|
|
jun phosphorylation
|
GO:0007258 |
28 |
1.000
|
Zebrafish Rat Fly |
|
|
positive regulation of fatty acid transport
|
GO:2000193 |
3 |
0.998
|
|
|
|
positive regulation of icosanoid secretion
|
GO:0032305 |
3 |
0.994
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
1 |
0.988
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.983
|
Human Zebrafish Mouse Rat Worm Fly |
|
|
negative regulation of jun kinase activity
|
GO:0043508 |
4 |
0.978
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.974
|
|
|
|
collateral sprouting
|
GO:0048668 |
2 |
0.965
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.957
|
|
|
|
prostaglandin secretion
|
GO:0032310 |
2 |
0.955
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.954
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.951
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.950
|
Zebrafish Rat Fly |
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.948
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.945
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.944
|
|
|
|
hyperosmotic response
|
GO:0006972 |
4 |
0.933
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.919
|
Human Zebrafish Rat Fly |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.903
|
Zebrafish Rat Fly |
|
|
chromatin modification
|
GO:0016568 |
298 |
0.903
|
|
|
|
positive regulation of organic acid transport
|
GO:0032892 |
3 |
0.902
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.901
|
Human Zebrafish Rat Worm Fly |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.900
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.884
|
Human Zebrafish Mouse Rat Worm Fly |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.878
|
Human Zebrafish Rat Worm Fly |
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.875
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.868
|
Rat |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.863
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.862
|
|
|
|
positive regulation of nitric oxide synthase biosynthetic process
|
GO:0051770 |
3 |
0.847
|
Rat |
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.844
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.835
|
Human Zebrafish Rat Worm Fly |
|
|
growth
|
GO:0040007 |
202 |
0.833
|
Rat |
|
|
embryonic digestive tract morphogenesis
|
GO:0048557 |
2 |
0.831
|
|
|
|
establishment of vesicle localization
|
GO:0051650 |
23 |
0.828
|
|
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.824
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.821
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.817
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.810
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.808
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.801
|
|
|
|
response to osmotic stress
|
GO:0006970 |
17 |
0.792
|
Human |
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.789
|
Human |
|
|
chromatin organization
|
GO:0006325 |
351 |
0.786
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.773
|
|
|
|
cellular response to arsenic containing substance
|
GO:0071243 |
4 |
0.771
|
|
|
|
ectodermal digestive tract morphogenesis
|
GO:0048567 |
1 |
0.766
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.763
|
Human Zebrafish Rat Worm Fly |
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.757
|
Zebrafish Rat Fly |
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.753
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.750
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.749
|
Rat |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.737
|
|
|
|
ectodermal digestive tract development
|
GO:0007439 |
1 |
0.735
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.734
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.725
|
|
|
|
desensitization of g protein coupled receptor protein signaling pathway by arrestin
|
GO:0002032 |
2 |
0.725
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.715
|
Human |
|
|
membrane organization
|
GO:0061024 |
292 |
0.713
|
|
|
|
neuron projection extension
|
GO:1990138 |
14 |
0.710
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.693
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.693
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.692
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.682
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.678
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.673
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.672
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.663
|
Human Zebrafish Rat Worm Fly |
|
|
regulation of interleukin 6 production
|
GO:0032675 |
37 |
0.659
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.656
|
Human |
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.653
|
Human Zebrafish Rat Fly |
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.653
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.651
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.647
|
Zebrafish Rat Fly |
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
21 |
0.646
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.644
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.638
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.633
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.632
|
Human Zebrafish Rat Worm Fly |
|
|
response to nitrosative stress
|
GO:0051409 |
4 |
0.618
|
|
|
|
axon extension
|
GO:0048675 |
13 |
0.616
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.610
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.605
|
|
|
|
regulation of icosanoid secretion
|
GO:0032303 |
4 |
0.601
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.589
|
|
|
|
positive regulation of macrophage derived foam cell differentiation
|
GO:0010744 |
7 |
0.586
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.583
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.568
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.552
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.548
|
Human Zebrafish Rat Worm Fly |
|
|
melanin metabolic process
|
GO:0006582 |
1 |
0.547
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.545
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.535
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.532
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.531
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.529
|
Fly |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.527
|
Human Zebrafish Rat Worm Fly |
|
|
neurogenesis
|
GO:0022008 |
169 |
0.521
|
Fly |
|
|
protein deacylation
|
GO:0035601 |
39 |
0.514
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.513
|
|
|
|
prostaglandin transport
|
GO:0015732 |
2 |
0.509
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.502
|
Fly |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.499
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.496
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.493
|
Zebrafish Rat Fly |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.489
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.486
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.484
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.480
|
|
|
|
developmental cell growth
|
GO:0048588 |
18 |
0.474
|
Rat |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.474
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.473
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.460
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.454
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.451
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.450
|
|
|
|
establishment of protein localization to mitochondrion
|
GO:0072655 |
22 |
0.448
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.445
|
Rat |
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.444
|
|
|
|
foam cell differentiation
|
GO:0090077 |
15 |
0.434
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.430
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.424
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.408
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.405
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.405
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.401
|
Fly |
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.400
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.399
|
Human Zebrafish Rat Worm Fly |
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.396
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.396
|
|
|
|
antibacterial humoral response
|
GO:0019731 |
24 |
0.392
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.392
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.391
|
Fly |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.383
|
|
|
|
cellular response to metal ion
|
GO:0071248 |
43 |
0.381
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.380
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.377
|
Human |
|
|
vascular endothelial growth factor receptor signaling pathway
|
GO:0048010 |
19 |
0.375
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.375
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.373
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.370
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.368
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.366
|
Human Zebrafish Rat Worm Fly |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.358
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.348
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.345
|
Human |
|
|
regulation of chromatin organization
|
GO:1902275 |
56 |
0.344
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.344
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.335
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.333
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.329
|
Human Zebrafish Rat Worm Fly |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.327
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.327
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.325
|
|
|
|
cellular response to vascular endothelial growth factor stimulus
|
GO:0035924 |
26 |
0.325
|
|
|
|
organic anion transport
|
GO:0015711 |
103 |
0.325
|
|
|
|
protein deacetylation
|
GO:0006476 |
38 |
0.324
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.316
|
Fly |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.314
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.310
|
|
|
|
regulation of prostaglandin secretion
|
GO:0032306 |
2 |
0.310
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.310
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.305
|
|
|
|
positive regulation of prostaglandin secretion
|
GO:0032308 |
1 |
0.301
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.300
|
|
|
|
stress induced premature senescence
|
GO:0090400 |
5 |
0.292
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.288
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.285
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.284
|
|
|
|
regulation of histone modification
|
GO:0031056 |
47 |
0.283
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.281
|
Human Zebrafish Rat Worm Fly |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.280
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
1 |
0.278
|
|
|
|
phagocytosis engulfment
|
GO:0006911 |
7 |
0.275
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.270
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.270
|
|
|
|
unsaturated fatty acid metabolic process
|
GO:0033559 |
37 |
0.270
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.269
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.269
|
Rat Fly |
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.266
|
|
|
|
cellular response to interleukin 1
|
GO:0071347 |
35 |
0.265
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.265
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.264
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.262
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.261
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.261
|
|
|
|
lipid localization
|
GO:0010876 |
106 |
0.258
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.249
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.246
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.246
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.245
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.244
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.240
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.240
|
|
|
|
cellular response to heat
|
GO:0034605 |
14 |
0.238
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.237
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.233
|
|
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
22 |
0.229
|
|
|
|
response to temperature stimulus
|
GO:0009266 |
22 |
0.228
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.226
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.225
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.224
|
|
|
|
macromolecule deacylation
|
GO:0098732 |
41 |
0.223
|
|
|
|
lipid transport
|
GO:0006869 |
90 |
0.221
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.220
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.219
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.216
|
Worm |
|
|
histone deacetylation
|
GO:0016575 |
32 |
0.215
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.215
|
Zebrafish Rat Fly |
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.213
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.210
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.208
|
|
|
|
positive regulation of rho protein signal transduction
|
GO:0035025 |
4 |
0.207
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.206
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.204
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.203
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.203
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.201
|
|
|
|
response to toxic substance
|
GO:0009636 |
37 |
0.201
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.201
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.199
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.199
|
|
|
|
dna dependent dna replication
|
GO:0006261 |
44 |
0.199
|
|
|
|
specification of symmetry
|
GO:0009799 |
16 |
0.199
|
Zebrafish |
|
|
organic acid transport
|
GO:0015849 |
65 |
0.199
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.198
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.195
|
Human Zebrafish Rat Worm Fly |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.195
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.194
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.194
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.192
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.190
|
|
|
|
icosanoid metabolic process
|
GO:0006690 |
35 |
0.189
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.189
|
|
|
|
regulation of chromatin modification
|
GO:1903308 |
51 |
0.186
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.186
|
Human Zebrafish Rat Worm Fly |
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.185
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.184
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.184
|
Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.183
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.183
|
|
|
|
regulation of symbiosis encompassing mutualism through parasitism
|
GO:0043903 |
109 |
0.182
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.181
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.178
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.178
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.178
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.177
|
|
|
|
regulation of transcription from rna polymerase ii promoter in response to stress
|
GO:0043618 |
17 |
0.177
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.177
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
50 |
0.177
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.177
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.176
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.173
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.173
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.173
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.173
|
Rat |
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
23 |
0.173
|
|
|
|
determination of digestive tract left right asymmetry
|
GO:0071907 |
6 |
0.172
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.172
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.172
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
0.171
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.171
|
|
|
|
regulation of macrophage derived foam cell differentiation
|
GO:0010743 |
14 |
0.170
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.169
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.168
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.167
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.167
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.167
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.165
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.164
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.163
|
|
|
|
negative regulation of protein binding
|
GO:0032091 |
35 |
0.160
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.159
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.159
|
|
|
|
regulation of determination of dorsal identity
|
GO:2000015 |
2 |
0.158
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.157
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.156
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.154
|
Fly |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.152
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.152
|
Zebrafish Rat Fly |
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.150
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.150
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.149
|
|
|
|
response to cadmium ion
|
GO:0046686 |
10 |
0.149
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.148
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.147
|
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
45 |
0.147
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.146
|
|
|
|
positive regulation of deacetylase activity
|
GO:0090045 |
6 |
0.145
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.144
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.143
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.142
|
|
|
|
apoptotic cell clearance
|
GO:0043277 |
12 |
0.142
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.141
|
Fly |
|
|
secondary metabolic process
|
GO:0019748 |
17 |
0.141
|
|
|
|
sensory perception of temperature stimulus
|
GO:0050951 |
1 |
0.141
|
|
|
|
icosanoid secretion
|
GO:0032309 |
11 |
0.141
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.141
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.139
|
Human Zebrafish Rat Worm Fly |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.138
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.138
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.136
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.135
|
|
|
|
inactivation of mapk activity
|
GO:0000188 |
5 |
0.135
|
|
|
|
activation of mapkk activity
|
GO:0000186 |
18 |
0.135
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.135
|
|
|
|
organic acid biosynthetic process
|
GO:0016053 |
97 |
0.135
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.134
|
Human Zebrafish Rat Worm Fly |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.134
|
|
|
|
fatty acid derivative biosynthetic process
|
GO:1901570 |
18 |
0.133
|
|
|
|
determination of bilateral symmetry
|
GO:0009855 |
15 |
0.132
|
Zebrafish |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.132
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.131
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.131
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.131
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.130
|
|
|
|
unsaturated fatty acid biosynthetic process
|
GO:0006636 |
21 |
0.130
|
|
|
|
fatty acid derivative transport
|
GO:1901571 |
11 |
0.129
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.129
|
|
|
|
response to heat
|
GO:0009408 |
21 |
0.127
|
Human |
|
|
fatty acid derivative metabolic process
|
GO:1901568 |
35 |
0.127
|
|
|
|
cellular response to cadmium ion
|
GO:0071276 |
8 |
0.125
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.125
|
|
|
|
cellular response to reactive oxygen species
|
GO:0034614 |
50 |
0.125
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.124
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.124
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.123
|
|
|
|
aging
|
GO:0007568 |
66 |
0.123
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.122
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.121
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.120
|
|
|
|
chemokine production
|
GO:0032602 |
32 |
0.118
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.117
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.117
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.117
|
|
|
|
prostanoid metabolic process
|
GO:0006692 |
17 |
0.117
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.116
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.113
|
|
|
|
cellular response to uv
|
GO:0034644 |
32 |
0.113
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.113
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.112
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.112
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.111
|
|
|
|
internal peptidyl lysine acetylation
|
GO:0018393 |
97 |
0.111
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.110
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.109
|
|
|
|
positive regulation of chemokine production
|
GO:0032722 |
22 |
0.109
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.109
|
|
|
|
regulation of lipid transport
|
GO:0032368 |
44 |
0.107
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.105
|
|
|
|
fatty acid biosynthetic process
|
GO:0006633 |
46 |
0.104
|
|
|
|
axon development
|
GO:0061564 |
34 |
0.104
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.103
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.102
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.101
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.101
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.099
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.099
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.098
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.098
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter in response to stress
|
GO:0036003 |
9 |
0.097
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.096
|
|
|
|
system process
|
GO:0003008 |
349 |
0.095
|
Rat |
|
|
regulation of nitric oxide synthase biosynthetic process
|
GO:0051769 |
6 |
0.094
|
Rat |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.094
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.094
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.093
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.093
|
|
|
|
determination of left right symmetry
|
GO:0007368 |
11 |
0.093
|
|
|
|
morphogenesis of an epithelial sheet
|
GO:0002011 |
12 |
0.092
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.092
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.091
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.091
|
Rat |
|
|
chemotaxis
|
GO:0006935 |
157 |
0.090
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.090
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.089
|
|
|
|
phototransduction
|
GO:0007602 |
3 |
0.088
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.088
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.087
|
Rat |
|
|
neuron development
|
GO:0048666 |
113 |
0.086
|
Fly |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.085
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.085
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.085
|
|
|
|
positive regulation of receptor internalization
|
GO:0002092 |
12 |
0.084
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.084
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.083
|
Rat |
|
|
phagocytosis
|
GO:0006909 |
42 |
0.083
|
|
|
|
histone acetylation
|
GO:0016573 |
93 |
0.082
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.080
|
|
|
|
positive regulation of lipid transport
|
GO:0032370 |
22 |
0.079
|
|
|
|
axonogenesis
|
GO:0007409 |
31 |
0.078
|
|
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.078
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.078
|
|
|
|
embryonic digestive tract development
|
GO:0048566 |
10 |
0.078
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.077
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.077
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
26 |
0.076
|
|
|
|
regulation of histone acetylation
|
GO:0035065 |
19 |
0.076
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.075
|
|
|
|
monocarboxylic acid biosynthetic process
|
GO:0072330 |
67 |
0.075
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.074
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.073
|
|
|
|
vesicle localization
|
GO:0051648 |
26 |
0.073
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.072
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.072
|
|
|
|
peptidyl tyrosine dephosphorylation
|
GO:0035335 |
36 |
0.070
|
|
|
|
protein polymerization
|
GO:0051258 |
71 |
0.070
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.069
|
|
|
|
pigment metabolic process
|
GO:0042440 |
16 |
0.069
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.069
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.069
|
|
|
|
epiboly
|
GO:0090504 |
9 |
0.068
|
|
|
|
epiboly involved in wound healing
|
GO:0090505 |
8 |
0.068
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.068
|
|
|
|
regulation of synaptic transmission dopaminergic
|
GO:0032225 |
4 |
0.067
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.066
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.066
|
|
|
|
wound healing spreading of epidermal cells
|
GO:0035313 |
6 |
0.066
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.066
|
|
|
|
macrophage derived foam cell differentiation
|
GO:0010742 |
15 |
0.066
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.066
|
Worm |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.065
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.065
|
|
|
|
embryonic ectodermal digestive tract development
|
GO:0048611 |
1 |
0.064
|
|
|
|
photoreceptor cell maintenance
|
GO:0045494 |
13 |
0.064
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.064
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.063
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
63 |
0.063
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.063
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.063
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.063
|
|
|
|
regulation of fatty acid biosynthetic process
|
GO:0042304 |
9 |
0.062
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
11 |
0.062
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.061
|
Rat |
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.061
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.060
|
|
|
|
carboxylic acid biosynthetic process
|
GO:0046394 |
97 |
0.060
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.060
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.060
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.059
|
|
|
|
prostaglandin metabolic process
|
GO:0006693 |
17 |
0.058
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.058
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.058
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.057
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.057
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.057
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.057
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.057
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.056
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.056
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.056
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.055
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.055
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.054
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.054
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.054
|
Rat |
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.054
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.054
|
Zebrafish Rat Fly |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.054
|
|
|
|
protein localization to mitochondrion
|
GO:0070585 |
25 |
0.054
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.054
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.053
|
|
|
|
cerebral cortex radially oriented cell migration
|
GO:0021799 |
1 |
0.053
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.053
|
|
|
|
regulation of dna replication
|
GO:0006275 |
68 |
0.052
|
Rat |
|
|
viral life cycle
|
GO:0019058 |
132 |
0.052
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.052
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.051
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.051
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.051
|
Rat |
|
|
nuclear transport
|
GO:0051169 |
179 |
0.051
|
|
|
|
fatty acid transport
|
GO:0015908 |
25 |
0.051
|
|
|
|
peptidyl lysine acetylation
|
GO:0018394 |
101 |
0.051
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.050
|
|
|
|
acid secretion
|
GO:0046717 |
12 |
0.050
|
|
|
|
behavioral response to ethanol
|
GO:0048149 |
2 |
0.050
|
|
|
|
nuclear dna replication
|
GO:0033260 |
6 |
0.050
|
|
|
|
protein targeting to mitochondrion
|
GO:0006626 |
19 |
0.050
|
|
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
32 |
0.049
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.049
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.049
|
|
|
|
myoblast differentiation
|
GO:0045445 |
21 |
0.049
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.048
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.048
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.048
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.048
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.048
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.048
|
|
|
|
positive regulation of histone modification
|
GO:0031058 |
29 |
0.048
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.048
|
|
|
|
internal protein amino acid acetylation
|
GO:0006475 |
101 |
0.047
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.047
|
|
|
|
eyelid development in camera type eye
|
GO:0061029 |
2 |
0.047
|
|
|
|
axon cargo transport
|
GO:0008088 |
2 |
0.046
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.046
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.046
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.045
|
|
