Homo sapiens

27 known processes

NEK4

NIMA (never in mitosis gene a)-related kinase 4

(Aliases: STK2,pp12301,MGC33171,NRK2)

NEK4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle process GO:0010564 266 0.102
Human
cellular ketone metabolic process GO:0042180 80 0.084
cellular amino acid metabolic process GO:0006520 116 0.077
female gamete generation GO:0007292 2 0.076
purine nucleoside triphosphate catabolic process GO:0009146 392 0.074
amine metabolic process GO:0009308 44 0.066
regulation of cellular amine metabolic process GO:0033238 11 0.066
mitotic cell cycle GO:0000278 326 0.065
regulation of cellular amino acid metabolic process GO:0006521 6 0.063
protein ubiquitination GO:0016567 314 0.058
cellular amine metabolic process GO:0044106 41 0.057
nucleoside phosphate catabolic process GO:1901292 412 0.056
regulation of cell cycle GO:0051726 393 0.054
Human
microtubule based process GO:0007017 210 0.051
post embryonic development GO:0009791 2 0.047
nucleotide catabolic process GO:0009166 408 0.047
regulation of cellular ketone metabolic process GO:0010565 50 0.044
purine ribonucleoside metabolic process GO:0046128 437 0.043
glycosyl compound catabolic process GO:1901658 413 0.041
nucleoside catabolic process GO:0009164 408 0.040
nucleoside triphosphate catabolic process GO:0009143 394 0.038
purine nucleotide catabolic process GO:0006195 405 0.038
cellular response to dna damage stimulus GO:0006974 379 0.037
purine containing compound catabolic process GO:0072523 411 0.035
positive regulation of cellular amine metabolic process GO:0033240 7 0.035
oogenesis GO:0048477 2 0.035
ribonucleoside catabolic process GO:0042454 406 0.034
mitotic cell cycle process GO:1903047 286 0.034
Human
purine nucleoside catabolic process GO:0006152 398 0.034
negative regulation of cellular protein metabolic process GO:0032269 353 0.033
cytoplasmic transport GO:0016482 379 0.033
anatomical structure formation involved in morphogenesis GO:0048646 284 0.032
maintenance of location GO:0051235 112 0.032
cellular macromolecular complex assembly GO:0034622 324 0.032
purine ribonucleotide catabolic process GO:0009154 404 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
organophosphate catabolic process GO:0046434 430 0.031
ribonucleoside triphosphate metabolic process GO:0009199 412 0.031
oocyte development GO:0048599 1 0.030
multicellular organismal aging GO:0010259 3 0.029
small molecule biosynthetic process GO:0044283 157 0.028
nucleoside triphosphate metabolic process GO:0009141 422 0.028
cell cell signaling GO:0007267 155 0.028
lipid metabolic process GO:0006629 381 0.028
cell projection organization GO:0030030 252 0.028
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.027
cellular component morphogenesis GO:0032989 314 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
regulation of cytoskeleton organization GO:0051493 177 0.027
ribonucleoside triphosphate catabolic process GO:0009203 391 0.027
negative regulation of protein metabolic process GO:0051248 391 0.027
regulation of cellular component biogenesis GO:0044087 281 0.027
regulation of protein localization GO:0032880 296 0.027
protein catabolic process GO:0030163 325 0.026
protein oligomerization GO:0051259 173 0.026
cell morphogenesis GO:0000902 296 0.026
negative regulation of programmed cell death GO:0043069 321 0.026
carbohydrate metabolic process GO:0005975 207 0.025
regulation of dna metabolic process GO:0051052 153 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
mitotic cell cycle phase transition GO:0044772 162 0.025
Human
ribonucleotide catabolic process GO:0009261 405 0.025
vesicle mediated transport GO:0016192 371 0.025
determination of adult lifespan GO:0008340 2 0.024
regulation of kinase activity GO:0043549 314 0.024
protein localization to organelle GO:0033365 280 0.024
chemical homeostasis GO:0048878 306 0.024
protein modification by small protein conjugation GO:0032446 342 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.024
regulation of cellular response to stress GO:0080135 244 0.024
positive regulation of hydrolase activity GO:0051345 331 0.023
mrna metabolic process GO:0016071 175 0.023
nervous system development GO:0007399 293 0.023
cell division GO:0051301 168 0.023
organic acid biosynthetic process GO:0016053 97 0.022
organelle assembly GO:0070925 176 0.022
rna processing GO:0006396 255 0.022
organonitrogen compound biosynthetic process GO:1901566 200 0.021
positive regulation of cellular component organization GO:0051130 376 0.021
purine ribonucleoside catabolic process GO:0046130 398 0.021
oocyte differentiation GO:0009994 2 0.021
positive regulation of catabolic process GO:0009896 310 0.021
single organism cellular localization GO:1902580 332 0.021
response to abiotic stimulus GO:0009628 336 0.021
positive regulation of protein phosphorylation GO:0001934 313 0.020
positive regulation of phosphorylation GO:0042327 394 0.020
cell projection assembly GO:0030031 126 0.020
negative regulation of cellular amine metabolic process GO:0033239 3 0.020
dna repair GO:0006281 198 0.020
response to oxygen containing compound GO:1901700 369 0.020
carboxylic acid biosynthetic process GO:0046394 97 0.020
membrane organization GO:0061024 292 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
cell projection morphogenesis GO:0048858 129 0.019
regulation of response to dna damage stimulus GO:2001020 94 0.019
dephosphorylation GO:0016311 209 0.019
monocarboxylic acid metabolic process GO:0032787 185 0.019
purine nucleoside monophosphate metabolic process GO:0009126 186 0.019
organelle fission GO:0048285 149 0.019
actin filament based process GO:0030029 224 0.019
protein maturation GO:0051604 233 0.019
neurotransmitter secretion GO:0007269 4 0.019
secretion GO:0046903 254 0.018
nuclear division GO:0000280 128 0.018
embryonic epithelial tube formation GO:0001838 4 0.018
microtubule cytoskeleton organization GO:0000226 176 0.018
negative regulation of cell cycle process GO:0010948 121 0.018
Human
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
single organism carbohydrate metabolic process GO:0044723 193 0.018
organic hydroxy compound metabolic process GO:1901615 147 0.018
cellular homeostasis GO:0019725 196 0.018
immune response GO:0006955 307 0.018
locomotory behavior GO:0007626 1 0.018
regulation of transferase activity GO:0051338 355 0.018
secretion by cell GO:0032940 226 0.017
segmentation GO:0035282 4 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
nitrogen compound transport GO:0071705 191 0.017
sister chromatid segregation GO:0000819 54 0.017
neuromuscular junction development GO:0007528 3 0.017
cell part morphogenesis GO:0032990 137 0.017
mitotic nuclear division GO:0007067 119 0.017
microtubule organizing center organization GO:0031023 62 0.017
endomembrane system organization GO:0010256 196 0.017
regulation of intracellular transport GO:0032386 195 0.017
spermatid differentiation GO:0048515 4 0.017
single organism membrane organization GO:0044802 268 0.017
positive regulation of transport GO:0051050 336 0.017
negative regulation of transferase activity GO:0051348 124 0.017
chromosome segregation GO:0007059 114 0.016
regulation of protein kinase activity GO:0045859 289 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
regulation of growth GO:0040008 165 0.016
ras protein signal transduction GO:0007265 73 0.016
wnt signaling pathway GO:0016055 156 0.016
ribonucleoside monophosphate catabolic process GO:0009158 158 0.016
cellular response to oxygen containing compound GO:1901701 276 0.016
cellular lipid metabolic process GO:0044255 303 0.016
regulation of mitotic cell cycle GO:0007346 189 0.016
Human
purine nucleoside monophosphate catabolic process GO:0009128 158 0.016
regulation of cell division GO:0051302 116 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.016
positive regulation of organelle organization GO:0010638 195 0.016
regulation of cell motility GO:2000145 299 0.016
negative regulation of cell death GO:0060548 345 0.016
biological adhesion GO:0022610 331 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.015
regulation of proteolysis GO:0030162 293 0.015
regulation of multi organism process GO:0043900 157 0.015
meiosis i GO:0007127 4 0.015
protein targeting GO:0006605 187 0.015
regulation of protein complex assembly GO:0043254 147 0.015
rna splicing GO:0008380 131 0.015
regulation of wnt signaling pathway GO:0030111 123 0.015
innate immune response GO:0045087 178 0.015
positive regulation of cellular component biogenesis GO:0044089 158 0.015
defense response GO:0006952 315 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
cytokinesis GO:0000910 96 0.015
positive regulation of cell death GO:0010942 263 0.015
regulation of cell differentiation GO:0045595 393 0.015
mapk cascade GO:0000165 288 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
sulfur compound metabolic process GO:0006790 101 0.014
positive regulation of immune system process GO:0002684 283 0.014
maintenance of protein location GO:0045185 57 0.014
cellular component disassembly GO:0022411 92 0.014
cilium assembly GO:0042384 63 0.014
negative regulation of organelle organization GO:0010639 126 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
positive regulation of cellular catabolic process GO:0031331 284 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
spermatid development GO:0007286 4 0.014
fatty acid metabolic process GO:0006631 115 0.014
regulation of microtubule based process GO:0032886 74 0.014
regeneration GO:0031099 4 0.014
negative regulation of protein modification process GO:0031400 200 0.014
compound eye development GO:0048749 1 0.014
canonical wnt signaling pathway GO:0060070 116 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
regulation of mapk cascade GO:0043408 262 0.014
protein processing GO:0016485 226 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
cellular protein catabolic process GO:0044257 261 0.014
signal transduction by phosphorylation GO:0023014 297 0.013
guanosine containing compound metabolic process GO:1901068 244 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
system process GO:0003008 349 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
response to hormone GO:0009725 175 0.013
mrna processing GO:0006397 133 0.013
cellular protein complex assembly GO:0043623 188 0.013
protein methylation GO:0006479 74 0.013
cilium morphogenesis GO:0060271 75 0.013
mitotic sister chromatid segregation GO:0000070 53 0.013
regulation of purine nucleotide metabolic process GO:1900542 264 0.013
atp catabolic process GO:0006200 157 0.013
intracellular protein transport GO:0006886 270 0.013
peripheral nervous system development GO:0007422 2 0.013
somitogenesis GO:0001756 2 0.013
cell adhesion GO:0007155 325 0.013
organelle localization GO:0051640 84 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
endocytosis GO:0006897 159 0.013
tube development GO:0035295 125 0.013
intracellular receptor signaling pathway GO:0030522 104 0.012
positive regulation of kinase activity GO:0033674 204 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
negative regulation of cell cycle GO:0045786 193 0.012
Human
chromatin organization GO:0006325 351 0.012
small gtpase mediated signal transduction GO:0007264 78 0.012
chromatin modification GO:0016568 298 0.012
cellular component assembly involved in morphogenesis GO:0010927 73 0.012
mrna splicing via spliceosome GO:0000398 89 0.012
positive regulation of gtp catabolic process GO:0033126 166 0.012
centrosome organization GO:0051297 58 0.012
covalent chromatin modification GO:0016569 254 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
response to other organism GO:0051707 261 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
regulation of microtubule cytoskeleton organization GO:0070507 61 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
regulation of protein transport GO:0051223 213 0.012
reproductive process GO:0022414 106 0.012
lipid modification GO:0030258 84 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
maintenance of protein location in cell GO:0032507 56 0.012
negative regulation of transport GO:0051051 176 0.012
macromolecule methylation GO:0043414 97 0.012
response to external biotic stimulus GO:0043207 261 0.012
positive regulation of protein kinase activity GO:0045860 190 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
cilium organization GO:0044782 68 0.011
growth GO:0040007 202 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
Human
rho protein signal transduction GO:0007266 26 0.011
endosomal transport GO:0016197 129 0.011
atp metabolic process GO:0046034 176 0.011
regulation of cellular component movement GO:0051270 334 0.011
positive regulation of transferase activity GO:0051347 227 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
negative regulation of kinase activity GO:0033673 106 0.011
regulation of protein ubiquitination GO:0031396 95 0.011
regulation of secretion by cell GO:1903530 177 0.011
neuron projection development GO:0031175 106 0.011
response to bacterium GO:0009617 144 0.011
receptor mediated endocytosis GO:0006898 84 0.011
neurogenesis GO:0022008 169 0.011
protein complex disassembly GO:0043241 52 0.011
response to cytokine GO:0034097 232 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
Human
central nervous system development GO:0007417 123 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
glycerophospholipid metabolic process GO:0006650 84 0.011
chemotaxis GO:0006935 157 0.011
rna interference GO:0016246 4 0.011
regulation of cell projection organization GO:0031344 107 0.011
regulation of cytokine production GO:0001817 232 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
interspecies interaction between organisms GO:0044419 156 0.011
nucleoside monophosphate catabolic process GO:0009125 159 0.011
cytokine production GO:0001816 247 0.011
regulation of response to external stimulus GO:0032101 222 0.011
positive regulation of protein transport GO:0051222 135 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
meiotic chromosome segregation GO:0045132 4 0.010
neural tube closure GO:0001843 3 0.010
cellular response to cytokine stimulus GO:0071345 181 0.010
epithelium development GO:0060429 227 0.010
response to radiation GO:0009314 151 0.010
regulation of protein catabolic process GO:0042176 155 0.010
nuclear transport GO:0051169 179 0.010
regulation of cell migration GO:0030334 289 0.010
regulation of locomotion GO:0040012 329 0.010
viral process GO:0016032 146 0.010
regulation of protein depolymerization GO:1901879 22 0.010
positive regulation of proteolysis GO:0045862 142 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
ubiquitin dependent protein catabolic process GO:0006511 206 0.010
tissue morphogenesis GO:0048729 96 0.010
mating GO:0007618 1 0.010
regulation of dna repair GO:0006282 47 0.010

NEK4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.035
inherited metabolic disorder DOID:655 242 0.024
central nervous system disease DOID:331 186 0.021
nervous system disease DOID:863 431 0.021
disease of cellular proliferation DOID:14566 174 0.017
cancer DOID:162 167 0.016
organ system cancer DOID:0050686 164 0.012
musculoskeletal system disease DOID:17 223 0.011