Homo sapiens

63 known processes

USP5

ubiquitin specific peptidase 5 (isopeptidase T)

(Aliases: ISOT)

USP5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone h3 s10 phosphorylation GO:0043987 3 0.322
protein acylation GO:0043543 138 0.281
regulation of cellular amine metabolic process GO:0033238 11 0.257
protein modification by small protein removal GO:0070646 92 0.245
protein deubiquitination GO:0016579 79 0.244
peptidyl lysine acetylation GO:0018394 101 0.218
cellular amine metabolic process GO:0044106 41 0.206
regulation of cellular ketone metabolic process GO:0010565 50 0.202
Yeast
cellular ketone metabolic process GO:0042180 80 0.193
Yeast
histone acetylation GO:0016573 93 0.184
chromatin organization GO:0006325 351 0.170
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.162
internal peptidyl lysine acetylation GO:0018393 97 0.153
histone h3 k14 acetylation GO:0044154 2 0.146
histone modification GO:0016570 251 0.133
cellular amino acid metabolic process GO:0006520 116 0.132
protein acetylation GO:0006473 116 0.126
internal protein amino acid acetylation GO:0006475 101 0.124
covalent chromatin modification GO:0016569 254 0.122
peptidyl lysine modification GO:0018205 144 0.120
post embryonic development GO:0009791 2 0.112
oogenesis GO:0048477 2 0.106
chromatin modification GO:0016568 298 0.098
cellular protein catabolic process GO:0044257 261 0.091
histone phosphorylation GO:0016572 16 0.079
negative regulation of protein modification process GO:0031400 200 0.079
regulation of gene expression epigenetic GO:0040029 73 0.078
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.076
multicellular organismal aging GO:0010259 3 0.073
proteasomal protein catabolic process GO:0010498 176 0.073
regulation of cell cycle GO:0051726 393 0.072
mitotic cell cycle process GO:1903047 286 0.066
modification dependent macromolecule catabolic process GO:0043632 212 0.066
modification dependent protein catabolic process GO:0019941 209 0.065
ncrna metabolic process GO:0034660 108 0.064
histone h3 k9 modification GO:0061647 11 0.062
ribonucleoside catabolic process GO:0042454 406 0.060
positive regulation of cellular component organization GO:0051130 376 0.058
regulation of chromatin organization GO:1902275 56 0.055
growth GO:0040007 202 0.055
amine metabolic process GO:0009308 44 0.055
protein polyubiquitination GO:0000209 110 0.055
nervous system development GO:0007399 293 0.052
Fly
histone h4 k12 acetylation GO:0043983 6 0.050
positive regulation of cellular amine metabolic process GO:0033240 7 0.050
rna processing GO:0006396 255 0.050
histone h3 acetylation GO:0043966 45 0.049
negative regulation of cell fate commitment GO:0010454 3 0.048
negative regulation of cellular protein metabolic process GO:0032269 353 0.048
cellular response to dna damage stimulus GO:0006974 379 0.047
regulation of mitotic cell cycle GO:0007346 189 0.046
nucleoside triphosphate catabolic process GO:0009143 394 0.045
regulation of proteasomal protein catabolic process GO:0061136 87 0.045
female gamete generation GO:0007292 2 0.044
regulation of cellular amino acid metabolic process GO:0006521 6 0.042
posttranscriptional regulation of gene expression GO:0010608 213 0.041
Human
negative regulation of catalytic activity GO:0043086 335 0.039
protein modification by small protein conjugation GO:0032446 342 0.039
determination of adult lifespan GO:0008340 2 0.039
ribonucleoside triphosphate catabolic process GO:0009203 391 0.038
positive regulation of organelle organization GO:0010638 195 0.037
cell fate commitment involved in pattern specification GO:0060581 1 0.037
purine nucleoside catabolic process GO:0006152 398 0.036
histone h4 acetylation GO:0043967 47 0.035
nucleotide catabolic process GO:0009166 408 0.035
specification of organ identity GO:0010092 3 0.035
double strand break repair GO:0006302 101 0.034
purine nucleotide catabolic process GO:0006195 405 0.034
negative regulation of phosphorus metabolic process GO:0010563 267 0.033
viral process GO:0016032 146 0.033
positive regulation of protein kinase activity GO:0045860 190 0.032
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.031
heart formation GO:0060914 2 0.029
cellular homeostasis GO:0019725 196 0.029
cell cycle phase transition GO:0044770 173 0.029
establishment of tissue polarity GO:0007164 3 0.029
nucleoside triphosphate metabolic process GO:0009141 422 0.029
defense response GO:0006952 315 0.029
purine nucleoside triphosphate catabolic process GO:0009146 392 0.029
segmentation GO:0035282 4 0.028
positive regulation of hydrolase activity GO:0051345 331 0.028
mitotic cell cycle GO:0000278 326 0.028
regulation of chromosome organization GO:0033044 103 0.028
regulation of protein stability GO:0031647 87 0.028
Human
protein localization to organelle GO:0033365 280 0.028
ubiquitin dependent protein catabolic process GO:0006511 206 0.028
negative regulation of phosphorylation GO:0042326 174 0.028
positive regulation of programmed cell death GO:0043068 249 0.027
hindbrain development GO:0030902 3 0.027
actin filament based process GO:0030029 224 0.026
regulation of cellular response to stress GO:0080135 244 0.026
regulation of histone acetylation GO:0035065 19 0.026
protein ubiquitination GO:0016567 314 0.026
neurogenesis GO:0022008 169 0.025
Fly
protein catabolic process GO:0030163 325 0.025
positive regulation of cellular catabolic process GO:0031331 284 0.025
regulation of transferase activity GO:0051338 355 0.025
purine nucleoside triphosphate metabolic process GO:0009144 412 0.025
negative regulation of multicellular organismal process GO:0051241 317 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
small gtpase mediated signal transduction GO:0007264 78 0.024
purine ribonucleoside metabolic process GO:0046128 437 0.024
negative regulation of protein metabolic process GO:0051248 391 0.024
glycosyl compound catabolic process GO:1901658 413 0.024
regulation of protein acetylation GO:1901983 25 0.024
peptidyl serine modification GO:0018209 106 0.023
establishment of planar polarity GO:0001736 3 0.023
neuron projection development GO:0031175 106 0.023
Fly
positive regulation of cellular protein catabolic process GO:1903364 37 0.023
ribonucleotide catabolic process GO:0009261 405 0.023
single organism cellular localization GO:1902580 332 0.023
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.023
positive regulation of chromatin modification GO:1903310 30 0.022
inner ear morphogenesis GO:0042472 4 0.022
translation GO:0006412 132 0.022
rna splicing GO:0008380 131 0.022
regulation of kinase activity GO:0043549 314 0.022
purine ribonucleotide catabolic process GO:0009154 404 0.022
cell projection assembly GO:0030031 126 0.021
cellular lipid metabolic process GO:0044255 303 0.021
spermatid development GO:0007286 4 0.021
nitrogen compound transport GO:0071705 191 0.021
cell morphogenesis involved in differentiation GO:0000904 144 0.021
cellular macromolecule catabolic process GO:0044265 380 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.021
nucleoside catabolic process GO:0009164 408 0.021
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.020
cellular response to endogenous stimulus GO:0071495 336 0.020
dna repair GO:0006281 198 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
regulation of microtubule based process GO:0032886 74 0.020
mrna metabolic process GO:0016071 175 0.020
regulation of protein catabolic process GO:0042176 155 0.020
chromatin mediated maintenance of transcription GO:0048096 2 0.020
organophosphate catabolic process GO:0046434 430 0.020
microtubule based process GO:0007017 210 0.019
motor neuron axon guidance GO:0008045 2 0.019
regulation of chromatin modification GO:1903308 51 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
lipid metabolic process GO:0006629 381 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
cell projection organization GO:0030030 252 0.019
Fly
interspecies interaction between organisms GO:0044419 156 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.018
monocarboxylic acid metabolic process GO:0032787 185 0.018
spermatid differentiation GO:0048515 4 0.018
purine containing compound catabolic process GO:0072523 411 0.018
positive regulation of chromosome organization GO:2001252 41 0.018
regulation of proteolysis GO:0030162 293 0.018
regulation of protein kinase activity GO:0045859 289 0.017
regulation of secretion by cell GO:1903530 177 0.017
guanosine containing compound metabolic process GO:1901068 244 0.017
retinal ganglion cell axon guidance GO:0031290 2 0.017
protein stabilization GO:0050821 64 0.017
Human
single organism reproductive process GO:0044702 98 0.017
regulation of growth GO:0040008 165 0.017
gtp metabolic process GO:0046039 239 0.017
locomotory behavior GO:0007626 1 0.017
positive regulation of protein catabolic process GO:0045732 75 0.017
negative regulation of kinase activity GO:0033673 106 0.017
alcohol metabolic process GO:0006066 114 0.017
endosomal transport GO:0016197 129 0.017
innate immune response GO:0045087 178 0.017
salivary gland morphogenesis GO:0007435 4 0.016
system process GO:0003008 349 0.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.016
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
neuron differentiation GO:0030182 138 0.016
Fly
ion homeostasis GO:0050801 230 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
regulation of small gtpase mediated signal transduction GO:0051056 156 0.016
regulation of actin filament based process GO:0032970 141 0.016
nucleocytoplasmic transport GO:0006913 176 0.016
dephosphorylation GO:0016311 209 0.016
positive regulation of catabolic process GO:0009896 310 0.016
developmental growth GO:0048589 48 0.015
maintenance of location GO:0051235 112 0.015
chemical homeostasis GO:0048878 306 0.015
protein k48 linked deubiquitination GO:0071108 19 0.015
ncrna processing GO:0034470 83 0.015
positive regulation of immune system process GO:0002684 283 0.015
positive regulation of histone modification GO:0031058 29 0.015
organ formation GO:0048645 3 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
negative regulation of mitotic cell cycle GO:0045930 102 0.015
isoprenoid metabolic process GO:0006720 39 0.015
regulation of ras protein signal transduction GO:0046578 155 0.015
cellular macromolecular complex assembly GO:0034622 324 0.015
regulation of homeostatic process GO:0032844 121 0.014
Fly
positive regulation of gtp catabolic process GO:0033126 166 0.014
regulation of protein sumoylation GO:0033233 13 0.014
cell cell signaling GO:0007267 155 0.014
cell development GO:0048468 328 0.014
Fly
regulation of cytoskeleton organization GO:0051493 177 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
carbohydrate metabolic process GO:0005975 207 0.014
Yeast
regulation of protein ubiquitination GO:0031396 95 0.014
dna integrity checkpoint GO:0031570 71 0.014
compound eye development GO:0048749 1 0.014
protein oligomerization GO:0051259 173 0.014
anterior posterior axis specification GO:0009948 2 0.014
trna metabolic process GO:0006399 35 0.014
signal transduction by phosphorylation GO:0023014 297 0.014
cell cycle checkpoint GO:0000075 117 0.014
regulation of viral process GO:0050792 103 0.014
negative regulation of cardioblast differentiation GO:0051892 2 0.014
positive regulation of kinase activity GO:0033674 204 0.014
neuromuscular junction development GO:0007528 3 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
regulation of peptidyl lysine acetylation GO:2000756 22 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
positive regulation of gtpase activity GO:0043547 166 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
trna processing GO:0008033 23 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
epithelial cell differentiation GO:0030855 141 0.014
macromolecule glycosylation GO:0043413 63 0.013
canonical wnt signaling pathway GO:0060070 116 0.013
chromatin remodeling GO:0006338 55 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
tube closure GO:0060606 3 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
glycosylation GO:0070085 71 0.013
biological adhesion GO:0022610 331 0.013
regulation of microtubule cytoskeleton organization GO:0070507 61 0.013
regulation of cell differentiation GO:0045595 393 0.013
oocyte development GO:0048599 1 0.013
cell fate determination GO:0001709 3 0.013
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.013
response to oxygen containing compound GO:1901700 369 0.013
cellular component morphogenesis GO:0032989 314 0.013
Fly
regulation of cell cycle process GO:0010564 266 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
regulation of multi organism process GO:0043900 157 0.013
regulation of cellular response to growth factor stimulus GO:0090287 76 0.013
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.012
regulation of response to external stimulus GO:0032101 222 0.012
organelle localization GO:0051640 84 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
cell adhesion GO:0007155 325 0.012
morphogenesis of a polarized epithelium GO:0001738 3 0.012
prostate gland development GO:0030850 3 0.012
response to abiotic stimulus GO:0009628 336 0.012
reproductive process GO:0022414 106 0.012
cytoplasmic transport GO:0016482 379 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
protein dephosphorylation GO:0006470 81 0.012
negative regulation of growth GO:0045926 97 0.012
oocyte differentiation GO:0009994 2 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
single organism membrane organization GO:0044802 268 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
response to external biotic stimulus GO:0043207 261 0.012
apoptotic signaling pathway GO:0097190 268 0.012
negative regulation of multi organism process GO:0043901 92 0.011
protein targeting GO:0006605 187 0.011
response to growth factor GO:0070848 205 0.011
intracellular protein transport GO:0006886 270 0.011
cell part morphogenesis GO:0032990 137 0.011
Fly
lipid biosynthetic process GO:0008610 177 0.011
rna interference GO:0016246 4 0.011
fatty acid metabolic process GO:0006631 115 0.011
convergent extension GO:0060026 1 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
regulation of dephosphorylation GO:0035303 96 0.011
multi organism cellular process GO:0044764 156 0.011
sodium ion transport GO:0006814 61 0.011
vesicle mediated transport GO:0016192 371 0.011
immune system development GO:0002520 195 0.011
neurological system process GO:0050877 163 0.011
signal transduction involved in regulation of gene expression GO:0023019 1 0.011
secretion by cell GO:0032940 226 0.011
stress activated mapk cascade GO:0051403 93 0.011
regeneration GO:0031099 4 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.011
immune response GO:0006955 307 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
microtubule polymerization or depolymerization GO:0031109 37 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
heart field specification GO:0003128 2 0.011
stress activated protein kinase signaling cascade GO:0031098 94 0.011
macromolecular complex disassembly GO:0032984 60 0.011
Fly
regulation of defense response GO:0031347 154 0.011
epidermis morphogenesis GO:0048730 3 0.011
mapk cascade GO:0000165 288 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
establishment of epithelial cell polarity GO:0090162 2 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
response to biotic stimulus GO:0009607 276 0.010
atp metabolic process GO:0046034 176 0.010
regulation of mapk cascade GO:0043408 262 0.010
sodium ion transmembrane transport GO:0035725 59 0.010
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.010
somatic stem cell maintenance GO:0035019 4 0.010
actin cytoskeleton organization GO:0030036 207 0.010
regulation of organ formation GO:0003156 4 0.010
negative regulation of cell fate specification GO:0009996 3 0.010
establishment of monopolar cell polarity GO:0061162 1 0.010
positive regulation of gene expression epigenetic GO:0045815 7 0.010
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
phospholipid metabolic process GO:0006644 99 0.010
developmental process involved in reproduction GO:0003006 66 0.010
negative regulation of transport GO:0051051 176 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
negative regulation of response to external stimulus GO:0032102 83 0.010
regulation of neurotransmitter secretion GO:0046928 3 0.010
glycerolipid metabolic process GO:0046486 107 0.010
enzyme linked receptor protein signaling pathway GO:0007167 303 0.010

USP5 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.017
central nervous system disease DOID:331 186 0.016
nervous system disease DOID:863 431 0.016
neurodegenerative disease DOID:1289 102 0.015
disease of metabolism DOID:0014667 295 0.014