Homo sapiens

143 known processes

TINF2

TERF1 (TRF1)-interacting nuclear factor 2

(Aliases: TIN2)

TINF2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
protein localization to chromosome telomeric region GO:0070198 6 0.999
negative regulation of telomere maintenance GO:0032205 9 0.999
telomere maintenance via telomere lengthening GO:0010833 9 0.999
regulation of telomere maintenance GO:0032204 13 0.998
negative regulation of telomere maintenance via telomerase GO:0032211 5 0.966
telomere capping GO:0016233 5 0.935
telomere maintenance GO:0000723 32 0.928
anatomical structure homeostasis GO:0060249 100 0.898
positive regulation of telomere maintenance GO:0032206 4 0.806
rna dependent dna replication GO:0006278 16 0.783
negative regulation of chromosome organization GO:2001251 48 0.760
negative regulation of homeostatic process GO:0032845 59 0.706
protein localization to organelle GO:0033365 280 0.611
protein localization to chromosome GO:0034502 30 0.577
regulation of homeostatic process GO:0032844 121 0.576
dna replication GO:0006260 116 0.550
positive regulation of dna metabolic process GO:0051054 73 0.538
negative regulation of dna replication GO:0008156 29 0.474
regulation of telomere maintenance via telomerase GO:0032210 6 0.456
regulation of microtubule polymerization GO:0031113 12 0.361
telomere maintenance via telomerase GO:0007004 8 0.343
negative regulation of organelle organization GO:0010639 126 0.328
regulation of transferase activity GO:0051338 355 0.322
negative regulation of telomerase activity GO:0051974 6 0.305
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.245
dna biosynthetic process GO:0071897 40 0.231
positive regulation of microtubule polymerization or depolymerization GO:0031112 8 0.224
cellular response to dna damage stimulus GO:0006974 379 0.206
positive regulation of organelle organization GO:0010638 195 0.197
negative regulation of cellular component organization GO:0051129 235 0.189
negative regulation of cell cycle GO:0045786 193 0.181
telomere organization GO:0032200 33 0.180
regulation of microtubule cytoskeleton organization GO:0070507 61 0.180
telomere assembly GO:0032202 5 0.177
negative regulation of cellular protein metabolic process GO:0032269 353 0.168
mitotic sister chromatid segregation GO:0000070 53 0.152
segmentation GO:0035282 4 0.147
negative regulation of transferase activity GO:0051348 124 0.146
regulation of dna biosynthetic process GO:2000278 18 0.145
cellular macromolecule catabolic process GO:0044265 380 0.131
regulation of protein complex assembly GO:0043254 147 0.131
cellular macromolecular complex assembly GO:0034622 324 0.130
glycoprotein biosynthetic process GO:0009101 91 0.124
cellular protein complex assembly GO:0043623 188 0.124
negative regulation of protein metabolic process GO:0051248 391 0.121
ubiquitin dependent protein catabolic process GO:0006511 206 0.118
regulation of protein processing GO:0070613 150 0.114
positive regulation of chromosome organization GO:2001252 41 0.112
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.111
modification dependent protein catabolic process GO:0019941 209 0.109
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.109
modification dependent macromolecule catabolic process GO:0043632 212 0.108
regulation of dna metabolic process GO:0051052 153 0.105
regulation of telomerase activity GO:0051972 9 0.105
cell cycle g2 m phase transition GO:0044839 43 0.102
negative regulation of catalytic activity GO:0043086 335 0.102
carbohydrate metabolic process GO:0005975 207 0.101
regulation of proteolysis GO:0030162 293 0.100
protein polyubiquitination GO:0000209 110 0.096
positive regulation of dna replication GO:0045740 35 0.094
protein oligomerization GO:0051259 173 0.093
mitotic cell cycle GO:0000278 326 0.091
regulation of dna binding GO:0051101 37 0.090
protein processing GO:0016485 226 0.090
positive regulation of cellular component biogenesis GO:0044089 158 0.090
regulation of cell cycle GO:0051726 393 0.089
regulation of protein polymerization GO:0032271 63 0.089
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.089
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.088
negative regulation of chromosome segregation GO:0051985 18 0.087
chromatin organization GO:0006325 351 0.085
regulation of microtubule based process GO:0032886 74 0.082
positive regulation of homeostatic process GO:0032846 47 0.081
mitotic cell cycle process GO:1903047 286 0.081
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.081
positive regulation of cell death GO:0010942 263 0.080
protein maturation GO:0051604 233 0.080
chromosome segregation GO:0007059 114 0.078
protein homooligomerization GO:0051260 100 0.077
regulation of cellular component biogenesis GO:0044087 281 0.074
protein catabolic process GO:0030163 325 0.072
nucleoside triphosphate metabolic process GO:0009141 422 0.072
post embryonic development GO:0009791 2 0.072
positive regulation of transferase activity GO:0051347 227 0.071
cellular protein catabolic process GO:0044257 261 0.071
sister chromatid segregation GO:0000819 54 0.070
chromatin modification GO:0016568 298 0.069
regulation of dna replication GO:0006275 68 0.068
nuclear division GO:0000280 128 0.067
positive regulation of programmed cell death GO:0043068 249 0.066
regulation of cytoskeleton organization GO:0051493 177 0.065
immune response GO:0006955 307 0.064
canonical wnt signaling pathway GO:0060070 116 0.063
negative regulation of cellular protein catabolic process GO:1903363 38 0.063
metaphase anaphase transition of cell cycle GO:0044784 21 0.062
regulation of mitosis GO:0007088 63 0.060
regulation of cell cycle process GO:0010564 266 0.059
regulation of canonical wnt signaling pathway GO:0060828 88 0.058
positive regulation of protein complex assembly GO:0031334 86 0.057
intracellular protein transport GO:0006886 270 0.056
replicative cell aging GO:0001302 3 0.056
negative regulation of dna biosynthetic process GO:2000279 11 0.056
proteasomal protein catabolic process GO:0010498 176 0.055
positive regulation of mitosis GO:0045840 25 0.054
protein polymerization GO:0051258 71 0.052
regulation of chromosome segregation GO:0051983 44 0.052
regulation of proteasomal protein catabolic process GO:0061136 87 0.051
cell division GO:0051301 168 0.050
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.049
membrane organization GO:0061024 292 0.049
negative regulation of dna metabolic process GO:0051053 57 0.048
negative regulation of sister chromatid segregation GO:0033046 17 0.047
regulation of mitotic cell cycle phase transition GO:1901990 118 0.046
negative regulation of proteolysis GO:0045861 132 0.045
locomotory behavior GO:0007626 1 0.043
negative regulation of mitotic cell cycle GO:0045930 102 0.043
microtubule cytoskeleton organization GO:0000226 176 0.042
negative regulation of protein processing GO:0010955 142 0.042
glycosyl compound catabolic process GO:1901658 413 0.042
regulation of growth GO:0040008 165 0.042
negative regulation of mitotic sister chromatid segregation GO:0033048 17 0.041
positive regulation of protein polymerization GO:0032273 45 0.041
positive regulation of cell cycle process GO:0090068 106 0.041
positive regulation of apoptotic process GO:0043065 246 0.041
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.040
system process GO:0003008 349 0.040
negative regulation of cell division GO:0051782 31 0.040
regulation of binding GO:0051098 111 0.040
cellular amine metabolic process GO:0044106 41 0.039
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.039
regulation of protein catabolic process GO:0042176 155 0.039
mitotic spindle checkpoint GO:0071174 18 0.039
regulation of mitotic sister chromatid segregation GO:0033047 27 0.038
protein ubiquitination GO:0016567 314 0.038
actin filament based process GO:0030029 224 0.037
regulation of cell division GO:0051302 116 0.037
negative regulation of catabolic process GO:0009895 104 0.037
lipid metabolic process GO:0006629 381 0.036
embryo development GO:0009790 123 0.036
circulatory system development GO:0072359 262 0.036
negative regulation of cell cycle process GO:0010948 121 0.036
regulation of cellular amino acid metabolic process GO:0006521 6 0.036
regulation of nuclear division GO:0051783 65 0.036
g2 m transition of mitotic cell cycle GO:0000086 41 0.036
mitotic nuclear division GO:0007067 119 0.035
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
negative regulation of cellular catabolic process GO:0031330 83 0.034
regulation of chromosome organization GO:0033044 103 0.033
cellular amino acid metabolic process GO:0006520 116 0.033
positive regulation of microtubule polymerization GO:0031116 6 0.032
positive regulation of cellular component organization GO:0051130 376 0.032
multicellular organismal aging GO:0010259 3 0.032
carbohydrate derivative biosynthetic process GO:1901137 207 0.032
positive regulation of mitotic cell cycle GO:0045931 60 0.031
neurological system process GO:0050877 163 0.031
single organism membrane organization GO:0044802 268 0.031
negative regulation of phosphate metabolic process GO:0045936 267 0.030
wnt signaling pathway GO:0016055 156 0.030
regulation of cellular protein catabolic process GO:1903362 96 0.030
positive regulation of dna biosynthetic process GO:2000573 8 0.030
cellular ketone metabolic process GO:0042180 80 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
regulation of protein maturation GO:1903317 150 0.029
regulation of cell cycle phase transition GO:1901987 126 0.029
purine ribonucleotide catabolic process GO:0009154 404 0.028
histone modification GO:0016570 251 0.028
cell type specific apoptotic process GO:0097285 125 0.028
cell cycle checkpoint GO:0000075 117 0.028
nucleoside triphosphate catabolic process GO:0009143 394 0.027
cell aging GO:0007569 52 0.027
cell cycle phase transition GO:0044770 173 0.027
regulation of wnt signaling pathway GO:0030111 123 0.027
negative regulation of protein catabolic process GO:0042177 59 0.027
urogenital system development GO:0001655 65 0.027
positive regulation of cell cycle GO:0045787 140 0.026
peptidyl serine modification GO:0018209 106 0.026
response to oxygen containing compound GO:1901700 369 0.026
spindle checkpoint GO:0031577 26 0.026
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.026
positive regulation of hydrolase activity GO:0051345 331 0.026
oogenesis GO:0048477 2 0.026
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.025
vesicle mediated transport GO:0016192 371 0.025
purine ribonucleoside catabolic process GO:0046130 398 0.025
cell projection organization GO:0030030 252 0.024
purine nucleoside catabolic process GO:0006152 398 0.024
regulation of immune response GO:0050776 201 0.023
cellular response to abiotic stimulus GO:0071214 117 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
cellular lipid metabolic process GO:0044255 303 0.023
purine nucleotide catabolic process GO:0006195 405 0.023
negative regulation of protein maturation GO:1903318 142 0.023
organelle fission GO:0048285 149 0.022
ribonucleotide catabolic process GO:0009261 405 0.022
determination of adult lifespan GO:0008340 2 0.022
glycosylation GO:0070085 71 0.022
neurotransmitter secretion GO:0007269 4 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
wound healing GO:0042060 115 0.022
positive regulation of binding GO:0051099 45 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.021
meiotic chromosome segregation GO:0045132 4 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
cellular response to oxygen containing compound GO:1901701 276 0.021
growth GO:0040007 202 0.021
negative regulation of mitosis GO:0045839 24 0.021
protein auto adp ribosylation GO:0070213 4 0.021
positive regulation of wnt signaling pathway GO:0030177 54 0.021
response to organic cyclic compound GO:0014070 204 0.020
nucleotide catabolic process GO:0009166 408 0.020
innate immune response GO:0045087 178 0.020
embryonic appendage morphogenesis GO:0035113 9 0.020
protein glycosylation GO:0006486 62 0.020
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.019
covalent chromatin modification GO:0016569 254 0.019
regulation of mitotic sister chromatid separation GO:0010965 27 0.019
positive regulation of immune system process GO:0002684 283 0.019
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.019
microtubule polymerization or depolymerization GO:0031109 37 0.019
cardiovascular system development GO:0072358 262 0.019
regionalization GO:0003002 29 0.019
amine metabolic process GO:0009308 44 0.019
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.019
purine containing compound catabolic process GO:0072523 411 0.019
epithelium development GO:0060429 227 0.018
nucleoside monophosphate metabolic process GO:0009123 191 0.018
ribonucleoside monophosphate catabolic process GO:0009158 158 0.018
single organism carbohydrate metabolic process GO:0044723 193 0.018
positive regulation of cell division GO:0051781 59 0.018
dna conformation change GO:0071103 113 0.018
regulation of kinase activity GO:0043549 314 0.018
protein modification by small protein conjugation GO:0032446 342 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
metal ion transport GO:0030001 272 0.018
tissue regeneration GO:0042246 3 0.018
biological adhesion GO:0022610 331 0.018
positive regulation of nuclear division GO:0051785 27 0.017
atp metabolic process GO:0046034 176 0.017
response to other organism GO:0051707 261 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
endosomal transport GO:0016197 129 0.017
regulation of protein kinase activity GO:0045859 289 0.017
response to external biotic stimulus GO:0043207 261 0.017
macromolecule glycosylation GO:0043413 63 0.017
mitotic cell cycle checkpoint GO:0007093 68 0.017
phospholipid metabolic process GO:0006644 99 0.017
oocyte differentiation GO:0009994 2 0.017
peptidyl serine phosphorylation GO:0018105 101 0.017
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.017
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.017
regulation of cellular ketone metabolic process GO:0010565 50 0.016
hematopoietic or lymphoid organ development GO:0048534 186 0.016
regulation of cellular response to stress GO:0080135 244 0.016
cell adhesion GO:0007155 325 0.016
response to organonitrogen compound GO:0010243 156 0.016
response to nitrogen compound GO:1901698 184 0.016
positive regulation of transport GO:0051050 336 0.016
protein poly adp ribosylation GO:0070212 3 0.016
protein localization to membrane GO:0072657 160 0.016
protein methylation GO:0006479 74 0.016
positive regulation of telomerase activity GO:0051973 4 0.016
nucleoside monophosphate catabolic process GO:0009125 159 0.016
nervous system development GO:0007399 293 0.016
response to bacterium GO:0009617 144 0.016
mrna metabolic process GO:0016071 175 0.016
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.015
mitotic spindle assembly checkpoint GO:0007094 14 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
positive regulation of developmental process GO:0051094 314 0.015
blastoderm segmentation GO:0007350 2 0.015
anterior posterior axis specification GO:0009948 2 0.015
inorganic ion transmembrane transport GO:0098660 231 0.015
cytokine production GO:0001816 247 0.015
limb morphogenesis GO:0035108 16 0.015
female gamete generation GO:0007292 2 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.015
dephosphorylation GO:0016311 209 0.015
mitotic cell cycle phase transition GO:0044772 162 0.015
tissue homeostasis GO:0001894 63 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
negative regulation of developmental process GO:0051093 247 0.015
regulation of cell activation GO:0050865 125 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
positive regulation of phosphorylation GO:0042327 394 0.015
transmembrane transport GO:0055085 399 0.015
regulation of mononuclear cell proliferation GO:0032944 65 0.014
organophosphate biosynthetic process GO:0090407 163 0.014
positive regulation of dna binding GO:0043388 17 0.014
negative regulation of apoptotic process GO:0043066 316 0.014
cation transport GO:0006812 331 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.014
organelle assembly GO:0070925 176 0.014
mapk cascade GO:0000165 288 0.014
small gtpase mediated signal transduction GO:0007264 78 0.014
regulation of ion transport GO:0043269 189 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
nerve development GO:0021675 4 0.014
negative regulation of binding GO:0051100 57 0.014
sensory perception GO:0007600 103 0.014
spermatid differentiation GO:0048515 4 0.014
photoreceptor cell maintenance GO:0045494 13 0.014
aging GO:0007568 66 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.013
glycerolipid metabolic process GO:0046486 107 0.013
divalent metal ion transport GO:0070838 152 0.013
inorganic cation transmembrane transport GO:0098662 194 0.013
vacuole organization GO:0007033 44 0.013
defense response GO:0006952 315 0.013
interspecies interaction between organisms GO:0044419 156 0.013
spindle elongation GO:0051231 4 0.013
response to biotic stimulus GO:0009607 276 0.013
calcium ion transport GO:0006816 147 0.013
immune effector process GO:0002252 159 0.013
oocyte development GO:0048599 1 0.013
cell activation GO:0001775 213 0.013
histone methylation GO:0016571 60 0.013
regeneration GO:0031099 4 0.013
ras protein signal transduction GO:0007265 73 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
lipid transport GO:0006869 90 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.013
memory GO:0007613 3 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
organophosphate catabolic process GO:0046434 430 0.013
cell cycle arrest GO:0007050 71 0.013
regulation of cytokine production GO:0001817 232 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.012
positive regulation of catabolic process GO:0009896 310 0.012
regulation of lymphocyte activation GO:0051249 103 0.012
epithelial cell differentiation GO:0030855 141 0.012
positive regulation of immune response GO:0050778 159 0.012
response to inorganic substance GO:0010035 127 0.012
nucleoside catabolic process GO:0009164 408 0.012
immune response regulating signaling pathway GO:0002764 97 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
spindle assembly checkpoint GO:0071173 17 0.012
positive regulation of cytokine production GO:0001819 167 0.012
ion transmembrane transport GO:0034220 338 0.012
glycerophospholipid metabolic process GO:0006650 84 0.012
response to lipid GO:0033993 206 0.012
leukocyte activation GO:0045321 164 0.012
defense response to other organism GO:0098542 129 0.012
pattern specification process GO:0007389 43 0.012
peptidyl threonine phosphorylation GO:0018107 41 0.012
regulation of secretion GO:0051046 194 0.012
negative regulation of immune system process GO:0002683 136 0.012
regulation of neurotransmitter secretion GO:0046928 3 0.012
neurogenesis GO:0022008 169 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
secretion GO:0046903 254 0.012
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
regulation of protein localization GO:0032880 296 0.012
melanin metabolic process GO:0006582 1 0.012
g protein coupled receptor signaling pathway GO:0007186 207 0.012
activation of immune response GO:0002253 114 0.012
glycerolipid biosynthetic process GO:0045017 51 0.012
peripheral nervous system development GO:0007422 2 0.012
cation transmembrane transport GO:0098655 238 0.012
cellular response to lipid GO:0071396 127 0.012
regulation of secretion by cell GO:1903530 177 0.011
cellular cation homeostasis GO:0030003 163 0.011
atp catabolic process GO:0006200 157 0.011
sensory perception of sound GO:0007605 37 0.011
adult locomotory behavior GO:0008344 1 0.011
cell morphogenesis GO:0000902 296 0.011
cellular response to radiation GO:0071478 65 0.011
peptidyl threonine modification GO:0018210 45 0.011
ribonucleoside catabolic process GO:0042454 406 0.011
single organism cellular localization GO:1902580 332 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
actin mediated cell contraction GO:0070252 12 0.011
limbic system development GO:0021761 3 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
associative learning GO:0008306 1 0.011
circadian behavior GO:0048512 2 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
mating GO:0007618 1 0.011
sensory perception of pain GO:0019233 4 0.011
negative regulation of cell cycle phase transition GO:1901988 89 0.011
regulation of leukocyte activation GO:0002694 115 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
secretion by cell GO:0032940 226 0.011
regulation of leukocyte proliferation GO:0070663 67 0.011
rhythmic behavior GO:0007622 2 0.011
positive regulation of locomotion GO:0040017 186 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
skeletal system development GO:0001501 79 0.011
negative regulation of wnt signaling pathway GO:0030178 69 0.010
spermatid development GO:0007286 4 0.010
regulation of protein transport GO:0051223 213 0.010
guanosine containing compound catabolic process GO:1901069 239 0.010
actin filament organization GO:0007015 128 0.010
ion homeostasis GO:0050801 230 0.010
protein adp ribosylation GO:0006471 9 0.010
blastocyst development GO:0001824 3 0.010
epithelial cell proliferation GO:0050673 128 0.010
divalent inorganic cation transport GO:0072511 158 0.010
gtp metabolic process GO:0046039 239 0.010
visual learning GO:0008542 1 0.010
mitotic spindle elongation GO:0000022 4 0.010
negative regulation of dna binding GO:0043392 18 0.010
response to peptidoglycan GO:0032494 3 0.010
tripartite regional subdivision GO:0007351 2 0.010
regulation of actin filament based process GO:0032970 141 0.010
regulation of endopeptidase activity GO:0052548 170 0.010
regulation of locomotion GO:0040012 329 0.010

TINF2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.021
musculoskeletal system disease DOID:17 223 0.020
central nervous system disease DOID:331 186 0.017
nervous system disease DOID:863 431 0.017
sensory system disease DOID:0050155 203 0.016
disease of metabolism DOID:0014667 295 0.016
lysosomal storage disease DOID:3211 47 0.014
inherited metabolic disorder DOID:655 242 0.014
cancer DOID:162 167 0.013
organ system cancer DOID:0050686 164 0.013
retinal disease DOID:5679 118 0.013
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
connective tissue disease DOID:65 109 0.011