Homo sapiens

81 known processes

SIX1

SIX homeobox 1

(Aliases: TIP39,DFNA23,BOS3)

SIX1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extraocular skeletal muscle development GO:0002074 1 0.302
Zebrafish
neuron fate commitment GO:0048663 2 0.221
Mouse
forebrain regionalization GO:0021871 3 0.172
Human
anatomical structure formation involved in morphogenesis GO:0048646 284 0.130
Mouse Fly
cell development GO:0048468 328 0.126
Zebrafish Mouse
system process GO:0003008 349 0.123
Mouse
organ morphogenesis GO:0009887 147 0.120
Mouse Fly
negative regulation of developmental process GO:0051093 247 0.119
Mouse
forebrain dorsal ventral pattern formation GO:0021798 1 0.110
Human
segmentation GO:0035282 4 0.108
regulation of cell differentiation GO:0045595 393 0.108
Zebrafish Mouse
covalent chromatin modification GO:0016569 254 0.108
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.104
Mouse
cellular component morphogenesis GO:0032989 314 0.099
positive regulation of developmental process GO:0051094 314 0.094
Mouse
post embryonic development GO:0009791 2 0.090
cranial nerve development GO:0021545 4 0.087
Mouse
epithelium development GO:0060429 227 0.082
Mouse
mesodermal cell fate commitment GO:0001710 2 0.079
negative regulation of cell fate specification GO:0009996 3 0.076
cell morphogenesis GO:0000902 296 0.073
chromatin organization GO:0006325 351 0.073
cellular response to dna damage stimulus GO:0006974 379 0.072
embryonic forelimb morphogenesis GO:0035115 4 0.071
histone modification GO:0016570 251 0.069
forelimb morphogenesis GO:0035136 4 0.067
negative regulation of protein metabolic process GO:0051248 391 0.066
chromatin modification GO:0016568 298 0.065
negative regulation of programmed cell death GO:0043069 321 0.065
Mouse
negative regulation of cell death GO:0060548 345 0.061
Mouse
somatic muscle development GO:0007525 1 0.061
amine metabolic process GO:0009308 44 0.060
mesodermal cell fate specification GO:0007501 2 0.059
response to abiotic stimulus GO:0009628 336 0.058
negative regulation of multicellular organismal process GO:0051241 317 0.058
Mouse
inner ear morphogenesis GO:0042472 4 0.058
Mouse
negative regulation of cell differentiation GO:0045596 171 0.057
positive regulation of cell proliferation GO:0008284 301 0.055
Mouse
hematopoietic or lymphoid organ development GO:0048534 186 0.053
Mouse
protein dephosphorylation GO:0006470 81 0.052
negative regulation of cellular protein metabolic process GO:0032269 353 0.052
embryonic morphogenesis GO:0048598 85 0.051
Mouse Fly
hindbrain development GO:0030902 3 0.051
post embryonic organ development GO:0048569 1 0.051
cellular ketone metabolic process GO:0042180 80 0.050
regulation of cell cycle GO:0051726 393 0.050
cell projection organization GO:0030030 252 0.048
regulation of proteolysis GO:0030162 293 0.047
negative regulation of apoptotic process GO:0043066 316 0.047
Mouse
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 4 0.047
central nervous system development GO:0007417 123 0.046
Human Zebrafish Mouse
nerve development GO:0021675 4 0.046
Mouse
dephosphorylation GO:0016311 209 0.045
dna repair GO:0006281 198 0.045
regulation of anatomical structure morphogenesis GO:0022603 286 0.045
Mouse
salivary gland morphogenesis GO:0007435 4 0.044
negative regulation of catalytic activity GO:0043086 335 0.044
neurogenesis GO:0022008 169 0.044
Zebrafish Mouse Fly
muscle structure development GO:0061061 98 0.044
Zebrafish Mouse
specification of organ identity GO:0010092 3 0.044
Mouse
compound eye development GO:0048749 1 0.043
Fly
chemotaxis GO:0006935 157 0.043
negative regulation of phosphate metabolic process GO:0045936 267 0.043
mitotic cell cycle GO:0000278 326 0.042
cell morphogenesis involved in differentiation GO:0000904 144 0.042
regulation of cellular ketone metabolic process GO:0010565 50 0.042
blastoderm segmentation GO:0007350 2 0.041
organ formation GO:0048645 3 0.041
Mouse
epithelial cell differentiation GO:0030855 141 0.041
Mouse
taxis GO:0042330 157 0.041
morphogenesis of embryonic epithelium GO:0016331 4 0.041
Mouse
regulation of cellular response to stress GO:0080135 244 0.041
regulation of cell migration GO:0030334 289 0.041
immune system development GO:0002520 195 0.040
Mouse
circulatory system development GO:0072359 262 0.039
Mouse
renal water homeostasis GO:0003091 4 0.039
regulation of cellular amine metabolic process GO:0033238 11 0.039
nervous system development GO:0007399 293 0.039
Human Zebrafish Mouse Fly
cellular amine metabolic process GO:0044106 41 0.039
regulation of cellular component movement GO:0051270 334 0.039
cellular response to endogenous stimulus GO:0071495 336 0.038
positive regulation of programmed cell death GO:0043068 249 0.038
regulation of peptidase activity GO:0052547 180 0.038
cell fate determination GO:0001709 3 0.037
cell part morphogenesis GO:0032990 137 0.037
multicellular organismal aging GO:0010259 3 0.036
spinal cord development GO:0021510 4 0.036
negative regulation of cell proliferation GO:0008285 228 0.036
growth GO:0040007 202 0.036
Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.036
muscle tissue development GO:0060537 62 0.036
Zebrafish Mouse
embryonic epithelial tube formation GO:0001838 4 0.036
Mouse
carbohydrate metabolic process GO:0005975 207 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
cellular amino acid metabolic process GO:0006520 116 0.036
positive regulation of dna metabolic process GO:0051054 73 0.035
determination of adult lifespan GO:0008340 2 0.035
regulation of endopeptidase activity GO:0052548 170 0.035
positive regulation of cell differentiation GO:0045597 211 0.035
positive regulation of apoptotic process GO:0043065 246 0.035
negative regulation of phosphorus metabolic process GO:0010563 267 0.034
response to radiation GO:0009314 151 0.034
generation of neurons GO:0048699 152 0.034
Zebrafish Mouse
positive regulation of cellular component organization GO:0051130 376 0.034
apoptotic signaling pathway GO:0097190 268 0.033
anterior posterior axis specification GO:0009948 2 0.033
double strand break repair GO:0006302 101 0.033
negative regulation of hydrolase activity GO:0051346 182 0.032
regulation of dna metabolic process GO:0051052 153 0.032
mitochondrion organization GO:0007005 156 0.032
actin filament based process GO:0030029 224 0.031
regulation of protein localization GO:0032880 296 0.031
Mouse
response to lipid GO:0033993 206 0.031
immune response GO:0006955 307 0.031
regulation of cell motility GO:2000145 299 0.031
protein processing GO:0016485 226 0.031
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.031
Mouse
thymus development GO:0048538 3 0.031
Mouse
single organism membrane organization GO:0044802 268 0.031
metencephalon development GO:0022037 2 0.030
gas transport GO:0015669 3 0.030
protein maturation GO:0051604 233 0.030
photoreceptor cell differentiation GO:0046530 2 0.030
pituitary gland development GO:0021983 2 0.030
Zebrafish
regulation of saliva secretion GO:0046877 2 0.029
motor neuron axon guidance GO:0008045 2 0.029
tube development GO:0035295 125 0.029
Zebrafish Mouse
head development GO:0060322 108 0.029
Human Zebrafish
urogenital system development GO:0001655 65 0.029
Human Mouse
digestive system development GO:0055123 75 0.029
Zebrafish
striated muscle tissue development GO:0014706 59 0.029
Zebrafish Mouse
cell projection morphogenesis GO:0048858 129 0.028
response to hormone GO:0009725 175 0.028
cellular macromolecule catabolic process GO:0044265 380 0.028
response to ionizing radiation GO:0010212 65 0.028
positive regulation of response to dna damage stimulus GO:2001022 43 0.028
female gamete generation GO:0007292 2 0.028
positive regulation of cellular amine metabolic process GO:0033240 7 0.027
oogenesis GO:0048477 2 0.027
canonical wnt signaling pathway GO:0060070 116 0.027
regulation of mitotic cell cycle GO:0007346 189 0.027
neuromuscular junction development GO:0007528 3 0.027
Mouse
sensory organ morphogenesis GO:0090596 21 0.027
Mouse Fly
regulation of kinase activity GO:0043549 314 0.027
actin mediated cell contraction GO:0070252 12 0.027
brain development GO:0007420 97 0.027
Human Zebrafish
canonical wnt signaling pathway involved in osteoblast differentiation GO:0044339 2 0.027
hindlimb morphogenesis GO:0035137 2 0.027
negative regulation of cell fate commitment GO:0010454 3 0.027
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.027
regulation of protein maturation GO:1903317 150 0.026
peptidyl tyrosine dephosphorylation GO:0035335 36 0.026
single organism carbohydrate metabolic process GO:0044723 193 0.026
tissue morphogenesis GO:0048729 96 0.026
Mouse
mitochondrial membrane organization GO:0007006 40 0.026
somatic stem cell maintenance GO:0035019 4 0.025
membrane organization GO:0061024 292 0.025
myoblast fusion GO:0007520 1 0.025
pattern specification process GO:0007389 43 0.025
Human Mouse
carbohydrate derivative biosynthetic process GO:1901137 207 0.025
heart formation GO:0060914 2 0.025
Mouse
memory GO:0007613 3 0.025
nucleoside catabolic process GO:0009164 408 0.025
cytoplasmic transport GO:0016482 379 0.025
regionalization GO:0003002 29 0.025
Human Mouse
mesenchyme development GO:0060485 59 0.024
Mouse
regulation of cell development GO:0060284 161 0.024
Zebrafish Mouse
neural tube patterning GO:0021532 2 0.024
regulation of cell cycle process GO:0010564 266 0.024
vesicle mediated transport GO:0016192 371 0.024
biological adhesion GO:0022610 331 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
positive regulation of cell death GO:0010942 263 0.024
mitotic cell cycle process GO:1903047 286 0.024
endocrine system development GO:0035270 26 0.024
Zebrafish Mouse Fly
positive regulation of digestive system process GO:0060456 2 0.024
epidermis morphogenesis GO:0048730 3 0.024
regulation of response to dna damage stimulus GO:2001020 94 0.024
regulation of locomotion GO:0040012 329 0.024
regulation of striated muscle tissue development GO:0016202 26 0.024
Mouse
cell adhesion GO:0007155 325 0.023
negative regulation of protein modification process GO:0031400 200 0.023
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.023
lipid metabolic process GO:0006629 381 0.023
mesonephros development GO:0001823 17 0.023
Mouse
gland development GO:0048732 48 0.023
Zebrafish Mouse Fly
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.023
wnt signaling pathway GO:0016055 156 0.023
syncytium formation by plasma membrane fusion GO:0000768 2 0.023
protein localization to organelle GO:0033365 280 0.023
forebrain neuron differentiation GO:0021879 3 0.023
negative regulation of cell cycle GO:0045786 193 0.023
ras protein signal transduction GO:0007265 73 0.023
regulation of growth GO:0040008 165 0.023
Mouse
somitogenesis GO:0001756 2 0.023
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.023
cell growth GO:0016049 160 0.023
regulation of mapk cascade GO:0043408 262 0.022
skeletal system development GO:0001501 79 0.022
Mouse
negative regulation of protein processing GO:0010955 142 0.022
actin filament based movement GO:0030048 17 0.022
response to oxygen containing compound GO:1901700 369 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
neuron projection development GO:0031175 106 0.022
anterior posterior axis specification embryo GO:0008595 2 0.022
reproductive process GO:0022414 106 0.022
Fly
nucleoside phosphate catabolic process GO:1901292 412 0.022
limbic system development GO:0021761 3 0.022
regulation of intracellular transport GO:0032386 195 0.022
sensory organ development GO:0007423 52 0.022
Human Zebrafish Mouse Fly
forebrain generation of neurons GO:0021872 3 0.022
negative regulation of proteolysis GO:0045861 132 0.022
mesonephric tubule formation GO:0072172 1 0.022
Mouse
positive regulation of organelle organization GO:0010638 195 0.022
positive regulation of dna repair GO:0045739 25 0.022
cardiovascular system development GO:0072358 262 0.022
Mouse
regulation of interleukin 1 mediated signaling pathway GO:2000659 3 0.022
male genitalia development GO:0030539 1 0.021
formation of primary germ layer GO:0001704 42 0.021
oocyte differentiation GO:0009994 2 0.021
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.021
metanephros development GO:0001656 16 0.021
Mouse
cell fate commitment GO:0045165 27 0.021
Mouse
positive regulation of cellular catabolic process GO:0031331 284 0.021
hair follicle morphogenesis GO:0031069 2 0.021
ribonucleoside catabolic process GO:0042454 406 0.021
peripheral nervous system development GO:0007422 2 0.021
Zebrafish
response to organic cyclic compound GO:0014070 204 0.021
single organism cellular localization GO:1902580 332 0.021
neuron differentiation GO:0030182 138 0.021
Zebrafish Mouse
soft palate development GO:0060023 3 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
negative regulation of protein maturation GO:1903318 142 0.021
regulation of dna repair GO:0006282 47 0.021
regulation of transferase activity GO:0051338 355 0.021
regulation of cellular component biogenesis GO:0044087 281 0.020
Mouse
nucleoside triphosphate metabolic process GO:0009141 422 0.020
stem cell development GO:0048864 69 0.020
response to wounding GO:0009611 168 0.020
purine containing compound catabolic process GO:0072523 411 0.020
one carbon compound transport GO:0019755 4 0.020
small gtpase mediated signal transduction GO:0007264 78 0.020
skeletal system morphogenesis GO:0048705 24 0.020
Mouse
reactive oxygen species biosynthetic process GO:1903409 4 0.020
menstrual cycle phase GO:0022601 2 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.020
cellular macromolecular complex assembly GO:0034622 324 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
purine nucleoside triphosphate catabolic process GO:0009146 392 0.019
rna processing GO:0006396 255 0.019
secretion GO:0046903 254 0.019
regulation of reactive oxygen species metabolic process GO:2000377 41 0.019
positive regulation of cell cycle GO:0045787 140 0.019
regulation of neural precursor cell proliferation GO:2000177 4 0.019
proteasomal protein catabolic process GO:0010498 176 0.019
associative learning GO:0008306 1 0.019
regulation of protein processing GO:0070613 150 0.019
adult locomotory behavior GO:0008344 1 0.019
glycoprotein metabolic process GO:0009100 110 0.019
embryonic camera type eye development GO:0031076 2 0.019
long term memory GO:0007616 2 0.019
extrinsic apoptotic signaling pathway GO:0097191 119 0.019
spermatid differentiation GO:0048515 4 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
positive regulation of immune system process GO:0002684 283 0.019
cellular lipid metabolic process GO:0044255 303 0.019
regulation of protein kinase activity GO:0045859 289 0.019
stem cell differentiation GO:0048863 93 0.019
cell aggregation GO:0098743 1 0.019
protein catabolic process GO:0030163 325 0.019
negative regulation of cellular component organization GO:0051129 235 0.019
modification dependent macromolecule catabolic process GO:0043632 212 0.019
renal system development GO:0072001 63 0.019
Human Mouse
embryonic skeletal system development GO:0048706 13 0.018
Mouse
organelle assembly GO:0070925 176 0.018
neuron projection morphogenesis GO:0048812 50 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
cyclic nucleotide metabolic process GO:0009187 82 0.018
posttranscriptional regulation of gene expression GO:0010608 213 0.018
ubiquitin dependent protein catabolic process GO:0006511 206 0.018
enzyme linked receptor protein signaling pathway GO:0007167 303 0.018
tissue regeneration GO:0042246 3 0.018
positive regulation of neural precursor cell proliferation GO:2000179 2 0.018
eye development GO:0001654 42 0.018
Human Zebrafish Fly
rhythmic behavior GO:0007622 2 0.018
apoptotic mitochondrial changes GO:0008637 57 0.018
locomotory behavior GO:0007626 1 0.018
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
innate immune response GO:0045087 178 0.018
negative regulation of protein phosphorylation GO:0001933 140 0.018
luteinizing hormone secretion GO:0032275 1 0.018
oocyte development GO:0048599 1 0.018
negative regulation of collagen metabolic process GO:0010713 3 0.018
neural crest cell development GO:0014032 3 0.018
regulation of binding GO:0051098 111 0.018
regulation of cell growth GO:0001558 135 0.018
oxidation reduction process GO:0055114 396 0.018
positive regulation of transport GO:0051050 336 0.018
reactive oxygen species metabolic process GO:0072593 75 0.018
regulation of mesonephros development GO:0061217 3 0.018
Mouse
ossification GO:0001503 121 0.018
organophosphate catabolic process GO:0046434 430 0.018
regulation of purine nucleotide metabolic process GO:1900542 264 0.018
neurological system process GO:0050877 163 0.018
Mouse
mitochondrial transport GO:0006839 60 0.018
mitotic cell cycle phase transition GO:0044772 162 0.017
tripartite regional subdivision GO:0007351 2 0.017
regulation of heart growth GO:0060420 4 0.017
positive regulation of proteolysis GO:0045862 142 0.017
canonical wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044338 2 0.017
osteoblast differentiation GO:0001649 92 0.017
cell activation GO:0001775 213 0.017
purine nucleoside triphosphate metabolic process GO:0009144 412 0.017
morphogenesis of a polarized epithelium GO:0001738 3 0.017
regulation of ureteric bud formation GO:0072106 1 0.017
Mouse
neural tube formation GO:0001841 3 0.017
signal transduction by phosphorylation GO:0023014 297 0.017
pulmonary vein morphogenesis GO:0060577 1 0.017
striated muscle cell differentiation GO:0051146 43 0.017
Zebrafish
regulation of nucleotide metabolic process GO:0006140 269 0.017
cellular response to oxygen containing compound GO:1901701 276 0.017
single organism reproductive process GO:0044702 98 0.017
Fly
mapk cascade GO:0000165 288 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
outflow tract septum morphogenesis GO:0003148 4 0.017
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 1 0.017
negative regulation of transferase activity GO:0051348 124 0.017
regeneration GO:0031099 4 0.017
vasculature development GO:0001944 181 0.017
Mouse
stem cell division GO:0017145 2 0.017
ventral spinal cord development GO:0021517 1 0.017
regulation of cysteine type endopeptidase activity GO:2000116 127 0.017
regulation of cytoplasmic transport GO:1903649 149 0.017
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.017
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.017
positive regulation of cardioblast differentiation GO:0051891 2 0.017
embryonic viscerocranium morphogenesis GO:0048703 1 0.017
embryonic organ morphogenesis GO:0048562 24 0.017
Mouse
glycosyl compound catabolic process GO:1901658 413 0.017
negative regulation of kinase activity GO:0033673 106 0.017
cardiac muscle cell contraction GO:0086003 4 0.017
ribonucleoside triphosphate metabolic process GO:0009199 412 0.017
nuclear transport GO:0051169 179 0.017
regulation of apoptotic signaling pathway GO:2001233 175 0.017
cellular protein catabolic process GO:0044257 261 0.017
hemopoiesis GO:0030097 180 0.016
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.016
appendage morphogenesis GO:0035107 16 0.016
regulation of organ formation GO:0003156 4 0.016
Mouse
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
regulation of sodium dependent phosphate transport GO:2000118 2 0.016
wound healing GO:0042060 115 0.016
kidney development GO:0001822 53 0.016
Human Mouse
spermatid development GO:0007286 4 0.016
regulation of epithelial cell proliferation GO:0050678 113 0.016
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.016
cardiac right ventricle morphogenesis GO:0003215 3 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
positive regulation of tooth mineralization GO:0070172 2 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
myeloid cell differentiation GO:0030099 117 0.016
dna packaging GO:0006323 77 0.016
embryo development GO:0009790 123 0.016
Mouse Fly
mesenchymal cell development GO:0014031 50 0.016
negative regulation of cellular component movement GO:0051271 106 0.016
negative regulation of cell motility GO:2000146 104 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
muscle organ development GO:0007517 56 0.016
Zebrafish Mouse
organ induction GO:0001759 4 0.016
Mouse
nitrogen compound transport GO:0071705 191 0.016
circadian behavior GO:0048512 2 0.016
defense response GO:0006952 315 0.016
mesenchymal cell differentiation GO:0048762 52 0.016
glycerol transport GO:0015793 5 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
response to salt stress GO:0009651 3 0.016
neuron development GO:0048666 113 0.015
Zebrafish
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.015
Mouse
cell fate specification GO:0001708 8 0.015
Mouse
ectodermal placode development GO:0071696 1 0.015
Mouse Fly
negative regulation of endopeptidase activity GO:0010951 84 0.015
maintenance of location GO:0051235 112 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
menstruation GO:0042703 1 0.015
cerebellum development GO:0021549 2 0.015
carbon dioxide transport GO:0015670 3 0.015
visual behavior GO:0007632 2 0.015
cellular response to nitrogen compound GO:1901699 144 0.015
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.015
forebrain development GO:0030900 26 0.015
Human Zebrafish
skin development GO:0043588 76 0.015
positive regulation of phosphorylation GO:0042327 394 0.015
response to drug GO:0042493 81 0.015
negative regulation of immune system process GO:0002683 136 0.015
cellular response to organic cyclic compound GO:0071407 127 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
cellular response to oxygen levels GO:0071453 55 0.015
cartilage condensation GO:0001502 1 0.015
embryonic hindlimb morphogenesis GO:0035116 2 0.015
hematopoietic stem cell differentiation GO:0060218 4 0.015
developmental programmed cell death GO:0010623 3 0.015
positive regulation of cell development GO:0010720 92 0.015
cellular response to lipid GO:0071396 127 0.015
limb morphogenesis GO:0035108 16 0.015
regulation of meiotic cell cycle GO:0051445 4 0.015
tube closure GO:0060606 3 0.015
sensory perception of smell GO:0007608 2 0.015
embryonic eye morphogenesis GO:0048048 2 0.015
nucleotide catabolic process GO:0009166 408 0.015
regulation of mitotic cell cycle phase transition GO:1901990 118 0.015
regulation of protein transport GO:0051223 213 0.015
prostate gland development GO:0030850 3 0.015
ectodermal placode formation GO:0060788 1 0.015
Mouse Fly
protein autophosphorylation GO:0046777 123 0.015
regulation of cardiac muscle cell proliferation GO:0060043 4 0.015
endodermal cell fate specification GO:0001714 4 0.015
embryonic placenta development GO:0001892 1 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 1 0.014
striated muscle adaptation GO:0014888 4 0.014
blood vessel morphogenesis GO:0048514 162 0.014
Mouse
dna conformation change GO:0071103 113 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
regulation of hormone levels GO:0010817 125 0.014
regulation of cell cycle phase transition GO:1901987 126 0.014
regulation of protein catabolic process GO:0042176 155 0.014
response to fungus GO:0009620 4 0.014
cell differentiation in spinal cord GO:0021515 1 0.014
negative regulation of peptidase activity GO:0010466 91 0.014
negative regulation of catabolic process GO:0009895 104 0.014
negative regulation of jun kinase activity GO:0043508 4 0.014
retinal ganglion cell axon guidance GO:0031290 2 0.014
negative regulation of mitotic cell cycle GO:0045930 102 0.014
rho protein signal transduction GO:0007266 26 0.014
aortic valve development GO:0003176 3 0.014
purine ribonucleotide biosynthetic process GO:0009152 79 0.014
lens development in camera type eye GO:0002088 2 0.014
regulation of leukocyte activation GO:0002694 115 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.014
cell division GO:0051301 168 0.014
cellular protein complex assembly GO:0043623 188 0.014
regulation of cardiac muscle tissue growth GO:0055021 4 0.014
eye photoreceptor cell differentiation GO:0001754 2 0.014
primary neural tube formation GO:0014020 3 0.014
endochondral bone morphogenesis GO:0060350 3 0.014
response to axon injury GO:0048678 1 0.014
rna splicing GO:0008380 131 0.014
neural crest cell migration GO:0001755 2 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.014
regulation of neurotransmitter secretion GO:0046928 3 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
purine nucleotide biosynthetic process GO:0006164 84 0.014
muscle cell differentiation GO:0042692 63 0.014
Zebrafish Mouse
neurotransmitter secretion GO:0007269 4 0.014
positive regulation of protein phosphorylation GO:0001934 313 0.014
myosin filament assembly GO:0031034 2 0.014
regulation of cell morphogenesis GO:0022604 153 0.013
regulation of chromosome organization GO:0033044 103 0.013
renal vesicle development GO:0072087 4 0.013
nucleotide biosynthetic process GO:0009165 109 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.013
cell type specific apoptotic process GO:0097285 125 0.013
Mouse
ribonucleotide catabolic process GO:0009261 405 0.013
developmental process involved in reproduction GO:0003006 66 0.013
negative regulation of gastrulation GO:2000542 4 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
protein localization to membrane GO:0072657 160 0.013
axis elongation GO:0003401 4 0.013
Mouse
sex determination GO:0007530 3 0.013
kidney epithelium development GO:0072073 25 0.013
Mouse
striated muscle contraction GO:0006941 52 0.013
endocytosis GO:0006897 159 0.013

SIX1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.039
nervous system disease DOID:863 431 0.039
eye and adnexa disease DOID:1492 150 0.036
eye disease DOID:5614 149 0.036
musculoskeletal system disease DOID:17 223 0.028
bone disease DOID:0080001 88 0.024
connective tissue disease DOID:65 109 0.024
cancer DOID:162 167 0.023
disease of cellular proliferation DOID:14566 174 0.023
organ system cancer DOID:0050686 164 0.018
muscular disease DOID:0080000 114 0.018
muscle tissue disease DOID:66 113 0.018
retinal disease DOID:5679 118 0.017
retinal degeneration DOID:8466 89 0.017
disease of metabolism DOID:0014667 295 0.016
bone development disease DOID:0080006 55 0.014
central nervous system disease DOID:331 186 0.014