Homo sapiens

67 known processes

DERL1

Der1-like domain family, member 1

(Aliases: PRO2577,DER1,FLJ42092,MGC3067,DER-1,FLJ13784)

DERL1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.999
cellular response to topologically incorrect protein GO:0035967 19 0.983
er nucleus signaling pathway GO:0006984 23 0.970
negative regulation of myeloid cell apoptotic process GO:0033033 4 0.931
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.920
protein n linked glycosylation via asparagine GO:0018279 10 0.918
response to endoplasmic reticulum stress GO:0034976 49 0.912
cellular macromolecule catabolic process GO:0044265 380 0.909
protein catabolic process GO:0030163 325 0.896
regulation of acute inflammatory response to antigenic stimulus GO:0002864 1 0.892
cellular response to unfolded protein GO:0034620 16 0.890
endoplasmic reticulum unfolded protein response GO:0030968 16 0.884
response to topologically incorrect protein GO:0035966 29 0.874
retrograde protein transport er to cytosol GO:0030970 5 0.847
glycosylation GO:0070085 71 0.847
modification dependent protein catabolic process GO:0019941 209 0.821
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.805
cellular protein catabolic process GO:0044257 261 0.802
cellular response to biotic stimulus GO:0071216 71 0.797
ubiquitin dependent protein catabolic process GO:0006511 206 0.793
peptidyl asparagine modification GO:0018196 11 0.763
macromolecule glycosylation GO:0043413 63 0.758
response to redox state GO:0051775 7 0.728
response to unfolded protein GO:0006986 24 0.723
negative regulation of acute inflammatory response GO:0002674 3 0.670
protein glycosylation GO:0006486 62 0.643
mitochondrial calcium ion homeostasis GO:0051560 11 0.583
reactive nitrogen species metabolic process GO:2001057 3 0.560
proteasomal protein catabolic process GO:0010498 176 0.536
single organism carbohydrate metabolic process GO:0044723 193 0.483
inflammatory cell apoptotic process GO:0006925 3 0.476
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.472
glycoprotein biosynthetic process GO:0009101 91 0.450
response to molecule of bacterial origin GO:0002237 82 0.395
regulation of apoptotic signaling pathway GO:2001233 175 0.387
modification dependent macromolecule catabolic process GO:0043632 212 0.387
cellular response to oxidative stress GO:0034599 85 0.357
negative regulation of nitric oxide synthase biosynthetic process GO:0051771 3 0.331
negative regulation of apoptotic signaling pathway GO:2001234 97 0.322
intrinsic apoptotic signaling pathway GO:0097193 127 0.297
response to lipopolysaccharide GO:0032496 70 0.290
cytoplasmic transport GO:0016482 379 0.287
cellular response to molecule of bacterial origin GO:0071219 62 0.242
carbohydrate derivative biosynthetic process GO:1901137 207 0.234
cellular response to lipopolysaccharide GO:0071222 57 0.230
response to biotic stimulus GO:0009607 276 0.226
apoptotic signaling pathway GO:0097190 268 0.224
post embryonic development GO:0009791 2 0.222
reactive oxygen species metabolic process GO:0072593 75 0.217
intracellular protein transport GO:0006886 270 0.212
nitric oxide metabolic process GO:0046209 22 0.210
cellular response to oxygen containing compound GO:1901701 276 0.202
negative regulation of response to wounding GO:1903035 47 0.201
protein n linked glycosylation GO:0006487 23 0.201
glycoprotein metabolic process GO:0009100 110 0.197
immune response GO:0006955 307 0.188
regulation of immune response GO:0050776 201 0.187
negative regulation of leukocyte apoptotic process GO:2000107 16 0.169
response to external biotic stimulus GO:0043207 261 0.163
negative regulation of cell death GO:0060548 345 0.162
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 12 0.162
defense response GO:0006952 315 0.155
golgi vesicle transport GO:0048193 80 0.146
cation homeostasis GO:0055080 189 0.121
protein localization to endoplasmic reticulum GO:0070972 19 0.121
response to bacterium GO:0009617 144 0.118
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.117
response to oxidative stress GO:0006979 121 0.116
protein localization to organelle GO:0033365 280 0.114
negative regulation of programmed cell death GO:0043069 321 0.105
response to wounding GO:0009611 168 0.105
response to other organism GO:0051707 261 0.102
negative regulation of intracellular signal transduction GO:1902532 183 0.090
regulation of response to external stimulus GO:0032101 222 0.090
negative regulation of response to external stimulus GO:0032102 83 0.089
maintenance of location GO:0051235 112 0.084
leukocyte apoptotic process GO:0071887 31 0.083
regulation of nitric oxide synthase biosynthetic process GO:0051769 6 0.083
protein modification by small protein conjugation GO:0032446 342 0.083
determination of adult lifespan GO:0008340 2 0.082
regulation of protein ubiquitination GO:0031396 95 0.079
single organism membrane organization GO:0044802 268 0.076
calcium ion homeostasis GO:0055074 122 0.073
regulation of protein transport GO:0051223 213 0.071
autophagy GO:0006914 88 0.066
inflammatory response GO:0006954 79 0.064
maintenance of location in cell GO:0051651 62 0.062
negative regulation of apoptotic process GO:0043066 316 0.061
cell type specific apoptotic process GO:0097285 125 0.058
response to oxygen containing compound GO:1901700 369 0.056
regulation of inflammatory response to antigenic stimulus GO:0002861 2 0.055
negative regulation of immune system process GO:0002683 136 0.054
regulation of leukocyte apoptotic process GO:2000106 25 0.054
ribonucleoside triphosphate catabolic process GO:0009203 391 0.054
protein ubiquitination GO:0016567 314 0.053
regulation of response to wounding GO:1903034 101 0.052
multicellular organismal aging GO:0010259 3 0.052
purine ribonucleoside catabolic process GO:0046130 398 0.051
carbohydrate metabolic process GO:0005975 207 0.050
acute inflammatory response GO:0002526 21 0.050
negative regulation of immune response GO:0050777 40 0.050
regulation of inflammatory response GO:0050727 46 0.050
golgi organization GO:0007030 38 0.049
regulation of acute inflammatory response GO:0002673 13 0.048
calcium mediated signaling using intracellular calcium source GO:0035584 7 0.048
cellular cation homeostasis GO:0030003 163 0.047
response to lipid GO:0033993 206 0.045
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.045
cation transport GO:0006812 331 0.045
establishment of protein localization to organelle GO:0072594 172 0.043
purine nucleoside triphosphate catabolic process GO:0009146 392 0.042
positive regulation of mitochondrial calcium ion concentration GO:0051561 8 0.038
protein oligomerization GO:0051259 173 0.037
cellular divalent inorganic cation homeostasis GO:0072503 128 0.037
nucleoside catabolic process GO:0009164 408 0.036
macrophage apoptotic process GO:0071888 1 0.035
regulation of protein localization GO:0032880 296 0.035
regulation of intracellular transport GO:0032386 195 0.035
metal ion homeostasis GO:0055065 169 0.035
positive regulation of cellular component organization GO:0051130 376 0.034
vesicle mediated transport GO:0016192 371 0.034
Worm
nitric oxide synthase biosynthetic process GO:0051767 6 0.034
regulation of protein deubiquitination GO:0090085 4 0.033
single organism cellular localization GO:1902580 332 0.033
chemical homeostasis GO:0048878 306 0.032
ribonucleoside triphosphate metabolic process GO:0009199 412 0.032
negative regulation of cell proliferation GO:0008285 228 0.032
regulation of macrophage apoptotic process GO:2000109 1 0.031
ribonucleoside catabolic process GO:0042454 406 0.031
protein targeting GO:0006605 187 0.031
negative regulation of inflammatory response GO:0050728 22 0.030
positive regulation of transport GO:0051050 336 0.029
embryonic placenta development GO:0001892 1 0.029
cellular response to starvation GO:0009267 58 0.029
lipid localization GO:0010876 106 0.028
nucleoside triphosphate catabolic process GO:0009143 394 0.028
organophosphate catabolic process GO:0046434 430 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.028
regulation of cytoplasmic transport GO:1903649 149 0.028
regulation of protein targeting GO:1903533 91 0.028
regulation of proteolysis GO:0030162 293 0.026
somitogenesis GO:0001756 2 0.025
protein import GO:0017038 130 0.025
er associated misfolded protein catabolic process GO:0071712 1 0.025
membrane organization GO:0061024 292 0.025
cellular metal ion homeostasis GO:0006875 146 0.024
metal ion transport GO:0030001 272 0.024
nucleoside phosphate catabolic process GO:1901292 412 0.024
protein localization to membrane GO:0072657 160 0.024
maintenance of protein location in cell GO:0032507 56 0.024
regulation of peptidase activity GO:0052547 180 0.024
glycosyl compound catabolic process GO:1901658 413 0.024
regulation of binding GO:0051098 111 0.024
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.024
negative regulation of cellular catabolic process GO:0031330 83 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
purine nucleoside catabolic process GO:0006152 398 0.023
regulation of establishment of protein localization GO:0070201 242 0.023
regulation of defense response GO:0031347 154 0.023
purine ribonucleotide catabolic process GO:0009154 404 0.022
ion homeostasis GO:0050801 230 0.022
protein homooligomerization GO:0051260 100 0.022
response to glucose GO:0009749 19 0.021
cellular homeostasis GO:0019725 196 0.021
protein maturation GO:0051604 233 0.019
nucleocytoplasmic transport GO:0006913 176 0.019
cellular calcium ion homeostasis GO:0006874 117 0.019
secretion by cell GO:0032940 226 0.018
regulation of anatomical structure morphogenesis GO:0022603 286 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
trabecula morphogenesis GO:0061383 2 0.018
cytosolic calcium ion homeostasis GO:0051480 89 0.018
response to starvation GO:0042594 59 0.018
autophagic vacuole assembly GO:0000045 19 0.018
positive regulation of protein transport GO:0051222 135 0.017
nitrogen compound transport GO:0071705 191 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
positive regulation of catabolic process GO:0009896 310 0.017
divalent inorganic cation transport GO:0072511 158 0.017
response to hexose GO:0009746 20 0.017
purine nucleoside triphosphate metabolic process GO:0009144 412 0.017
cellular ion homeostasis GO:0006873 168 0.017
negative regulation of catabolic process GO:0009895 104 0.017
positive regulation of developmental process GO:0051094 314 0.017
transmembrane transport GO:0055085 399 0.017
protein modification by small protein removal GO:0070646 92 0.017
positive regulation of cellular protein catabolic process GO:1903364 37 0.017
purine containing compound catabolic process GO:0072523 411 0.017
actin filament based process GO:0030029 224 0.016
embryonic epithelial tube formation GO:0001838 4 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
cellular response to extracellular stimulus GO:0031668 72 0.016
chromatin modification GO:0016568 298 0.016
cellular chemical homeostasis GO:0055082 180 0.016
regulation of cellular component biogenesis GO:0044087 281 0.016
regulation of protein maturation GO:1903317 150 0.016
regulation of cysteine type endopeptidase activity GO:2000116 127 0.016
adult locomotory behavior GO:0008344 1 0.015
regulation of protein binding GO:0043393 66 0.015
anterior posterior axis specification GO:0009948 2 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
organophosphate ester transport GO:0015748 32 0.015
regulation of cellular amino acid metabolic process GO:0006521 6 0.015
endomembrane system organization GO:0010256 196 0.015
gtp catabolic process GO:0006184 237 0.015
myosin filament organization GO:0031033 2 0.015
establishment of protein localization to mitochondrion GO:0072655 22 0.015
divalent metal ion transport GO:0070838 152 0.014
ion transmembrane transport GO:0034220 338 0.014
cell projection organization GO:0030030 252 0.014
divalent inorganic cation homeostasis GO:0072507 136 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
polysaccharide metabolic process GO:0005976 33 0.014
maintenance of protein location GO:0045185 57 0.014
aging GO:0007568 66 0.014
regulation of cellular ketone metabolic process GO:0010565 50 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
negative regulation of transport GO:0051051 176 0.014
locomotory behavior GO:0007626 1 0.014
reproductive process GO:0022414 106 0.014
Worm
protein k63 linked deubiquitination GO:0070536 21 0.013
myeloid cell apoptotic process GO:0033028 7 0.013
single organism reproductive process GO:0044702 98 0.013
Worm
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
protein localization to nucleus GO:0034504 136 0.013
purine ribonucleoside metabolic process GO:0046128 437 0.013
protein import into nucleus GO:0006606 104 0.013
myosin filament assembly GO:0031034 2 0.013
hindbrain development GO:0030902 3 0.013
regulation of cellular protein catabolic process GO:1903362 96 0.013
negative regulation of inflammatory response to antigenic stimulus GO:0002862 2 0.013
cellular protein complex assembly GO:0043623 188 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
ossification GO:0001503 121 0.013
cellular response to nutrient levels GO:0031669 69 0.012
regulation of intracellular protein transport GO:0033157 123 0.012
er to golgi vesicle mediated transport GO:0006888 19 0.012
segmentation GO:0035282 4 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
cell growth GO:0016049 160 0.011
regulation of cell migration GO:0030334 289 0.011
response to disaccharide GO:0034285 1 0.011
positive regulation of organelle organization GO:0010638 195 0.011
regulation of protein complex assembly GO:0043254 147 0.011
mitochondrion organization GO:0007005 156 0.011
nucleotide catabolic process GO:0009166 408 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
organelle localization GO:0051640 84 0.011
regulation of growth GO:0040008 165 0.011
biological adhesion GO:0022610 331 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
gtp metabolic process GO:0046039 239 0.011
protein targeting to membrane GO:0006612 42 0.010
secretion GO:0046903 254 0.010
positive regulation of apoptotic process GO:0043065 246 0.010
cation transmembrane transport GO:0098655 238 0.010
morphogenesis of embryonic epithelium GO:0016331 4 0.010
covalent chromatin modification GO:0016569 254 0.010
glycoprotein catabolic process GO:0006516 7 0.010
regulation of cellular component movement GO:0051270 334 0.010
multicellular organismal metabolic process GO:0044236 34 0.010

DERL1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.027
nervous system disease DOID:863 431 0.027
disease of cellular proliferation DOID:14566 174 0.021
organ system cancer DOID:0050686 164 0.021
cancer DOID:162 167 0.021
neurodegenerative disease DOID:1289 102 0.019
brain disease DOID:936 73 0.013
syndrome DOID:225 17 0.010