Homo sapiens

31 known processes

WIPI1

WD repeat domain, phosphoinositide interacting 1

(Aliases: ATG18,ATG18A,WIPI49,FLJ10055)

WIPI1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of locomotion GO:0040012 329 0.139
positive regulation of transport GO:0051050 336 0.130
regulation of leukocyte migration GO:0002685 63 0.096
ion transmembrane transport GO:0034220 338 0.088
metal ion transport GO:0030001 272 0.077
regulation of cellular component movement GO:0051270 334 0.074
myeloid leukocyte migration GO:0097529 62 0.069
negative regulation of cell death GO:0060548 345 0.065
extrinsic apoptotic signaling pathway GO:0097191 119 0.064
apoptotic signaling pathway GO:0097190 268 0.064
regulation of ion transport GO:0043269 189 0.063
transmembrane transport GO:0055085 399 0.062
regulation of ion transmembrane transport GO:0034765 132 0.060
negative regulation of transport GO:0051051 176 0.060
ras protein signal transduction GO:0007265 73 0.058
post embryonic development GO:0009791 2 0.057
Fly
negative regulation of cellular component organization GO:0051129 235 0.055
positive regulation of cell migration GO:0030335 172 0.055
positive regulation of cell motility GO:2000147 177 0.054
cation transport GO:0006812 331 0.053
multicellular organismal aging GO:0010259 3 0.052
positive regulation of locomotion GO:0040017 186 0.052
vesicle mediated transport GO:0016192 371 0.052
regulation of apoptotic signaling pathway GO:2001233 175 0.051
regulation of cell migration GO:0030334 289 0.051
cell chemotaxis GO:0060326 112 0.051
immune response GO:0006955 307 0.050
regulation of cytokine production GO:0001817 232 0.050
negative regulation of programmed cell death GO:0043069 321 0.049
positive regulation of catabolic process GO:0009896 310 0.047
purine ribonucleoside metabolic process GO:0046128 437 0.047
positive regulation of immune system process GO:0002684 283 0.047
regulation of cell motility GO:2000145 299 0.047
determination of adult lifespan GO:0008340 2 0.046
eosinophil chemotaxis GO:0048245 8 0.045
leukocyte migration GO:0050900 107 0.045
cellular ketone metabolic process GO:0042180 80 0.044
positive regulation of cellular catabolic process GO:0031331 284 0.044
positive regulation of leukocyte migration GO:0002687 46 0.044
purine containing compound catabolic process GO:0072523 411 0.042
purine nucleoside triphosphate metabolic process GO:0009144 412 0.041
negative regulation of apoptotic process GO:0043066 316 0.040
cellular amino acid metabolic process GO:0006520 116 0.040
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.040
regulation of metal ion transport GO:0010959 120 0.040
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
cytokine production GO:0001816 247 0.039
positive regulation of ion transport GO:0043270 87 0.039
rho protein signal transduction GO:0007266 26 0.038
regulation of lymphocyte mediated immunity GO:0002706 33 0.038
purine nucleoside catabolic process GO:0006152 398 0.038
regulation of protein localization GO:0032880 296 0.038
regulation of immune response GO:0050776 201 0.038
small gtpase mediated signal transduction GO:0007264 78 0.038
positive regulation of hydrolase activity GO:0051345 331 0.038
secretion GO:0046903 254 0.037
regulation of transmembrane transport GO:0034762 139 0.037
cellular macromolecule catabolic process GO:0044265 380 0.037
i kappab kinase nf kappab signaling GO:0007249 166 0.037
ribonucleoside catabolic process GO:0042454 406 0.036
regulation of calcium ion transport GO:0051924 79 0.036
negative regulation of apoptotic signaling pathway GO:2001234 97 0.036
lipid biosynthetic process GO:0008610 177 0.036
cellular amine metabolic process GO:0044106 41 0.035
urate transport GO:0015747 3 0.035
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.035
oogenesis GO:0048477 2 0.034
amine metabolic process GO:0009308 44 0.034
nucleotide catabolic process GO:0009166 408 0.034
ribonucleotide catabolic process GO:0009261 405 0.034
purine ribonucleoside catabolic process GO:0046130 398 0.033
ribonucleoside triphosphate catabolic process GO:0009203 391 0.033
purine nucleoside triphosphate catabolic process GO:0009146 392 0.032
response to hormone GO:0009725 175 0.032
positive regulation of ion transmembrane transport GO:0034767 40 0.031
t cell tolerance induction GO:0002517 4 0.031
intrinsic apoptotic signaling pathway GO:0097193 127 0.031
regulation of cellular component biogenesis GO:0044087 281 0.031
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.031
positive regulation of transmembrane transport GO:0034764 41 0.031
neutrophil chemotaxis GO:0030593 24 0.031
leukocyte chemotaxis GO:0030595 76 0.030
female gamete generation GO:0007292 2 0.030
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.030
regulation of cellular ketone metabolic process GO:0010565 50 0.030
gtp catabolic process GO:0006184 237 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.030
organophosphate catabolic process GO:0046434 430 0.029
regulation of nucleotide catabolic process GO:0030811 205 0.029
nucleoside catabolic process GO:0009164 408 0.029
regulation of purine nucleotide metabolic process GO:1900542 264 0.029
granulocyte migration GO:0097530 40 0.029
immune effector process GO:0002252 159 0.028
Fly
leukocyte activation GO:0045321 164 0.028
membrane organization GO:0061024 292 0.028
response to oxygen containing compound GO:1901700 369 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.028
cellular protein catabolic process GO:0044257 261 0.028
negative regulation of catalytic activity GO:0043086 335 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.027
positive regulation of phosphorylation GO:0042327 394 0.027
glycosyl compound catabolic process GO:1901658 413 0.027
nucleoside phosphate catabolic process GO:1901292 412 0.027
positive regulation of cellular component organization GO:0051130 376 0.027
cytoplasmic transport GO:0016482 379 0.027
calcium ion transport GO:0006816 147 0.027
regulation of leukocyte mediated immunity GO:0002703 38 0.026
regulation of secretion GO:0051046 194 0.026
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.026
epithelial cell differentiation GO:0030855 141 0.026
divalent inorganic cation transport GO:0072511 158 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.026
protein catabolic process GO:0030163 325 0.026
positive regulation of protein phosphorylation GO:0001934 313 0.026
regulation of tolerance induction GO:0002643 4 0.026
regulation of vesicle mediated transport GO:0060627 130 0.026
reactive oxygen species metabolic process GO:0072593 75 0.026
gtp metabolic process GO:0046039 239 0.025
enzyme linked receptor protein signaling pathway GO:0007167 303 0.025
single organism cellular localization GO:1902580 332 0.025
carbohydrate metabolic process GO:0005975 207 0.025
actin filament based process GO:0030029 224 0.025
secretion by cell GO:0032940 226 0.025
regulation of gtpase activity GO:0043087 180 0.025
single organism membrane organization GO:0044802 268 0.025
guanosine containing compound catabolic process GO:1901069 239 0.025
cellular macromolecular complex assembly GO:0034622 324 0.024
regulation of anatomical structure morphogenesis GO:0022603 286 0.024
calcium ion import GO:0070509 23 0.024
regulation of cellular response to stress GO:0080135 244 0.024
regulation of proteolysis GO:0030162 293 0.024
neutrophil migration GO:1990266 25 0.024
endosomal transport GO:0016197 129 0.023
positive regulation of cellular amine metabolic process GO:0033240 7 0.023
positive regulation of gtp catabolic process GO:0033126 166 0.023
positive regulation of calcium ion transport GO:0051928 51 0.023
regulation of immune effector process GO:0002697 91 0.023
Fly
regulation of nucleotide metabolic process GO:0006140 269 0.023
cell type specific apoptotic process GO:0097285 125 0.023
taxis GO:0042330 157 0.023
negative regulation of intracellular signal transduction GO:1902532 183 0.023
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
positive regulation of gtpase activity GO:0043547 166 0.022
cell substrate adhesion GO:0031589 132 0.022
nucleoside triphosphate catabolic process GO:0009143 394 0.022
single organism carbohydrate metabolic process GO:0044723 193 0.022
innate immune response GO:0045087 178 0.022
endomembrane system organization GO:0010256 196 0.022
regulation of gtp catabolic process GO:0033124 180 0.022
actin cytoskeleton organization GO:0030036 207 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.022
maintenance of location GO:0051235 112 0.022
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
positive regulation of apoptotic process GO:0043065 246 0.022
regulation of ras protein signal transduction GO:0046578 155 0.022
positive regulation of nucleotide catabolic process GO:0030813 185 0.021
locomotory behavior GO:0007626 1 0.021
positive regulation of organelle organization GO:0010638 195 0.021
regulation of cell cycle GO:0051726 393 0.021
cellular response to endogenous stimulus GO:0071495 336 0.021
divalent metal ion transport GO:0070838 152 0.021
chemotaxis GO:0006935 157 0.021
lipid metabolic process GO:0006629 381 0.021
protein localization to organelle GO:0033365 280 0.021
oxidation reduction process GO:0055114 396 0.020
biological adhesion GO:0022610 331 0.020
positive regulation of cellular component biogenesis GO:0044089 158 0.020
regulation of ras gtpase activity GO:0032318 128 0.020
regulation of small gtpase mediated signal transduction GO:0051056 156 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
regeneration GO:0031099 4 0.020
regulation of purine nucleotide catabolic process GO:0033121 205 0.020
response to biotic stimulus GO:0009607 276 0.020
Fly
cellular ion homeostasis GO:0006873 168 0.020
immune system development GO:0002520 195 0.020
cellular response to hormone stimulus GO:0032870 125 0.020
epithelium development GO:0060429 227 0.020
establishment of protein localization to membrane GO:0090150 121 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
lymphocyte mediated immunity GO:0002449 48 0.020
regulation of transferase activity GO:0051338 355 0.019
positive regulation of nucleoside metabolic process GO:0045979 186 0.019
cation transmembrane transport GO:0098655 238 0.019
golgi vesicle transport GO:0048193 80 0.019
cell activation GO:0001775 213 0.019
regulation of protein kinase activity GO:0045859 289 0.019
regulation of nucleoside metabolic process GO:0009118 209 0.019
negative regulation of multicellular organismal process GO:0051241 317 0.019
regulation of protein catabolic process GO:0042176 155 0.019
regulation of reactive oxygen species metabolic process GO:2000377 41 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
defense response GO:0006952 315 0.019
Fly
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
positive regulation of transferase activity GO:0051347 227 0.019
protein processing GO:0016485 226 0.019
cellular component morphogenesis GO:0032989 314 0.019
anion transport GO:0006820 161 0.019
negative regulation of protein metabolic process GO:0051248 391 0.018
protein oligomerization GO:0051259 173 0.018
microtubule based process GO:0007017 210 0.018
leukocyte mediated immunity GO:0002443 59 0.018
cell morphogenesis GO:0000902 296 0.018
positive regulation of ras gtpase activity GO:0032320 117 0.018
protein maturation GO:0051604 233 0.018
positive regulation of secretion by cell GO:1903532 108 0.018
segmentation GO:0035282 4 0.018
regulation of t cell tolerance induction GO:0002664 4 0.018
regulation of protein maturation GO:1903317 150 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
sulfur compound metabolic process GO:0006790 101 0.018
negative regulation of cellular protein metabolic process GO:0032269 353 0.018
cell division GO:0051301 168 0.018
protein localization to membrane GO:0072657 160 0.018
regulation of protein complex assembly GO:0043254 147 0.018
memory GO:0007613 3 0.018
system process GO:0003008 349 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.018
positive regulation of protein kinase activity GO:0045860 190 0.017
protein ubiquitination GO:0016567 314 0.017
regulation of secretion by cell GO:1903530 177 0.017
regulation of leukocyte activation GO:0002694 115 0.017
regulation of establishment of protein localization GO:0070201 242 0.017
regulation of kinase activity GO:0043549 314 0.017
mapk cascade GO:0000165 288 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.017
sodium ion transmembrane transport GO:0035725 59 0.017
nucleoside triphosphate metabolic process GO:0009141 422 0.017
compound eye development GO:0048749 1 0.017
monovalent inorganic cation transport GO:0015672 128 0.017
eosinophil migration GO:0072677 10 0.017
cell adhesion GO:0007155 325 0.016
response to fungus GO:0009620 4 0.016
organic anion transport GO:0015711 103 0.016
cellular chemical homeostasis GO:0055082 180 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
regulation of cell cycle process GO:0010564 266 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
positive regulation of cell cycle GO:0045787 140 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
glycerolipid metabolic process GO:0046486 107 0.016
glycoprotein metabolic process GO:0009100 110 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
cellular homeostasis GO:0019725 196 0.016
cellular lipid metabolic process GO:0044255 303 0.016
reactive oxygen species biosynthetic process GO:1903409 4 0.015
dephosphorylation GO:0016311 209 0.015
regulation of t cell activation GO:0050863 77 0.015
autophagy GO:0006914 88 0.015
blastoderm segmentation GO:0007350 2 0.015
positive regulation of cytoskeleton organization GO:0051495 83 0.015
cation homeostasis GO:0055080 189 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
metal ion homeostasis GO:0055065 169 0.015
monocarboxylic acid metabolic process GO:0032787 185 0.015
regulation of protein secretion GO:0050708 86 0.015
adult locomotory behavior GO:0008344 1 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.015
positive chemotaxis GO:0050918 33 0.015
inorganic cation transmembrane transport GO:0098662 194 0.015
cellular protein complex assembly GO:0043623 188 0.015
plasma membrane organization GO:0007009 115 0.015
neuromuscular junction development GO:0007528 3 0.015
regulation of lymphocyte apoptotic process GO:0070228 15 0.015
cell development GO:0048468 328 0.015
Fly
regulation of cell activation GO:0050865 125 0.015
response to external biotic stimulus GO:0043207 261 0.014
Fly
negative regulation of cell proliferation GO:0008285 228 0.014
organophosphate biosynthetic process GO:0090407 163 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
cellular response to external stimulus GO:0071496 111 0.014
Human Fly
ion homeostasis GO:0050801 230 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
growth GO:0040007 202 0.014
cellular cation homeostasis GO:0030003 163 0.014
positive regulation of secretion GO:0051047 116 0.014
response to other organism GO:0051707 261 0.014
Fly
negative regulation of phosphate metabolic process GO:0045936 267 0.014
protein localization to plasma membrane GO:0072659 93 0.014
inorganic ion transmembrane transport GO:0098660 231 0.014
positive regulation of developmental process GO:0051094 314 0.014
regulation of intracellular transport GO:0032386 195 0.014
chemical homeostasis GO:0048878 306 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
regulation of lymphocyte activation GO:0051249 103 0.014
regulation of t cell proliferation GO:0042129 42 0.014
regulation of response to external stimulus GO:0032101 222 0.014
Fly
mitotic cell cycle process GO:1903047 286 0.013
rac protein signal transduction GO:0016601 12 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
negative regulation of protein processing GO:0010955 142 0.013
cardiovascular system development GO:0072358 262 0.013
cellular response to lipid GO:0071396 127 0.013
response to lipid GO:0033993 206 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
cell growth GO:0016049 160 0.013
negative regulation of developmental process GO:0051093 247 0.013
endocytosis GO:0006897 159 0.013
response to organic cyclic compound GO:0014070 204 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.013
regulation of protein transport GO:0051223 213 0.013
nervous system development GO:0007399 293 0.013
tripartite regional subdivision GO:0007351 2 0.013
spermatid differentiation GO:0048515 4 0.013
oocyte differentiation GO:0009994 2 0.013
inner ear morphogenesis GO:0042472 4 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
protein secretion GO:0009306 98 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.013
positive regulation of hormone biosynthetic process GO:0046886 4 0.013
regulation of rho protein signal transduction GO:0035023 79 0.013
anterior posterior axis specification GO:0009948 2 0.013
regulation of protein processing GO:0070613 150 0.013
monocyte chemotaxis GO:0002548 20 0.013
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.013
response to starvation GO:0042594 59 0.013
Human Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
circulatory system development GO:0072359 262 0.012
response to growth factor GO:0070848 205 0.012
tissue regeneration GO:0042246 3 0.012
regulation of adaptive immune response GO:0002819 33 0.012
nitrogen compound transport GO:0071705 191 0.012
regulation of actin filament based process GO:0032970 141 0.012
sodium ion transport GO:0006814 61 0.012
positive regulation of kinase activity GO:0033674 204 0.012
intracellular protein transport GO:0006886 270 0.012
carboxylic acid transport GO:0046942 63 0.012
mitotic cell cycle GO:0000278 326 0.012
protein homooligomerization GO:0051260 100 0.012
cellular response to glucocorticoid stimulus GO:0071385 4 0.012
blastocyst development GO:0001824 3 0.012
negative regulation of protein maturation GO:1903318 142 0.012
oocyte development GO:0048599 1 0.012
t cell cytokine production GO:0002369 12 0.012
cytokine production involved in immune response GO:0002367 27 0.012
lymphocyte activation GO:0046649 133 0.012
regulation of cell adhesion GO:0030155 166 0.012
establishment of protein localization to plasma membrane GO:0090002 68 0.012
neural crest cell development GO:0014032 3 0.012
mating GO:0007618 1 0.011
hindbrain development GO:0030902 3 0.011
response to nitrogen compound GO:1901698 184 0.011
regulation of cell differentiation GO:0045595 393 0.011
sequestering of metal ion GO:0051238 24 0.011
cell projection assembly GO:0030031 126 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
morphogenesis of a polarized epithelium GO:0001738 3 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
defense response to fungus GO:0050832 4 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
vasculature development GO:0001944 181 0.011
cellular response to nutrient levels GO:0031669 69 0.011
Human Fly
leukocyte apoptotic process GO:0071887 31 0.011
regulation of endocytosis GO:0030100 72 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
reactive nitrogen species metabolic process GO:2001057 3 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
cerebellum development GO:0021549 2 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
negative regulation of cellular component movement GO:0051271 106 0.011
positive regulation of cell adhesion GO:0045785 84 0.011
negative regulation of cell motility GO:2000146 104 0.011
nerve development GO:0021675 4 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
neurological system process GO:0050877 163 0.011
response to abiotic stimulus GO:0009628 336 0.011
cell cycle phase transition GO:0044770 173 0.011
meiotic chromosome segregation GO:0045132 4 0.011
cellular response to extracellular stimulus GO:0031668 72 0.011
Human Fly
t cell activation GO:0042110 99 0.011
negative regulation of catabolic process GO:0009895 104 0.011
regulation of protein localization to plasma membrane GO:1903076 40 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
negative regulation of cell cycle GO:0045786 193 0.011
response to hypoxia GO:0001666 96 0.011
organic acid transport GO:0015849 65 0.011
adaptive immune response GO:0002250 49 0.010
regulation of protein binding GO:0043393 66 0.010
peptidyl serine modification GO:0018209 106 0.010
blood vessel morphogenesis GO:0048514 162 0.010
activated t cell proliferation GO:0050798 13 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
regulation of defense response GO:0031347 154 0.010
Fly
negative regulation of locomotion GO:0040013 118 0.010
substrate adhesion dependent cell spreading GO:0034446 41 0.010
positive regulation of cell death GO:0010942 263 0.010
epidermis morphogenesis GO:0048730 3 0.010
regulation of actin cytoskeleton organization GO:0032956 116 0.010
negative regulation of endocytosis GO:0045806 19 0.010
spermatid development GO:0007286 4 0.010
cellular response to dna damage stimulus GO:0006974 379 0.010
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.010
peripheral nervous system development GO:0007422 2 0.010
positive regulation of aldosterone metabolic process GO:0032346 2 0.010
wnt signaling pathway GO:0016055 156 0.010
negative regulation of protein modification process GO:0031400 200 0.010
positive regulation of mapk cascade GO:0043410 190 0.010
anion transmembrane transport GO:0098656 76 0.010
regulation of dna metabolic process GO:0051052 153 0.010
phospholipid metabolic process GO:0006644 99 0.010
negative regulation of proteolysis GO:0045861 132 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
sensory perception of pain GO:0019233 4 0.010
establishment of protein localization to organelle GO:0072594 172 0.010

WIPI1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.095
inherited metabolic disorder DOID:655 242 0.095
lysosomal storage disease DOID:3211 47 0.063
disease of cellular proliferation DOID:14566 174 0.036
musculoskeletal system disease DOID:17 223 0.030
connective tissue disease DOID:65 109 0.028
cancer DOID:162 167 0.022
sensory system disease DOID:0050155 203 0.022
nervous system disease DOID:863 431 0.022
eye and adnexa disease DOID:1492 150 0.017
organ system cancer DOID:0050686 164 0.016
retinal disease DOID:5679 118 0.016
eye disease DOID:5614 149 0.016
central nervous system disease DOID:331 186 0.014
muscular disease DOID:0080000 114 0.013
muscle tissue disease DOID:66 113 0.013
cardiovascular system disease DOID:1287 106 0.011
retinal degeneration DOID:8466 89 0.010