Homo sapiens

75 known processes

PRPS1

phosphoribosyl pyrophosphate synthetase 1

(Aliases: CMTX5,ARTS,DFN2,PPRibP,DFNX1,PRSI,KIAA0967)

PRPS1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate derivative biosynthetic process GO:1901137 207 0.191
Rat
post embryonic development GO:0009791 2 0.166
nucleosome assembly GO:0006334 50 0.159
vesicle mediated transport GO:0016192 371 0.154
nucleoside phosphate biosynthetic process GO:1901293 109 0.088
purine ribonucleoside metabolic process GO:0046128 437 0.087
Rat
nucleoside biosynthetic process GO:0009163 26 0.074
Rat
nucleotide biosynthetic process GO:0009165 109 0.070
ras protein signal transduction GO:0007265 73 0.067
ribonucleoside triphosphate metabolic process GO:0009199 412 0.066
protein modification by small protein conjugation GO:0032446 342 0.066
cellular amino acid metabolic process GO:0006520 116 0.063
purine ribonucleotide catabolic process GO:0009154 404 0.062
nucleoside triphosphate catabolic process GO:0009143 394 0.061
single organism cellular localization GO:1902580 332 0.058
cytoplasmic transport GO:0016482 379 0.058
nervous system development GO:0007399 293 0.057
mitotic cell cycle GO:0000278 326 0.057
protein ubiquitination GO:0016567 314 0.056
locomotory behavior GO:0007626 1 0.056
purine ribonucleoside catabolic process GO:0046130 398 0.055
ribonucleoside catabolic process GO:0042454 406 0.054
small gtpase mediated signal transduction GO:0007264 78 0.053
adult locomotory behavior GO:0008344 1 0.052
cellular amine metabolic process GO:0044106 41 0.052
histone modification GO:0016570 251 0.051
chromatin assembly or disassembly GO:0006333 78 0.048
anterior posterior axis specification GO:0009948 2 0.047
cell projection organization GO:0030030 252 0.045
nucleoside triphosphate metabolic process GO:0009141 422 0.044
nucleoside phosphate catabolic process GO:1901292 412 0.043
urate metabolic process GO:0046415 11 0.043
chromatin assembly GO:0031497 61 0.043
oogenesis GO:0048477 2 0.042
chromatin modification GO:0016568 298 0.042
transmembrane transport GO:0055085 399 0.042
nuclear division GO:0000280 128 0.041
apoptotic signaling pathway GO:0097190 268 0.041
chromatin organization GO:0006325 351 0.041
dna strand elongation involved in dna replication GO:0006271 3 0.040
nucleobase biosynthetic process GO:0046112 4 0.039
regulation of meiotic cell cycle GO:0051445 4 0.039
amine metabolic process GO:0009308 44 0.038
ribose phosphate biosynthetic process GO:0046390 82 0.038
Rat
guanosine containing compound catabolic process GO:1901069 239 0.037
dna conformation change GO:0071103 113 0.037
purine nucleotide biosynthetic process GO:0006164 84 0.037
response to abiotic stimulus GO:0009628 336 0.037
nucleoside catabolic process GO:0009164 408 0.037
cell morphogenesis GO:0000902 296 0.037
ribonucleotide catabolic process GO:0009261 405 0.036
cellular component disassembly GO:0022411 92 0.035
regulation of intracellular protein transport GO:0033157 123 0.035
positive regulation of apoptotic process GO:0043065 246 0.035
growth GO:0040007 202 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.034
neuron development GO:0048666 113 0.034
nuclear migration GO:0007097 1 0.034
purine nucleoside triphosphate metabolic process GO:0009144 412 0.033
protein modification by small protein removal GO:0070646 92 0.033
neuron differentiation GO:0030182 138 0.033
mitotic cell cycle process GO:1903047 286 0.033
glycosyl compound catabolic process GO:1901658 413 0.033
cell development GO:0048468 328 0.032
nitrogen compound transport GO:0071705 191 0.032
regulation of proteolysis GO:0030162 293 0.032
cell part morphogenesis GO:0032990 137 0.031
single organism carbohydrate metabolic process GO:0044723 193 0.031
reproductive process GO:0022414 106 0.031
cellular macromolecular complex assembly GO:0034622 324 0.031
cellular protein catabolic process GO:0044257 261 0.031
cellular macromolecule catabolic process GO:0044265 380 0.030
purine containing compound biosynthetic process GO:0072522 88 0.030
organophosphate catabolic process GO:0046434 430 0.029
ornithine metabolic process GO:0006591 3 0.029
ribonucleoside monophosphate metabolic process GO:0009161 187 0.029
Rat
generation of neurons GO:0048699 152 0.029
sex differentiation GO:0007548 45 0.029
alpha amino acid metabolic process GO:1901605 72 0.029
regulation of small gtpase mediated signal transduction GO:0051056 156 0.029
purine containing compound catabolic process GO:0072523 411 0.028
response to other organism GO:0051707 261 0.028
nucleus localization GO:0051647 1 0.028
positive regulation of transferase activity GO:0051347 227 0.028
regulation of growth GO:0040008 165 0.028
guanosine containing compound metabolic process GO:1901068 244 0.027
purine nucleoside catabolic process GO:0006152 398 0.026
cellular component morphogenesis GO:0032989 314 0.026
reproductive structure development GO:0048608 55 0.026
organic acid biosynthetic process GO:0016053 97 0.026
nucleotide catabolic process GO:0009166 408 0.025
negative regulation of cellular component organization GO:0051129 235 0.025
mitochondrion organization GO:0007005 156 0.025
cellular response to endogenous stimulus GO:0071495 336 0.025
regulation of cellular component movement GO:0051270 334 0.025
cellular response to dna damage stimulus GO:0006974 379 0.025
blastocyst development GO:0001824 3 0.025
purine nucleotide catabolic process GO:0006195 405 0.025
protein import GO:0017038 130 0.025
negative regulation of protein metabolic process GO:0051248 391 0.025
cellular ketone metabolic process GO:0042180 80 0.025
protein catabolic process GO:0030163 325 0.024
nucleoside monophosphate metabolic process GO:0009123 191 0.024
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
nucleosome organization GO:0034728 66 0.024
negative regulation of meiotic cell cycle GO:0051447 2 0.024
dna catabolic process GO:0006308 49 0.024
establishment of organelle localization GO:0051656 59 0.024
protein localization to organelle GO:0033365 280 0.024
intracellular protein transport GO:0006886 270 0.023
protein maturation GO:0051604 233 0.023
photoreceptor cell differentiation GO:0046530 2 0.023
negative regulation of intracellular signal transduction GO:1902532 183 0.023
multicellular organismal aging GO:0010259 3 0.023
purine nucleoside triphosphate catabolic process GO:0009146 392 0.022
modification dependent protein catabolic process GO:0019941 209 0.022
positive regulation of developmental process GO:0051094 314 0.022
organophosphate biosynthetic process GO:0090407 163 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
rna interference GO:0016246 4 0.022
cell morphogenesis involved in differentiation GO:0000904 144 0.022
covalent chromatin modification GO:0016569 254 0.022
protein processing GO:0016485 226 0.022
intrinsic apoptotic signaling pathway GO:0097193 127 0.021
regulation of transferase activity GO:0051338 355 0.021
nuclear transport GO:0051169 179 0.021
regulation of cellular response to stress GO:0080135 244 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
negative regulation of cell differentiation GO:0045596 171 0.021
histone exchange GO:0043486 3 0.020
mitotic nuclear division GO:0007067 119 0.020
carbohydrate metabolic process GO:0005975 207 0.020
dna packaging GO:0006323 77 0.020
regulation of ligase activity GO:0051340 29 0.020
regulation of ras protein signal transduction GO:0046578 155 0.020
embryo development GO:0009790 123 0.020
Worm
regulation of cell differentiation GO:0045595 393 0.020
regulation of protein catabolic process GO:0042176 155 0.020
positive regulation of feeding behavior GO:2000253 1 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
defense response GO:0006952 315 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
blastoderm segmentation GO:0007350 2 0.018
negative regulation of peptidase activity GO:0010466 91 0.018
establishment of nucleus localization GO:0040023 1 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.018
positive regulation of immune system process GO:0002684 283 0.018
neuron projection development GO:0031175 106 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
cell projection morphogenesis GO:0048858 129 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.018
Rat
regulation of meiosis GO:0040020 3 0.017
ribonucleoside biosynthetic process GO:0042455 25 0.017
Rat
negative regulation of protein processing GO:0010955 142 0.017
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.017
purine nucleoside monophosphate catabolic process GO:0009128 158 0.017
modification dependent macromolecule catabolic process GO:0043632 212 0.017
female gamete generation GO:0007292 2 0.017
organelle localization GO:0051640 84 0.017
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.017
microtubule based process GO:0007017 210 0.017
ribonucleotide biosynthetic process GO:0009260 81 0.017
Rat
intracellular mrna localization GO:0008298 1 0.017
negative regulation of multicellular organismal process GO:0051241 317 0.017
positive regulation of phosphorylation GO:0042327 394 0.017
cellular response to hormone stimulus GO:0032870 125 0.017
response to oxygen containing compound GO:1901700 369 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
regulation of immune response GO:0050776 201 0.016
regulation of cell growth GO:0001558 135 0.016
single organism membrane organization GO:0044802 268 0.016
response to external biotic stimulus GO:0043207 261 0.016
regulation of protein transport GO:0051223 213 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
regulation of protein targeting GO:1903533 91 0.016
monocarboxylic acid metabolic process GO:0032787 185 0.016
negative regulation of cell death GO:0060548 345 0.016
lipid metabolic process GO:0006629 381 0.016
ubiquitin dependent protein catabolic process GO:0006511 206 0.016
glutamine family amino acid metabolic process GO:0009064 17 0.016
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.016
cellular response to cytokine stimulus GO:0071345 181 0.015
regulation of protein localization GO:0032880 296 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
regulation of mitotic cell cycle GO:0007346 189 0.015
regulation of protein maturation GO:1903317 150 0.015
tripartite regional subdivision GO:0007351 2 0.015
embryo development ending in birth or egg hatching GO:0009792 34 0.015
Worm
positive regulation of immune response GO:0050778 159 0.015
chordate embryonic development GO:0043009 34 0.015
mrna metabolic process GO:0016071 175 0.015
immune response GO:0006955 307 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
Rat
response to drug GO:0042493 81 0.015
establishment of protein localization to organelle GO:0072594 172 0.014
behavioral defense response GO:0002209 0 0.014
oxidation reduction process GO:0055114 396 0.014
ribonucleoside monophosphate catabolic process GO:0009158 158 0.014
establishment or maintenance of cell polarity GO:0007163 31 0.014
lipid biosynthetic process GO:0008610 177 0.014
dna replication independent nucleosome assembly GO:0006336 27 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
regulation of behavior GO:0050795 82 0.014
segmentation GO:0035282 4 0.014
regulation of multi organism process GO:0043900 157 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
cell adhesion GO:0007155 325 0.013
determination of adult lifespan GO:0008340 2 0.013
neurogenesis GO:0022008 169 0.013
endocytosis GO:0006897 159 0.013
mitochondrial transport GO:0006839 60 0.013
response to radiation GO:0009314 151 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
negative regulation of cellular protein metabolic process GO:0032269 353 0.013
leading strand elongation GO:0006272 1 0.013
nucleoside monophosphate catabolic process GO:0009125 159 0.013
leukocyte activation GO:0045321 164 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
protein alkylation GO:0008213 74 0.013
reproduction GO:0000003 63 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
cell activation GO:0001775 213 0.013
regulation of cytoplasmic transport GO:1903649 149 0.012
positive regulation of cell proliferation GO:0008284 301 0.012
response to virus GO:0009615 126 0.012
cell growth GO:0016049 160 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
atp metabolic process GO:0046034 176 0.012
protein localization to nucleus GO:0034504 136 0.012
positive regulation of hydrolase activity GO:0051345 331 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
positive regulation of apoptotic signaling pathway GO:2001235 70 0.012
detection of stimulus GO:0051606 85 0.012
meiotic chromosome segregation GO:0045132 4 0.011
regulation of protein processing GO:0070613 150 0.011
chromosome segregation GO:0007059 114 0.011
protein targeting GO:0006605 187 0.011
neuromuscular junction development GO:0007528 3 0.011
regulation of feeding behavior GO:0060259 3 0.011
mitotic dna integrity checkpoint GO:0044774 30 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
positive regulation of growth GO:0045927 58 0.011
cellular lipid metabolic process GO:0044255 303 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
behavior GO:0007610 112 0.011
nuclear export GO:0051168 69 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.011
translesion synthesis GO:0019985 8 0.011
negative regulation of transferase activity GO:0051348 124 0.011
positive regulation of transmembrane transport GO:0034764 41 0.011
small molecule biosynthetic process GO:0044283 157 0.011
single organism nuclear import GO:1902593 104 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
innate immune response GO:0045087 178 0.011
dna repair GO:0006281 198 0.011
mapk cascade GO:0000165 288 0.011
regulation of mapk cascade GO:0043408 262 0.010
cardiac muscle cell contraction GO:0086003 4 0.010
protein dna complex subunit organization GO:0071824 80 0.010
oocyte development GO:0048599 1 0.010
protein deubiquitination GO:0016579 79 0.010
protein acylation GO:0043543 138 0.010
glycosyl compound biosynthetic process GO:1901659 27 0.010
Rat
negative regulation of endopeptidase activity GO:0010951 84 0.010
sensory perception GO:0007600 103 0.010
gonad development GO:0008406 34 0.010
organic anion transport GO:0015711 103 0.010
peptidyl glutamic acid modification GO:0018200 4 0.010
ion transmembrane transport GO:0034220 338 0.010
positive regulation of cellular catabolic process GO:0031331 284 0.010
protein k63 linked ubiquitination GO:0070534 31 0.010
establishment of cell polarity GO:0030010 22 0.010

PRPS1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.090
sensory system disease DOID:0050155 203 0.031
nervous system disease DOID:863 431 0.031
central nervous system disease DOID:331 186 0.019
neurodegenerative disease DOID:1289 102 0.019
eye and adnexa disease DOID:1492 150 0.017
cancer DOID:162 167 0.017
disease of cellular proliferation DOID:14566 174 0.017
retinal disease DOID:5679 118 0.016
retinal degeneration DOID:8466 89 0.016
eye disease DOID:5614 149 0.016
disease of mental health DOID:150 70 0.016
organ system cancer DOID:0050686 164 0.011
neuromuscular disease DOID:440 38 0.006
neuropathy DOID:870 52 0.006
charcot marie tooth disease DOID:10595 33 0.002
auditory system disease DOID:2742 53 0.002
nonsyndromic deafness DOID:0050563 50 0.002
x linked disease DOID:0050735 14 0.001
charcot marie tooth disease type x DOID:0050542 3 0.000