Homo sapiens

30 known processes

SKA1

spindle and kinetochore associated complex subunit 1

(Aliases: MGC10200,C18orf24)

SKA1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
microtubule polymerization or depolymerization GO:0031109 37 0.931
mitotic nuclear division GO:0007067 119 0.903
regulation of microtubule cytoskeleton organization GO:0070507 61 0.854
regulation of microtubule based process GO:0032886 74 0.801
organelle fission GO:0048285 149 0.796
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.796
microtubule cytoskeleton organization GO:0000226 176 0.785
mitotic cell cycle process GO:1903047 286 0.694
sister chromatid segregation GO:0000819 54 0.683
nuclear division GO:0000280 128 0.625
regulation of cytoskeleton organization GO:0051493 177 0.518
mitotic cell cycle GO:0000278 326 0.461
mitotic sister chromatid segregation GO:0000070 53 0.432
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.428
regulation of mitosis GO:0007088 63 0.419
microtubule based process GO:0007017 210 0.384
centrosome cycle GO:0007098 32 0.375
regulation of mitotic sister chromatid segregation GO:0033047 27 0.365
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.351
negative regulation of mitotic cell cycle GO:0045930 102 0.274
g2 m transition of mitotic cell cycle GO:0000086 41 0.243
somatic stem cell division GO:0048103 1 0.227
cell division GO:0051301 168 0.214
chromosome segregation GO:0007059 114 0.197
mitotic sister chromatid separation GO:0051306 18 0.196
regulation of mitotic sister chromatid separation GO:0010965 27 0.161
regulation of mitotic cell cycle phase transition GO:1901990 118 0.156
protein processing GO:0016485 226 0.155
chromosome separation GO:0051304 23 0.149
regulation of cell cycle phase transition GO:1901987 126 0.148
cell cycle phase transition GO:0044770 173 0.145
mitotic cytokinesis GO:0000281 19 0.140
cell cycle checkpoint GO:0000075 117 0.138
positive regulation of cell cycle GO:0045787 140 0.136
modification dependent macromolecule catabolic process GO:0043632 212 0.131
regulation of cell cycle process GO:0010564 266 0.128
wnt signaling pathway GO:0016055 156 0.122
regulation of chromosome segregation GO:0051983 44 0.121
centrosome organization GO:0051297 58 0.120
metaphase anaphase transition of cell cycle GO:0044784 21 0.115
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.113
neuronal stem cell division GO:0036445 1 0.108
regulation of protein catabolic process GO:0042176 155 0.107
negative regulation of cellular protein metabolic process GO:0032269 353 0.096
neuroblast proliferation GO:0007405 4 0.095
negative regulation of protein metabolic process GO:0051248 391 0.093
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.088
regulation of cell cycle GO:0051726 393 0.083
microtubule anchoring GO:0034453 24 0.081
positive regulation of mitotic cell cycle phase transition GO:1901992 19 0.081
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.078
negative regulation of cell cycle process GO:0010948 121 0.077
cellular macromolecule catabolic process GO:0044265 380 0.077
negative regulation of mitosis GO:0045839 24 0.076
single organism cellular localization GO:1902580 332 0.076
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.075
mitotic cell cycle phase transition GO:0044772 162 0.075
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.073
negative regulation of sister chromatid segregation GO:0033046 17 0.072
positive regulation of cellular catabolic process GO:0031331 284 0.071
eye photoreceptor cell differentiation GO:0001754 2 0.071
regulation of locomotion GO:0040012 329 0.068
regulation of chromosome organization GO:0033044 103 0.065
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.065
positive regulation of catabolic process GO:0009896 310 0.065
regulation of mitotic cell cycle GO:0007346 189 0.065
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.064
centriole replication GO:0007099 13 0.063
regulation of cellular protein catabolic process GO:1903362 96 0.063
negative regulation of cell cycle phase transition GO:1901988 89 0.061
regulation of cell division GO:0051302 116 0.060
regulation of proteasomal protein catabolic process GO:0061136 87 0.058
posttranscriptional regulation of gene expression GO:0010608 213 0.057
mitotic spindle organization GO:0007052 27 0.057
protein catabolic process GO:0030163 325 0.057
positive regulation of wnt signaling pathway GO:0030177 54 0.054
modification dependent protein catabolic process GO:0019941 209 0.053
regulation of cell differentiation GO:0045595 393 0.052
cytokinesis GO:0000910 96 0.051
regulation of protein processing GO:0070613 150 0.049
attachment of spindle microtubules to kinetochore GO:0008608 17 0.048
spermatid development GO:0007286 4 0.048
mitotic cell cycle checkpoint GO:0007093 68 0.047
mitotic spindle assembly checkpoint GO:0007094 14 0.047
regulation of sister chromatid segregation GO:0033045 27 0.047
negative regulation of catabolic process GO:0009895 104 0.046
positive regulation of protein phosphorylation GO:0001934 313 0.046
neuron differentiation GO:0030182 138 0.044
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.043
protein autophosphorylation GO:0046777 123 0.043
nervous system development GO:0007399 293 0.043
stem cell division GO:0017145 2 0.041
protein localization to mitochondrion GO:0070585 25 0.041
negative regulation of protein processing GO:0010955 142 0.040
male meiosis GO:0007140 1 0.040
centrosome separation GO:0051299 3 0.039
spindle organization GO:0007051 53 0.039
positive regulation of protein kinase activity GO:0045860 190 0.039
covalent chromatin modification GO:0016569 254 0.039
protein dephosphorylation GO:0006470 81 0.038
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.038
negative regulation of organelle organization GO:0010639 126 0.038
purine ribonucleoside catabolic process GO:0046130 398 0.038
proteasomal protein catabolic process GO:0010498 176 0.038
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.037
regulation of cellular component movement GO:0051270 334 0.037
negative regulation of chromosome segregation GO:0051985 18 0.037
chromatin organization GO:0006325 351 0.036
nucleoside triphosphate catabolic process GO:0009143 394 0.036
maintenance of location in cell GO:0051651 62 0.035
positive regulation of protein catabolic process GO:0045732 75 0.035
maintenance of location GO:0051235 112 0.035
cellular protein catabolic process GO:0044257 261 0.035
negative regulation of cellular catabolic process GO:0031330 83 0.035
regulation of cell development GO:0060284 161 0.034
protein modification by small protein conjugation GO:0032446 342 0.033
regulation of cellular ketone metabolic process GO:0010565 50 0.033
regulation of protein stability GO:0031647 87 0.032
microtubule organizing center organization GO:0031023 62 0.032
cytoskeleton dependent cytokinesis GO:0061640 22 0.032
negative regulation of cell cycle GO:0045786 193 0.032
positive regulation of cytoskeleton organization GO:0051495 83 0.032
positive regulation of cell cycle phase transition GO:1901989 22 0.031
positive regulation of cellular component organization GO:0051130 376 0.031
cellular ketone metabolic process GO:0042180 80 0.031
cell development GO:0048468 328 0.030
negative regulation of proteolysis GO:0045861 132 0.030
purine nucleoside catabolic process GO:0006152 398 0.030
ribonucleotide catabolic process GO:0009261 405 0.029
cell type specific apoptotic process GO:0097285 125 0.029
nucleoside triphosphate metabolic process GO:0009141 422 0.029
membrane organization GO:0061024 292 0.029
negative regulation of protein catabolic process GO:0042177 59 0.028
establishment or maintenance of cell polarity GO:0007163 31 0.028
regulation of cytokinesis GO:0032465 45 0.028
regulation of cell cycle g2 m phase transition GO:1902749 22 0.028
negative regulation of multicellular organismal process GO:0051241 317 0.028
purine nucleotide catabolic process GO:0006195 405 0.028
purine nucleoside triphosphate metabolic process GO:0009144 412 0.027
negative regulation of cytokinesis GO:0032466 3 0.027
regulation of kinase activity GO:0043549 314 0.027
biological adhesion GO:0022610 331 0.027
positive regulation of organelle organization GO:0010638 195 0.027
negative regulation of cell division GO:0051782 31 0.027
cellular amino acid metabolic process GO:0006520 116 0.026
chromatin modification GO:0016568 298 0.026
purine nucleoside triphosphate catabolic process GO:0009146 392 0.026
spindle assembly involved in mitosis GO:0090307 12 0.026
maintenance of protein location GO:0045185 57 0.026
oogenesis GO:0048477 2 0.026
developmental process involved in reproduction GO:0003006 66 0.026
nucleoside phosphate catabolic process GO:1901292 412 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
photoreceptor cell differentiation GO:0046530 2 0.025
regulation of phosphatase activity GO:0010921 81 0.025
regulation of protein kinase activity GO:0045859 289 0.024
ribonucleoside triphosphate metabolic process GO:0009199 412 0.024
mitotic centrosome separation GO:0007100 1 0.024
reproductive process GO:0022414 106 0.024
post embryonic development GO:0009791 2 0.023
mitotic spindle checkpoint GO:0071174 18 0.023
regulation of protein maturation GO:1903317 150 0.023
positive regulation of phosphorylation GO:0042327 394 0.023
regulation of transferase activity GO:0051338 355 0.023
protein maturation GO:0051604 233 0.023
positive regulation of mitosis GO:0045840 25 0.023
blastocyst development GO:0001824 3 0.023
single organism membrane organization GO:0044802 268 0.023
regulation of neural precursor cell proliferation GO:2000177 4 0.023
cellular amine metabolic process GO:0044106 41 0.023
anatomical structure formation involved in morphogenesis GO:0048646 284 0.023
regulation of cell migration GO:0030334 289 0.023
female gamete generation GO:0007292 2 0.023
nucleoside monophosphate metabolic process GO:0009123 191 0.022
dna repair GO:0006281 198 0.022
regulation of nuclear division GO:0051783 65 0.022
protein depolymerization GO:0051261 30 0.021
organophosphate catabolic process GO:0046434 430 0.021
negative regulation of mitotic sister chromatid segregation GO:0033048 17 0.021
purine nucleoside monophosphate metabolic process GO:0009126 186 0.021
cell cycle g2 m phase transition GO:0044839 43 0.020
regulation of proteolysis GO:0030162 293 0.020
positive regulation of cell cycle g2 m phase transition GO:1902751 8 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.020
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.020
cardiovascular system development GO:0072358 262 0.020
response to abiotic stimulus GO:0009628 336 0.020
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
regeneration GO:0031099 4 0.019
negative regulation of cellular component organization GO:0051129 235 0.019
vesicle mediated transport GO:0016192 371 0.019
glycosyl compound catabolic process GO:1901658 413 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.019
negative regulation of developmental process GO:0051093 247 0.019
response to radiation GO:0009314 151 0.018
amine metabolic process GO:0009308 44 0.018
histone modification GO:0016570 251 0.018
maintenance of protein location in cell GO:0032507 56 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
regulation of cellular amine metabolic process GO:0033238 11 0.018
negative regulation of cytoskeleton organization GO:0051494 45 0.018
regulation of wnt signaling pathway GO:0030111 123 0.018
ubiquitin dependent protein catabolic process GO:0006511 206 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.018
ribonucleoside monophosphate metabolic process GO:0009161 187 0.018
positive regulation of cellular protein catabolic process GO:1903364 37 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
centrosome duplication GO:0051298 28 0.017
regulation of protein localization GO:0032880 296 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
neuroblast division GO:0055057 1 0.017
mitochondrial fission GO:0000266 14 0.017
dephosphorylation GO:0016311 209 0.016
ribonucleoside monophosphate catabolic process GO:0009158 158 0.016
negative regulation of protein maturation GO:1903318 142 0.016
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.016
regulation of cell motility GO:2000145 299 0.016
protein ubiquitination GO:0016567 314 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
metaphase plate congression GO:0051310 18 0.016
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.016
peptidyl serine modification GO:0018209 106 0.016
asymmetric neuroblast division GO:0055059 1 0.015
neurogenesis GO:0022008 169 0.015
positive regulation of mitotic cell cycle GO:0045931 60 0.015
positive regulation of proteolysis GO:0045862 142 0.015
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.015
positive regulation of transferase activity GO:0051347 227 0.015
endomembrane system organization GO:0010256 196 0.015
cellular response to dna damage stimulus GO:0006974 379 0.015
sensory organ development GO:0007423 52 0.015
intracellular protein transport GO:0006886 270 0.015
cell adhesion GO:0007155 325 0.015
cellular component disassembly GO:0022411 92 0.014
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.014
regulation of immune response GO:0050776 201 0.014
cytoplasmic transport GO:0016482 379 0.014
cellular response to radiation GO:0071478 65 0.014
purine containing compound catabolic process GO:0072523 411 0.014
regulation of binding GO:0051098 111 0.014
positive regulation of mitotic sister chromatid separation GO:1901970 6 0.014
determination of adult lifespan GO:0008340 2 0.014
regulation of neuroblast proliferation GO:1902692 3 0.014
generation of neurons GO:0048699 152 0.014
positive regulation of transport GO:0051050 336 0.014
embryonic placenta development GO:0001892 1 0.014
regulation of growth GO:0040008 165 0.013
positive regulation of cell division GO:0051781 59 0.013
positive regulation of cell cycle process GO:0090068 106 0.013
spindle assembly checkpoint GO:0071173 17 0.013
negative regulation of cell death GO:0060548 345 0.013
response to light stimulus GO:0009416 87 0.013
protein dna complex subunit organization GO:0071824 80 0.013
epithelium development GO:0060429 227 0.013
protein complex disassembly GO:0043241 52 0.013
response to fungus GO:0009620 4 0.013
cellular lipid metabolic process GO:0044255 303 0.013
protein targeting GO:0006605 187 0.013
organelle assembly GO:0070925 176 0.013
exit from mitosis GO:0010458 10 0.013
positive regulation of hydrolase activity GO:0051345 331 0.013
peptidyl serine phosphorylation GO:0018105 101 0.013
reproduction GO:0000003 63 0.013
positive regulation of chromosome segregation GO:0051984 9 0.013
negative regulation of cellular protein catabolic process GO:1903363 38 0.012
atp catabolic process GO:0006200 157 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
cell fate determination GO:0001709 3 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
double strand break repair via homologous recombination GO:0000724 50 0.012
nucleoside catabolic process GO:0009164 408 0.012
asymmetric stem cell division GO:0098722 1 0.012
negative regulation of stem cell proliferation GO:2000647 3 0.012
defense response GO:0006952 315 0.012
purine ribonucleoside metabolic process GO:0046128 437 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.011
dna packaging GO:0006323 77 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
dna replication GO:0006260 116 0.011
multicellular organismal aging GO:0010259 3 0.011
meiotic chromosome segregation GO:0045132 4 0.011
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.011
negative regulation of chromosome organization GO:2001251 48 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
cellular protein complex assembly GO:0043623 188 0.011
regulation of cell adhesion GO:0030155 166 0.011
positive regulation of neural precursor cell proliferation GO:2000179 2 0.011
regulation of nervous system development GO:0051960 88 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.011
regulation of spindle organization GO:0090224 10 0.011
protein stabilization GO:0050821 64 0.011
regulation of response to external stimulus GO:0032101 222 0.011
positive regulation of neuron death GO:1901216 14 0.011
microtubule polymerization GO:0046785 18 0.011
dna biosynthetic process GO:0071897 40 0.011
system process GO:0003008 349 0.011
cellular chemical homeostasis GO:0055082 180 0.011
neuron apoptotic process GO:0051402 39 0.011
embryo development GO:0009790 123 0.010
neuromuscular junction development GO:0007528 3 0.010
leukocyte activation GO:0045321 164 0.010
positive regulation of cellular component movement GO:0051272 181 0.010
heart development GO:0007507 95 0.010
response to oxygen containing compound GO:1901700 369 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
gtp catabolic process GO:0006184 237 0.010
regulation of response to dna damage stimulus GO:2001020 94 0.010
cellular response to abiotic stimulus GO:0071214 117 0.010

SKA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.027
hematopoietic system disease DOID:74 100 0.027
disease of cellular proliferation DOID:14566 174 0.018
cancer DOID:162 167 0.018
organ system cancer DOID:0050686 164 0.015
central nervous system disease DOID:331 186 0.011
nervous system disease DOID:863 431 0.011
neurodegenerative disease DOID:1289 102 0.011