Homo sapiens

54 known processes

TPX2

TPX2, microtubule-associated, homolog (Xenopus laevis)

(Aliases: REPP86,HCA519,HCTP4,p100,FLS353,GD:C20orf1,C20orf2,C20orf1,DIL-2,DIL2)

TPX2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic nuclear division GO:0007067 119 0.887
nuclear division GO:0000280 128 0.850
sister chromatid segregation GO:0000819 54 0.848
organelle fission GO:0048285 149 0.740
spindle midzone assembly GO:0051255 4 0.736
mitotic spindle midzone assembly GO:0051256 4 0.695
spindle assembly involved in mitosis GO:0090307 12 0.694
microtubule cytoskeleton organization GO:0000226 176 0.681
spindle assembly GO:0051225 29 0.662
cytokinesis GO:0000910 96 0.632
mitotic sister chromatid segregation GO:0000070 53 0.629
microtubule based process GO:0007017 210 0.600
regulation of cell cycle GO:0051726 393 0.595
mitotic cell cycle GO:0000278 326 0.568
mitotic cell cycle process GO:1903047 286 0.549
chromosome segregation GO:0007059 114 0.539
meiotic chromosome segregation GO:0045132 4 0.534
cytoskeleton dependent cytokinesis GO:0061640 22 0.526
spindle elongation GO:0051231 4 0.473
microtubule polymerization or depolymerization GO:0031109 37 0.404
single organism cellular localization GO:1902580 332 0.401
mitotic spindle elongation GO:0000022 4 0.336
cellular protein complex disassembly GO:0043624 36 0.321
establishment of organelle localization GO:0051656 59 0.302
spindle organization GO:0007051 53 0.288
establishment of nucleus localization GO:0040023 1 0.287
cellular macromolecular complex assembly GO:0034622 324 0.282
ubiquitin dependent protein catabolic process GO:0006511 206 0.242
purine nucleoside monophosphate catabolic process GO:0009128 158 0.236
atp catabolic process GO:0006200 157 0.221
ribonucleoside triphosphate catabolic process GO:0009203 391 0.221
dna conformation change GO:0071103 113 0.212
nucleus localization GO:0051647 1 0.202
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.195
mitotic spindle organization GO:0007052 27 0.194
cellular macromolecule catabolic process GO:0044265 380 0.192
organelle localization GO:0051640 84 0.185
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.183
establishment of spindle localization GO:0051293 12 0.182
regulation of microtubule based process GO:0032886 74 0.179
cell division GO:0051301 168 0.171
regulation of spindle organization GO:0090224 10 0.163
spindle stabilization GO:0043146 4 0.162
cellular protein complex assembly GO:0043623 188 0.162
nucleoside triphosphate catabolic process GO:0009143 394 0.158
mitotic cytokinesis GO:0000281 19 0.158
microtubule anchoring GO:0034453 24 0.154
positive regulation of cell cycle GO:0045787 140 0.153
regulation of mitotic cell cycle GO:0007346 189 0.150
nuclear migration GO:0007097 1 0.147
regulation of cell cycle process GO:0010564 266 0.139
negative regulation of cellular component organization GO:0051129 235 0.133
nucleoside triphosphate metabolic process GO:0009141 422 0.131
microtubule nucleation GO:0007020 6 0.129
regulation of chromosome segregation GO:0051983 44 0.125
ribonucleoside monophosphate metabolic process GO:0009161 187 0.123
purine ribonucleotide catabolic process GO:0009154 404 0.122
regulation of cytoplasmic transport GO:1903649 149 0.115
mitotic cell cycle phase transition GO:0044772 162 0.112
ribonucleoside catabolic process GO:0042454 406 0.112
centrosome organization GO:0051297 58 0.109
regulation of protein localization GO:0032880 296 0.106
ribonucleotide catabolic process GO:0009261 405 0.104
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.104
oocyte differentiation GO:0009994 2 0.104
meiotic nuclear division GO:0007126 10 0.103
regulation of mitotic sister chromatid segregation GO:0033047 27 0.099
ribonucleoside triphosphate metabolic process GO:0009199 412 0.099
chromatin organization GO:0006325 351 0.097
maintenance of location in cell GO:0051651 62 0.096
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.096
organelle assembly GO:0070925 176 0.095
negative regulation of cell cycle GO:0045786 193 0.091
dna packaging GO:0006323 77 0.091
macromolecular complex disassembly GO:0032984 60 0.088
single fertilization GO:0007338 11 0.086
meiosis i GO:0007127 4 0.083
female gamete generation GO:0007292 2 0.082
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.079
purine nucleoside triphosphate catabolic process GO:0009146 392 0.077
regulation of microtubule cytoskeleton organization GO:0070507 61 0.076
nucleoside monophosphate catabolic process GO:0009125 159 0.075
protein depolymerization GO:0051261 30 0.075
nucleoside catabolic process GO:0009164 408 0.075
nucleoside monophosphate metabolic process GO:0009123 191 0.075
maintenance of location GO:0051235 112 0.074
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.073
modification dependent macromolecule catabolic process GO:0043632 212 0.073
nervous system development GO:0007399 293 0.072
purine nucleoside monophosphate metabolic process GO:0009126 186 0.071
chromatin modification GO:0016568 298 0.068
protein processing GO:0016485 226 0.066
nucleotide catabolic process GO:0009166 408 0.066
positive regulation of developmental process GO:0051094 314 0.065
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.064
intracellular protein transport GO:0006886 270 0.063
organophosphate catabolic process GO:0046434 430 0.062
purine ribonucleoside catabolic process GO:0046130 398 0.062
nucleocytoplasmic transport GO:0006913 176 0.061
cell cycle phase transition GO:0044770 173 0.060
protein complex disassembly GO:0043241 52 0.060
cell development GO:0048468 328 0.060
regulation of cytokinesis GO:0032465 45 0.060
cellular response to dna damage stimulus GO:0006974 379 0.059
protein maturation GO:0051604 233 0.058
post embryonic development GO:0009791 2 0.056
purine nucleoside catabolic process GO:0006152 398 0.056
regulation of cellular component biogenesis GO:0044087 281 0.056
positive regulation of cell cycle process GO:0090068 106 0.055
positive regulation of cellular component organization GO:0051130 376 0.055
nucleoside phosphate catabolic process GO:1901292 412 0.054
cellular amino acid metabolic process GO:0006520 116 0.053
oogenesis GO:0048477 2 0.052
regulation of cell differentiation GO:0045595 393 0.052
regulation of cytoskeleton organization GO:0051493 177 0.052
cell morphogenesis GO:0000902 296 0.051
purine ribonucleoside metabolic process GO:0046128 437 0.051
regulation of intracellular protein transport GO:0033157 123 0.051
positive regulation of proteolysis GO:0045862 142 0.049
regulation of cell division GO:0051302 116 0.049
regeneration GO:0031099 4 0.049
negative regulation of protein metabolic process GO:0051248 391 0.048
regulation of establishment of protein localization GO:0070201 242 0.047
mitotic centrosome separation GO:0007100 1 0.047
protein dephosphorylation GO:0006470 81 0.047
purine containing compound catabolic process GO:0072523 411 0.046
regulation of nucleocytoplasmic transport GO:0046822 98 0.045
regulation of cell cycle phase transition GO:1901987 126 0.045
regulation of protein localization to nucleus GO:1900180 85 0.044
glycosyl compound catabolic process GO:1901658 413 0.044
cellular component disassembly GO:0022411 92 0.044
maintenance of protein location GO:0045185 57 0.044
ras protein signal transduction GO:0007265 73 0.042
protein import into nucleus GO:0006606 104 0.042
positive regulation of cytokinesis GO:0032467 29 0.042
purine nucleoside triphosphate metabolic process GO:0009144 412 0.042
microtubule organizing center organization GO:0031023 62 0.042
positive regulation of protein transport GO:0051222 135 0.041
positive regulation of transferase activity GO:0051347 227 0.041
negative regulation of proteolysis GO:0045861 132 0.040
vesicle mediated transport GO:0016192 371 0.039
microtubule depolymerization GO:0007019 18 0.039
centrosome duplication GO:0051298 28 0.038
histone modification GO:0016570 251 0.038
proteasomal protein catabolic process GO:0010498 176 0.037
microtubule based movement GO:0007018 32 0.037
establishment of cell polarity GO:0030010 22 0.037
protein catabolic process GO:0030163 325 0.037
protein targeting to nucleus GO:0044744 104 0.036
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.036
negative regulation of cellular protein metabolic process GO:0032269 353 0.035
regulation of intracellular transport GO:0032386 195 0.035
protein localization to nucleus GO:0034504 136 0.035
establishment of spindle orientation GO:0051294 9 0.034
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.034
centrosome separation GO:0051299 3 0.033
protein targeting GO:0006605 187 0.033
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.033
dephosphorylation GO:0016311 209 0.033
single organism reproductive process GO:0044702 98 0.033
anatomical structure formation involved in morphogenesis GO:0048646 284 0.033
small gtpase mediated signal transduction GO:0007264 78 0.033
establishment or maintenance of cell polarity GO:0007163 31 0.032
negative regulation of mitotic cell cycle GO:0045930 102 0.032
negative regulation of protein complex disassembly GO:0043242 20 0.032
embryo development GO:0009790 123 0.032
protein polymerization GO:0051258 71 0.032
cell projection organization GO:0030030 252 0.032
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.031
modification dependent protein catabolic process GO:0019941 209 0.031
regulation of protein polymerization GO:0032271 63 0.031
response to hormone GO:0009725 175 0.031
chromosome condensation GO:0030261 15 0.031
positive regulation of catabolic process GO:0009896 310 0.030
nuclear import GO:0051170 106 0.030
negative regulation of cell cycle process GO:0010948 121 0.029
regulation of transferase activity GO:0051338 355 0.029
negative regulation of peptidase activity GO:0010466 91 0.029
mitotic sister chromatid separation GO:0051306 18 0.029
reproduction GO:0000003 63 0.029
regulation of transcription factor import into nucleus GO:0042990 39 0.028
attachment of spindle microtubules to kinetochore GO:0008608 17 0.028
ribonucleoside monophosphate catabolic process GO:0009158 158 0.028
meiotic cell cycle GO:0051321 13 0.028
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.027
cellular component morphogenesis GO:0032989 314 0.027
regulation of nuclear division GO:0051783 65 0.027
cytoplasmic transport GO:0016482 379 0.027
positive regulation of mitosis GO:0045840 25 0.027
protein localization to organelle GO:0033365 280 0.027
establishment of protein localization to organelle GO:0072594 172 0.027
response to organic cyclic compound GO:0014070 204 0.027
regulation of proteolysis GO:0030162 293 0.026
regulation of mitotic spindle organization GO:0060236 6 0.026
protein ubiquitination GO:0016567 314 0.026
negative regulation of protein processing GO:0010955 142 0.026
mrna processing GO:0006397 133 0.026
neurogenesis GO:0022008 169 0.025
positive regulation of cellular catabolic process GO:0031331 284 0.025
sister chromatid biorientation GO:0031134 2 0.024
cellular homeostasis GO:0019725 196 0.024
reproductive process GO:0022414 106 0.024
cellular ketone metabolic process GO:0042180 80 0.024
regulation of protein complex assembly GO:0043254 147 0.024
positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 2 0.024
response to oxygen containing compound GO:1901700 369 0.024
metaphase plate congression GO:0051310 18 0.023
negative regulation of hydrolase activity GO:0051346 182 0.023
covalent chromatin modification GO:0016569 254 0.023
regulation of kinase activity GO:0043549 314 0.023
regulation of binding GO:0051098 111 0.023
reciprocal dna recombination GO:0035825 4 0.023
regulation of protein import into nucleus GO:0042306 78 0.022
regulation of protein processing GO:0070613 150 0.022
purine nucleotide catabolic process GO:0006195 405 0.021
intracellular mrna localization GO:0008298 1 0.021
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.021
negative regulation of phosphorus metabolic process GO:0010563 267 0.021
dna recombination GO:0006310 77 0.021
histone serine phosphorylation GO:0035404 4 0.020
dna repair GO:0006281 198 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
neuroblast proliferation GO:0007405 4 0.020
anterior posterior axis specification GO:0009948 2 0.020
lung cell differentiation GO:0060479 1 0.020
neuron differentiation GO:0030182 138 0.019
negative regulation of organelle organization GO:0010639 126 0.019
regulation of purine nucleotide catabolic process GO:0033121 205 0.019
positive regulation of cell division GO:0051781 59 0.019
circulatory system development GO:0072359 262 0.019
positive regulation of exit from mitosis GO:0031536 2 0.019
oocyte development GO:0048599 1 0.019
growth GO:0040007 202 0.019
cell cycle checkpoint GO:0000075 117 0.019
cardiovascular system development GO:0072358 262 0.018
protein import GO:0017038 130 0.018
coenzyme metabolic process GO:0006732 65 0.018
negative regulation of cell death GO:0060548 345 0.018
regulation of peptidase activity GO:0052547 180 0.018
blood vessel morphogenesis GO:0048514 162 0.018
cellular amine metabolic process GO:0044106 41 0.018
endocytosis GO:0006897 159 0.018
oocyte maturation GO:0001556 1 0.018
cell morphogenesis involved in differentiation GO:0000904 144 0.018
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.018
response to organophosphorus GO:0046683 41 0.018
protein modification by small protein conjugation GO:0032446 342 0.017
developmental growth GO:0048589 48 0.017
cell part morphogenesis GO:0032990 137 0.017
regulation of mitotic cell cycle phase transition GO:1901990 118 0.017
fertilization GO:0009566 12 0.017
regulation of cellular protein catabolic process GO:1903362 96 0.017
regulation of cellular amine metabolic process GO:0033238 11 0.017
regulation of cell development GO:0060284 161 0.017
blastocyst development GO:0001824 3 0.017
regulation of multi organism process GO:0043900 157 0.017
negative regulation of programmed cell death GO:0043069 321 0.017
chromosome separation GO:0051304 23 0.017
determination of adult lifespan GO:0008340 2 0.017
positive regulation of intracellular transport GO:0032388 104 0.017
signal transduction by phosphorylation GO:0023014 297 0.017
response to nitrogen compound GO:1901698 184 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.017
single organism nuclear import GO:1902593 104 0.017
regulation of protein transport GO:0051223 213 0.016
epithelium development GO:0060429 227 0.016
negative regulation of protein maturation GO:1903318 142 0.016
generation of neurons GO:0048699 152 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
positive regulation of transport GO:0051050 336 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
regulation of protein catabolic process GO:0042176 155 0.016
nucleotide biosynthetic process GO:0009165 109 0.016
negative regulation of endopeptidase activity GO:0010951 84 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
microtubule polymerization GO:0046785 18 0.016
regulation of protein maturation GO:1903317 150 0.015
somatic stem cell division GO:0048103 1 0.015
immune system development GO:0002520 195 0.015
peptidyl threonine modification GO:0018210 45 0.015
negative regulation of transport GO:0051051 176 0.015
neuron development GO:0048666 113 0.015
positive regulation of mitotic sister chromatid separation GO:1901970 6 0.015
spindle checkpoint GO:0031577 26 0.015
single organism membrane organization GO:0044802 268 0.015
regulation of nervous system development GO:0051960 88 0.015
negative regulation of cell differentiation GO:0045596 171 0.015
ribosome assembly GO:0042255 9 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.014
peptidyl serine phosphorylation GO:0018105 101 0.014
response to drug GO:0042493 81 0.014
positive regulation of chromosome organization GO:2001252 41 0.014
regulation of mitotic sister chromatid separation GO:0010965 27 0.014
establishment of chromosome localization GO:0051303 20 0.014
regulation of protein targeting GO:1903533 91 0.014
response to hypoxia GO:0001666 96 0.014
cytokinesis completion of separation GO:0007109 3 0.014
posttranscriptional regulation of gene expression GO:0010608 213 0.014
regulation of small gtpase mediated signal transduction GO:0051056 156 0.014
mapk cascade GO:0000165 288 0.014
regulation of cellular ketone metabolic process GO:0010565 50 0.014
regulation of response to dna damage stimulus GO:2001020 94 0.013
histone phosphorylation GO:0016572 16 0.013
positive regulation of organelle organization GO:0010638 195 0.013
regulation of chromosome organization GO:0033044 103 0.013
reciprocal meiotic recombination GO:0007131 4 0.013
regulation of protein stability GO:0031647 87 0.013
positive regulation of phosphorylation GO:0042327 394 0.013
maintenance of protein location in cell GO:0032507 56 0.013
negative regulation of cell cycle phase transition GO:1901988 89 0.013
regulation of proteasomal protein catabolic process GO:0061136 87 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
cell projection morphogenesis GO:0048858 129 0.012
regulation of cellular amino acid metabolic process GO:0006521 6 0.012
regulation of cellular response to stress GO:0080135 244 0.012
response to purine containing compound GO:0014074 40 0.012
peptidyl serine modification GO:0018209 106 0.012
male meiosis GO:0007140 1 0.012
reproductive structure development GO:0048608 55 0.012
regulation of protein binding GO:0043393 66 0.012
multi organism reproductive process GO:0044703 54 0.012
negative regulation of cytoskeleton organization GO:0051494 45 0.012
actin filament based process GO:0030029 224 0.012
secretion GO:0046903 254 0.012
mitotic chromosome condensation GO:0007076 11 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.011
positive regulation of intracellular protein transport GO:0090316 76 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
cytokinetic process GO:0032506 12 0.011
atp metabolic process GO:0046034 176 0.011
response to radiation GO:0009314 151 0.011
protein polyubiquitination GO:0000209 110 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
regulation of mitosis GO:0007088 63 0.011
microtubule bundle formation GO:0001578 15 0.011
positive regulation of protein polymerization GO:0032273 45 0.011
protein localization to chromosome centromeric region GO:0071459 12 0.011
stress activated protein kinase signaling cascade GO:0031098 94 0.011
actin cytoskeleton organization GO:0030036 207 0.011
cellular lipid metabolic process GO:0044255 303 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
positive regulation of protein kinase activity GO:0045860 190 0.010
tube morphogenesis GO:0035239 95 0.010
anatomical structure homeostasis GO:0060249 100 0.010
neuroblast division GO:0055057 1 0.010
positive regulation of kinase activity GO:0033674 204 0.010
defense response GO:0006952 315 0.010
response to oxygen levels GO:0070482 100 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.010
regulation of cell adhesion GO:0030155 166 0.010
chemical homeostasis GO:0048878 306 0.010
positive regulation of nuclear division GO:0051785 27 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
endomembrane system organization GO:0010256 196 0.010
response to light stimulus GO:0009416 87 0.010

TPX2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.258
cancer DOID:162 167 0.173
organ system cancer DOID:0050686 164 0.041
breast cancer DOID:1612 21 0.014
thoracic cancer DOID:5093 21 0.014
gastrointestinal system cancer DOID:3119 52 0.013