Homo sapiens

19 known processes

SHANK1

SH3 and multiple ankyrin repeat domains 1

(Aliases: synamon,SSTRIP,SPANK-1)

SHANK1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of wnt protein secretion GO:0061358 1 0.212
opioid receptor signaling pathway GO:0038003 4 0.204
somatostatin receptor signaling pathway GO:0038169 1 0.130
cellular amino acid metabolic process GO:0006520 116 0.127
adenylate cyclase inhibiting opioid receptor signaling pathway GO:0031635 1 0.126
somatostatin signaling pathway GO:0038170 1 0.122
nervous system development GO:0007399 293 0.114
Mouse Rat
regulation of cellular amino acid metabolic process GO:0006521 6 0.090
positive regulation of transport GO:0051050 336 0.087
ion transmembrane transport GO:0034220 338 0.082
Mouse
g protein coupled receptor signaling pathway GO:0007186 207 0.080
cation transmembrane transport GO:0098655 238 0.076
positive regulation of large conductance calcium activated potassium channel activity GO:1902608 2 0.075
regulation of protein localization GO:0032880 296 0.073
transmembrane transport GO:0055085 399 0.067
Mouse
positive regulation of cellular amine metabolic process GO:0033240 7 0.066
regulation of large conductance calcium activated potassium channel activity GO:1902606 2 0.066
amine metabolic process GO:0009308 44 0.064
protein localization to organelle GO:0033365 280 0.063
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.063
cellular ketone metabolic process GO:0042180 80 0.062
positive regulation of glucocorticoid secretion GO:2000851 4 0.062
peripheral nervous system development GO:0007422 2 0.060
cytoplasmic transport GO:0016482 379 0.060
positive regulation of cellular component organization GO:0051130 376 0.059
Rat
cellular amine metabolic process GO:0044106 41 0.054
response to oxygen containing compound GO:1901700 369 0.052
negative regulation of cellular component organization GO:0051129 235 0.051
Mouse
reactive nitrogen species metabolic process GO:2001057 3 0.051
cellular macromolecule catabolic process GO:0044265 380 0.051
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.051
hindbrain development GO:0030902 3 0.051
regulation of cellular amine metabolic process GO:0033238 11 0.051
negative regulation of multicellular organismal process GO:0051241 317 0.049
post embryonic development GO:0009791 2 0.048
regulation of ion transmembrane transporter activity GO:0032412 72 0.048
Mouse
lipid metabolic process GO:0006629 381 0.047
regulation of transporter activity GO:0032409 82 0.047
Mouse
regulation of establishment of protein localization GO:0070201 242 0.046
reactive oxygen species metabolic process GO:0072593 75 0.046
regulation of cellular component biogenesis GO:0044087 281 0.043
Mouse
regulation of transmembrane transporter activity GO:0022898 74 0.043
Mouse
central nervous system development GO:0007417 123 0.042
behavioral response to ethanol GO:0048149 2 0.042
regulation of protein transport GO:0051223 213 0.041
protein catabolic process GO:0030163 325 0.041
small gtpase mediated signal transduction GO:0007264 78 0.040
cellular response to oxygen containing compound GO:1901701 276 0.040
organonitrogen compound biosynthetic process GO:1901566 200 0.039
response to biotic stimulus GO:0009607 276 0.039
chemical homeostasis GO:0048878 306 0.038
negative regulation of cytosolic calcium ion concentration GO:0051481 1 0.037
regulation of cell cycle GO:0051726 393 0.037
vesicle mediated transport GO:0016192 371 0.036
regulation of reactive oxygen species metabolic process GO:2000377 41 0.036
positive regulation of phosphorylation GO:0042327 394 0.036
nuclear transport GO:0051169 179 0.035
immune response GO:0006955 307 0.034
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.034
regulation of cellular ketone metabolic process GO:0010565 50 0.034
cell development GO:0048468 328 0.033
Mouse Rat
metencephalon development GO:0022037 2 0.033
cellular response to endogenous stimulus GO:0071495 336 0.032
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.032
response to abiotic stimulus GO:0009628 336 0.031
small molecule catabolic process GO:0044282 92 0.031
segmentation GO:0035282 4 0.031
cellular macromolecular complex assembly GO:0034622 324 0.031
memory GO:0007613 3 0.031
Mouse
regulation of cell cycle process GO:0010564 266 0.030
defense response GO:0006952 315 0.030
regulation of protein complex assembly GO:0043254 147 0.030
positive regulation of developmental process GO:0051094 314 0.030
Rat
response to organic cyclic compound GO:0014070 204 0.030
female gamete generation GO:0007292 2 0.030
cation transport GO:0006812 331 0.030
nucleocytoplasmic transport GO:0006913 176 0.030
cellular response to dna damage stimulus GO:0006974 379 0.030
purine containing compound catabolic process GO:0072523 411 0.029
cellular protein catabolic process GO:0044257 261 0.029
regulation of ion transport GO:0043269 189 0.029
Mouse
nucleotide catabolic process GO:0009166 408 0.028
neuron projection development GO:0031175 106 0.028
Mouse Rat
nucleoside triphosphate metabolic process GO:0009141 422 0.028
locomotory behavior GO:0007626 1 0.028
positive regulation of secretion by cell GO:1903532 108 0.028
head development GO:0060322 108 0.028
nucleoside phosphate catabolic process GO:1901292 412 0.028
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.028
organophosphate catabolic process GO:0046434 430 0.028
regulation of secretion by cell GO:1903530 177 0.028
intracellular protein transport GO:0006886 270 0.027
regulation of proteolysis GO:0030162 293 0.027
cell projection organization GO:0030030 252 0.027
Mouse Rat
negative regulation of catalytic activity GO:0043086 335 0.027
cell cell signaling GO:0007267 155 0.027
Mouse
single organism cellular localization GO:1902580 332 0.026
multicellular organismal aging GO:0010259 3 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
negative regulation of transport GO:0051051 176 0.026
secretion by cell GO:0032940 226 0.026
establishment of protein localization to organelle GO:0072594 172 0.026
secretion GO:0046903 254 0.026
ribonucleotide catabolic process GO:0009261 405 0.026
cellular response to toxic substance GO:0097237 4 0.026
negative regulation of reactive oxygen species biosynthetic process GO:1903427 1 0.025
cellular response to hormone stimulus GO:0032870 125 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.025
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.025
chromatin organization GO:0006325 351 0.025
cell morphogenesis GO:0000902 296 0.025
Mouse
system process GO:0003008 349 0.025
ras protein signal transduction GO:0007265 73 0.024
protein secretion GO:0009306 98 0.024
protein targeting to nucleus GO:0044744 104 0.024
positive regulation of cell death GO:0010942 263 0.024
determination of adult lifespan GO:0008340 2 0.024
proteasomal protein catabolic process GO:0010498 176 0.024
cell division GO:0051301 168 0.024
chromatin modification GO:0016568 298 0.024
cellular component morphogenesis GO:0032989 314 0.024
Mouse
guanosine containing compound catabolic process GO:1901069 239 0.024
mitotic cell cycle GO:0000278 326 0.024
positive regulation of protein phosphorylation GO:0001934 313 0.024
regulation of cell projection organization GO:0031344 107 0.024
Rat
oogenesis GO:0048477 2 0.023
inorganic cation transmembrane transport GO:0098662 194 0.023
nucleoside catabolic process GO:0009164 408 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
anion transport GO:0006820 161 0.023
histone modification GO:0016570 251 0.023
positive regulation of catabolic process GO:0009896 310 0.023
defense response to other organism GO:0098542 129 0.023
peptidyl serine modification GO:0018209 106 0.023
lipid localization GO:0010876 106 0.023
protein localization to nucleus GO:0034504 136 0.023
response to virus GO:0009615 126 0.022
protein targeting GO:0006605 187 0.022
negative regulation of cellular protein metabolic process GO:0032269 353 0.022
regulation of cell development GO:0060284 161 0.021
Rat
nuclear import GO:0051170 106 0.021
purine ribonucleoside catabolic process GO:0046130 398 0.021
motor neuron axon guidance GO:0008045 2 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
regulation of anatomical structure morphogenesis GO:0022603 286 0.021
reactive oxygen species biosynthetic process GO:1903409 4 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
response to external biotic stimulus GO:0043207 261 0.021
regulation of protein secretion GO:0050708 86 0.021
single organism nuclear import GO:1902593 104 0.021
regulation of cell motility GO:2000145 299 0.021
inorganic ion transmembrane transport GO:0098660 231 0.021
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.021
purine ribonucleoside metabolic process GO:0046128 437 0.020
associative learning GO:0008306 1 0.020
Mouse
cellular protein complex assembly GO:0043623 188 0.020
defense response to virus GO:0051607 71 0.020
biological adhesion GO:0022610 331 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
cerebellum development GO:0021549 2 0.020
negative regulation of hydrolase activity GO:0051346 182 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
regulation of wnt protein secretion GO:0061356 1 0.019
regulation of synaptic plasticity GO:0048167 3 0.019
regulation of locomotion GO:0040012 329 0.019
negative regulation of camp mediated signaling GO:0043951 4 0.019
regulation of cell division GO:0051302 116 0.019
negative regulation of organelle organization GO:0010639 126 0.019
Mouse
protein import GO:0017038 130 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
oxidation reduction process GO:0055114 396 0.019
wnt protein secretion GO:0061355 1 0.019
muscle contraction GO:0006936 73 0.019
regulation of cellular response to stress GO:0080135 244 0.019
response to other organism GO:0051707 261 0.018
adult locomotory behavior GO:0008344 1 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.018
covalent chromatin modification GO:0016569 254 0.018
protein import into nucleus GO:0006606 104 0.018
neuromuscular junction development GO:0007528 3 0.018
regulation of cytoskeleton organization GO:0051493 177 0.018
Mouse
divalent inorganic cation homeostasis GO:0072507 136 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
regulation of intracellular transport GO:0032386 195 0.018
second messenger mediated signaling GO:0019932 78 0.018
fatty acid metabolic process GO:0006631 115 0.018
response to oxygen levels GO:0070482 100 0.018
blastoderm segmentation GO:0007350 2 0.018
positive regulation of secretion GO:0051047 116 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
regulation of vesicle mediated transport GO:0060627 130 0.018
regulation of protein catabolic process GO:0042176 155 0.018
cellular calcium ion homeostasis GO:0006874 117 0.018
guanosine containing compound metabolic process GO:1901068 244 0.017
cellular homeostasis GO:0019725 196 0.017
generation of neurons GO:0048699 152 0.017
Mouse Rat
cortisol secretion GO:0043400 4 0.017
dephosphorylation GO:0016311 209 0.017
cellular response to nitrogen compound GO:1901699 144 0.017
cell projection assembly GO:0030031 126 0.017
single organism membrane organization GO:0044802 268 0.017
cell projection morphogenesis GO:0048858 129 0.017
Mouse
response to hormone GO:0009725 175 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
protein processing GO:0016485 226 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
regulation of transmembrane transport GO:0034762 139 0.016
Mouse
regulation of cellular component movement GO:0051270 334 0.016
regulation of protein processing GO:0070613 150 0.016
regulation of cell differentiation GO:0045595 393 0.016
Rat
regulation of secretion GO:0051046 194 0.016
cellular ion homeostasis GO:0006873 168 0.016
regulation of cell morphogenesis GO:0022604 153 0.016
regulation of neuron differentiation GO:0045664 70 0.016
Rat
regulation of protein kinase activity GO:0045859 289 0.016
positive regulation of gtp catabolic process GO:0033126 166 0.016
positive regulation of monocyte chemotactic protein 1 production GO:0071639 3 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
negative regulation of developmental process GO:0051093 247 0.015
cellular cation homeostasis GO:0030003 163 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
protein maturation GO:0051604 233 0.015
metal ion transport GO:0030001 272 0.015
protein modification by small protein conjugation GO:0032446 342 0.015
cellular lipid metabolic process GO:0044255 303 0.015
glycosyl compound catabolic process GO:1901658 413 0.015
regulation of gtp catabolic process GO:0033124 180 0.015
regulation of cytokine production GO:0001817 232 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
regulation of cation channel activity GO:2001257 33 0.015
cyclic nucleotide mediated signaling GO:0019935 26 0.015
negative regulation of protein modification process GO:0031400 200 0.015
regulation of cell adhesion GO:0030155 166 0.015
calcium ion homeostasis GO:0055074 122 0.015
positive regulation of cellular component biogenesis GO:0044089 158 0.015
positive regulation of cell cycle process GO:0090068 106 0.015
cellular response to glucocorticoid stimulus GO:0071385 4 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
response to decreased oxygen levels GO:0036293 96 0.015
peptidyl serine phosphorylation GO:0018105 101 0.015
positive regulation of apoptotic process GO:0043065 246 0.014
protein ubiquitination GO:0016567 314 0.014
response to nitrogen compound GO:1901698 184 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
spermatid differentiation GO:0048515 4 0.014
neuropeptide signaling pathway GO:0007218 19 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
Rat
positive regulation of cellular catabolic process GO:0031331 284 0.014
ion homeostasis GO:0050801 230 0.014
positive regulation of protein transport GO:0051222 135 0.014
regulation of cortisol secretion GO:0051462 4 0.014
regulation of transferase activity GO:0051338 355 0.014
cellular chemical homeostasis GO:0055082 180 0.014
protein oligomerization GO:0051259 173 0.014
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.014
regulation of growth GO:0040008 165 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
glial cell migration GO:0008347 4 0.014
immune effector process GO:0002252 159 0.014
cardiovascular system development GO:0072358 262 0.014
response to hypoxia GO:0001666 96 0.014
monocarboxylic acid metabolic process GO:0032787 185 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
actin cytoskeleton organization GO:0030036 207 0.013
Mouse
modification dependent protein catabolic process GO:0019941 209 0.013
cellular response to hypoxia GO:0071456 51 0.013
cell adhesion GO:0007155 325 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
circadian behavior GO:0048512 2 0.013
glucocorticoid secretion GO:0035933 4 0.013
negative regulation of protein transport GO:0051224 75 0.013
epithelial cell differentiation GO:0030855 141 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
regulation of kinase activity GO:0043549 314 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
microtubule based process GO:0007017 210 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
spermatid development GO:0007286 4 0.013
lipid catabolic process GO:0016042 84 0.013
positive regulation of cell development GO:0010720 92 0.013
Rat
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
cytokinesis GO:0000910 96 0.013
gtp catabolic process GO:0006184 237 0.013
mitotic cell cycle process GO:1903047 286 0.012
compound eye development GO:0048749 1 0.012
cellular response to oxygen levels GO:0071453 55 0.012
metal ion homeostasis GO:0055065 169 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
maintenance of location GO:0051235 112 0.012
negative regulation of immune system process GO:0002683 136 0.012
cellular response to organic cyclic compound GO:0071407 127 0.012
regulation of multi organism process GO:0043900 157 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
response to cytokine GO:0034097 232 0.012
regulation of ras gtpase activity GO:0032318 128 0.012
mapk cascade GO:0000165 288 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
regulation of response to external stimulus GO:0032101 222 0.012
negative regulation of synaptic transmission GO:0050805 2 0.012
organic hydroxy compound transport GO:0015850 63 0.012
rna processing GO:0006396 255 0.012
response to oxidative stress GO:0006979 121 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
negative regulation of protein complex assembly GO:0031333 43 0.012
peptidyl lysine modification GO:0018205 144 0.012
regulation of protein maturation GO:1903317 150 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
nerve development GO:0021675 4 0.012
regeneration GO:0031099 4 0.012
nitrogen compound transport GO:0071705 191 0.012
cytokine production GO:0001816 247 0.012
ribose phosphate biosynthetic process GO:0046390 82 0.011
negative regulation of protein maturation GO:1903318 142 0.011
regulation of gtpase activity GO:0043087 180 0.011
rho protein signal transduction GO:0007266 26 0.011
response to lipid GO:0033993 206 0.011
single organism cell adhesion GO:0098602 179 0.011
lipid transport GO:0006869 90 0.011
response to nutrient levels GO:0031667 81 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
response to organonitrogen compound GO:0010243 156 0.011
peptidyl tyrosine modification GO:0018212 170 0.011
response to extracellular stimulus GO:0009991 85 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
neurological system process GO:0050877 163 0.011
organ formation GO:0048645 3 0.011
protein polymerization GO:0051258 71 0.011
positive regulation of locomotion GO:0040017 186 0.011
membrane organization GO:0061024 292 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.011
positive regulation of proteolysis GO:0045862 142 0.011
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
organic acid catabolic process GO:0016054 71 0.011
hormone transport GO:0009914 68 0.011
osteoblast differentiation GO:0001649 92 0.011
negative regulation of cell cycle GO:0045786 193 0.011
response to axon injury GO:0048678 1 0.011
methylation GO:0032259 106 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
ameboidal type cell migration GO:0001667 135 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
positive regulation of organelle organization GO:0010638 195 0.011
small molecule biosynthetic process GO:0044283 157 0.011
positive regulation of ion transmembrane transporter activity GO:0032414 29 0.011
negative regulation of proteolysis GO:0045861 132 0.011
purine nucleotide biosynthetic process GO:0006164 84 0.011
regulation of hormone levels GO:0010817 125 0.011
protein localization to membrane GO:0072657 160 0.011
apoptotic signaling pathway GO:0097190 268 0.011
purine containing compound biosynthetic process GO:0072522 88 0.011
gtp metabolic process GO:0046039 239 0.011
positive regulation of intracellular transport GO:0032388 104 0.011
regulation of lipid transport GO:0032368 44 0.010
ribonucleotide biosynthetic process GO:0009260 81 0.010
regulation of proteasomal protein catabolic process GO:0061136 87 0.010
neuron development GO:0048666 113 0.010
Mouse Rat
protein autophosphorylation GO:0046777 123 0.010
signal transduction by phosphorylation GO:0023014 297 0.010
regulation of intracellular protein transport GO:0033157 123 0.010
negative regulation of secretion by cell GO:1903531 52 0.010
positive regulation of gtpase activity GO:0043547 166 0.010
neurotransmitter secretion GO:0007269 4 0.010
negative regulation of secretion GO:0051048 58 0.010
negative regulation of protein processing GO:0010955 142 0.010
regulation of response to dna damage stimulus GO:2001020 94 0.010
regulation of protein serine threonine kinase activity GO:0071900 179 0.010
regulation of peptidase activity GO:0052547 180 0.010
endomembrane system organization GO:0010256 196 0.010
dna repair GO:0006281 198 0.010
hemopoiesis GO:0030097 180 0.010
monovalent inorganic cation transport GO:0015672 128 0.010
positive regulation of cell division GO:0051781 59 0.010
negative regulation of catabolic process GO:0009895 104 0.010
carboxylic acid catabolic process GO:0046395 71 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010
positive regulation of kinase activity GO:0033674 204 0.010
oocyte differentiation GO:0009994 2 0.010
actin filament based process GO:0030029 224 0.010
Mouse
anterior posterior axis specification GO:0009948 2 0.010
negative regulation of protein phosphorylation GO:0001933 140 0.010

SHANK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.022
nervous system disease DOID:863 431 0.022
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
disease of metabolism DOID:0014667 295 0.011
disease of cellular proliferation DOID:14566 174 0.010