Homo sapiens

11 known processes

KRT4

keratin 4

(Aliases: K4,CK-4,CYK4,FLJ31692,CK4)

KRT4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
keratinization GO:0031424 2 0.885
Human
hair follicle morphogenesis GO:0031069 2 0.637
Human
epidermis morphogenesis GO:0048730 3 0.527
Human
keratinocyte differentiation GO:0030216 36 0.359
Human
golgi to plasma membrane cftr protein transport GO:0043000 1 0.228
hair cycle GO:0042633 28 0.191
Human
intermediate filament based process GO:0045103 17 0.180
Human
epithelium development GO:0060429 227 0.179
Human
epidermal cell differentiation GO:0009913 45 0.177
Human
skin development GO:0043588 76 0.156
Human
epidermis development GO:0008544 59 0.145
Human
epithelial cell differentiation GO:0030855 141 0.100
Human
intermediate filament organization GO:0045109 10 0.093
Human
negative regulation of cell death GO:0060548 345 0.092
system process GO:0003008 349 0.083
immune response GO:0006955 307 0.078
Human
lipid metabolic process GO:0006629 381 0.077
intermediate filament cytoskeleton organization GO:0045104 17 0.062
Human
multicellular organismal homeostasis GO:0048871 67 0.061
Human
complement activation GO:0006956 19 0.055
Human
post embryonic development GO:0009791 2 0.052
retina homeostasis GO:0001895 42 0.052
Human
negative regulation of programmed cell death GO:0043069 321 0.047
negative regulation of apoptotic process GO:0043066 316 0.046
multicellular organismal aging GO:0010259 3 0.045
neurological system process GO:0050877 163 0.045
testosterone biosynthetic process GO:0061370 2 0.045
tissue regeneration GO:0042246 3 0.044
Zebrafish
defense response GO:0006952 315 0.043
Human
cellular lipid metabolic process GO:0044255 303 0.042
tissue migration GO:0090130 119 0.041
Human
humoral immune response GO:0006959 49 0.041
Human
regeneration GO:0031099 4 0.041
Zebrafish
organ morphogenesis GO:0009887 147 0.041
Human
regulation of cellular component movement GO:0051270 334 0.041
small molecule biosynthetic process GO:0044283 157 0.041
determination of adult lifespan GO:0008340 2 0.040
epoxygenase p450 pathway GO:0019373 3 0.040
negative regulation of catalytic activity GO:0043086 335 0.039
cellular ketone metabolic process GO:0042180 80 0.039
purine containing compound catabolic process GO:0072523 411 0.038
response to lipid GO:0033993 206 0.037
protein processing GO:0016485 226 0.037
tissue morphogenesis GO:0048729 96 0.037
Human
cellular component morphogenesis GO:0032989 314 0.036
actin filament based process GO:0030029 224 0.036
organic hydroxy compound metabolic process GO:1901615 147 0.036
protein maturation GO:0051604 233 0.035
response to other organism GO:0051707 261 0.035
hormone metabolic process GO:0042445 61 0.035
anatomical structure formation involved in morphogenesis GO:0048646 284 0.035
amine metabolic process GO:0009308 44 0.034
oxidation reduction process GO:0055114 396 0.034
positive regulation of immune system process GO:0002684 283 0.033
Human
single organism membrane organization GO:0044802 268 0.033
fatty acid metabolic process GO:0006631 115 0.033
regulation of locomotion GO:0040012 329 0.033
memory GO:0007613 3 0.033
positive regulation of cell proliferation GO:0008284 301 0.032
fatty acid omega oxidation GO:0010430 2 0.032
cellular amine metabolic process GO:0044106 41 0.031
innate immune response GO:0045087 178 0.031
Human
purine ribonucleoside metabolic process GO:0046128 437 0.030
keratinocyte migration GO:0051546 6 0.030
Human
cellular amino acid metabolic process GO:0006520 116 0.030
segmentation GO:0035282 4 0.029
epithelial cell migration GO:0010631 119 0.029
Human
growth GO:0040007 202 0.029
Zebrafish
negative regulation of peptidase activity GO:0010466 91 0.029
single organism cellular localization GO:1902580 332 0.029
cytoplasmic transport GO:0016482 379 0.028
keratinocyte activation GO:0032980 1 0.028
Human
epithelial cell proliferation GO:0050673 128 0.028
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.027
regulation of proteolysis GO:0030162 293 0.027
response to oxygen containing compound GO:1901700 369 0.027
anatomical structure homeostasis GO:0060249 100 0.027
Human
protein localization to membrane GO:0072657 160 0.027
membrane organization GO:0061024 292 0.027
intracellular protein transport GO:0006886 270 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
cellular response to cytokine stimulus GO:0071345 181 0.026
purine nucleotide catabolic process GO:0006195 405 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.026
ribonucleoside catabolic process GO:0042454 406 0.025
nucleoside catabolic process GO:0009164 408 0.025
chemical homeostasis GO:0048878 306 0.024
renal water homeostasis GO:0003091 4 0.024
regulation of cellular amino acid metabolic process GO:0006521 6 0.024
organelle assembly GO:0070925 176 0.024
negative regulation of hydrolase activity GO:0051346 182 0.024
tongue development GO:0043586 1 0.024
locomotory behavior GO:0007626 1 0.024
negative regulation of protein metabolic process GO:0051248 391 0.024
vesicle mediated transport GO:0016192 371 0.024
atp metabolic process GO:0046034 176 0.024
actin filament based movement GO:0030048 17 0.023
actin mediated cell contraction GO:0070252 12 0.023
cation transmembrane transport GO:0098655 238 0.023
regulation of protein maturation GO:1903317 150 0.023
nucleoside phosphate catabolic process GO:1901292 412 0.023
response to biotic stimulus GO:0009607 276 0.023
immune effector process GO:0002252 159 0.023
Human
long chain fatty acid metabolic process GO:0001676 30 0.023
sex determination GO:0007530 3 0.023
regulation of protein processing GO:0070613 150 0.023
negative regulation of interferon gamma secretion GO:1902714 1 0.022
small gtpase mediated signal transduction GO:0007264 78 0.022
epithelium migration GO:0090132 119 0.022
Human
purine ribonucleotide catabolic process GO:0009154 404 0.022
protein activation cascade GO:0072376 22 0.022
Human
purine ribonucleoside catabolic process GO:0046130 398 0.022
positive regulation of immune response GO:0050778 159 0.021
Human
organophosphate catabolic process GO:0046434 430 0.021
mapk cascade GO:0000165 288 0.021
lipid biosynthetic process GO:0008610 177 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.021
cellular modified amino acid metabolic process GO:0006575 64 0.021
defense response to fungus GO:0050832 4 0.021
tissue homeostasis GO:0001894 63 0.021
Human
morphogenesis of an epithelium GO:0002009 60 0.021
Human
nucleoside triphosphate metabolic process GO:0009141 422 0.021
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
ion transmembrane transport GO:0034220 338 0.020
blastoderm segmentation GO:0007350 2 0.020
cell activation GO:0001775 213 0.020
Human
alcohol metabolic process GO:0006066 114 0.020
nucleotide catabolic process GO:0009166 408 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
activation of immune response GO:0002253 114 0.020
Human
ras protein signal transduction GO:0007265 73 0.020
regulation of peptidase activity GO:0052547 180 0.020
regulation of cell cycle process GO:0010564 266 0.020
salivary gland morphogenesis GO:0007435 4 0.019
reactive oxygen species biosynthetic process GO:1903409 4 0.019
biological adhesion GO:0022610 331 0.019
cellular macromolecule catabolic process GO:0044265 380 0.019
cellular response to dna damage stimulus GO:0006974 379 0.019
negative regulation of cellular component movement GO:0051271 106 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
cloacal septation GO:0060197 1 0.019
regulation of cellular ketone metabolic process GO:0010565 50 0.019
regulation of cell migration GO:0030334 289 0.019
maintenance of location GO:0051235 112 0.019
regulation of endopeptidase activity GO:0052548 170 0.019
establishment of protein localization to membrane GO:0090150 121 0.018
cellular response to endogenous stimulus GO:0071495 336 0.018
response to organic cyclic compound GO:0014070 204 0.018
reactive nitrogen species metabolic process GO:2001057 3 0.018
muscle cell differentiation GO:0042692 63 0.018
inorganic ion transmembrane transport GO:0098660 231 0.018
regulation of immune response GO:0050776 201 0.018
Human
response to external biotic stimulus GO:0043207 261 0.018
striated muscle cell differentiation GO:0051146 43 0.018
anion transport GO:0006820 161 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
response to abiotic stimulus GO:0009628 336 0.018
female gamete generation GO:0007292 2 0.018
negative regulation of proteolysis GO:0045861 132 0.017
muscle structure development GO:0061061 98 0.017
aging GO:0007568 66 0.017
Human
actin cytoskeleton organization GO:0030036 207 0.017
regulation of cell motility GO:2000145 299 0.017
regulation of cell cycle GO:0051726 393 0.017
purine nucleoside triphosphate catabolic process GO:0009146 392 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
positive regulation of hydrolase activity GO:0051345 331 0.017
molting cycle GO:0042303 28 0.017
Human
anterior posterior axis specification GO:0009948 2 0.017
reactive oxygen species metabolic process GO:0072593 75 0.017
neuromuscular junction development GO:0007528 3 0.017
negative regulation of protein maturation GO:1903318 142 0.017
ameboidal type cell migration GO:0001667 135 0.017
Human
cellular component assembly involved in morphogenesis GO:0010927 73 0.017
somatic stem cell maintenance GO:0035019 4 0.016
response to radiation GO:0009314 151 0.016
endomembrane system organization GO:0010256 196 0.016
striated muscle contraction GO:0006941 52 0.016
transmembrane transport GO:0055085 399 0.016
embryonic forelimb morphogenesis GO:0035115 4 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.016
adult locomotory behavior GO:0008344 1 0.016
mitotic cell cycle GO:0000278 326 0.016
linoleic acid metabolic process GO:0043651 4 0.016
negative regulation of developmental process GO:0051093 247 0.016
spermatid differentiation GO:0048515 4 0.016
carboxylic acid biosynthetic process GO:0046394 97 0.016
cellular macromolecular complex assembly GO:0034622 324 0.016
oocyte development GO:0048599 1 0.016
dephosphorylation GO:0016311 209 0.016
negative regulation of endopeptidase activity GO:0010951 84 0.016
response to fungus GO:0009620 4 0.016
muscle cell development GO:0055001 29 0.016
golgi vesicle transport GO:0048193 80 0.016
regulation of cellular amine metabolic process GO:0033238 11 0.016
cellular response to oxygen containing compound GO:1901701 276 0.016
regulation of nucleotide catabolic process GO:0030811 205 0.016
hair cycle process GO:0022405 12 0.016
Human
nucleoside triphosphate catabolic process GO:0009143 394 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
negative regulation of locomotion GO:0040013 118 0.016
prostate gland development GO:0030850 3 0.016
ribonucleotide catabolic process GO:0009261 405 0.015
positive regulation of phosphorylation GO:0042327 394 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
positive regulation of catabolic process GO:0009896 310 0.015
positive regulation of cellular amine metabolic process GO:0033240 7 0.015
protein oligomerization GO:0051259 173 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
rhythmic behavior GO:0007622 2 0.015
cardiovascular system development GO:0072358 262 0.015
cell morphogenesis GO:0000902 296 0.015
nucleoside monophosphate catabolic process GO:0009125 159 0.015
histone modification GO:0016570 251 0.015
organic acid biosynthetic process GO:0016053 97 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
regulation of mitotic cell cycle GO:0007346 189 0.015
nervous system development GO:0007399 293 0.015
regulation of nucleoside metabolic process GO:0009118 209 0.015
negative regulation of protein processing GO:0010955 142 0.015
protein localization to plasma membrane GO:0072659 93 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
isoprenoid metabolic process GO:0006720 39 0.015
negative regulation of cell proliferation GO:0008285 228 0.015
positive regulation of nucleotide catabolic process GO:0030813 185 0.015
monocarboxylic acid metabolic process GO:0032787 185 0.015
oogenesis GO:0048477 2 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.014
terpenoid metabolic process GO:0006721 27 0.014
regulation of reactive oxygen species metabolic process GO:2000377 41 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
compound eye development GO:0048749 1 0.014
chromatin organization GO:0006325 351 0.014
circadian behavior GO:0048512 2 0.014
cell adhesion GO:0007155 325 0.014
protein catabolic process GO:0030163 325 0.014
mitotic cell cycle process GO:1903047 286 0.014
oxidative stress induced premature senescence GO:0090403 3 0.014
vitamin k catabolic process GO:0042377 2 0.014
coenzyme metabolic process GO:0006732 65 0.014
establishment of protein localization to plasma membrane GO:0090002 68 0.014
regulation of cell differentiation GO:0045595 393 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
response to growth factor GO:0070848 205 0.014
chromatin modification GO:0016568 298 0.014
cardiac muscle cell contraction GO:0086003 4 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
protein acylation GO:0043543 138 0.014
protein localization to organelle GO:0033365 280 0.014
cell growth GO:0016049 160 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
post embryonic organ development GO:0048569 1 0.014
regulation of cytoskeleton organization GO:0051493 177 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
regulation of mapk cascade GO:0043408 262 0.013
cellular protein catabolic process GO:0044257 261 0.013
regulation of male gonad development GO:2000018 4 0.013
positive regulation of dermatome development GO:0061184 3 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
sensory perception of pain GO:0019233 4 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
spermatid development GO:0007286 4 0.013
actomyosin structure organization GO:0031032 59 0.013
response to estrogen GO:0043627 47 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
positive regulation of organelle organization GO:0010638 195 0.013
positive regulation of transport GO:0051050 336 0.013
regulation of cell adhesion GO:0030155 166 0.013
water homeostasis GO:0030104 14 0.013
peripheral nervous system development GO:0007422 2 0.013
canonical wnt signaling pathway involved in osteoblast differentiation GO:0044339 2 0.013
cellular protein complex assembly GO:0043623 188 0.013
regulation of transferase activity GO:0051338 355 0.013
hindlimb morphogenesis GO:0035137 2 0.013
defense response to other organism GO:0098542 129 0.013
signal transduction by phosphorylation GO:0023014 297 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.012
regulation of secretion GO:0051046 194 0.012
morphogenesis of embryonic epithelium GO:0016331 4 0.012
cofactor metabolic process GO:0051186 87 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
negative regulation of cell migration GO:0030336 102 0.012
regulation of protein catabolic process GO:0042176 155 0.012
forebrain regionalization GO:0021871 3 0.012
embryonic epithelial tube formation GO:0001838 4 0.012
oocyte differentiation GO:0009994 2 0.012
muscle system process GO:0003012 81 0.012
response to wounding GO:0009611 168 0.012
Zebrafish
pulmonary valve formation GO:0003193 1 0.012
negative regulation of cell motility GO:2000146 104 0.012
cellular hormone metabolic process GO:0034754 41 0.012
covalent chromatin modification GO:0016569 254 0.012
nitrogen compound transport GO:0071705 191 0.012
mitochondrion organization GO:0007005 156 0.012
negative regulation of androgen biosynthetic process GO:2000180 1 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
plasma membrane organization GO:0007009 115 0.012
positive regulation of kinase activity GO:0033674 204 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
keratinocyte proliferation GO:0043616 17 0.012
Human
microtubule based process GO:0007017 210 0.012
phylloquinone metabolic process GO:0042374 2 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
regulation of response to external stimulus GO:0032101 222 0.012
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.012
negative regulation of transport GO:0051051 176 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
positive regulation of cellular component movement GO:0051272 181 0.012
cell projection organization GO:0030030 252 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
menaquinone catabolic process GO:0042361 2 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
regulation of gtpase activity GO:0043087 180 0.012
response to virus GO:0009615 126 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
regulation of actin filament based process GO:0032970 141 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
tube development GO:0035295 125 0.012
response to hormone GO:0009725 175 0.012
positive regulation of programmed cell death GO:0043068 249 0.011
tripartite regional subdivision GO:0007351 2 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
lipid localization GO:0010876 106 0.011
circulatory system development GO:0072359 262 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
startle response GO:0001964 3 0.011
vitamin e metabolic process GO:0042360 1 0.011
negative regulation of catabolic process GO:0009895 104 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
regulation of hormone levels GO:0010817 125 0.011
ion homeostasis GO:0050801 230 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
response to cytokine GO:0034097 232 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
neuroblast proliferation GO:0007405 4 0.011
atp catabolic process GO:0006200 157 0.011
fatty acid derivative catabolic process GO:1901569 2 0.011
glycerolipid metabolic process GO:0046486 107 0.011
protein targeting GO:0006605 187 0.011
hindbrain development GO:0030902 3 0.011
isoquinoline alkaloid metabolic process GO:0033076 1 0.011
cell cycle checkpoint GO:0000075 117 0.011
positive regulation of cell differentiation GO:0045597 211 0.011
leukotriene catabolic process GO:0036100 2 0.011
regulation of growth GO:0040008 165 0.011
response to activity GO:0014823 0 0.011
regulation of multi organism process GO:0043900 157 0.011
cardiac muscle contraction GO:0060048 34 0.011
interspecies interaction between organisms GO:0044419 156 0.011
blastocyst development GO:0001824 3 0.011
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 4 0.011
protein modification by small protein removal GO:0070646 92 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
response to axon injury GO:0048678 1 0.011
purine nucleoside monophosphate catabolic process GO:0009128 158 0.011
rna processing GO:0006396 255 0.011
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.011
regulation of body fluid levels GO:0050878 99 0.011
cell division GO:0051301 168 0.011
limbic system development GO:0021761 3 0.011
response to transforming growth factor beta GO:0071559 94 0.011
monocarboxylic acid biosynthetic process GO:0072330 67 0.011
cellular response to lipid GO:0071396 127 0.011
myosin filament assembly GO:0031034 2 0.011
positive regulation of cell cycle process GO:0090068 106 0.011
positive regulation of cell death GO:0010942 263 0.011
steroid metabolic process GO:0008202 94 0.011
cell cycle phase transition GO:0044770 173 0.011
negative regulation of cell cycle phase transition GO:1901988 89 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.010
protein ubiquitination GO:0016567 314 0.010
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.010
gtp catabolic process GO:0006184 237 0.010
positive regulation of mapk cascade GO:0043410 190 0.010
myosin filament organization GO:0031033 2 0.010
vitamin k biosynthetic process GO:0042371 2 0.010
positive regulation of transferase activity GO:0051347 227 0.010
somitogenesis GO:0001756 2 0.010
regulation of glial cell proliferation GO:0060251 4 0.010
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.010
av node cell to bundle of his cell communication GO:0086067 4 0.010
regulation of actin cytoskeleton organization GO:0032956 116 0.010
inorganic anion transmembrane transport GO:0098661 47 0.010
hepoxilin biosynthetic process GO:0051122 1 0.010
anion transmembrane transport GO:0098656 76 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
regulation of mitotic cell cycle phase transition GO:1901990 118 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010
response to decreased oxygen levels GO:0036293 96 0.010
regulation of protein transport GO:0051223 213 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
negative regulation of phosphate metabolic process GO:0045936 267 0.010
regulation of cellular response to stress GO:0080135 244 0.010
protein homooligomerization GO:0051260 100 0.010
rho protein signal transduction GO:0007266 26 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
post golgi vesicle mediated transport GO:0006892 36 0.010

KRT4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.040
sensory system disease DOID:0050155 203 0.040
nervous system disease DOID:863 431 0.040
musculoskeletal system disease DOID:17 223 0.028
eye and adnexa disease DOID:1492 150 0.026
inherited metabolic disorder DOID:655 242 0.024
eye disease DOID:5614 149 0.023
retinal disease DOID:5679 118 0.023
skin disease DOID:37 33 0.021
integumentary system disease DOID:16 43 0.021
central nervous system disease DOID:331 186 0.019
cancer DOID:162 167 0.017
disease of cellular proliferation DOID:14566 174 0.017
organ system cancer DOID:0050686 164 0.017
retinal degeneration DOID:8466 89 0.015
bone disease DOID:0080001 88 0.013
connective tissue disease DOID:65 109 0.013
muscular disease DOID:0080000 114 0.011
muscle tissue disease DOID:66 113 0.011
auditory system disease DOID:2742 53 0.010