukocyte activation GO:0002696 80 0.014
eye photoreceptor cell differentiation GO:0001754 2 0.014
response to starvation GO:0042594 59 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
leukocyte activation GO:0045321 164 0.014
regulation of phosphoprotein phosphatase activity GO:0043666 23 0.014
oocyte development GO:0048599 1 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
regulation of defense response GO:0031347 154 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.013
amine metabolic process GO:0009308 44 0.013
regulation of cell cycle process GO:0010564 266 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
negative regulation of nitric oxide synthase biosynthetic process GO:0051771 3 0.013
signal release GO:0023061 70 0.013
positive regulation of gtp catabolic process GO:0033126 166 0.013
regulation of leukocyte activation GO:0002694 115 0.013
protein targeting to nucleus GO:0044744 104 0.013
regulation of acute inflammatory response to antigenic stimulus GO:0002864 1 0.013
developmental growth GO:0048589 48 0.013
regulation of purine nucleotide metabolic process GO:1900542 264 0.013
response to cytokine GO:0034097 232 0.013
reproduction GO:0000003 63 0.013
cellular protein complex assembly GO:0043623 188 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
positive regulation of locomotion GO:0040017 186 0.013
gtp metabolic process GO:0046039 239 0.013
protein secretion GO:0009306 98 0.013
sex determination GO:0007530 3 0.012
regulation of protein catabolic process GO:0042176 155 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
regulation of cellular protein catabolic process GO:1903362 96 0.012
regulation of cell migration GO:0030334 289 0.012
cellular response to lipid GO:0071396 127 0.012
peptidyl asparagine modification GO:0018196 11 0.012
negative regulation of myeloid cell apoptotic process GO:0033033 4 0.012
regulation of immune response GO:0050776 201 0.012
microtubule based process GO:0007017 210 0.012
immune effector process GO:0002252 159 0.012
regulation of response to wounding GO:1903034 101 0.012
regulation of dna replication GO:0006275 68 0.012
cellular response to molecule of bacterial origin GO:0071219 62 0.012
regulation of response to external stimulus GO:0032101 222 0.012
hemopoiesis GO:0030097 180 0.012
nuclear import GO:0051170 106 0.012
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
male genitalia development GO:0030539 1 0.012
nuclear transport GO:0051169 179 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.011
positive regulation of cell cycle process GO:0090068 106 0.011
actin filament based process GO:0030029 224 0.011
cellular response to extracellular stimulus GO:0031668 72 0.011
response to decreased oxygen levels GO:0036293 96 0.011
regulation of kinase activity GO:0043549 314 0.011
response to toxic substance GO:0009636 37 0.011
activation of signaling protein activity involved in unfolded protein response GO:0006987 3 0.011
positive regulation of organelle organization GO:0010638 195 0.011
response to extracellular stimulus GO:0009991 85 0.011
negative regulation of developmental process GO:0051093 247 0.011
regulation of cytokine production GO:0001817 232 0.011
cellular response to topologically incorrect protein GO:0035967 19 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
inflammatory response GO:0006954 79 0.011
regulation of mitotic cell cycle GO:0007346 189 0.011
positive regulation of alpha beta t cell differentiation GO:0046638 4 0.011
positive regulation of kinase activity GO:0033674 204 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
cell killing GO:0001906 34 0.011
defense response GO:0006952 315 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
rna processing GO:0006396 255 0.010
regulation of intracellular transport GO:0032386 195 0.010
segmentation GO:0035282 4 0.010
positive regulation of cellular amine metabolic process GO:0033240 7 0.010
mrna metabolic process GO:0016071 175 0.010
lymphocyte activation GO:0046649 133 0.010
neurological system process GO:0050877 163 0.010
Mouse
sensory organ development GO:0007423 52 0.010
regulation of cell substrate adhesion GO:0010810 68 0.010
response to oxygen levels GO:0070482 100 0.010
negative regulation of immune system process GO:0002683 136 0.010
oocyte differentiation GO:0009994 2 0.010

MANF disease predictions

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 55 0.087
bone disease DOID:0080001 88 0.087
musculoskeletal system disease DOID:17 223 0.087
connective tissue disease DOID:65 109 0.087
osteochondrodysplasia DOID:2256 35 0.037
myopathy DOID:423 104 0.035
muscular disease DOID:0080000 114 0.035
muscle tissue disease DOID:66 113 0.035
cancer DOID:162 167 0.024
disease of cellular proliferation DOID:14566 174 0.024
disease of metabolism DOID:0014667 295 0.017
inherited metabolic disorder DOID:655 242 0.017
muscular dystrophy DOID:9884 51 0.010