Homo sapiens

146 known processes

MLL5

myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)

(Aliases: FLJ14026,MGC70452,FLJ10078,HDCMC04P,KMT2E)

MLL5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular amine metabolic process GO:0033240 7 0.395
regulation of cellular amino acid metabolic process GO:0006521 6 0.309
cellular amine metabolic process GO:0044106 41 0.300
histone modification GO:0016570 251 0.297
chromatin modification GO:0016568 298 0.256
chromatin organization GO:0006325 351 0.228
regulation of cellular ketone metabolic process GO:0010565 50 0.220
regulation of cellular amine metabolic process GO:0033238 11 0.210
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.200
cellular amino acid metabolic process GO:0006520 116 0.195
cellular ketone metabolic process GO:0042180 80 0.188
protein modification by small protein conjugation GO:0032446 342 0.182
amine metabolic process GO:0009308 44 0.182
covalent chromatin modification GO:0016569 254 0.165
protein ubiquitination GO:0016567 314 0.157
regulation of cell differentiation GO:0045595 393 0.139
methylation GO:0032259 106 0.121
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.082
positive regulation of catabolic process GO:0009896 310 0.081
histone lysine methylation GO:0034968 50 0.077
actin filament based process GO:0030029 224 0.076
hemopoiesis GO:0030097 180 0.076
regulation of cellular response to stress GO:0080135 244 0.069
small gtpase mediated signal transduction GO:0007264 78 0.066
regulation of mapk cascade GO:0043408 262 0.065
negative regulation of catalytic activity GO:0043086 335 0.062
ribonucleoside triphosphate catabolic process GO:0009203 391 0.061
ras protein signal transduction GO:0007265 73 0.061
negative regulation of cellular protein metabolic process GO:0032269 353 0.060
negative regulation of multicellular organismal process GO:0051241 317 0.058
positive regulation of organelle organization GO:0010638 195 0.057
determination of adult lifespan GO:0008340 2 0.055
post embryonic development GO:0009791 2 0.055
signal transduction by phosphorylation GO:0023014 297 0.054
circulatory system development GO:0072359 262 0.053
positive regulation of cellular component organization GO:0051130 376 0.050
hematopoietic or lymphoid organ development GO:0048534 186 0.048
immune response GO:0006955 307 0.047
cellular response to endogenous stimulus GO:0071495 336 0.047
positive regulation of chromosome organization GO:2001252 41 0.047
positive regulation of cellular catabolic process GO:0031331 284 0.047
peptidyl lysine modification GO:0018205 144 0.045
macromolecule methylation GO:0043414 97 0.043
peptidyl lysine acetylation GO:0018394 101 0.043
negative regulation of protein metabolic process GO:0051248 391 0.042
oxidation reduction process GO:0055114 396 0.040
regulation of immune response GO:0050776 201 0.040
regulation of cell cycle GO:0051726 393 0.040
negative regulation of protein modification process GO:0031400 200 0.039
cellular macromolecule catabolic process GO:0044265 380 0.038
protein acetylation GO:0006473 116 0.037
response to organic cyclic compound GO:0014070 204 0.037
regulation of cell division GO:0051302 116 0.036
myeloid cell differentiation GO:0030099 117 0.036
mapk cascade GO:0000165 288 0.036
cellular macromolecular complex assembly GO:0034622 324 0.036
ribonucleotide catabolic process GO:0009261 405 0.035
leukocyte activation GO:0045321 164 0.035
Mouse
behavior GO:0007610 112 0.035
negative regulation of cellular amine metabolic process GO:0033239 3 0.035
regulation of chromosome organization GO:0033044 103 0.035
cardiovascular system development GO:0072358 262 0.034
purine nucleoside triphosphate metabolic process GO:0009144 412 0.034
lymphocyte activation GO:0046649 133 0.033
regulation of cell cycle process GO:0010564 266 0.033
negative regulation of cell differentiation GO:0045596 171 0.033
ribonucleoside triphosphate metabolic process GO:0009199 412 0.032
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.031
histone methylation GO:0016571 60 0.031
guanosine containing compound metabolic process GO:1901068 244 0.031
cytokine production GO:0001816 247 0.031
system process GO:0003008 349 0.031
purine nucleoside triphosphate catabolic process GO:0009146 392 0.030
motor neuron axon guidance GO:0008045 2 0.030
ubiquitin dependent protein catabolic process GO:0006511 206 0.030
negative regulation of phosphate metabolic process GO:0045936 267 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.030
nucleoside catabolic process GO:0009164 408 0.030
nucleotide catabolic process GO:0009166 408 0.029
actin cytoskeleton organization GO:0030036 207 0.029
secretion by cell GO:0032940 226 0.029
oogenesis GO:0048477 2 0.029
neurological system process GO:0050877 163 0.029
ribonucleoside catabolic process GO:0042454 406 0.029
positive regulation of immune response GO:0050778 159 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.029
protein catabolic process GO:0030163 325 0.028
organ morphogenesis GO:0009887 147 0.028
negative regulation of phosphorylation GO:0042326 174 0.028
compound eye development GO:0048749 1 0.028
regulation of histone modification GO:0031056 47 0.028
hematopoietic progenitor cell differentiation GO:0002244 38 0.028
cellular response to organic cyclic compound GO:0071407 127 0.028
protein deacylation GO:0035601 39 0.027
multicellular organismal aging GO:0010259 3 0.027
nucleoside triphosphate metabolic process GO:0009141 422 0.027
cell morphogenesis GO:0000902 296 0.027
positive regulation of cell proliferation GO:0008284 301 0.026
regulation of small gtpase mediated signal transduction GO:0051056 156 0.026
anatomical structure formation involved in morphogenesis GO:0048646 284 0.026
gtp metabolic process GO:0046039 239 0.026
negative regulation of cellular component organization GO:0051129 235 0.026
purine nucleotide catabolic process GO:0006195 405 0.026
glycosyl compound catabolic process GO:1901658 413 0.026
regulation of cellular component biogenesis GO:0044087 281 0.026
regulation of cytoskeleton organization GO:0051493 177 0.025
female gamete generation GO:0007292 2 0.025
positive regulation of immune system process GO:0002684 283 0.025
gtp catabolic process GO:0006184 237 0.025
guanosine containing compound catabolic process GO:1901069 239 0.025
regulation of gtpase activity GO:0043087 180 0.025
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.025
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
embryonic camera type eye development GO:0031076 2 0.024
regulation of protein catabolic process GO:0042176 155 0.024
neuromuscular junction development GO:0007528 3 0.024
positive regulation of nucleoside metabolic process GO:0045979 186 0.023
histone h3 k9 modification GO:0061647 11 0.023
cellular response to dna damage stimulus GO:0006974 379 0.023
sensory perception of sound GO:0007605 37 0.023
regulation of proteasomal protein catabolic process GO:0061136 87 0.023
regulation of chromatin modification GO:1903308 51 0.023
purine containing compound catabolic process GO:0072523 411 0.022
forelimb morphogenesis GO:0035136 4 0.022
regulation of heart growth GO:0060420 4 0.022
positive regulation of phosphorylation GO:0042327 394 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
blastoderm segmentation GO:0007350 2 0.022
lipid metabolic process GO:0006629 381 0.022
sensory perception GO:0007600 103 0.022
regulation of mononuclear cell proliferation GO:0032944 65 0.022
regulation of purine nucleotide catabolic process GO:0033121 205 0.022
rna processing GO:0006396 255 0.022
cell division GO:0051301 168 0.022
nucleoside triphosphate catabolic process GO:0009143 394 0.022
regulation of secretion by cell GO:1903530 177 0.022
defense response GO:0006952 315 0.022
response to hormone GO:0009725 175 0.021
histone deacetylation GO:0016575 32 0.021
regulation of protein transport GO:0051223 213 0.021
response to biotic stimulus GO:0009607 276 0.021
metal ion transport GO:0030001 272 0.021
chemotaxis GO:0006935 157 0.021
positive regulation of gtpase activity GO:0043547 166 0.021
negative regulation of phosphorus metabolic process GO:0010563 267 0.021
neurogenesis GO:0022008 169 0.021
segmentation GO:0035282 4 0.021
rho protein signal transduction GO:0007266 26 0.021
reproductive process GO:0022414 106 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.021
mitotic nuclear division GO:0007067 119 0.021
regulation of anatomical structure morphogenesis GO:0022603 286 0.021
protein alkylation GO:0008213 74 0.020
protein methylation GO:0006479 74 0.020
purine nucleoside catabolic process GO:0006152 398 0.020
cell development GO:0048468 328 0.020
positive regulation of nucleotide catabolic process GO:0030813 185 0.020
dephosphorylation GO:0016311 209 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
secretion GO:0046903 254 0.020
regulation of nucleoside metabolic process GO:0009118 209 0.020
purine ribonucleoside catabolic process GO:0046130 398 0.019
response to other organism GO:0051707 261 0.019
mitotic cell cycle GO:0000278 326 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
protein polyubiquitination GO:0000209 110 0.019
nervous system development GO:0007399 293 0.019
regulation of secretion GO:0051046 194 0.019
histone acetylation GO:0016573 93 0.019
embryonic placenta development GO:0001892 1 0.019
rna catabolic process GO:0006401 71 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
immune response regulating signaling pathway GO:0002764 97 0.019
tube development GO:0035295 125 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
negative regulation of programmed cell death GO:0043069 321 0.018
regulation of synaptic plasticity GO:0048167 3 0.018
protein deacetylation GO:0006476 38 0.018
modification dependent macromolecule catabolic process GO:0043632 212 0.018
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.018
cellular component morphogenesis GO:0032989 314 0.018
regulation of cell activation GO:0050865 125 0.018
peptidyl lysine methylation GO:0018022 37 0.018
regulation of transferase activity GO:0051338 355 0.018
regulation of neurotransmitter secretion GO:0046928 3 0.017
intracellular receptor signaling pathway GO:0030522 104 0.017
positive regulation of protein phosphorylation GO:0001934 313 0.017
regulation of immune effector process GO:0002697 91 0.017
mrna metabolic process GO:0016071 175 0.017
dna templated transcription initiation GO:0006352 35 0.017
cellular response to lipid GO:0071396 127 0.017
response to abiotic stimulus GO:0009628 336 0.017
cell projection organization GO:0030030 252 0.017
regulation of proteolysis GO:0030162 293 0.017
epithelial cell differentiation GO:0030855 141 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
protein acylation GO:0043543 138 0.017
protein maturation GO:0051604 233 0.017
gene silencing GO:0016458 49 0.017
positive regulation of transferase activity GO:0051347 227 0.017
b cell activation GO:0042113 33 0.016
regulation of leukocyte activation GO:0002694 115 0.016
epithelium development GO:0060429 227 0.016
growth GO:0040007 202 0.016
myeloid leukocyte differentiation GO:0002573 60 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
response to external biotic stimulus GO:0043207 261 0.016
regulation of response to external stimulus GO:0032101 222 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.016
aging GO:0007568 66 0.016
response to wounding GO:0009611 168 0.016
mitotic cell cycle process GO:1903047 286 0.016
positive regulation of histone modification GO:0031058 29 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
cellular response to glucocorticoid stimulus GO:0071385 4 0.015
heart development GO:0007507 95 0.015
immune response activating signal transduction GO:0002757 90 0.015
multicellular organismal reproductive process GO:0048609 40 0.015
single organism reproductive process GO:0044702 98 0.015
immune effector process GO:0002252 159 0.015
Mouse
positive regulation of mapk cascade GO:0043410 190 0.015
positive regulation of transport GO:0051050 336 0.015
cell projection morphogenesis GO:0048858 129 0.015
cation transport GO:0006812 331 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
immune system development GO:0002520 195 0.014
neuron projection development GO:0031175 106 0.014
protein processing GO:0016485 226 0.014
regulation of multi organism process GO:0043900 157 0.014
regulation of protein kinase activity GO:0045859 289 0.014
regulation of gtp catabolic process GO:0033124 180 0.014
innate immune response GO:0045087 178 0.014
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.014
spinal cord development GO:0021510 4 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.014
negative regulation of developmental process GO:0051093 247 0.014
dna replication GO:0006260 116 0.014
lymphocyte proliferation GO:0046651 70 0.014
negative regulation of synaptic transmission GO:0050805 2 0.014
t cell activation GO:0042110 99 0.014
negative regulation of cell death GO:0060548 345 0.014
neurotransmitter secretion GO:0007269 4 0.014
negative regulation of hydrolase activity GO:0051346 182 0.013
negative regulation of secretion by cell GO:1903531 52 0.013
leukocyte differentiation GO:0002521 98 0.013
regulation of defense response GO:0031347 154 0.013
response to oxygen containing compound GO:1901700 369 0.013
multi organism reproductive process GO:0044703 54 0.013
cellular protein complex assembly GO:0043623 188 0.013
embryonic eye morphogenesis GO:0048048 2 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
myosin filament organization GO:0031033 2 0.013
sensory perception of mechanical stimulus GO:0050954 37 0.013
regulation of chromatin organization GO:1902275 56 0.013
peptidyl tyrosine phosphorylation GO:0018108 170 0.013
negative regulation of organelle organization GO:0010639 126 0.013
muscle structure development GO:0061061 98 0.013
negative regulation of protein maturation GO:1903318 142 0.013
negative regulation of t cell cytokine production GO:0002725 4 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.013
negative regulation of transport GO:0051051 176 0.013
response to radiation GO:0009314 151 0.013
negative regulation of immune system process GO:0002683 136 0.012
regulation of protein maturation GO:1903317 150 0.012
organelle fission GO:0048285 149 0.012
positive regulation of chromatin modification GO:1903310 30 0.012
cytokinesis GO:0000910 96 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
striated muscle myosin thick filament assembly GO:0071688 2 0.012
actin filament organization GO:0007015 128 0.012
cell morphogenesis involved in differentiation GO:0000904 144 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
biological adhesion GO:0022610 331 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
regulation of protein stability GO:0031647 87 0.012
negative regulation of catabolic process GO:0009895 104 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
mrna catabolic process GO:0006402 56 0.012
positive regulation of protein catabolic process GO:0045732 75 0.012
negative regulation of mapk cascade GO:0043409 56 0.012
macromolecule deacylation GO:0098732 41 0.012
cell part morphogenesis GO:0032990 137 0.012
cellular polysaccharide catabolic process GO:0044247 4 0.012
maintenance of location GO:0051235 112 0.012
memory GO:0007613 3 0.012
organelle assembly GO:0070925 176 0.012
locomotory behavior GO:0007626 1 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
negative regulation of secretion GO:0051048 58 0.012
regulation of ras gtpase activity GO:0032318 128 0.011
regulation of canonical wnt signaling pathway GO:0060828 88 0.011
negative regulation of proteolysis GO:0045861 132 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
embryonic viscerocranium morphogenesis GO:0048703 1 0.011
salivary gland morphogenesis GO:0007435 4 0.011
response to nitrogen compound GO:1901698 184 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
head development GO:0060322 108 0.011
internal peptidyl lysine acetylation GO:0018393 97 0.011
sister chromatid cohesion GO:0007062 24 0.011
protein oligomerization GO:0051259 173 0.011
cell activation GO:0001775 213 0.011
Mouse
positive regulation of gtp catabolic process GO:0033126 166 0.011
chromosome segregation GO:0007059 114 0.011
cellular protein catabolic process GO:0044257 261 0.011
blood vessel morphogenesis GO:0048514 162 0.011
protein modification by small protein removal GO:0070646 92 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
peptidyl lysine trimethylation GO:0018023 10 0.011
angiogenesis GO:0001525 147 0.011
mrna processing GO:0006397 133 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
regulation of synaptic vesicle exocytosis GO:2000300 2 0.010
antigen receptor mediated signaling pathway GO:0050851 38 0.010
viral transcription GO:0019083 35 0.010
ion transmembrane transport GO:0034220 338 0.010
peptidyl serine modification GO:0018209 106 0.010
embryonic camera type eye morphogenesis GO:0048596 2 0.010
regulation of innate immune response GO:0045088 97 0.010
regulation of protein processing GO:0070613 150 0.010
negative regulation of defense response GO:0031348 47 0.010
regulation of cytokine production GO:0001817 232 0.010
transmembrane transport GO:0055085 399 0.010
regulation of lymphocyte proliferation GO:0050670 64 0.010
inner ear morphogenesis GO:0042472 4 0.010
interspecies interaction between organisms GO:0044419 156 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.010
lymphocyte differentiation GO:0030098 35 0.010
regulation of map kinase activity GO:0043405 108 0.010
positive regulation of proteolysis GO:0045862 142 0.010

MLL5 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.012
nervous system disease DOID:863 431 0.012