Homo sapiens

185 known processes

PNP

purine nucleoside phosphorylase

(Aliases: MGC125916,FLJ97312,MGC125915,FLJ94043,PRO1837,PUNP,NP,MGC117396,FLJ97288)

PNP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleoside catabolic process GO:0009164 408 0.351
nucleoside triphosphate catabolic process GO:0009143 394 0.279
purine ribonucleoside metabolic process GO:0046128 437 0.229
purine nucleoside catabolic process GO:0006152 398 0.210
purine containing compound catabolic process GO:0072523 411 0.205
glycosyl compound catabolic process GO:1901658 413 0.204
purine nucleotide catabolic process GO:0006195 405 0.203
nucleoside triphosphate metabolic process GO:0009141 422 0.199
Mouse
nucleoside phosphate catabolic process GO:1901292 412 0.196
ribonucleoside triphosphate catabolic process GO:0009203 391 0.175
ribonucleotide catabolic process GO:0009261 405 0.165
organophosphate catabolic process GO:0046434 430 0.156
purine ribonucleoside catabolic process GO:0046130 398 0.147
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.142
purine ribonucleotide catabolic process GO:0009154 404 0.134
nucleotide catabolic process GO:0009166 408 0.129
purine nucleoside triphosphate catabolic process GO:0009146 392 0.129
purine nucleoside triphosphate metabolic process GO:0009144 412 0.122
Mouse
cellular response to dna damage stimulus GO:0006974 379 0.121
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.112
cellular lipid metabolic process GO:0044255 303 0.106
cellular amine metabolic process GO:0044106 41 0.105
ribonucleoside catabolic process GO:0042454 406 0.104
post embryonic development GO:0009791 2 0.098
ribonucleoside monophosphate metabolic process GO:0009161 187 0.096
regulation of transmembrane transporter activity GO:0022898 74 0.091
lipid metabolic process GO:0006629 381 0.091
cation transport GO:0006812 331 0.089
transmembrane transport GO:0055085 399 0.088
regulation of nucleoside metabolic process GO:0009118 209 0.086
organonitrogen compound biosynthetic process GO:1901566 200 0.083
regulation of reactive oxygen species metabolic process GO:2000377 41 0.080
nucleoside monophosphate metabolic process GO:0009123 191 0.079
response to oxygen containing compound GO:1901700 369 0.077
regulation of transmembrane transport GO:0034762 139 0.075
cellular response to external stimulus GO:0071496 111 0.073
atp catabolic process GO:0006200 157 0.071
negative regulation of catalytic activity GO:0043086 335 0.071
determination of adult lifespan GO:0008340 2 0.070
multicellular organismal aging GO:0010259 3 0.070
guanosine containing compound catabolic process GO:1901069 239 0.069
Mouse
response to organic cyclic compound GO:0014070 204 0.069
regulation of purine nucleotide metabolic process GO:1900542 264 0.064
purine nucleoside monophosphate catabolic process GO:0009128 158 0.064
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.064
Mouse
response to abiotic stimulus GO:0009628 336 0.063
Mouse
regulation of purine nucleotide catabolic process GO:0033121 205 0.061
amine metabolic process GO:0009308 44 0.059
response to lipid GO:0033993 206 0.059
modification dependent protein catabolic process GO:0019941 209 0.059
lipid biosynthetic process GO:0008610 177 0.058
positive regulation of programmed cell death GO:0043068 249 0.057
cellular ion homeostasis GO:0006873 168 0.057
organophosphate biosynthetic process GO:0090407 163 0.055
ion transmembrane transport GO:0034220 338 0.055
ribonucleoside triphosphate metabolic process GO:0009199 412 0.055
Mouse
cellular amino acid metabolic process GO:0006520 116 0.055
regeneration GO:0031099 4 0.054
single organism cellular localization GO:1902580 332 0.052
organic hydroxy compound metabolic process GO:1901615 147 0.052
carbohydrate metabolic process GO:0005975 207 0.049
response to biotic stimulus GO:0009607 276 0.049
ribonucleoside monophosphate catabolic process GO:0009158 158 0.049
negative regulation of cellular protein metabolic process GO:0032269 353 0.049
positive regulation of apoptotic process GO:0043065 246 0.048
regulation of nucleotide catabolic process GO:0030811 205 0.047
regulation of cellular response to stress GO:0080135 244 0.047
Mouse
atp metabolic process GO:0046034 176 0.046
cellular lipid catabolic process GO:0044242 65 0.046
vesicle mediated transport GO:0016192 371 0.046
protein oligomerization GO:0051259 173 0.044
gtp metabolic process GO:0046039 239 0.043
Mouse
regulation of nucleotide metabolic process GO:0006140 269 0.043
negative regulation of protein metabolic process GO:0051248 391 0.043
cellular macromolecule catabolic process GO:0044265 380 0.042
positive regulation of catabolic process GO:0009896 310 0.042
reactive oxygen species metabolic process GO:0072593 75 0.042
response to external biotic stimulus GO:0043207 261 0.042
regulation of cell cycle process GO:0010564 266 0.042
single organism carbohydrate metabolic process GO:0044723 193 0.042
gtp catabolic process GO:0006184 237 0.041
negative regulation of ion transport GO:0043271 39 0.041
regulation of ion transmembrane transporter activity GO:0032412 72 0.041
purine nucleoside monophosphate metabolic process GO:0009126 186 0.041
modification dependent macromolecule catabolic process GO:0043632 212 0.040
metal ion homeostasis GO:0055065 169 0.040
negative regulation of phosphorus metabolic process GO:0010563 267 0.040
protein catabolic process GO:0030163 325 0.040
cellular metal ion homeostasis GO:0006875 146 0.040
ion homeostasis GO:0050801 230 0.039
cofactor biosynthetic process GO:0051188 31 0.039
guanosine containing compound metabolic process GO:1901068 244 0.038
Mouse
response to other organism GO:0051707 261 0.038
cell development GO:0048468 328 0.038
positive regulation of nucleotide metabolic process GO:0045981 230 0.037
protein localization to organelle GO:0033365 280 0.037
metal ion transport GO:0030001 272 0.037
lipid catabolic process GO:0016042 84 0.037
chemical homeostasis GO:0048878 306 0.036
protein processing GO:0016485 226 0.036
anatomical structure formation involved in morphogenesis GO:0048646 284 0.035
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.035
regulation of transferase activity GO:0051338 355 0.035
system process GO:0003008 349 0.034
blood circulation GO:0008015 113 0.034
cellular protein catabolic process GO:0044257 261 0.034
reactive nitrogen species metabolic process GO:2001057 3 0.034
nervous system development GO:0007399 293 0.033
oogenesis GO:0048477 2 0.033
cytoplasmic transport GO:0016482 379 0.033
regulation of atp catabolic process GO:1903289 25 0.032
anion transport GO:0006820 161 0.032
nucleoside monophosphate catabolic process GO:0009125 159 0.031
regulation of proteolysis GO:0030162 293 0.031
innate immune response GO:0045087 178 0.031
negative regulation of phosphate metabolic process GO:0045936 267 0.031
positive regulation of cellular catabolic process GO:0031331 284 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.030
small molecule biosynthetic process GO:0044283 157 0.030
cofactor metabolic process GO:0051186 87 0.030
cellular homeostasis GO:0019725 196 0.030
protein homooligomerization GO:0051260 100 0.030
regulation of atp metabolic process GO:1903578 29 0.030
cellular response to endogenous stimulus GO:0071495 336 0.030
negative regulation of phosphorylation GO:0042326 174 0.030
regulation of dna metabolic process GO:0051052 153 0.029
Mouse
regulation of cell cycle GO:0051726 393 0.029
defense response GO:0006952 315 0.029
regulation of oxidoreductase activity GO:0051341 43 0.029
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.029
ribonucleotide biosynthetic process GO:0009260 81 0.029
Mouse
cation homeostasis GO:0055080 189 0.028
nucleotide biosynthetic process GO:0009165 109 0.028
actin filament based process GO:0030029 224 0.028
response to oxidative stress GO:0006979 121 0.028
response to cytokine GO:0034097 232 0.027
positive regulation of transport GO:0051050 336 0.027
cellular chemical homeostasis GO:0055082 180 0.027
positive regulation of cell proliferation GO:0008284 301 0.027
mitotic cell cycle process GO:1903047 286 0.027
regulation of locomotion GO:0040012 329 0.026
response to inorganic substance GO:0010035 127 0.026
response to nitrogen compound GO:1901698 184 0.026
negative regulation of hydrolase activity GO:0051346 182 0.026
regulation of ion transport GO:0043269 189 0.026
oxidation reduction process GO:0055114 396 0.026
actin cytoskeleton organization GO:0030036 207 0.026
nucleoside phosphate biosynthetic process GO:1901293 109 0.025
maintenance of location GO:0051235 112 0.025
membrane lipid metabolic process GO:0006643 53 0.025
regulation of atpase activity GO:0043462 25 0.025
positive regulation of transmembrane transport GO:0034764 41 0.025
negative regulation of transport GO:0051051 176 0.025
negative regulation of cellular component organization GO:0051129 235 0.025
regulation of protein transport GO:0051223 213 0.025
lymphocyte activation GO:0046649 133 0.024
signal transduction by phosphorylation GO:0023014 297 0.024
ribose phosphate biosynthetic process GO:0046390 82 0.024
Mouse
cellular response to oxygen containing compound GO:1901701 276 0.024
biological adhesion GO:0022610 331 0.024
meiosis i GO:0007127 4 0.024
positive regulation of nucleotide catabolic process GO:0030813 185 0.024
locomotory behavior GO:0007626 1 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
dephosphorylation GO:0016311 209 0.023
regulation of protein localization GO:0032880 296 0.023
negative regulation of apoptotic process GO:0043066 316 0.023
Mouse
positive regulation of organelle organization GO:0010638 195 0.023
regulation of cytoplasmic transport GO:1903649 149 0.023
negative regulation of organelle organization GO:0010639 126 0.023
negative regulation of cell proliferation GO:0008285 228 0.022
organic anion transport GO:0015711 103 0.022
response to bacterium GO:0009617 144 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.022
negative regulation of intracellular signal transduction GO:1902532 183 0.022
cellular response to inorganic substance GO:0071241 45 0.022
female gamete generation GO:0007292 2 0.022
negative regulation of protein modification process GO:0031400 200 0.022
protein targeting GO:0006605 187 0.022
regulation of protein serine threonine kinase activity GO:0071900 179 0.022
cation transmembrane transport GO:0098655 238 0.022
ubiquitin dependent protein catabolic process GO:0006511 206 0.022
endocytosis GO:0006897 159 0.022
carbohydrate derivative biosynthetic process GO:1901137 207 0.021
Mouse
protein modification by small protein conjugation GO:0032446 342 0.021
positive regulation of developmental process GO:0051094 314 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.021
cellular modified amino acid metabolic process GO:0006575 64 0.021
receptor mediated endocytosis GO:0006898 84 0.021
response to extracellular stimulus GO:0009991 85 0.020
positive regulation of immune system process GO:0002684 283 0.020
cellular cation homeostasis GO:0030003 163 0.020
response to organonitrogen compound GO:0010243 156 0.020
rna processing GO:0006396 255 0.020
neurological system process GO:0050877 163 0.020
regulation of membrane potential GO:0042391 95 0.020
cell cycle g1 s phase transition GO:0044843 80 0.020
organic hydroxy compound biosynthetic process GO:1901617 71 0.020
methylation GO:0032259 106 0.020
positive regulation of nucleoside metabolic process GO:0045979 186 0.019
negative regulation of transmembrane transport GO:0034763 29 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
regulation of cytokine production GO:0001817 232 0.019
cellular divalent inorganic cation homeostasis GO:0072503 128 0.019
sequestering of calcium ion GO:0051208 17 0.019
regulation of intracellular transport GO:0032386 195 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
regulation of endopeptidase activity GO:0052548 170 0.019
neurogenesis GO:0022008 169 0.019
morphogenesis of embryonic epithelium GO:0016331 4 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
circulatory system process GO:0003013 113 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.018
growth GO:0040007 202 0.018
reactive oxygen species biosynthetic process GO:1903409 4 0.018
inorganic ion transmembrane transport GO:0098660 231 0.018
regulation of cellular amino acid metabolic process GO:0006521 6 0.018
immune response GO:0006955 307 0.018
oocyte development GO:0048599 1 0.017
carboxylic acid biosynthetic process GO:0046394 97 0.017
negative regulation of cell death GO:0060548 345 0.017
Mouse
blastoderm segmentation GO:0007350 2 0.017
regulation of ion transmembrane transport GO:0034765 132 0.017
single organism reproductive process GO:0044702 98 0.017
regulation of peptidase activity GO:0052547 180 0.017
intracellular protein transport GO:0006886 270 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.017
chromatin modification GO:0016568 298 0.017
phospholipid metabolic process GO:0006644 99 0.017
positive regulation of cellular component organization GO:0051130 376 0.016
negative regulation of protein maturation GO:1903318 142 0.016
ras protein signal transduction GO:0007265 73 0.016
g1 s transition of mitotic cell cycle GO:0000082 78 0.016
melanin metabolic process GO:0006582 1 0.016
regulation of immune response GO:0050776 201 0.016
Mouse
generation of neurons GO:0048699 152 0.016
single organism membrane organization GO:0044802 268 0.016
protein ubiquitination GO:0016567 314 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
apoptotic mitochondrial changes GO:0008637 57 0.016
Mouse
cellular response to extracellular stimulus GO:0031668 72 0.016
cellular response to oxidative stress GO:0034599 85 0.016
regulation of protein maturation GO:1903317 150 0.016
negative regulation of protein processing GO:0010955 142 0.016
regulation of synaptic plasticity GO:0048167 3 0.016
positive regulation of transferase activity GO:0051347 227 0.016
regulation of cytoskeleton organization GO:0051493 177 0.016
protein import GO:0017038 130 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
positive regulation of cell death GO:0010942 263 0.016
response to virus GO:0009615 126 0.015
sequestering of metal ion GO:0051238 24 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.015
circulatory system development GO:0072359 262 0.015
nitrogen compound transport GO:0071705 191 0.015
positive regulation of cell cycle process GO:0090068 106 0.015
response to growth factor GO:0070848 205 0.015
cellular protein complex assembly GO:0043623 188 0.015
positive regulation of hydrolase activity GO:0051345 331 0.015
reproductive process GO:0022414 106 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
response to hormone GO:0009725 175 0.015
mapk cascade GO:0000165 288 0.015
mitochondrial transport GO:0006839 60 0.015
regulation of cell migration GO:0030334 289 0.015
cellular response to metal ion GO:0071248 43 0.015
regulation of cell cycle phase transition GO:1901987 126 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
regulation of mapk cascade GO:0043408 262 0.015
regulation of protein processing GO:0070613 150 0.015
cell division GO:0051301 168 0.014
sphingolipid metabolic process GO:0006665 38 0.014
cytokinesis GO:0000910 96 0.014
response to tumor necrosis factor GO:0034612 76 0.014
segmentation GO:0035282 4 0.014
inorganic cation transmembrane transport GO:0098662 194 0.014
calcium ion transport GO:0006816 147 0.014
epithelial cell migration GO:0010631 119 0.014
regulation of cellular ketone metabolic process GO:0010565 50 0.014
regulation of protein catabolic process GO:0042176 155 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
regulation of defense response GO:0031347 154 0.014
cell projection organization GO:0030030 252 0.014
lipid localization GO:0010876 106 0.014
negative regulation of transferase activity GO:0051348 124 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
Mouse
embryo development GO:0009790 123 0.014
tissue regeneration GO:0042246 3 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
protein maturation GO:0051604 233 0.014
response to wounding GO:0009611 168 0.014
behavior GO:0007610 112 0.014
toxin transport GO:1901998 4 0.013
regulation of cell motility GO:2000145 299 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
regulation of anatomical structure size GO:0090066 101 0.013
calcium ion homeostasis GO:0055074 122 0.013
tissue migration GO:0090130 119 0.013
immune effector process GO:0002252 159 0.013
Mouse
regulation of kinase activity GO:0043549 314 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
oocyte differentiation GO:0009994 2 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
mitotic cell cycle GO:0000278 326 0.013
divalent inorganic cation transport GO:0072511 158 0.013
stress activated protein kinase signaling cascade GO:0031098 94 0.013
response to metal ion GO:0010038 84 0.013
mitotic cell cycle phase transition GO:0044772 162 0.013
regulation of cellular component movement GO:0051270 334 0.013
organic acid biosynthetic process GO:0016053 97 0.013
polyamine metabolic process GO:0006595 4 0.013
response to fungus GO:0009620 4 0.013
regulation of lipid metabolic process GO:0019216 96 0.013
regulation of cell division GO:0051302 116 0.013
positive regulation of blood pressure GO:0045777 3 0.013
organelle assembly GO:0070925 176 0.013
negative regulation of transporter activity GO:0032410 25 0.012
ceramide metabolic process GO:0006672 25 0.012
macromolecular complex disassembly GO:0032984 60 0.012
cell adhesion GO:0007155 325 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
developmental process involved in reproduction GO:0003006 66 0.012
pyrimidine ribonucleoside metabolic process GO:0046131 11 0.012
negative regulation of reactive oxygen species biosynthetic process GO:1903427 1 0.012
regulation of leukocyte activation GO:0002694 115 0.012
t cell activation GO:0042110 99 0.012
microtubule cytoskeleton organization GO:0000226 176 0.012
anterior posterior axis specification GO:0009948 2 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
regulation of binding GO:0051098 111 0.012
positive regulation of cell migration GO:0030335 172 0.012
secretion by cell GO:0032940 226 0.012
mitotic spindle elongation GO:0000022 4 0.012
heart development GO:0007507 95 0.012
negative regulation of apoptotic signaling pathway GO:2001234 97 0.012
leukocyte activation GO:0045321 164 0.012
protein tetramerization GO:0051262 47 0.012
oocyte maturation GO:0001556 1 0.012
mitochondrion organization GO:0007005 156 0.012
Mouse
positive regulation of gtpase activity GO:0043547 166 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
regulation of homeostatic process GO:0032844 121 0.012
microtubule based process GO:0007017 210 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
regulation of growth GO:0040008 165 0.012
reproductive structure development GO:0048608 55 0.012
positive regulation of phosphorylation GO:0042327 394 0.012
single organism cell adhesion GO:0098602 179 0.012
cellular response to lipid GO:0071396 127 0.012
defense response to other organism GO:0098542 129 0.011
liposaccharide metabolic process GO:1903509 27 0.011
coenzyme biosynthetic process GO:0009108 24 0.011
regulation of protein complex assembly GO:0043254 147 0.011
positive regulation of cell differentiation GO:0045597 211 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
release of cytochrome c from mitochondria GO:0001836 35 0.011
nuclear division GO:0000280 128 0.011
positive regulation of cytoskeleton organization GO:0051495 83 0.011
dna biosynthetic process GO:0071897 40 0.011
alcohol metabolic process GO:0006066 114 0.011
glycoprotein metabolic process GO:0009100 110 0.011
response to steroid hormone GO:0048545 80 0.011
adult locomotory behavior GO:0008344 1 0.011
epithelium development GO:0060429 227 0.011
wound healing GO:0042060 115 0.011
response to reactive oxygen species GO:0000302 61 0.011
glycolipid metabolic process GO:0006664 27 0.011
spermatid differentiation GO:0048515 4 0.011
response to drug GO:0042493 81 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.011
positive regulation of meiotic cell cycle GO:0051446 2 0.011
cell activation GO:0001775 213 0.011
jnk cascade GO:0007254 80 0.011
circadian behavior GO:0048512 2 0.011
positive regulation of apoptotic signaling pathway GO:2001235 70 0.011
leukocyte proliferation GO:0070661 74 0.011
regulation of innate immune response GO:0045088 97 0.011
cellular response to abiotic stimulus GO:0071214 117 0.011
regulation of transporter activity GO:0032409 82 0.011
cellular component disassembly GO:0022411 92 0.010
protein import into mitochondrial matrix GO:0030150 1 0.010
response to ionizing radiation GO:0010212 65 0.010
Mouse
meiotic chromosome segregation GO:0045132 4 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.010
dna repair GO:0006281 198 0.010
Mouse
peptide metabolic process GO:0006518 51 0.010
leukocyte migration GO:0050900 107 0.010
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.010
cellular component morphogenesis GO:0032989 314 0.010
detection of stimulus GO:0051606 85 0.010
replicative cell aging GO:0001302 3 0.010

PNP disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.143
inherited metabolic disorder DOID:655 242 0.143
disease of cellular proliferation DOID:14566 174 0.044
cancer DOID:162 167 0.029
organ system cancer DOID:0050686 164 0.023
sensory system disease DOID:0050155 203 0.017
nervous system disease DOID:863 431 0.017
gastrointestinal system cancer DOID:3119 52 0.011
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011
immune system disease DOID:2914 155 0.004
combined t cell and b cell immunodeficiency DOID:628 12 0.001
primary immunodeficiency disease DOID:612 36 0.001