|
|
regulation of interleukin 1 mediated signaling pathway
|
GO:2000659 |
3 |
0.998
|
Human |
|
|
negative regulation of interleukin 1 mediated signaling pathway
|
GO:2000660 |
2 |
0.870
|
Human |
|
|
negative regulation of jun kinase activity
|
GO:0043508 |
4 |
0.830
|
Human |
|
|
negative regulation of tumor necrosis factor mediated signaling pathway
|
GO:0010804 |
7 |
0.562
|
Human |
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.516
|
Human |
|
|
cellular response to interleukin 1
|
GO:0071347 |
35 |
0.482
|
Human |
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
42 |
0.386
|
Human |
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.384
|
Human |
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.375
|
Human |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.329
|
Human |
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.286
|
Human |
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.274
|
Human |
|
|
negative regulation of response to cytokine stimulus
|
GO:0060761 |
25 |
0.270
|
Human |
|
|
negative regulation of leukocyte differentiation
|
GO:1902106 |
24 |
0.255
|
Human |
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.252
|
Human |
|
|
negative regulation of binding
|
GO:0051100 |
57 |
0.251
|
Human |
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.251
|
Human |
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.241
|
Human |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.225
|
Human |
|
|
appendage morphogenesis
|
GO:0035107 |
16 |
0.224
|
Human |
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.218
|
Human |
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.217
|
Human |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.214
|
Human |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.210
|
Human |
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.200
|
Human |
|
|
midbrain development
|
GO:0030901 |
45 |
0.194
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.192
|
Human |
|
|
regulation of binding
|
GO:0051098 |
111 |
0.188
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.182
|
Human |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.173
|
Human |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.171
|
Human |
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.169
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.168
|
Human |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.168
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.162
|
Human |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.153
|
Human |
|
|
negative regulation of myeloid leukocyte differentiation
|
GO:0002762 |
16 |
0.142
|
Human |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.141
|
Human |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.138
|
Human |
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.137
|
Human |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.136
|
Human |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.136
|
Human |
|
|
regulation of tumor necrosis factor mediated signaling pathway
|
GO:0010803 |
12 |
0.134
|
Human |
|
|
regulation of transcription regulatory region dna binding
|
GO:2000677 |
15 |
0.134
|
Human |
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.132
|
Human |
|
|
interleukin 1 mediated signaling pathway
|
GO:0070498 |
12 |
0.131
|
Human |
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.130
|
Human |
|
|
limb morphogenesis
|
GO:0035108 |
16 |
0.130
|
Human |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.130
|
Human |
|
|
substantia nigra development
|
GO:0021762 |
45 |
0.129
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.126
|
Human |
|
|
neural nucleus development
|
GO:0048857 |
47 |
0.125
|
|
|
|
regulation of dna binding
|
GO:0051101 |
37 |
0.115
|
Human |
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.114
|
Human |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.113
|
Human |
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.113
|
Human |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.110
|
Human |
|
|
immune system development
|
GO:0002520 |
195 |
0.110
|
Human |
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.109
|
Human |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.107
|
Human |
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.106
|
Human |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.098
|
Human |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.098
|
Human |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.097
|
Human |
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.096
|
Human |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.096
|
Human |
|
|
appendage development
|
GO:0048736 |
23 |
0.091
|
Human |
|
|
nervous system development
|
GO:0007399 |
293 |
0.090
|
|
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.089
|
Human |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.087
|
Human |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.086
|
Human |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.085
|
Human |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.083
|
Human |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.083
|
Human |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.081
|
Human |
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.081
|
Human |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.080
|
Human |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.080
|
Human |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.071
|
Human |
|
|
brain development
|
GO:0007420 |
97 |
0.069
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.068
|
Human |
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.064
|
Human |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.061
|
Human |
|
|
limb development
|
GO:0060173 |
23 |
0.052
|
Human |
|
|
negative regulation of osteoclast differentiation
|
GO:0045671 |
8 |
0.048
|
Human |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.046
|
|
|
|
head development
|
GO:0060322 |
108 |
0.045
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
46 |
0.042
|
Human |
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.039
|
Human |
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.036
|
Human |
|
|
central nervous system development
|
GO:0007417 |
123 |
0.034
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.034
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.031
|
|
|
|
negative regulation of dna binding
|
GO:0043392 |
18 |
0.030
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.029
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.028
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.026
|
|
|
|
negative regulation of transcription regulatory region dna binding
|
GO:2000678 |
6 |
0.026
|
Human |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.026
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.025
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.025
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.025
|
Human |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.024
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter during mitosis
|
GO:0046022 |
1 |
0.023
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.023
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.021
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.021
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.021
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.020
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.020
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.020
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.020
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.019
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.018
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.018
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.018
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.018
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.018
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.018
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.018
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.017
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.017
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
27 |
0.017
|
Human |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.017
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.017
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.017
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.017
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.017
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.017
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.017
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.017
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.017
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.017
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.016
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.016
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.016
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.016
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.016
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.016
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.016
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.016
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.016
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.015
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.015
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.015
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.015
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.015
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.015
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.015
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.015
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.015
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.015
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.015
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.015
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.015
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.015
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.015
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.014
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.014
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.014
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.014
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.014
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.014
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.014
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.013
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.013
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.013
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.013
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.013
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.013
|
|
|
|
regulation of transcription during mitosis
|
GO:0045896 |
2 |
0.013
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.013
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.013
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.013
|
|
|
|
regulation of transcription from rna polymerase ii promoter mitotic
|
GO:0046021 |
1 |
0.013
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.013
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.013
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.013
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.012
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.012
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.012
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.012
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.012
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.012
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.012
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.012
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.012
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.012
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.012
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.012
|
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.012
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.012
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.012
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.012
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.012
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.012
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.012
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.012
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.012
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.012
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.012
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.012
|
|
|
|
methylation
|
GO:0032259 |
106 |
0.012
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.012
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.011
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.011
|
|
|
|
forelimb morphogenesis
|
GO:0035136 |
4 |
0.011
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.011
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.011
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.011
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.011
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.011
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.011
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.011
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.011
|
|
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.011
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.011
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.011
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.011
|
|
|
|
nucleic acid phosphodiester bond hydrolysis
|
GO:0090305 |
102 |
0.011
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.011
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.011
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.011
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.011
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.011
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.011
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.011
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.011
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.011
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.011
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.011
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.011
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.011
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.011
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.011
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.011
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.010
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.010
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.010
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.010
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.010
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.010
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.010
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.010
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.010
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.010
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.010
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
1 |
0.010
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.010
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.010
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.010
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.010
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.010
|
|