Homo sapiens

274 known processes

SPHK1

sphingosine kinase 1

(Aliases: SPHK)

SPHK1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of keratinocyte migration GO:0051547 4 0.564
response to cytokine GO:0034097 232 0.280
cytokine production GO:0001816 247 0.265
Mouse
positive regulation of cell motility GO:2000147 177 0.262
cell substrate adhesion GO:0031589 132 0.258
positive regulation of cellular amine metabolic process GO:0033240 7 0.252
regulation of cellular component movement GO:0051270 334 0.241
positive regulation of cell proliferation GO:0008284 301 0.225
biological adhesion GO:0022610 331 0.222
regulation of cellular ketone metabolic process GO:0010565 50 0.221
defense response GO:0006952 315 0.221
Mouse
positive regulation of protein phosphorylation GO:0001934 313 0.214
Rat
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.211
extrinsic apoptotic signaling pathway GO:0097191 119 0.208
organ morphogenesis GO:0009887 147 0.208
regulation of anatomical structure morphogenesis GO:0022603 286 0.204
apoptotic signaling pathway GO:0097190 268 0.203
anatomical structure formation involved in morphogenesis GO:0048646 284 0.197
vasculature development GO:0001944 181 0.196
cellular amino acid metabolic process GO:0006520 116 0.188
cellular amine metabolic process GO:0044106 41 0.174
regulation of peptidase activity GO:0052547 180 0.171
immune response GO:0006955 307 0.164
angiogenesis involved in wound healing GO:0060055 4 0.158
kinin cascade GO:0002254 1 0.153
regulation of cellular amino acid metabolic process GO:0006521 6 0.143
amine metabolic process GO:0009308 44 0.142
cellular component morphogenesis GO:0032989 314 0.141
regulation of proteolysis GO:0030162 293 0.140
positive regulation of keratinocyte migration GO:0051549 4 0.140
regulation of locomotion GO:0040012 329 0.136
regulation of cytokine production GO:0001817 232 0.133
Mouse
protein maturation GO:0051604 233 0.133
post embryonic development GO:0009791 2 0.132
positive regulation of cell migration GO:0030335 172 0.131
cellular response to endogenous stimulus GO:0071495 336 0.128
positive regulation of cell death GO:0010942 263 0.125
response to organic cyclic compound GO:0014070 204 0.122
Rat
regulation of defense response GO:0031347 154 0.122
single organismal cell cell adhesion GO:0016337 148 0.118
cellular response to biotic stimulus GO:0071216 71 0.118
cardiovascular system development GO:0072358 262 0.114
positive regulation of immune system process GO:0002684 283 0.112
regulation of cellular component biogenesis GO:0044087 281 0.111
regeneration GO:0031099 4 0.109
positive regulation of fibrinolysis GO:0051919 4 0.109
negative regulation of cell death GO:0060548 345 0.108
regulation of cell adhesion GO:0030155 166 0.107
regulation of apoptotic signaling pathway GO:2001233 175 0.107
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.107
regulation of leukocyte migration GO:0002685 63 0.104
cell matrix adhesion GO:0007160 85 0.104
blood vessel morphogenesis GO:0048514 162 0.104
regulation of protein localization GO:0032880 296 0.103
innate immune response GO:0045087 178 0.102
regulation of cell motility GO:2000145 299 0.100
response to abiotic stimulus GO:0009628 336 0.100
enzyme linked receptor protein signaling pathway GO:0007167 303 0.100
circulatory system development GO:0072359 262 0.097
positive regulation of defense response GO:0031349 87 0.095
i kappab kinase nf kappab signaling GO:0007249 166 0.094
regulation of response to wounding GO:1903034 101 0.094
response to inorganic substance GO:0010035 127 0.094
Rat
response to oxygen containing compound GO:1901700 369 0.094
Rat
regulation of endopeptidase activity GO:0052548 170 0.093
positive regulation of developmental process GO:0051094 314 0.093
cell adhesion GO:0007155 325 0.092
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.092
negative regulation of apoptotic process GO:0043066 316 0.092
regulation of cellular amine metabolic process GO:0033238 11 0.092
positive regulation of phosphorylation GO:0042327 394 0.091
Rat
positive regulation of cellular component movement GO:0051272 181 0.090
positive regulation of locomotion GO:0040017 186 0.089
protein processing GO:0016485 226 0.089
response to biotic stimulus GO:0009607 276 0.085
ion transmembrane transport GO:0034220 338 0.083
leukotriene production involved in inflammatory response GO:0002540 1 0.082
cellular response to oxygen containing compound GO:1901701 276 0.081
Rat
positive regulation of apoptotic process GO:0043065 246 0.080
positive regulation of programmed cell death GO:0043068 249 0.079
response to bacterium GO:0009617 144 0.079
negative regulation of plasminogen activation GO:0010757 4 0.072
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.072
female gamete generation GO:0007292 2 0.072
cellular ketone metabolic process GO:0042180 80 0.071
cellular response to lipid GO:0071396 127 0.071
response to organonitrogen compound GO:0010243 156 0.071
Rat
purine nucleotide catabolic process GO:0006195 405 0.070
positive regulation of hydrolase activity GO:0051345 331 0.070
regulation of cell migration GO:0030334 289 0.070
regulation of nucleotide metabolic process GO:0006140 269 0.070
negative regulation of hydrolase activity GO:0051346 182 0.070
cell development GO:0048468 328 0.069
Rat
negative regulation of programmed cell death GO:0043069 321 0.069
negative regulation of catalytic activity GO:0043086 335 0.069
cell morphogenesis GO:0000902 296 0.068
response to wounding GO:0009611 168 0.067
regulation of angiogenesis GO:0045765 92 0.067
plasminogen activation GO:0031639 11 0.067
taxis GO:0042330 157 0.066
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.066
immune response activating signal transduction GO:0002757 90 0.066
negative regulation of cellular protein metabolic process GO:0032269 353 0.065
rho protein signal transduction GO:0007266 26 0.064
positive regulation of cellular component organization GO:0051130 376 0.064
Rat
inflammatory response GO:0006954 79 0.063
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.061
cell projection organization GO:0030030 252 0.061
Rat
regulation of response to external stimulus GO:0032101 222 0.061
negative regulation of apoptotic signaling pathway GO:2001234 97 0.060
response to mechanical stimulus GO:0009612 51 0.059
nervous system development GO:0007399 293 0.057
Mouse Rat
regulation of immune response GO:0050776 201 0.057
regulation of purine nucleotide metabolic process GO:1900542 264 0.056
leukocyte migration GO:0050900 107 0.055
regulation of protein processing GO:0070613 150 0.055
negative regulation of cell proliferation GO:0008285 228 0.055
cell activation GO:0001775 213 0.053
small gtpase mediated signal transduction GO:0007264 78 0.053
single organism carbohydrate metabolic process GO:0044723 193 0.052
actin filament based process GO:0030029 224 0.052
purine nucleoside triphosphate metabolic process GO:0009144 412 0.051
peptidyl tyrosine modification GO:0018212 170 0.050
negative regulation of proteolysis GO:0045861 132 0.050
organonitrogen compound biosynthetic process GO:1901566 200 0.050
nucleotide catabolic process GO:0009166 408 0.050
tissue morphogenesis GO:0048729 96 0.050
signal transduction by phosphorylation GO:0023014 297 0.049
negative regulation of multicellular organismal process GO:0051241 317 0.049
carbohydrate metabolic process GO:0005975 207 0.049
negative regulation of cellular component organization GO:0051129 235 0.049
cellular macromolecular complex assembly GO:0034622 324 0.048
response to molecule of bacterial origin GO:0002237 82 0.048
locomotory behavior GO:0007626 1 0.048
positive regulation of immune response GO:0050778 159 0.047
regulation of reactive oxygen species metabolic process GO:2000377 41 0.047
cellular response to external stimulus GO:0071496 111 0.046
Rat
vascular wound healing GO:0061042 4 0.046
sensory perception of smell GO:0007608 2 0.046
response to lipopolysaccharide GO:0032496 70 0.046
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.045
regulation of wound healing GO:0061041 56 0.045
regulation of protein complex assembly GO:0043254 147 0.045
regulation of transferase activity GO:0051338 355 0.045
regulation of cell differentiation GO:0045595 393 0.045
Rat
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.044
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.043
negative regulation of protein processing GO:0010955 142 0.043
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.043
wound healing GO:0042060 115 0.043
negative regulation of developmental process GO:0051093 247 0.043
receptor metabolic process GO:0043112 81 0.042
growth GO:0040007 202 0.042
erk1 and erk2 cascade GO:0070371 104 0.041
response to external biotic stimulus GO:0043207 261 0.041
cellular response to mechanical stimulus GO:0071260 39 0.041
negative regulation of peptidase activity GO:0010466 91 0.041
ribonucleotide catabolic process GO:0009261 405 0.040
neuromuscular junction development GO:0007528 3 0.040
system process GO:0003008 349 0.040
regulation of binding GO:0051098 111 0.040
ribonucleoside triphosphate catabolic process GO:0009203 391 0.040
regulation of protein kinase activity GO:0045859 289 0.040
regulation of establishment of protein localization GO:0070201 242 0.040
cellular macromolecule catabolic process GO:0044265 380 0.039
peptidyl tyrosine phosphorylation GO:0018108 170 0.039
protein catabolic process GO:0030163 325 0.039
regulation of astrocyte differentiation GO:0048710 3 0.039
negative regulation of protein metabolic process GO:0051248 391 0.039
gtp metabolic process GO:0046039 239 0.038
purine ribonucleoside catabolic process GO:0046130 398 0.038
carbohydrate derivative biosynthetic process GO:1901137 207 0.038
cellular response to interleukin 1 GO:0071347 35 0.038
response to increased oxygen levels GO:0036296 4 0.038
neurogenesis GO:0022008 169 0.037
Rat
response to lipid GO:0033993 206 0.037
Rat
formation of primary germ layer GO:0001704 42 0.037
purine containing compound catabolic process GO:0072523 411 0.037
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.037
cellular response to cytokine stimulus GO:0071345 181 0.037
regulation of multi organism process GO:0043900 157 0.037
positive regulation of response to external stimulus GO:0032103 88 0.036
endothelial cell apoptotic process GO:0072577 26 0.036
immune response regulating signaling pathway GO:0002764 97 0.036
regulation of nucleoside metabolic process GO:0009118 209 0.036
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.036
nucleoside triphosphate catabolic process GO:0009143 394 0.036
hemopoiesis GO:0030097 180 0.036
regulation of cell morphogenesis GO:0022604 153 0.036
purine nucleoside catabolic process GO:0006152 398 0.036
cyclic nucleotide metabolic process GO:0009187 82 0.036
myeloid cell differentiation GO:0030099 117 0.036
positive regulation of mapk cascade GO:0043410 190 0.036
angiogenesis GO:0001525 147 0.035
regulation of cell substrate adhesion GO:0010810 68 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.034
ribonucleoside triphosphate metabolic process GO:0009199 412 0.034
positive regulation of odontogenesis GO:0042482 3 0.034
regulation of cysteine type endopeptidase activity GO:2000116 127 0.033
response to hormone GO:0009725 175 0.033
Rat
protein localization to membrane GO:0072657 160 0.033
purine ribonucleotide catabolic process GO:0009154 404 0.033
cellular response to hormone stimulus GO:0032870 125 0.033
multi organism cellular process GO:0044764 156 0.033
response to extracellular stimulus GO:0009991 85 0.033
Rat
negative regulation of intracellular signal transduction GO:1902532 183 0.032
vesicle mediated transport GO:0016192 371 0.032
activation of immune response GO:0002253 114 0.032
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.032
response to other organism GO:0051707 261 0.032
positive regulation of acute inflammatory response GO:0002675 2 0.032
negative regulation of endopeptidase activity GO:0010951 84 0.032
ameboidal type cell migration GO:0001667 135 0.031
regulation of kinase activity GO:0043549 314 0.031
cellular response to growth factor stimulus GO:0071363 197 0.031
Rat
positive regulation of macrophage chemotaxis GO:0010759 3 0.031
cell chemotaxis GO:0060326 112 0.031
positive regulation of gtpase activity GO:0043547 166 0.031
interspecies interaction between organisms GO:0044419 156 0.031
tissue regeneration GO:0042246 3 0.030
viral process GO:0016032 146 0.030
oxidation reduction process GO:0055114 396 0.030
response to oxidative stress GO:0006979 121 0.030
Rat
regulation of body fluid levels GO:0050878 99 0.030
regulation of plasminogen activation GO:0010755 7 0.030
regulation of fibrinolysis GO:0051917 8 0.030
positive regulation of apoptotic signaling pathway GO:2001235 70 0.030
reproductive process GO:0022414 106 0.030
Rat
tube morphogenesis GO:0035239 95 0.030
compound eye development GO:0048749 1 0.029
negative regulation of phosphorus metabolic process GO:0010563 267 0.029
chemical homeostasis GO:0048878 306 0.029
viral life cycle GO:0019058 132 0.029
response to reactive oxygen species GO:0000302 61 0.029
Rat
activation of innate immune response GO:0002218 55 0.029
mapk cascade GO:0000165 288 0.029
cellular protein catabolic process GO:0044257 261 0.029
positive regulation of nucleotide metabolic process GO:0045981 230 0.029
regulation of nucleotide catabolic process GO:0030811 205 0.029
positive regulation of cellular component biogenesis GO:0044089 158 0.029
protein oligomerization GO:0051259 173 0.029
cell cell signaling GO:0007267 155 0.029
Rat
positive regulation of cell adhesion GO:0045785 84 0.029
secretion by cell GO:0032940 226 0.029
Rat
regulation of epithelial cell migration GO:0010632 93 0.029
chemotaxis GO:0006935 157 0.028
regulation of vasculature development GO:1901342 97 0.028
epithelial cell differentiation GO:0030855 141 0.028
response to hyperoxia GO:0055093 4 0.028
skeletal system development GO:0001501 79 0.028
cellular response to abiotic stimulus GO:0071214 117 0.028
epithelium development GO:0060429 227 0.028
cellular response to organic cyclic compound GO:0071407 127 0.028
regulation of chemotaxis GO:0050920 74 0.028
lipid metabolic process GO:0006629 381 0.028
cellular response to ammonium ion GO:0071242 4 0.028
actin cytoskeleton organization GO:0030036 207 0.028
regulation of purine nucleotide catabolic process GO:0033121 205 0.028
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.027
connective tissue development GO:0061448 39 0.027
response to alcohol GO:0097305 64 0.027
cellular response to molecule of bacterial origin GO:0071219 62 0.027
negative regulation of protein maturation GO:1903318 142 0.027
cellular response to lipopolysaccharide GO:0071222 57 0.027
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.027
guanosine containing compound catabolic process GO:1901069 239 0.027
response to tumor necrosis factor GO:0034612 76 0.027
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.026
positive regulation of plasminogen activation GO:0010756 3 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
cytokine mediated signaling pathway GO:0019221 109 0.026
positive regulation of interleukin 5 production GO:0032754 3 0.026
positive regulation of cytokine production GO:0001819 167 0.026
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.026
purine ribonucleoside metabolic process GO:0046128 437 0.026
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.026
positive regulation of organelle organization GO:0010638 195 0.026
epithelial cell development GO:0002064 34 0.026
regulation of cell matrix adhesion GO:0001952 42 0.026
cellular response to oxidative stress GO:0034599 85 0.026
Rat
multicellular organismal aging GO:0010259 3 0.026
protein secretion GO:0009306 98 0.026
morphogenesis of embryonic epithelium GO:0016331 4 0.026
regulation of cellular response to stress GO:0080135 244 0.026
positive regulation of protein kinase activity GO:0045860 190 0.026
tube development GO:0035295 125 0.026
regulation of protein maturation GO:1903317 150 0.025
regulation of gtpase activity GO:0043087 180 0.025
guanosine containing compound metabolic process GO:1901068 244 0.025
regulation of gtp catabolic process GO:0033124 180 0.025
regulation of cell cell adhesion GO:0022407 57 0.025
glycoprotein metabolic process GO:0009100 110 0.025
negative regulation of cell motility GO:2000146 104 0.025
positive regulation of cell differentiation GO:0045597 211 0.025
Rat
regulation of glial cell differentiation GO:0045685 3 0.025
cell projection morphogenesis GO:0048858 129 0.025
membrane organization GO:0061024 292 0.025
embryonic morphogenesis GO:0048598 85 0.025
reactive oxygen species metabolic process GO:0072593 75 0.024
regulation of mapk cascade GO:0043408 262 0.024
establishment of protein localization to plasma membrane GO:0090002 68 0.024
regulation of growth GO:0040008 165 0.024
zymogen activation GO:0031638 70 0.024
negative regulation of cellular component movement GO:0051271 106 0.024
ras protein signal transduction GO:0007265 73 0.024
positive regulation of gtp catabolic process GO:0033126 166 0.024
regulation of leukocyte activation GO:0002694 115 0.024
collagen catabolic process GO:0030574 10 0.024
nucleoside catabolic process GO:0009164 408 0.024
collagen metabolic process GO:0032963 28 0.024
decidualization GO:0046697 4 0.023
glycoprotein biosynthetic process GO:0009101 91 0.023
embryo development GO:0009790 123 0.023
pattern recognition receptor signaling pathway GO:0002221 48 0.023
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.023
digestive system development GO:0055123 75 0.023
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.023
positive regulation of peptidase activity GO:0010952 88 0.023
ribonucleoside catabolic process GO:0042454 406 0.023
innate immune response activating signal transduction GO:0002758 48 0.023
regulation of cell development GO:0060284 161 0.023
Rat
negative regulation of immune system process GO:0002683 136 0.023
positive regulation of transport GO:0051050 336 0.023
cellular response to glucagon stimulus GO:0071377 1 0.022
morphogenesis of an epithelium GO:0002009 60 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.022
organophosphate catabolic process GO:0046434 430 0.022
cell junction assembly GO:0034329 67 0.022
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.022
positive regulation of leukocyte chemotaxis GO:0002690 38 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.022
positive regulation of gliogenesis GO:0014015 4 0.022
positive regulation of protein complex assembly GO:0031334 86 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
purine containing compound biosynthetic process GO:0072522 88 0.021
cell growth GO:0016049 160 0.021
regulation of ion transport GO:0043269 189 0.021
cell part morphogenesis GO:0032990 137 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
positive regulation of innate immune response GO:0045089 79 0.021
neuron projection regeneration GO:0031102 1 0.021
chronic inflammatory response GO:0002544 2 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
regulation of cell projection organization GO:0031344 107 0.021
Rat
positive regulation of cell projection organization GO:0031346 64 0.021
Rat
regulation of endothelial cell apoptotic process GO:2000351 24 0.021
circadian behavior GO:0048512 2 0.021
positive regulation of catabolic process GO:0009896 310 0.021
mesenchymal cell development GO:0014031 50 0.021
single organism reproductive process GO:0044702 98 0.021
cellular response to tumor necrosis factor GO:0071356 63 0.021
regulation of cell growth GO:0001558 135 0.021
multicellular organismal metabolic process GO:0044236 34 0.021
regulation of cytoskeleton organization GO:0051493 177 0.020
oogenesis GO:0048477 2 0.020
behavior GO:0007610 112 0.020
response to nitrogen compound GO:1901698 184 0.020
Rat
epithelial cell proliferation GO:0050673 128 0.020
positive regulation of cell activation GO:0050867 81 0.020
skin development GO:0043588 76 0.020
single organism membrane organization GO:0044802 268 0.020
leukocyte chemotaxis GO:0030595 76 0.020
embryonic epithelial tube formation GO:0001838 4 0.020
osteoblast differentiation GO:0001649 92 0.020
transmembrane transport GO:0055085 399 0.020
determination of adult lifespan GO:0008340 2 0.020
regulation of innate immune response GO:0045088 97 0.020
negative regulation of locomotion GO:0040013 118 0.020
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.020
organic anion transport GO:0015711 103 0.020
stress activated protein kinase signaling cascade GO:0031098 94 0.020
segmentation GO:0035282 4 0.020
cellular response to nitrogen compound GO:1901699 144 0.020
positive regulation of fibroblast migration GO:0010763 3 0.020
leukocyte activation GO:0045321 164 0.020
epithelial cell migration GO:0010631 119 0.019
reproductive system development GO:0061458 56 0.019
response to potassium ion GO:0035864 5 0.019
glycosyl compound catabolic process GO:1901658 413 0.019
neural tube formation GO:0001841 3 0.019
regulation of cell cycle GO:0051726 393 0.019
microtubule based process GO:0007017 210 0.019
cellular response to hydrogen peroxide GO:0070301 37 0.019
Rat
regulation of ras gtpase activity GO:0032318 128 0.019
regulation of inflammatory response GO:0050727 46 0.019
cellular response to dna damage stimulus GO:0006974 379 0.019
immune system development GO:0002520 195 0.019
positive regulation of proteolysis GO:0045862 142 0.019
response to low density lipoprotein particle GO:0055098 4 0.019
cellular protein complex assembly GO:0043623 188 0.019
cellular component assembly involved in morphogenesis GO:0010927 73 0.019
neuron development GO:0048666 113 0.019
Rat
neurological system process GO:0050877 163 0.019
rhythmic behavior GO:0007622 2 0.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.019
regulation of vascular wound healing GO:0061043 2 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
peptidyl serine modification GO:0018209 106 0.018
positive regulation of angiogenesis GO:0045766 51 0.018
regulation of rho protein signal transduction GO:0035023 79 0.018
regulation of small gtpase mediated signal transduction GO:0051056 156 0.018
positive regulation of cellular catabolic process GO:0031331 284 0.018
regulation of meiotic cell cycle GO:0051445 4 0.018
axon regeneration GO:0031103 1 0.018
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.018
cellular chemical homeostasis GO:0055082 180 0.018
cellular component disassembly GO:0022411 92 0.018
cellular response to reactive oxygen species GO:0034614 50 0.018
Rat
regulation of secretion by cell GO:1903530 177 0.018
Rat
blood coagulation GO:0007596 76 0.018
single organism cellular localization GO:1902580 332 0.017
ossification GO:0001503 121 0.017
regulation of cellular response to growth factor stimulus GO:0090287 76 0.017
organelle assembly GO:0070925 176 0.017
positive regulation of nucleotide catabolic process GO:0030813 185 0.017
positive regulation of leukocyte migration GO:0002687 46 0.017
cell adhesion mediated by integrin GO:0033627 27 0.017
regulation of vesicle mediated transport GO:0060627 130 0.017
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.017
primary neural tube formation GO:0014020 3 0.017
positive regulation of lymphocyte activation GO:0051251 73 0.017
positive regulation of kinase activity GO:0033674 204 0.017
response to interleukin 1 GO:0070555 47 0.017
Rat
nerve development GO:0021675 4 0.017
endocytosis GO:0006897 159 0.017
cell type specific apoptotic process GO:0097285 125 0.017
branching involved in salivary gland morphogenesis GO:0060445 1 0.017
response to metal ion GO:0010038 84 0.017
Rat
establishment of protein localization to membrane GO:0090150 121 0.017
cellular lipid metabolic process GO:0044255 303 0.016
cellular homeostasis GO:0019725 196 0.016
positive regulation of behavior GO:0048520 60 0.016
cdc42 protein signal transduction GO:0032488 4 0.016
tyrosine phosphorylation of stat protein GO:0007260 33 0.016
response to hydrogen peroxide GO:0042542 40 0.016
Rat
negative regulation of response to wounding GO:1903035 47 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
protein ubiquitination GO:0016567 314 0.016
regulation of synaptic plasticity GO:0048167 3 0.016
response to hexose GO:0009746 20 0.016
regulation of hemostasis GO:1900046 42 0.016
regulation of secretion GO:0051046 194 0.016
Rat
cell morphogenesis involved in differentiation GO:0000904 144 0.016
positive regulation of leukocyte activation GO:0002696 80 0.016
muscle structure development GO:0061061 98 0.016
cellular response to oxygen levels GO:0071453 55 0.016
actin filament organization GO:0007015 128 0.016
regulation of protein transport GO:0051223 213 0.016
response to peptide hormone GO:0043434 61 0.016
negative regulation of blood coagulation GO:0030195 22 0.016
epithelium migration GO:0090132 119 0.016
immune effector process GO:0002252 159 0.016
lipid localization GO:0010876 106 0.015
adult locomotory behavior GO:0008344 1 0.015
cellular response to lipoprotein particle stimulus GO:0071402 1 0.015
regulation of protein localization to plasma membrane GO:1903076 40 0.015
mitotic cell cycle GO:0000278 326 0.015
blood vessel development GO:0001568 172 0.015
positive regulation of t helper cell differentiation GO:0045624 2 0.015
response to activity GO:0014823 0 0.015
regulation of blood coagulation GO:0030193 42 0.015
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.015
response to axon injury GO:0048678 1 0.015
endochondral bone morphogenesis GO:0060350 3 0.015
response to growth factor GO:0070848 205 0.015
Rat
response to transforming growth factor beta GO:0071559 94 0.015
coagulation GO:0050817 78 0.015
single organism cell adhesion GO:0098602 179 0.015
positive regulation of axon extension GO:0045773 4 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
developmental process involved in reproduction GO:0003006 66 0.015
neuron differentiation GO:0030182 138 0.015
Rat
negative regulation of protein modification process GO:0031400 200 0.015
anion transmembrane transport GO:0098656 76 0.015
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.015
motor neuron axon guidance GO:0008045 2 0.015
embryonic viscerocranium morphogenesis GO:0048703 1 0.015
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.015
secretion GO:0046903 254 0.015
Rat
organophosphate biosynthetic process GO:0090407 163 0.015
muscle organ development GO:0007517 56 0.015
protein localization to plasma membrane GO:0072659 93 0.015

SPHK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 88 0.052
musculoskeletal system disease DOID:17 223 0.052
connective tissue disease DOID:65 109 0.052
central nervous system disease DOID:331 186 0.029
neurodegenerative disease DOID:1289 102 0.029
nervous system disease DOID:863 431 0.029
disease of metabolism DOID:0014667 295 0.029
cancer DOID:162 167 0.026
disease of cellular proliferation DOID:14566 174 0.026
organ system cancer DOID:0050686 164 0.026
sensory system disease DOID:0050155 203 0.016
eye and adnexa disease DOID:1492 150 0.016
eye disease DOID:5614 149 0.016