Homo sapiens

0 known processes

EIF5

eukaryotic translation initiation factor 5

(Aliases: EIF-5A)

EIF5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
determination of adult lifespan GO:0008340 2 0.538
protein import into mitochondrial matrix GO:0030150 1 0.470
multicellular organismal aging GO:0010259 3 0.431
growth GO:0040007 202 0.236
negative regulation of apoptotic process GO:0043066 316 0.213
microtubule cytoskeleton organization GO:0000226 176 0.199
female gamete generation GO:0007292 2 0.148
cellular macromolecule catabolic process GO:0044265 380 0.147
cellular response to dna damage stimulus GO:0006974 379 0.133
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.132
innate immune response GO:0045087 178 0.126
transmission of nerve impulse GO:0019226 11 0.120
receptor mediated endocytosis GO:0006898 84 0.119
Worm
protein catabolic process GO:0030163 325 0.106
polyamine metabolic process GO:0006595 4 0.097
neuroblast proliferation GO:0007405 4 0.088
cellular protein catabolic process GO:0044257 261 0.084
cellular amino acid metabolic process GO:0006520 116 0.083
negative regulation of programmed cell death GO:0043069 321 0.082
negative regulation of phosphorylation GO:0042326 174 0.076
negative regulation of protein metabolic process GO:0051248 391 0.075
protein localization to mitochondrion GO:0070585 25 0.074
regulation of cellular response to stress GO:0080135 244 0.073
covalent chromatin modification GO:0016569 254 0.072
establishment of protein localization to mitochondrion GO:0072655 22 0.068
oogenesis GO:0048477 2 0.067
mitotic cell cycle GO:0000278 326 0.065
response to abiotic stimulus GO:0009628 336 0.062
positive regulation of organelle organization GO:0010638 195 0.058
protein transmembrane transport GO:0071806 25 0.058
positive regulation of growth GO:0045927 58 0.057
protein import GO:0017038 130 0.056
regulation of cell growth GO:0001558 135 0.055
transmembrane transport GO:0055085 399 0.054
regulation of peptidase activity GO:0052547 180 0.051
gtp metabolic process GO:0046039 239 0.049
ubiquitin dependent protein catabolic process GO:0006511 206 0.048
protein refolding GO:0042026 14 0.048
regulation of growth GO:0040008 165 0.048
stem cell division GO:0017145 2 0.047
negative regulation of cellular component organization GO:0051129 235 0.045
proteasomal protein catabolic process GO:0010498 176 0.045
cellular amine metabolic process GO:0044106 41 0.044
spermatid development GO:0007286 4 0.044
axon cargo transport GO:0008088 2 0.043
cell fate determination GO:0001709 3 0.043
regulation of intracellular transport GO:0032386 195 0.042
negative regulation of cell death GO:0060548 345 0.042
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.042
response to cytokine GO:0034097 232 0.041
purine ribonucleoside metabolic process GO:0046128 437 0.041
nuclear division GO:0000280 128 0.041
negative regulation of protein phosphorylation GO:0001933 140 0.041
aging GO:0007568 66 0.040
negative regulation of protein processing GO:0010955 142 0.039
neural tube formation GO:0001841 3 0.039
regulation of proteasomal protein catabolic process GO:0061136 87 0.039
wound healing GO:0042060 115 0.038
mitotic cell cycle process GO:1903047 286 0.038
dna repair GO:0006281 198 0.037
intracellular protein transmembrane import GO:0044743 23 0.037
tissue regeneration GO:0042246 3 0.037
mitochondrion organization GO:0007005 156 0.037
negative regulation of axonogenesis GO:0050771 4 0.037
protein ubiquitination GO:0016567 314 0.036
negative regulation of cell growth GO:0030308 83 0.035
spermatid differentiation GO:0048515 4 0.035
single organism cellular localization GO:1902580 332 0.035
regulation of establishment of protein localization GO:0070201 242 0.035
regulation of immune response GO:0050776 201 0.034
intracellular protein transport GO:0006886 270 0.034
amine metabolic process GO:0009308 44 0.034
response to external biotic stimulus GO:0043207 261 0.034
establishment of protein localization to organelle GO:0072594 172 0.034
apoptotic signaling pathway GO:0097190 268 0.033
mitochondrial transport GO:0006839 60 0.033
regulation of cell cycle process GO:0010564 266 0.032
dephosphorylation GO:0016311 209 0.031
regulation of protein maturation GO:1903317 150 0.031
metal ion transport GO:0030001 272 0.030
microtubule based process GO:0007017 210 0.030
cell development GO:0048468 328 0.030
positive regulation of cell death GO:0010942 263 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
single organism carbohydrate metabolic process GO:0044723 193 0.029
meiotic chromosome segregation GO:0045132 4 0.029
regeneration GO:0031099 4 0.029
regulation of kinase activity GO:0043549 314 0.029
nuclear transport GO:0051169 179 0.029
regulation of dna metabolic process GO:0051052 153 0.029
positive regulation of dna metabolic process GO:0051054 73 0.028
regulation of membrane potential GO:0042391 95 0.028
protein localization to organelle GO:0033365 280 0.028
axon ensheathment in central nervous system GO:0032291 1 0.028
negative regulation of catalytic activity GO:0043086 335 0.027
regulation of protein processing GO:0070613 150 0.027
positive regulation of hydrolase activity GO:0051345 331 0.027
protein stabilization GO:0050821 64 0.027
locomotory behavior GO:0007626 1 0.026
embryo development GO:0009790 123 0.026
Worm
regulation of cellular component movement GO:0051270 334 0.026
posttranscriptional regulation of gene expression GO:0010608 213 0.026
regulation of cell cycle phase transition GO:1901987 126 0.026
morphogenesis of embryonic epithelium GO:0016331 4 0.025
organelle assembly GO:0070925 176 0.025
nucleus localization GO:0051647 1 0.025
ribonucleotide catabolic process GO:0009261 405 0.025
regulation of cytoplasmic transport GO:1903649 149 0.025
negative regulation of phosphorus metabolic process GO:0010563 267 0.024
vesicle mediated transport GO:0016192 371 0.024
Worm
protein maturation GO:0051604 233 0.024
positive regulation of cell growth GO:0030307 48 0.024
negative regulation of intracellular signal transduction GO:1902532 183 0.024
protein processing GO:0016485 226 0.024
reactive oxygen species metabolic process GO:0072593 75 0.024
negative regulation of proteolysis GO:0045861 132 0.023
negative regulation of protein maturation GO:1903318 142 0.023
chromatin organization GO:0006325 351 0.023
cellular chemical homeostasis GO:0055082 180 0.023
reproduction GO:0000003 63 0.023
Worm
positive regulation of cellular catabolic process GO:0031331 284 0.023
developmental growth GO:0048589 48 0.023
cell growth GO:0016049 160 0.023
negative regulation of axon extension GO:0030517 2 0.022
negative regulation of hydrolase activity GO:0051346 182 0.022
blood coagulation GO:0007596 76 0.022
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.022
endocytosis GO:0006897 159 0.022
Worm
defense response GO:0006952 315 0.022
nuclear migration GO:0007097 1 0.022
immune response GO:0006955 307 0.022
regulation of mapk cascade GO:0043408 262 0.021
peptidyl serine modification GO:0018209 106 0.021
peptidyl serine phosphorylation GO:0018105 101 0.021
regulation of cell morphogenesis GO:0022604 153 0.021
anatomical structure homeostasis GO:0060249 100 0.021
positive regulation of apoptotic process GO:0043065 246 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.021
cell cycle phase transition GO:0044770 173 0.021
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.021
nucleoside phosphate catabolic process GO:1901292 412 0.021
purine containing compound biosynthetic process GO:0072522 88 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
regulation of stress activated mapk cascade GO:0032872 84 0.020
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.020
positive regulation of programmed cell death GO:0043068 249 0.020
neurological system process GO:0050877 163 0.020
regulation of meiotic cell cycle GO:0051445 4 0.020
multicellular organismal signaling GO:0035637 34 0.020
protein secretion GO:0009306 98 0.020
cation transport GO:0006812 331 0.020
regulation of proteolysis GO:0030162 293 0.020
amine biosynthetic process GO:0009309 4 0.020
negative regulation of catabolic process GO:0009895 104 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
mitotic cell cycle phase transition GO:0044772 162 0.019
anterior posterior axis specification embryo GO:0008595 2 0.019
regulation of apoptotic signaling pathway GO:2001233 175 0.019
protein targeting to mitochondrion GO:0006626 19 0.019
regulation of protein kinase activity GO:0045859 289 0.019
meiosis i GO:0007127 4 0.019
regulation of jnk cascade GO:0046328 73 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
cell activation GO:0001775 213 0.019
carbohydrate metabolic process GO:0005975 207 0.019
mitotic cell cycle checkpoint GO:0007093 68 0.018
cellular ion homeostasis GO:0006873 168 0.018
regulation of protein stability GO:0031647 87 0.018
response to wounding GO:0009611 168 0.018
histone modification GO:0016570 251 0.018
signal transduction by phosphorylation GO:0023014 297 0.018
negative regulation of kinase activity GO:0033673 106 0.018
divalent metal ion transport GO:0070838 152 0.018
secretion by cell GO:0032940 226 0.018
regulation of cytokine production GO:0001817 232 0.018
calcium ion transport GO:0006816 147 0.018
regulation of endopeptidase activity GO:0052548 170 0.018
positive regulation of transferase activity GO:0051347 227 0.018
calcium mediated signaling GO:0019722 44 0.017
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.017
regulation of neural precursor cell proliferation GO:2000177 4 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
cytokine mediated signaling pathway GO:0019221 109 0.017
neuron development GO:0048666 113 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
negative regulation of transferase activity GO:0051348 124 0.017
g protein coupled receptor signaling pathway GO:0007186 207 0.017
organophosphate catabolic process GO:0046434 430 0.017
neurogenesis GO:0022008 169 0.017
protein targeting GO:0006605 187 0.017
chemical homeostasis GO:0048878 306 0.017
methylation GO:0032259 106 0.017
negative regulation of protein modification process GO:0031400 200 0.017
cellular macromolecular complex assembly GO:0034622 324 0.017
heart development GO:0007507 95 0.017
photoreceptor cell differentiation GO:0046530 2 0.016
cation homeostasis GO:0055080 189 0.016
protein localization to membrane GO:0072657 160 0.016
positive regulation of peptidase activity GO:0010952 88 0.016
hemopoiesis GO:0030097 180 0.016
circulatory system development GO:0072359 262 0.016
regulation of locomotion GO:0040012 329 0.016
sperm motility GO:0030317 6 0.016
neuroblast division GO:0055057 1 0.016
cellular homeostasis GO:0019725 196 0.016
nucleoside triphosphate catabolic process GO:0009143 394 0.016
nucleoside catabolic process GO:0009164 408 0.016
regulation of translation GO:0006417 89 0.016
response to radiation GO:0009314 151 0.016
cellular carbohydrate metabolic process GO:0044262 84 0.015
adult locomotory behavior GO:0008344 1 0.015
asymmetric stem cell division GO:0098722 1 0.015
post embryonic development GO:0009791 2 0.015
Worm
response to biotic stimulus GO:0009607 276 0.015
establishment of nucleus localization GO:0040023 1 0.015
intrinsic apoptotic signaling pathway GO:0097193 127 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
positive regulation of cellular component movement GO:0051272 181 0.015
response to virus GO:0009615 126 0.014
extrinsic apoptotic signaling pathway GO:0097191 119 0.014
translational initiation GO:0006413 48 0.014
regulation of cellular ketone metabolic process GO:0010565 50 0.014
regulation of homeostatic process GO:0032844 121 0.014
adenylate cyclase activating adrenergic receptor signaling pathway GO:0071880 3 0.014
response to topologically incorrect protein GO:0035966 29 0.014
negative regulation of protein catabolic process GO:0042177 59 0.014
cell cell signaling GO:0007267 155 0.014
regulation of ion transport GO:0043269 189 0.014
single organism membrane organization GO:0044802 268 0.014
protein autophosphorylation GO:0046777 123 0.014
regulation of protein localization GO:0032880 296 0.014
asymmetric neuroblast division GO:0055059 1 0.014
regulation of ion transmembrane transporter activity GO:0032412 72 0.013
system process GO:0003008 349 0.013
negative regulation of cell cycle GO:0045786 193 0.013
positive regulation of proteolysis GO:0045862 142 0.013
stress activated mapk cascade GO:0051403 93 0.013
dna replication GO:0006260 116 0.013
organic hydroxy compound metabolic process GO:1901615 147 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
regulation of protein catabolic process GO:0042176 155 0.013
regulation of secretion by cell GO:1903530 177 0.013
nitrogen compound transport GO:0071705 191 0.013
cognition GO:0050890 43 0.013
protein deubiquitination GO:0016579 79 0.013
regulation of cell cycle GO:0051726 393 0.013
cellular protein complex assembly GO:0043623 188 0.013
limbic system development GO:0021761 3 0.013
regulation of protein serine threonine kinase activity GO:0071900 179 0.013
camp mediated signaling GO:0019933 23 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
mitotic nuclear division GO:0007067 119 0.012
regulation of protein targeting GO:1903533 91 0.012
regulation of cellular component biogenesis GO:0044087 281 0.012
response to other organism GO:0051707 261 0.012
oocyte differentiation GO:0009994 2 0.012
syncytium formation by plasma membrane fusion GO:0000768 2 0.012
immune system development GO:0002520 195 0.012
neuron projection development GO:0031175 106 0.012
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.012
cell morphogenesis GO:0000902 296 0.012
response to parathyroid hormone GO:0071107 3 0.012
positive regulation of locomotion GO:0040017 186 0.012
response to oxygen containing compound GO:1901700 369 0.012
metal ion homeostasis GO:0055065 169 0.012
memory GO:0007613 3 0.012
negative regulation of protein ubiquitination GO:0031397 35 0.012
mitotic spindle organization GO:0007052 27 0.012
negative regulation of organelle organization GO:0010639 126 0.012
response to drug GO:0042493 81 0.012
nervous system development GO:0007399 293 0.012
divalent inorganic cation transport GO:0072511 158 0.012
ion homeostasis GO:0050801 230 0.012
single organism nuclear import GO:1902593 104 0.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
cell part morphogenesis GO:0032990 137 0.012
somitogenesis GO:0001756 2 0.012
cell projection morphogenesis GO:0048858 129 0.012
dna catabolic process GO:0006308 49 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
spindle elongation GO:0051231 4 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.011
nucleoside triphosphate metabolic process GO:0009141 422 0.011
positive regulation of transport GO:0051050 336 0.011
anterior posterior axis specification GO:0009948 2 0.011
ribonucleoside triphosphate metabolic process GO:0009199 412 0.011
protein folding GO:0006457 38 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
response to unfolded protein GO:0006986 24 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
regulation of cell motility GO:2000145 299 0.011
cell cycle checkpoint GO:0000075 117 0.011
nuclear import GO:0051170 106 0.011
modification dependent macromolecule catabolic process GO:0043632 212 0.011
chromatin modification GO:0016568 298 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
regulation of protein ubiquitination GO:0031396 95 0.011
peptidyl lysine acetylation GO:0018394 101 0.011
regulation of calcium ion transport GO:0051924 79 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
maintenance of location GO:0051235 112 0.011
negative regulation of cell development GO:0010721 48 0.011
protein import into nucleus GO:0006606 104 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
regulation of response to external stimulus GO:0032101 222 0.011
jnk cascade GO:0007254 80 0.011
cellular calcium ion homeostasis GO:0006874 117 0.011
intracellular protein transmembrane transport GO:0065002 24 0.010
regulation of ras gtpase activity GO:0032318 128 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
positive regulation of translation GO:0045727 35 0.010
somatic stem cell division GO:0048103 1 0.010
response to endoplasmic reticulum stress GO:0034976 49 0.010
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.010
regulation of map kinase activity GO:0043405 108 0.010
protein k48 linked ubiquitination GO:0070936 38 0.010
negative regulation of cell cycle phase transition GO:1901988 89 0.010
centrosome organization GO:0051297 58 0.010
regulation of body fluid levels GO:0050878 99 0.010

EIF5 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.023
nervous system disease DOID:863 431 0.018
sensory system disease DOID:0050155 203 0.018
central nervous system disease DOID:331 186 0.017
cancer DOID:162 167 0.011
disease of cellular proliferation DOID:14566 174 0.011
organ system cancer DOID:0050686 164 0.011
developmental disorder of mental health DOID:0060037 29 0.011
disease of mental health DOID:150 70 0.011
inherited metabolic disorder DOID:655 242 0.010