Homo sapiens

0 known processes

MAP2K6

mitogen-activated protein kinase kinase 6

(Aliases: PRKMK6,MAPKK6,MEK6,SAPKK3,MKK6)

MAP2K6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
p38mapk cascade GO:0038066 9 0.731
Worm
regulation of synaptic vesicle exocytosis GO:2000300 2 0.659
response to salt stress GO:0009651 3 0.603
mapk cascade GO:0000165 288 0.523
Human Mouse Rat Worm
regulation of peroxidase activity GO:2000468 2 0.512
regulation of kidney size GO:0035564 2 0.469
regulation of protein serine threonine kinase activity GO:0071900 179 0.456
Human Mouse Rat Worm
regulation of synaptic vesicle recycling GO:1903421 1 0.406
cartilage condensation GO:0001502 1 0.405
stress activated protein kinase signaling cascade GO:0031098 94 0.392
Human Worm
cellular response to ammonium ion GO:0071242 4 0.336
positive regulation of protein phosphorylation GO:0001934 313 0.320
Human Mouse Rat Worm
regulation of mapk cascade GO:0043408 262 0.319
Human Mouse Rat Worm
neurotransmitter secretion GO:0007269 4 0.314
regulation of transferase activity GO:0051338 355 0.312
Human Mouse Rat Worm
regulation of map kinase activity GO:0043405 108 0.304
Human Mouse Rat Worm
positive regulation of map kinase activity GO:0043406 80 0.284
Human Mouse Rat Worm
signal transduction by phosphorylation GO:0023014 297 0.282
Human Mouse Rat Worm
positive regulation of transferase activity GO:0051347 227 0.254
Human Mouse Rat Worm
positive regulation of mapk cascade GO:0043410 190 0.250
Human Mouse Rat Worm
regulation of synaptic vesicle endocytosis GO:1900242 1 0.234
ras protein signal transduction GO:0007265 73 0.227
stress activated mapk cascade GO:0051403 93 0.208
Human Worm
synaptic vesicle exocytosis GO:0016079 3 0.188
response to inorganic substance GO:0010035 127 0.176
Worm
regulation of stress activated mapk cascade GO:0032872 84 0.167
response to cytokine GO:0034097 232 0.167
Human
jnk cascade GO:0007254 80 0.158
determination of adult lifespan GO:0008340 2 0.154
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 3 0.149
activation of protein kinase activity GO:0032147 90 0.147
Human Mouse Rat Worm
regulation of jnk cascade GO:0046328 73 0.147
regulation of protein kinase activity GO:0045859 289 0.138
Human Mouse Rat Worm
multicellular organismal aging GO:0010259 3 0.133
response to nitrosative stress GO:0051409 4 0.131
response to abiotic stimulus GO:0009628 336 0.129
Human
ribonucleotide catabolic process GO:0009261 405 0.129
negative regulation of catalytic activity GO:0043086 335 0.123
ribonucleoside triphosphate catabolic process GO:0009203 391 0.120
response to uv GO:0009411 73 0.118
Human
regulation of neurotransmitter secretion GO:0046928 3 0.118
positive regulation of phosphorylation GO:0042327 394 0.115
Human Mouse Rat Worm
post embryonic development GO:0009791 2 0.114
Worm
positive regulation of protein kinase activity GO:0045860 190 0.113
Human Mouse Rat Worm
regulation of kinase activity GO:0043549 314 0.111
Human Mouse Rat Worm
response to oxygen containing compound GO:1901700 369 0.103
Rat Worm
response to radiation GO:0009314 151 0.099
Human
positive regulation of catabolic process GO:0009896 310 0.098
glycosyl compound catabolic process GO:1901658 413 0.097
regulation of cellular amino acid metabolic process GO:0006521 6 0.096
small gtpase mediated signal transduction GO:0007264 78 0.095
establishment of planar polarity GO:0001736 3 0.092
peptidyl threonine modification GO:0018210 45 0.092
regulation of cellular response to stress GO:0080135 244 0.092
peptidyl serine phosphorylation GO:0018105 101 0.091
purine ribonucleoside metabolic process GO:0046128 437 0.090
positive regulation of kinase activity GO:0033674 204 0.089
Human Mouse Rat Worm
nucleotide catabolic process GO:0009166 408 0.089
positive regulation of cellular amine metabolic process GO:0033240 7 0.088
oogenesis GO:0048477 2 0.087
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.087
cellular response to oxygen containing compound GO:1901701 276 0.085
Rat
peptidyl serine modification GO:0018209 106 0.085
purine ribonucleoside catabolic process GO:0046130 398 0.084
positive regulation of cell size GO:0045793 3 0.082
nucleoside triphosphate metabolic process GO:0009141 422 0.082
regulation of cellular response to oxidative stress GO:1900407 26 0.082
purine nucleotide catabolic process GO:0006195 405 0.080
guanosine containing compound metabolic process GO:1901068 244 0.079
purine ribonucleotide catabolic process GO:0009154 404 0.079
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.079
Human Mouse Rat Worm
response to endoplasmic reticulum stress GO:0034976 49 0.079
dephosphorylation GO:0016311 209 0.079
system process GO:0003008 349 0.078
Mouse
negative regulation of phosphate metabolic process GO:0045936 267 0.077
erk1 and erk2 cascade GO:0070371 104 0.077
negative regulation of phosphorus metabolic process GO:0010563 267 0.077
cellular response to arsenic containing substance GO:0071243 4 0.076
regulation of gtp catabolic process GO:0033124 180 0.075
mitochondrion distribution GO:0048311 3 0.075
response to metal ion GO:0010038 84 0.075
hyperosmotic response GO:0006972 4 0.075
synaptic vesicle endocytosis GO:0048488 2 0.074
positive regulation of hydrolase activity GO:0051345 331 0.074
peptidyl threonine phosphorylation GO:0018107 41 0.073
purine containing compound catabolic process GO:0072523 411 0.073
negative regulation of non canonical wnt signaling pathway GO:2000051 1 0.073
purine nucleoside triphosphate metabolic process GO:0009144 412 0.072
single organism carbohydrate metabolic process GO:0044723 193 0.072
posttranscriptional regulation of gene expression GO:0010608 213 0.070
positive regulation of gtpase activity GO:0043547 166 0.070
synaptic vesicle recycling GO:0036465 3 0.070
negative regulation of protein modification process GO:0031400 200 0.070
activation of mapkk activity GO:0000186 18 0.070
response to biotic stimulus GO:0009607 276 0.069
Worm
positive regulation of apoptotic process GO:0043065 246 0.069
Rat
regulation of exocytosis GO:0017157 46 0.065
apoptotic signaling pathway GO:0097190 268 0.065
protein autophosphorylation GO:0046777 123 0.065
regulation of postsynaptic membrane potential GO:0060078 1 0.064
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.064
positive regulation of transport GO:0051050 336 0.063
Rat
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.063
negative regulation of protein phosphorylation GO:0001933 140 0.062
positive regulation of stress activated mapk cascade GO:0032874 60 0.062
circulatory system process GO:0003013 113 0.062
Mouse
amine metabolic process GO:0009308 44 0.062
chemical homeostasis GO:0048878 306 0.061
negative regulation of protein metabolic process GO:0051248 391 0.061
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.061
cellular response to organic cyclic compound GO:0071407 127 0.061
cellular response to lipid GO:0071396 127 0.061
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.060
lipid metabolic process GO:0006629 381 0.060
positive regulation of p38mapk cascade GO:1900745 8 0.060
regulation of cellular component size GO:0032535 82 0.060
innate immune response GO:0045087 178 0.059
Worm
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.059
regulation of establishment of protein localization GO:0070201 242 0.059
protein localization to organelle GO:0033365 280 0.058
regulation of cytokine production GO:0001817 232 0.058
locomotory behavior GO:0007626 1 0.058
cellular lipid metabolic process GO:0044255 303 0.058
regulation of neural precursor cell proliferation GO:2000177 4 0.058
ribonucleoside triphosphate metabolic process GO:0009199 412 0.058
female gamete generation GO:0007292 2 0.057
dopamine receptor signaling pathway GO:0007212 10 0.057
nervous system development GO:0007399 293 0.057
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.057
regulation of cellular amine metabolic process GO:0033238 11 0.057
gtp catabolic process GO:0006184 237 0.057
regulation of translation GO:0006417 89 0.056
nucleoside phosphate catabolic process GO:1901292 412 0.055
neuroblast proliferation GO:0007405 4 0.055
regulation of chromatin organization GO:1902275 56 0.055
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.054
cellular ketone metabolic process GO:0042180 80 0.054
blood circulation GO:0008015 113 0.054
Mouse
regulation of anatomical structure size GO:0090066 101 0.054
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.054
chromatin organization GO:0006325 351 0.053
response to reactive oxygen species GO:0000302 61 0.053
Worm
jun phosphorylation GO:0007258 28 0.053
purine nucleoside catabolic process GO:0006152 398 0.053
dendritic spine morphogenesis GO:0060997 3 0.053
myoblast fusion GO:0007520 1 0.053
establishment of protein localization to organelle GO:0072594 172 0.053
positive regulation of nucleotide metabolic process GO:0045981 230 0.052
response to nitrogen compound GO:1901698 184 0.052
cytoplasmic transport GO:0016482 379 0.052
cytokine production GO:0001816 247 0.052
positive regulation of gtp catabolic process GO:0033126 166 0.051
defense response GO:0006952 315 0.051
Worm
sex determination GO:0007530 3 0.051
negative regulation of transferase activity GO:0051348 124 0.051
negative regulation of cellular component organization GO:0051129 235 0.050
regulation of ion homeostasis GO:2000021 73 0.050
cellular response to endogenous stimulus GO:0071495 336 0.050
regulation of nucleotide catabolic process GO:0030811 205 0.049
activation of innate immune response GO:0002218 55 0.048
Worm
cellular response to monoamine stimulus GO:0071868 7 0.048
membrane organization GO:0061024 292 0.048
regulation of intracellular transport GO:0032386 195 0.048
regulation of protein localization GO:0032880 296 0.048
immune response GO:0006955 307 0.047
Worm
positive regulation of nucleoside metabolic process GO:0045979 186 0.047
response to oxidative stress GO:0006979 121 0.047
Worm
ion homeostasis GO:0050801 230 0.047
response to osmotic stress GO:0006970 17 0.047
Human
monocarboxylic acid metabolic process GO:0032787 185 0.047
cation transport GO:0006812 331 0.047
regulation of secretion GO:0051046 194 0.046
Rat
regulation of gtpase activity GO:0043087 180 0.046
innate immune response activating signal transduction GO:0002758 48 0.046
Worm
memory GO:0007613 3 0.045
activation of immune response GO:0002253 114 0.045
Worm
mucosal immune response GO:0002385 21 0.044
morphogenesis of a polarized epithelium GO:0001738 3 0.044
reactive oxygen species metabolic process GO:0072593 75 0.044
regulation of immune response GO:0050776 201 0.044
Worm
positive regulation of nucleotide catabolic process GO:0030813 185 0.044
ribonucleoside catabolic process GO:0042454 406 0.044
activation of mapk activity GO:0000187 45 0.043
Human Mouse Rat Worm
cell morphogenesis GO:0000902 296 0.043
nucleoside triphosphate catabolic process GO:0009143 394 0.043
positive regulation of cellular catabolic process GO:0031331 284 0.043
hematopoietic or lymphoid organ development GO:0048534 186 0.043
negative regulation of transport GO:0051051 176 0.042
purine nucleoside triphosphate catabolic process GO:0009146 392 0.041
anatomical structure formation involved in morphogenesis GO:0048646 284 0.041
regulation of nucleoside metabolic process GO:0009118 209 0.041
negative regulation of intracellular signal transduction GO:1902532 183 0.041
cellular response to dna damage stimulus GO:0006974 379 0.041
positive regulation of immune system process GO:0002684 283 0.040
Worm
positive regulation of myotube differentiation GO:0010831 3 0.040
organophosphate catabolic process GO:0046434 430 0.040
negative regulation of cellular protein metabolic process GO:0032269 353 0.040
response to manganese ion GO:0010042 2 0.040
regulation of multi organism process GO:0043900 157 0.039
Worm
establishment of tissue polarity GO:0007164 3 0.039
protein ubiquitination GO:0016567 314 0.039
cell adhesion GO:0007155 325 0.039
regulation of intracellular protein transport GO:0033157 123 0.039
immune response activating signal transduction GO:0002757 90 0.039
Worm
hemopoiesis GO:0030097 180 0.039
cardiovascular system development GO:0072358 262 0.039
regulation of dna metabolic process GO:0051052 153 0.039
regulation of defense response GO:0031347 154 0.039
Worm
regulation of oxidative stress induced cell death GO:1903201 24 0.038
regulation of erk1 and erk2 cascade GO:0070372 99 0.038
cellular component morphogenesis GO:0032989 314 0.038
nucleoside catabolic process GO:0009164 408 0.038
regulation of nucleotide metabolic process GO:0006140 269 0.038
regulation of cell differentiation GO:0045595 393 0.038
negative regulation of organelle organization GO:0010639 126 0.038
mitotic cell cycle process GO:1903047 286 0.037
regulation of homeostatic process GO:0032844 121 0.037
regulation of small gtpase mediated signal transduction GO:0051056 156 0.037
autophagy GO:0006914 88 0.037
cellular response to genistein GO:0071412 1 0.037
negative regulation of protein binding GO:0032091 35 0.037
secretion by cell GO:0032940 226 0.036
rho protein signal transduction GO:0007266 26 0.036
negative regulation of protein processing GO:0010955 142 0.036
negative regulation of cell cycle GO:0045786 193 0.036
intracellular protein transport GO:0006886 270 0.036
positive regulation of jnk cascade GO:0046330 52 0.036
negative regulation of protein kinase activity GO:0006469 98 0.036
cellular response to metal ion GO:0071248 43 0.036
chromatin modification GO:0016568 298 0.036
response to organonitrogen compound GO:0010243 156 0.035
translation GO:0006412 132 0.035
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.035
protein maturation GO:0051604 233 0.035
cellular response to inorganic substance GO:0071241 45 0.035
regulation of response to oxidative stress GO:1902882 26 0.035
cellular response to nitrogen compound GO:1901699 144 0.035
regulation of binding GO:0051098 111 0.034
positive regulation of protein autoubiquitination GO:1902499 2 0.034
cellular response to reactive oxygen species GO:0034614 50 0.034
regulation of protein transport GO:0051223 213 0.034
meiotic chromosome segregation GO:0045132 4 0.033
vesicle mediated transport GO:0016192 371 0.033
motor neuron axon guidance GO:0008045 2 0.032
rna interference GO:0016246 4 0.032
cerebral cortex cell migration GO:0021795 3 0.032
fatty acid metabolic process GO:0006631 115 0.032
regeneration GO:0031099 4 0.032
regulation of cell morphogenesis GO:0022604 153 0.032
specification of organ identity GO:0010092 3 0.032
response to transition metal nanoparticle GO:1990267 29 0.032
heart formation GO:0060914 2 0.032
positive regulation of programmed cell death GO:0043068 249 0.032
Rat
regulation of vesicle mediated transport GO:0060627 130 0.031
defense response to other organism GO:0098542 129 0.031
Worm
negative regulation of phosphorylation GO:0042326 174 0.031
peptidyl tyrosine dephosphorylation GO:0035335 36 0.031
cellular response to organonitrogen compound GO:0071417 124 0.031
embryonic epithelial tube formation GO:0001838 4 0.031
segmentation GO:0035282 4 0.031
negative regulation of binding GO:0051100 57 0.031
mitochondrion organization GO:0007005 156 0.030
regulation of membrane potential GO:0042391 95 0.030
proteasomal protein catabolic process GO:0010498 176 0.030
negative regulation of erk1 and erk2 cascade GO:0070373 14 0.030
engulfment of apoptotic cell GO:0043652 2 0.030
gtp metabolic process GO:0046039 239 0.030
cellular amine metabolic process GO:0044106 41 0.029
cellular response to oxidative stress GO:0034599 85 0.029
single organism cellular localization GO:1902580 332 0.029
peptidyl lysine modification GO:0018205 144 0.029
intrinsic apoptotic signaling pathway GO:0097193 127 0.029
negative regulation of apoptotic process GO:0043066 316 0.029
neuromuscular junction development GO:0007528 3 0.029
regulation of cell cycle process GO:0010564 266 0.029
regulation of locomotion GO:0040012 329 0.029
immune response regulating signaling pathway GO:0002764 97 0.029
Worm
enzyme linked receptor protein signaling pathway GO:0007167 303 0.029
response to fungus GO:0009620 4 0.029
response to mechanical stimulus GO:0009612 51 0.029
Human
immune system development GO:0002520 195 0.029
negative regulation of catabolic process GO:0009895 104 0.029
carbohydrate metabolic process GO:0005975 207 0.029
chromatin assembly GO:0031497 61 0.029
regulation of purine nucleotide metabolic process GO:1900542 264 0.028
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.028
regulation of cell cycle GO:0051726 393 0.028
response to hydrogen peroxide GO:0042542 40 0.028
cellular amino acid metabolic process GO:0006520 116 0.028
somitogenesis GO:0001756 2 0.028
growth GO:0040007 202 0.028
cell death in response to oxidative stress GO:0036473 29 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.028
response to lipid GO:0033993 206 0.028
oxidation reduction process GO:0055114 396 0.028
epithelium development GO:0060429 227 0.027
axis elongation GO:0003401 4 0.027
regulation of ion transmembrane transport GO:0034765 132 0.027
regulation of ras gtpase activity GO:0032318 128 0.027
monosaccharide metabolic process GO:0005996 74 0.027
regulation of secretion by cell GO:1903530 177 0.027
protein autoubiquitination GO:0051865 37 0.027
regulation of protein binding GO:0043393 66 0.027
regulation of purine nucleotide catabolic process GO:0033121 205 0.027
regulation of cell maturation GO:1903429 3 0.027
secretion GO:0046903 254 0.027
Rat
protein catabolic process GO:0030163 325 0.027
regulation of cytoplasmic transport GO:1903649 149 0.027
regulation of chromosome organization GO:0033044 103 0.026
regulation of anatomical structure morphogenesis GO:0022603 286 0.026
positive regulation of jun kinase activity GO:0043507 23 0.026
histone modification GO:0016570 251 0.026
single organism cell adhesion GO:0098602 179 0.026
regulation of ras protein signal transduction GO:0046578 155 0.026
negative regulation of kinase activity GO:0033673 106 0.026
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 3 0.026
Rat
heart contraction GO:0060047 62 0.025
Mouse
cation homeostasis GO:0055080 189 0.025
regulation of proteolysis GO:0030162 293 0.025
embryonic camera type eye morphogenesis GO:0048596 2 0.025
g protein coupled receptor signaling pathway GO:0007186 207 0.025
neurological system process GO:0050877 163 0.025
retinal ganglion cell axon guidance GO:0031290 2 0.025
positive regulation of proteolysis GO:0045862 142 0.025
cellular macromolecule catabolic process GO:0044265 380 0.025
response to muramyl dipeptide GO:0032495 4 0.025
organ morphogenesis GO:0009887 147 0.025
leukocyte activation GO:0045321 164 0.025
positive regulation of organelle organization GO:0010638 195 0.025
regulation of cellular component biogenesis GO:0044087 281 0.025
response to light stimulus GO:0009416 87 0.025
Human
oocyte development GO:0048599 1 0.025
protein dephosphorylation GO:0006470 81 0.025
divalent inorganic cation transport GO:0072511 158 0.025
negative regulation of hydrolase activity GO:0051346 182 0.025
oocyte differentiation GO:0009994 2 0.024
cellular response to hydrogen peroxide GO:0070301 37 0.024
positive regulation of cellular component organization GO:0051130 376 0.024
circulatory system development GO:0072359 262 0.024
regulation of response to external stimulus GO:0032101 222 0.024
negative regulation of cellular catabolic process GO:0031330 83 0.024
negative regulation of mapk cascade GO:0043409 56 0.024
protein processing GO:0016485 226 0.024
heart induction GO:0003129 4 0.024
regulation of mitotic cell cycle GO:0007346 189 0.024
guanosine containing compound catabolic process GO:1901069 239 0.024
peptidyl tyrosine phosphorylation GO:0018108 170 0.024
positive regulation of protein catabolic process GO:0045732 75 0.024
positive regulation of defense response GO:0031349 87 0.024
Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.023
long chain fatty acid metabolic process GO:0001676 30 0.023
biological adhesion GO:0022610 331 0.023
forelimb morphogenesis GO:0035136 4 0.023
nuclear transport GO:0051169 179 0.023
regulation of wnt signaling pathway GO:0030111 123 0.023
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.023
organ or tissue specific immune response GO:0002251 22 0.023
positive regulation of behavior GO:0048520 60 0.023
Worm
glial cell migration GO:0008347 4 0.023
protein targeting GO:0006605 187 0.023
response to other organism GO:0051707 261 0.023
Worm
rna processing GO:0006396 255 0.023
dna conformation change GO:0071103 113 0.023
positive regulation of cell proliferation GO:0008284 301 0.023
regulation of autophagy GO:0010506 52 0.023
positive regulation of striated muscle cell differentiation GO:0051155 9 0.023
cellular cation homeostasis GO:0030003 163 0.023
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 2 0.023
regulation of peptidase activity GO:0052547 180 0.023
response to molecule of bacterial origin GO:0002237 82 0.023
regulation of oxidoreductase activity GO:0051341 43 0.023
cell projection assembly GO:0030031 126 0.022
olfactory lobe development GO:0021988 5 0.022
cellular homeostasis GO:0019725 196 0.022
endocytosis GO:0006897 159 0.022
regulation of synaptic plasticity GO:0048167 3 0.022
regulation of protein maturation GO:1903317 150 0.022
microtubule based process GO:0007017 210 0.022
canonical wnt signaling pathway GO:0060070 116 0.022
negative regulation of protein maturation GO:1903318 142 0.022
behavior GO:0007610 112 0.022
Worm
regulation of meiotic cell cycle GO:0051445 4 0.022
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.022
regulation of heart morphogenesis GO:2000826 4 0.021
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.021
regulation of mitochondrion organization GO:0010821 54 0.021
t cell differentiation in thymus GO:0033077 4 0.021
ion transmembrane transport GO:0034220 338 0.021
tissue regeneration GO:0042246 3 0.021
neural tube formation GO:0001841 3 0.021
negative regulation of developmental process GO:0051093 247 0.021
cellular response to external stimulus GO:0071496 111 0.021
Human
nerve development GO:0021675 4 0.021
organelle fission GO:0048285 149 0.021
mesenchyme development GO:0060485 59 0.021
peripheral nervous system development GO:0007422 2 0.021
inactivation of mapk activity GO:0000188 5 0.021
cellular response to growth factor stimulus GO:0071363 197 0.021
mitochondrial transport GO:0006839 60 0.021
cellular divalent inorganic cation homeostasis GO:0072503 128 0.021
regulation of transmembrane transport GO:0034762 139 0.021
hindbrain development GO:0030902 3 0.021
protein modification by small protein conjugation GO:0032446 342 0.021
regulation of tumor necrosis factor production GO:0032680 43 0.021
organ formation GO:0048645 3 0.021
regulation of microtubule based process GO:0032886 74 0.021
kidney development GO:0001822 53 0.021
defense response to fungus GO:0050832 4 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
single organism membrane organization GO:0044802 268 0.020
anatomical structure homeostasis GO:0060249 100 0.020
positive regulation of myoblast fusion GO:1901741 1 0.020
positive regulation of secretion GO:0051047 116 0.020
Rat
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.020
negative regulation of response to oxidative stress GO:1902883 18 0.020
endomembrane system organization GO:0010256 196 0.020
inner ear morphogenesis GO:0042472 4 0.020
mrna processing GO:0006397 133 0.020
cell growth GO:0016049 160 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.020
urogenital system development GO:0001655 65 0.020
regulation of protein processing GO:0070613 150 0.020
exploration behavior GO:0035640 1 0.020
myeloid cell differentiation GO:0030099 117 0.020
positive regulation of g protein coupled receptor protein signaling pathway GO:0045745 9 0.020
mammary gland formation GO:0060592 1 0.020
cellular response to lipopolysaccharide GO:0071222 57 0.019
positive regulation of intracellular protein transport GO:0090316 76 0.019
cell junction maintenance GO:0034331 4 0.019
cellular response to mechanical stimulus GO:0071260 39 0.019
Human
anterior posterior axis specification GO:0009948 2 0.019
cell activation GO:0001775 213 0.019
cardiac muscle contraction GO:0060048 34 0.019
Mouse
blood vessel morphogenesis GO:0048514 162 0.019
dna replication GO:0006260 116 0.019
response to heat GO:0009408 21 0.019
Human
protein acylation GO:0043543 138 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
extrinsic apoptotic signaling pathway GO:0097191 119 0.019
synaptic transmission GO:0007268 61 0.019
positive regulation of protein transport GO:0051222 135 0.019
transmembrane transport GO:0055085 399 0.019
mrna metabolic process GO:0016071 175 0.019
lymphocyte activation GO:0046649 133 0.019
syncytium formation by plasma membrane fusion GO:0000768 2 0.019
metencephalon development GO:0022037 2 0.019
sensory perception of pain GO:0019233 4 0.019
cellular protein catabolic process GO:0044257 261 0.019
signal release GO:0023061 70 0.019
stem cell division GO:0017145 2 0.019
negative regulation of map kinase activity GO:0043407 27 0.018
regulation of response to reactive oxygen species GO:1901031 12 0.018
regulation of lamellipodium morphogenesis GO:2000392 4 0.018
negative regulation of oxidative stress induced cell death GO:1903202 17 0.018
cell development GO:0048468 328 0.018
internal protein amino acid acetylation GO:0006475 101 0.018
response to growth factor GO:0070848 205 0.018
positive regulation of multi organism process GO:0043902 56 0.018
Worm
cell death in response to hydrogen peroxide GO:0036474 10 0.018
regulation of heart induction GO:0090381 2 0.018
exocytosis GO:0006887 71 0.018
neural tube patterning GO:0021532 2 0.018
establishment of monopolar cell polarity GO:0061162 1 0.018
striated muscle contraction GO:0006941 52 0.018
Mouse
regulation of myoblast fusion GO:1901739 1 0.018
lipid oxidation GO:0034440 33 0.018
regulation of cellular component movement GO:0051270 334 0.018
regulation of excitatory postsynaptic membrane potential GO:0060079 1 0.018
cell cell signaling GO:0007267 155 0.018
maintenance of location GO:0051235 112 0.018
head development GO:0060322 108 0.018
calcium ion homeostasis GO:0055074 122 0.018
compound eye development GO:0048749 1 0.018
regulation of response to wounding GO:1903034 101 0.018
positive regulation of immune response GO:0050778 159 0.018
Worm
regulation of chromatin modification GO:1903308 51 0.018
cellular response to molecule of bacterial origin GO:0071219 62 0.018
regulation of growth GO:0040008 165 0.017
microtubule cytoskeleton organization GO:0000226 176 0.017
actin filament based movement GO:0030048 17 0.017
regulation of mitochondrial membrane potential GO:0051881 23 0.017
regulation of proteasomal protein catabolic process GO:0061136 87 0.017
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
regulation of microtubule cytoskeleton organization GO:0070507 61 0.017
generation of neurons GO:0048699 152 0.017

MAP2K6 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.103
nervous system disease DOID:863 431 0.103
parkinson s disease DOID:14330 18 0.064
synucleinopathy DOID:0050890 22 0.064
neurodegenerative disease DOID:1289 102 0.064
musculoskeletal system disease DOID:17 223 0.025
disease of metabolism DOID:0014667 295 0.020
inherited metabolic disorder DOID:655 242 0.019