Homo sapiens

36 known processes

MLL3

myeloid/lymphoid or mixed-lineage leukemia 3

(Aliases: KMT2C,FLJ38309,HALR,MGC119851,MGC119852,MGC119853,DKFZp686C08112,FLJ12625,KIAA1506)

MLL3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin organization GO:0006325 351 0.956
chromatin modification GO:0016568 298 0.940
protein alkylation GO:0008213 74 0.921
covalent chromatin modification GO:0016569 254 0.900
histone lysine methylation GO:0034968 50 0.839
histone h3 k4 methylation GO:0051568 27 0.793
histone modification GO:0016570 251 0.731
cellular response to dna damage stimulus GO:0006974 379 0.521
macromolecule methylation GO:0043414 97 0.454
determination of adult lifespan GO:0008340 2 0.433
embryonic placenta development GO:0001892 1 0.425
methylation GO:0032259 106 0.336
multicellular organismal aging GO:0010259 3 0.306
amine metabolic process GO:0009308 44 0.301
cardiovascular system development GO:0072358 262 0.301
protein methylation GO:0006479 74 0.225
peptidyl lysine methylation GO:0018022 37 0.222
dna templated transcription initiation GO:0006352 35 0.198
cellular ketone metabolic process GO:0042180 80 0.183
regulation of cellular ketone metabolic process GO:0010565 50 0.155
histone methylation GO:0016571 60 0.153
protein acetylation GO:0006473 116 0.146
cellular amino acid metabolic process GO:0006520 116 0.138
primary neural tube formation GO:0014020 3 0.133
circulatory system development GO:0072359 262 0.125
positive regulation of catabolic process GO:0009896 310 0.118
regulation of protein serine threonine kinase activity GO:0071900 179 0.111
heart development GO:0007507 95 0.100
post embryonic development GO:0009791 2 0.084
internal peptidyl lysine acetylation GO:0018393 97 0.079
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.078
cell activation GO:0001775 213 0.072
regulation of response to dna damage stimulus GO:2001020 94 0.071
neuron projection development GO:0031175 106 0.069
small gtpase mediated signal transduction GO:0007264 78 0.068
nervous system development GO:0007399 293 0.066
regulation of protein complex assembly GO:0043254 147 0.065
single organism reproductive process GO:0044702 98 0.065
positive regulation of cell differentiation GO:0045597 211 0.063
response to axon injury GO:0048678 1 0.062
cellular amine metabolic process GO:0044106 41 0.061
cellular component morphogenesis GO:0032989 314 0.061
leukocyte activation GO:0045321 164 0.057
regulation of growth GO:0040008 165 0.057
signal transduction by phosphorylation GO:0023014 297 0.057
immune response GO:0006955 307 0.056
cell projection morphogenesis GO:0048858 129 0.054
histone h3 k27 demethylation GO:0071557 3 0.054
cellular macromolecular complex assembly GO:0034622 324 0.054
regulation of protein kinase activity GO:0045859 289 0.053
actin cytoskeleton organization GO:0030036 207 0.052
embryonic organ development GO:0048568 36 0.052
purine ribonucleotide catabolic process GO:0009154 404 0.052
positive regulation of protein kinase activity GO:0045860 190 0.051
positive regulation of protein phosphorylation GO:0001934 313 0.051
neuron projection regeneration GO:0031102 1 0.050
actin filament based process GO:0030029 224 0.049
positive regulation of organelle organization GO:0010638 195 0.048
Fly
segmentation GO:0035282 4 0.048
immune system development GO:0002520 195 0.047
reproductive process GO:0022414 106 0.047
chordate embryonic development GO:0043009 34 0.046
myeloid cell differentiation GO:0030099 117 0.046
protein dna complex subunit organization GO:0071824 80 0.046
negative regulation of cellular protein metabolic process GO:0032269 353 0.045
negative regulation of protein metabolic process GO:0051248 391 0.045
mapk cascade GO:0000165 288 0.045
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.045
positive regulation of mapk cascade GO:0043410 190 0.044
regulation of mapk cascade GO:0043408 262 0.044
glycosyl compound catabolic process GO:1901658 413 0.044
embryonic epithelial tube formation GO:0001838 4 0.041
collateral sprouting GO:0048668 2 0.041
immune effector process GO:0002252 159 0.041
regulation of protein processing GO:0070613 150 0.041
histone demethylation GO:0016577 15 0.041
response to organic cyclic compound GO:0014070 204 0.040
Human
regulation of cellular amine metabolic process GO:0033238 11 0.040
mrna metabolic process GO:0016071 175 0.040
regeneration GO:0031099 4 0.040
regulation of kinase activity GO:0043549 314 0.039
head development GO:0060322 108 0.039
cell part morphogenesis GO:0032990 137 0.038
positive regulation of nucleotide catabolic process GO:0030813 185 0.038
regulation of neurotransmitter secretion GO:0046928 3 0.038
brain development GO:0007420 97 0.037
actin filament organization GO:0007015 128 0.037
protein acylation GO:0043543 138 0.037
purine nucleotide catabolic process GO:0006195 405 0.037
peptidyl lysine dimethylation GO:0018027 3 0.037
guanosine containing compound catabolic process GO:1901069 239 0.037
negative regulation of protein maturation GO:1903318 142 0.036
cellular response to organic cyclic compound GO:0071407 127 0.036
protein deacylation GO:0035601 39 0.036
anterior posterior axis specification GO:0009948 2 0.036
morphogenesis of embryonic epithelium GO:0016331 4 0.036
negative regulation of programmed cell death GO:0043069 321 0.036
peptidyl threonine modification GO:0018210 45 0.035
purine ribonucleoside catabolic process GO:0046130 398 0.035
anatomical structure homeostasis GO:0060249 100 0.034
regulation of multi organism process GO:0043900 157 0.034
ubiquitin dependent protein catabolic process GO:0006511 206 0.033
response to salt stress GO:0009651 3 0.033
regulation of developmental growth GO:0048638 30 0.033
female gamete generation GO:0007292 2 0.033
regulation of gene expression epigenetic GO:0040029 73 0.032
gene silencing GO:0016458 49 0.032
response to steroid hormone GO:0048545 80 0.031
Human
purine nucleoside catabolic process GO:0006152 398 0.031
negative regulation of intracellular signal transduction GO:1902532 183 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
hematopoietic or lymphoid organ development GO:0048534 186 0.031
regulation of map kinase activity GO:0043405 108 0.031
regulation of purine nucleotide metabolic process GO:1900542 264 0.031
nucleoside triphosphate metabolic process GO:0009141 422 0.031
protein processing GO:0016485 226 0.031
response to acid chemical GO:0001101 66 0.030
regulation of myeloid leukocyte differentiation GO:0002761 39 0.030
peptidyl threonine phosphorylation GO:0018107 41 0.030
purine nucleoside triphosphate catabolic process GO:0009146 392 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
cellular protein catabolic process GO:0044257 261 0.029
oogenesis GO:0048477 2 0.029
regulation of cellular response to stress GO:0080135 244 0.029
single organism carbohydrate metabolic process GO:0044723 193 0.029
regulation of small gtpase mediated signal transduction GO:0051056 156 0.029
response to oxygen containing compound GO:1901700 369 0.029
negative regulation of cellular amine metabolic process GO:0033239 3 0.028
protein ubiquitination GO:0016567 314 0.028
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.028
peptidyl serine modification GO:0018209 106 0.028
cell development GO:0048468 328 0.027
intracellular receptor signaling pathway GO:0030522 104 0.027
Human
nucleotide catabolic process GO:0009166 408 0.027
cell projection organization GO:0030030 252 0.027
tube closure GO:0060606 3 0.027
nucleoside triphosphate catabolic process GO:0009143 394 0.027
regulation of nucleotide metabolic process GO:0006140 269 0.027
hemopoiesis GO:0030097 180 0.027
peptidyl lysine modification GO:0018205 144 0.026
axon regeneration GO:0031103 1 0.026
positive regulation of cell proliferation GO:0008284 301 0.026
Human
regulation of purine nucleotide catabolic process GO:0033121 205 0.026
regulation of protein maturation GO:1903317 150 0.026
cell morphogenesis GO:0000902 296 0.026
transdifferentiation GO:0060290 2 0.026
ameboidal type cell migration GO:0001667 135 0.026
antimicrobial humoral response GO:0019730 26 0.026
regulation of response to external stimulus GO:0032101 222 0.026
neutrophil mediated immunity GO:0002446 4 0.025
tube development GO:0035295 125 0.025
positive regulation of cellular component organization GO:0051130 376 0.025
Fly
ribonucleotide catabolic process GO:0009261 405 0.025
dephosphorylation GO:0016311 209 0.025
regulation of locomotion GO:0040012 329 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
regulation of nucleoside metabolic process GO:0009118 209 0.024
cellular response to oxygen containing compound GO:1901701 276 0.024
protein maturation GO:0051604 233 0.024
organophosphate catabolic process GO:0046434 430 0.024
blood vessel development GO:0001568 172 0.023
negative regulation of proteolysis GO:0045861 132 0.023
embryo development GO:0009790 123 0.023
positive regulation of cellular amine metabolic process GO:0033240 7 0.023
negative regulation of catabolic process GO:0009895 104 0.023
dna damage checkpoint GO:0000077 68 0.023
epithelium development GO:0060429 227 0.022
ras protein signal transduction GO:0007265 73 0.022
gtp catabolic process GO:0006184 237 0.022
aging GO:0007568 66 0.022
positive regulation of gtpase activity GO:0043547 166 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
protein catabolic process GO:0030163 325 0.022
regulation of immune response GO:0050776 201 0.022
endothelial cell migration GO:0043542 86 0.022
negative regulation of apoptotic process GO:0043066 316 0.022
purine containing compound catabolic process GO:0072523 411 0.022
response to wounding GO:0009611 168 0.021
nucleoside catabolic process GO:0009164 408 0.021
cellular response to growth factor stimulus GO:0071363 197 0.021
response to estrogen GO:0043627 47 0.021
Human
negative regulation of cellular component organization GO:0051129 235 0.021
regulation of protein catabolic process GO:0042176 155 0.021
regulation of nucleotide catabolic process GO:0030811 205 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.021
carbohydrate metabolic process GO:0005975 207 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.020
negative regulation of chromatin silencing GO:0031936 4 0.020
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.020
rna catabolic process GO:0006401 71 0.020
behavior GO:0007610 112 0.020
mitotic sister chromatid segregation GO:0000070 53 0.020
reactive nitrogen species metabolic process GO:2001057 3 0.019
establishment of nucleus localization GO:0040023 1 0.019
system process GO:0003008 349 0.019
tissue migration GO:0090130 119 0.019
blood vessel morphogenesis GO:0048514 162 0.019
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.019
protein dealkylation GO:0008214 17 0.019
regulation of proteasomal protein catabolic process GO:0061136 87 0.019
nuclear migration GO:0007097 1 0.019
cell morphogenesis involved in differentiation GO:0000904 144 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
regulation of synaptic vesicle transport GO:1902803 3 0.019
compound eye development GO:0048749 1 0.019
Fly
purine ribonucleoside metabolic process GO:0046128 437 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.019
demethylation GO:0070988 37 0.018
ribonucleoside triphosphate metabolic process GO:0009199 412 0.018
response to nitrogen compound GO:1901698 184 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.018
neuromuscular junction development GO:0007528 3 0.018
cell growth GO:0016049 160 0.018
regulation of autophagy GO:0010506 52 0.018
positive regulation of immune system process GO:0002684 283 0.018
negative regulation of synaptic transmission GO:0050805 2 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
regulation of dna metabolic process GO:0051052 153 0.018
multi organism reproductive process GO:0044703 54 0.018
guanosine containing compound metabolic process GO:1901068 244 0.018
negative regulation of phosphorylation GO:0042326 174 0.018
negative regulation of ruffle assembly GO:1900028 3 0.017
negative regulation of protein modification process GO:0031400 200 0.017
protein autophosphorylation GO:0046777 123 0.017
regulation of cellular component movement GO:0051270 334 0.017
macromolecule deacylation GO:0098732 41 0.017
regulation of chromosome organization GO:0033044 103 0.017
Fly
respiratory gaseous exchange GO:0007585 3 0.017
vasculature development GO:0001944 181 0.017
apoptotic signaling pathway GO:0097190 268 0.017
cation transmembrane transport GO:0098655 238 0.017
positive regulation of cell death GO:0010942 263 0.017
regulation of transferase activity GO:0051338 355 0.017
blastoderm segmentation GO:0007350 2 0.017
neurotransmitter secretion GO:0007269 4 0.017
nucleosome organization GO:0034728 66 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
inner ear morphogenesis GO:0042472 4 0.016
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.016
gtp metabolic process GO:0046039 239 0.016
regulation of granulocyte differentiation GO:0030852 11 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
mitotic cell cycle checkpoint GO:0007093 68 0.016
cellular carbohydrate metabolic process GO:0044262 84 0.016
negative regulation of cell cycle process GO:0010948 121 0.016
cellular response to lipid GO:0071396 127 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.016
epithelium migration GO:0090132 119 0.016
cytokine production GO:0001816 247 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
positive regulation of transferase activity GO:0051347 227 0.016
regulation of cellular component biogenesis GO:0044087 281 0.016
interleukin 6 production GO:0032635 37 0.016
maintenance of location GO:0051235 112 0.015
cellular macromolecule catabolic process GO:0044265 380 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.015
nucleus localization GO:0051647 1 0.015
rna 3 end processing GO:0031123 35 0.015
positive regulation of kinase activity GO:0033674 204 0.015
positive regulation of growth GO:0045927 58 0.015
positive regulation of cell growth GO:0030307 48 0.015
response to other organism GO:0051707 261 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.015
organonitrogen compound biosynthetic process GO:1901566 200 0.015
erythrocyte homeostasis GO:0034101 31 0.015
reactive oxygen species biosynthetic process GO:1903409 4 0.015
neural tube formation GO:0001841 3 0.015
metencephalon development GO:0022037 2 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
response to retinoic acid GO:0032526 33 0.015
inorganic cation transmembrane transport GO:0098662 194 0.014
developmental process involved in reproduction GO:0003006 66 0.014
rho protein signal transduction GO:0007266 26 0.014
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.014
regulation of gtpase activity GO:0043087 180 0.014
activation of protein kinase activity GO:0032147 90 0.014
positive regulation of myeloid cell differentiation GO:0045639 39 0.014
histone acetylation GO:0016573 93 0.014
dna repair GO:0006281 198 0.014
leukocyte mediated immunity GO:0002443 59 0.014
negative regulation of cell cycle GO:0045786 193 0.014
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.014
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.014
endocytosis GO:0006897 159 0.014
negative regulation of protein processing GO:0010955 142 0.013
positive regulation of gtp catabolic process GO:0033126 166 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.013
synaptic vesicle exocytosis GO:0016079 3 0.013
cytoplasmic transport GO:0016482 379 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.013
regulation of protein transport GO:0051223 213 0.013
epithelial cell proliferation GO:0050673 128 0.013
reproductive structure development GO:0048608 55 0.013
regulation of gtp catabolic process GO:0033124 180 0.013
endocardial cell differentiation GO:0060956 2 0.013
dna integrity checkpoint GO:0031570 71 0.013
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
negative regulation of organelle organization GO:0010639 126 0.013
dna conformation change GO:0071103 113 0.013
positive regulation of leukocyte differentiation GO:1902107 37 0.013
reproductive system development GO:0061458 56 0.013
positive regulation of cytokine production GO:0001819 167 0.013
telomere organization GO:0032200 33 0.012
histone lysine demethylation GO:0070076 14 0.012
oocyte differentiation GO:0009994 2 0.012
neurogenesis GO:0022008 169 0.012
positive regulation of dna metabolic process GO:0051054 73 0.012
protein modification by small protein conjugation GO:0032446 342 0.012
lymphocyte activation GO:0046649 133 0.012
protein polymerization GO:0051258 71 0.012
internal protein amino acid acetylation GO:0006475 101 0.012
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.012
neural tube closure GO:0001843 3 0.012
cellular amide metabolic process GO:0043603 69 0.012
oocyte development GO:0048599 1 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
regulation of erk1 and erk2 cascade GO:0070372 99 0.012
response to organonitrogen compound GO:0010243 156 0.012
canonical wnt signaling pathway GO:0060070 116 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.012
myosin filament organization GO:0031033 2 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
forelimb morphogenesis GO:0035136 4 0.012
cell cycle phase transition GO:0044770 173 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
cellular protein complex assembly GO:0043623 188 0.012
regulation of chromatin modification GO:1903308 51 0.011
Fly
spermatid differentiation GO:0048515 4 0.011
response to radiation GO:0009314 151 0.011
locomotory behavior GO:0007626 1 0.011
erythrocyte development GO:0048821 3 0.011
response to abiotic stimulus GO:0009628 336 0.011
vesicle mediated transport GO:0016192 371 0.011
regulation of dephosphorylation GO:0035303 96 0.011
mitotic cell cycle process GO:1903047 286 0.011
regulation of synaptic vesicle exocytosis GO:2000300 2 0.011
protein demethylation GO:0006482 17 0.011
divalent inorganic cation transport GO:0072511 158 0.011
mrna processing GO:0006397 133 0.011
cellular response to acid chemical GO:0071229 44 0.011
establishment of organelle localization GO:0051656 59 0.011
microtubule based process GO:0007017 210 0.011
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.011
ncrna processing GO:0034470 83 0.011
regulation of epithelial cell migration GO:0010632 93 0.011
actin filament polymerization GO:0030041 45 0.011
ion transmembrane transport GO:0034220 338 0.011
regulation of myeloid cell differentiation GO:0045637 81 0.011
negative regulation of peptidase activity GO:0010466 91 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
mrna catabolic process GO:0006402 56 0.010
regulation of cell division GO:0051302 116 0.010
multicellular organismal reproductive process GO:0048609 40 0.010
regulation of secretion by cell GO:1903530 177 0.010
photoreceptor cell differentiation GO:0046530 2 0.010
rna processing GO:0006396 255 0.010
memory GO:0007613 3 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
regulation of proteolysis GO:0030162 293 0.010
regulation of peptidase activity GO:0052547 180 0.010
regulation of b cell activation GO:0050864 24 0.010
cellular lipid metabolic process GO:0044255 303 0.010
mitotic cell cycle GO:0000278 326 0.010
peptidyl serine phosphorylation GO:0018105 101 0.010
positive regulation of transport GO:0051050 336 0.010
positive regulation of hydrolase activity GO:0051345 331 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.010
actin filament bundle organization GO:0061572 54 0.010
striated muscle myosin thick filament assembly GO:0071688 2 0.010
regulation of cell cycle process GO:0010564 266 0.010
cell cell junction organization GO:0045216 69 0.010
neurological system process GO:0050877 163 0.010
negative regulation of cellular protein catabolic process GO:1903363 38 0.010

MLL3 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.016
nervous system disease DOID:863 431 0.016
disease of cellular proliferation DOID:14566 174 0.014
immune system disease DOID:2914 155 0.013
hematopoietic system disease DOID:74 100 0.013
cancer DOID:162 167 0.010
organ system cancer DOID:0050686 164 0.010