Homo sapiens

69 known processes

NEK2

NIMA (never in mitosis gene a)-related kinase 2

(Aliases: HsPK21,NEK2A,NLK1)

NEK2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic cell cycle process GO:1903047 286 0.602
Mouse Fly
microtubule organizing center organization GO:0031023 62 0.569
microtubule cytoskeleton organization GO:0000226 176 0.545
mitotic cell cycle GO:0000278 326 0.542
Mouse Fly
spindle assembly GO:0051225 29 0.528
Mouse
cytokinesis GO:0000910 96 0.524
regulation of cell cycle GO:0051726 393 0.520
Fly
male meiosis GO:0007140 1 0.510
microtubule based process GO:0007017 210 0.488
spindle organization GO:0007051 53 0.384
Mouse
spindle assembly involved in mitosis GO:0090307 12 0.331
Mouse
centrosome organization GO:0051297 58 0.330
cytoskeleton dependent cytokinesis GO:0061640 22 0.328
meiotic chromosome segregation GO:0045132 4 0.318
spindle stabilization GO:0043146 4 0.317
regulation of mitotic cell cycle GO:0007346 189 0.315
Fly
organelle assembly GO:0070925 176 0.308
Mouse
cellular macromolecular complex assembly GO:0034622 324 0.279
establishment of organelle localization GO:0051656 59 0.253
sister chromatid biorientation GO:0031134 2 0.244
nuclear division GO:0000280 128 0.242
Mouse Fly
mitotic sister chromatid segregation GO:0000070 53 0.242
Mouse
sister chromatid segregation GO:0000819 54 0.239
Mouse
spindle elongation GO:0051231 4 0.236
cell division GO:0051301 168 0.229
Fly
positive regulation of protein phosphorylation GO:0001934 313 0.220
ubiquitin dependent protein catabolic process GO:0006511 206 0.219
organelle localization GO:0051640 84 0.195
regulation of chromosome segregation GO:0051983 44 0.192
microtubule polymerization or depolymerization GO:0031109 37 0.189
protein depolymerization GO:0051261 30 0.185
chromosome segregation GO:0007059 114 0.184
cellular protein complex assembly GO:0043623 188 0.174
post embryonic development GO:0009791 2 0.157
negative regulation of organelle organization GO:0010639 126 0.152
protein polymerization GO:0051258 71 0.148
macromolecular complex disassembly GO:0032984 60 0.147
negative regulation of cellular component organization GO:0051129 235 0.144
mitotic nuclear division GO:0007067 119 0.141
Mouse Fly
regulation of cell differentiation GO:0045595 393 0.139
stem cell division GO:0017145 2 0.137
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.136
Mouse
single organism cellular localization GO:1902580 332 0.132
positive regulation of cell cycle GO:0045787 140 0.132
dephosphorylation GO:0016311 209 0.130
regulation of cell cycle process GO:0010564 266 0.129
Fly
histone serine phosphorylation GO:0035404 4 0.126
microtubule polymerization GO:0046785 18 0.125
nucleoside triphosphate metabolic process GO:0009141 422 0.121
regulation of microtubule based process GO:0032886 74 0.119
microtubule based movement GO:0007018 32 0.119
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.118
nucleotide catabolic process GO:0009166 408 0.117
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.114
establishment of nucleus localization GO:0040023 1 0.111
attachment of spindle microtubules to kinetochore GO:0008608 17 0.110
protein dephosphorylation GO:0006470 81 0.106
organelle fission GO:0048285 149 0.105
Mouse Fly
peptidyl serine phosphorylation GO:0018105 101 0.103
regulation of mitotic sister chromatid segregation GO:0033047 27 0.102
cellular component disassembly GO:0022411 92 0.100
negative regulation of mitotic cell cycle GO:0045930 102 0.098
cellular macromolecule catabolic process GO:0044265 380 0.094
regulation of cell division GO:0051302 116 0.093
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.092
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.087
neurogenesis GO:0022008 169 0.087
Zebrafish
purine nucleoside triphosphate metabolic process GO:0009144 412 0.086
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.084
negative regulation of cell size GO:0045792 3 0.084
ribonucleoside catabolic process GO:0042454 406 0.083
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.081
positive regulation of organelle organization GO:0010638 195 0.081
anatomical structure formation involved in morphogenesis GO:0048646 284 0.080
female gamete generation GO:0007292 2 0.078
negative regulation of catalytic activity GO:0043086 335 0.077
organophosphate catabolic process GO:0046434 430 0.076
regulation of transferase activity GO:0051338 355 0.075
purine nucleoside monophosphate metabolic process GO:0009126 186 0.075
regulation of spindle organization GO:0090224 10 0.074
negative regulation of cell cycle GO:0045786 193 0.074
protein modification by small protein conjugation GO:0032446 342 0.073
regulation of mitotic sister chromatid separation GO:0010965 27 0.072
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.071
ribonucleoside triphosphate metabolic process GO:0009199 412 0.068
spindle midzone assembly GO:0051255 4 0.068
regulation of mitosis GO:0007088 63 0.068
Fly
protein complex disassembly GO:0043241 52 0.068
mitotic sister chromatid separation GO:0051306 18 0.068
cellular component morphogenesis GO:0032989 314 0.067
heart development GO:0007507 95 0.066
mitotic spindle midzone assembly GO:0051256 4 0.066
nucleoside monophosphate catabolic process GO:0009125 159 0.065
oogenesis GO:0048477 2 0.065
regulation of cytoskeleton organization GO:0051493 177 0.065
positive regulation of cell division GO:0051781 59 0.064
mitotic cell cycle phase transition GO:0044772 162 0.064
positive regulation of cell cycle process GO:0090068 106 0.063
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.062
nucleoside monophosphate metabolic process GO:0009123 191 0.062
chromatin organization GO:0006325 351 0.062
ribonucleoside monophosphate metabolic process GO:0009161 187 0.061
protein polyubiquitination GO:0000209 110 0.061
vesicle mediated transport GO:0016192 371 0.061
maintenance of location GO:0051235 112 0.060
centrosome separation GO:0051299 3 0.060
metaphase plate congression GO:0051310 18 0.060
regulation of proteasomal protein catabolic process GO:0061136 87 0.058
negative regulation of protein metabolic process GO:0051248 391 0.058
positive regulation of mitosis GO:0045840 25 0.058
nervous system development GO:0007399 293 0.057
Zebrafish
positive regulation of protein kinase activity GO:0045860 190 0.057
maintenance of location in cell GO:0051651 62 0.057
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.057
ribonucleoside monophosphate catabolic process GO:0009158 158 0.056
microtubule anchoring GO:0034453 24 0.056
negative regulation of cell differentiation GO:0045596 171 0.055
regulation of cellular component movement GO:0051270 334 0.055
regulation of protein kinase activity GO:0045859 289 0.055
spindle checkpoint GO:0031577 26 0.054
negative regulation of cellular protein metabolic process GO:0032269 353 0.054
embryo development GO:0009790 123 0.053
Mouse
negative regulation of phosphatase activity GO:0010923 61 0.053
somatic stem cell division GO:0048103 1 0.052
negative regulation of proteolysis GO:0045861 132 0.051
peptidyl serine modification GO:0018209 106 0.050
negative regulation of programmed cell death GO:0043069 321 0.050
atp catabolic process GO:0006200 157 0.050
regulation of meiotic cell cycle GO:0051445 4 0.050
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.049
mitotic spindle elongation GO:0000022 4 0.049
regulation of microtubule cytoskeleton organization GO:0070507 61 0.049
cell development GO:0048468 328 0.049
Zebrafish
nucleoside triphosphate catabolic process GO:0009143 394 0.048
cell cycle phase transition GO:0044770 173 0.047
modification dependent macromolecule catabolic process GO:0043632 212 0.046
proteasomal protein catabolic process GO:0010498 176 0.046
atp metabolic process GO:0046034 176 0.046
mitotic metaphase plate congression GO:0007080 14 0.046
nucleus localization GO:0051647 1 0.046
mitotic centrosome separation GO:0007100 1 0.045
cell projection organization GO:0030030 252 0.045
peptidyl tyrosine dephosphorylation GO:0035335 36 0.044
regulation of cellular amino acid metabolic process GO:0006521 6 0.044
neuroblast proliferation GO:0007405 4 0.044
ribonucleoside triphosphate catabolic process GO:0009203 391 0.044
regulation of proteolysis GO:0030162 293 0.044
mitotic cytokinesis GO:0000281 19 0.043
protein localization to organelle GO:0033365 280 0.043
nucleoside phosphate catabolic process GO:1901292 412 0.043
regulation of cellular component biogenesis GO:0044087 281 0.042
regulation of cellular protein catabolic process GO:1903362 96 0.042
cytoplasmic transport GO:0016482 379 0.042
purine ribonucleoside catabolic process GO:0046130 398 0.042
positive regulation of cellular protein catabolic process GO:1903364 37 0.042
small gtpase mediated signal transduction GO:0007264 78 0.041
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.041
regeneration GO:0031099 4 0.041
protein processing GO:0016485 226 0.040
reproductive process GO:0022414 106 0.040
modification dependent protein catabolic process GO:0019941 209 0.040
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.040
stem cell differentiation GO:0048863 93 0.039
chromosome separation GO:0051304 23 0.039
regulation of protein processing GO:0070613 150 0.038
cellular protein complex disassembly GO:0043624 36 0.038
regulation of protein maturation GO:1903317 150 0.038
ribonucleotide catabolic process GO:0009261 405 0.038
protein maturation GO:0051604 233 0.038
regulation of binding GO:0051098 111 0.038
Mouse
endomembrane system organization GO:0010256 196 0.037
purine nucleoside triphosphate catabolic process GO:0009146 392 0.036
positive regulation of cellular catabolic process GO:0031331 284 0.036
intracellular protein transport GO:0006886 270 0.036
regulation of cell cycle phase transition GO:1901987 126 0.035
regulation of cell migration GO:0030334 289 0.034
cell morphogenesis GO:0000902 296 0.034
regulation of nuclear division GO:0051783 65 0.034
Fly
regulation of cytokinesis GO:0032465 45 0.033
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.033
regulation of dephosphorylation GO:0035303 96 0.032
meiosis i GO:0007127 4 0.031
positive regulation of phosphorylation GO:0042327 394 0.031
response to oxidative stress GO:0006979 121 0.031
positive regulation of dna metabolic process GO:0051054 73 0.030
tissue regeneration GO:0042246 3 0.030
negative regulation of cell division GO:0051782 31 0.030
metaphase anaphase transition of cell cycle GO:0044784 21 0.030
cellular protein catabolic process GO:0044257 261 0.030
negative regulation of cell cycle process GO:0010948 121 0.029
negative regulation of phosphorus metabolic process GO:0010563 267 0.029
immune system development GO:0002520 195 0.029
positive regulation of catabolic process GO:0009896 310 0.029
positive regulation of cellular component organization GO:0051130 376 0.029
regulation of cellular response to stress GO:0080135 244 0.029
regulation of sister chromatid segregation GO:0033045 27 0.028
regulation of cellular ketone metabolic process GO:0010565 50 0.028
negative regulation of phosphate metabolic process GO:0045936 267 0.028
regulation of intracellular protein transport GO:0033157 123 0.028
single organism membrane organization GO:0044802 268 0.028
actin filament based process GO:0030029 224 0.028
regulation of cell motility GO:2000145 299 0.028
regulation of chromosome organization GO:0033044 103 0.027
centrosome cycle GO:0007098 32 0.027
regulation of kinase activity GO:0043549 314 0.027
positive regulation of mitotic cell cycle GO:0045931 60 0.027
positive regulation of mitotic sister chromatid separation GO:1901970 6 0.027
canonical wnt signaling pathway GO:0060070 116 0.026
negative regulation of protein processing GO:0010955 142 0.026
neuroblast division GO:0055057 1 0.026
cellular amino acid metabolic process GO:0006520 116 0.026
endocytosis GO:0006897 159 0.026
oocyte differentiation GO:0009994 2 0.025
regulation of locomotion GO:0040012 329 0.025
positive regulation of cell differentiation GO:0045597 211 0.025
cellular response to dna damage stimulus GO:0006974 379 0.025
negative regulation of protein maturation GO:1903318 142 0.025
reproduction GO:0000003 63 0.025
regulation of cytoplasmic transport GO:1903649 149 0.025
regulation of wnt signaling pathway GO:0030111 123 0.024
Fly
regulation of endopeptidase activity GO:0052548 170 0.024
purine nucleoside catabolic process GO:0006152 398 0.024
positive regulation of protein catabolic process GO:0045732 75 0.024
regulation of protein catabolic process GO:0042176 155 0.023
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.023
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.023
nucleocytoplasmic transport GO:0006913 176 0.023
nuclear transport GO:0051169 179 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
generation of neurons GO:0048699 152 0.023
Zebrafish
negative regulation of developmental process GO:0051093 247 0.023
regulation of intracellular transport GO:0032386 195 0.023
negative regulation of mitosis GO:0045839 24 0.023
activation of protein kinase activity GO:0032147 90 0.023
regulation of mitotic cell cycle phase transition GO:1901990 118 0.022
purine nucleoside monophosphate catabolic process GO:0009128 158 0.022
meiotic nuclear division GO:0007126 10 0.022
digestive tract morphogenesis GO:0048546 56 0.022
glycosyl compound catabolic process GO:1901658 413 0.021
negative regulation of dephosphorylation GO:0035305 63 0.021
chromatin modification GO:0016568 298 0.021
single organism reproductive process GO:0044702 98 0.021
purine ribonucleotide catabolic process GO:0009154 404 0.021
microtubule depolymerization GO:0007019 18 0.021
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
negative regulation of hydrolase activity GO:0051346 182 0.021
cell projection morphogenesis GO:0048858 129 0.020
negative regulation of cell cycle phase transition GO:1901988 89 0.020
somatic muscle development GO:0007525 1 0.020
regulation of cell development GO:0060284 161 0.020
positive regulation of cytokinesis GO:0032467 29 0.020
protein targeting GO:0006605 187 0.020
ras protein signal transduction GO:0007265 73 0.020
negative regulation of cell death GO:0060548 345 0.020
circulatory system development GO:0072359 262 0.020
tube morphogenesis GO:0035239 95 0.020
cilium morphogenesis GO:0060271 75 0.019
cell part morphogenesis GO:0032990 137 0.019
cell growth GO:0016049 160 0.019
dna conformation change GO:0071103 113 0.019
peptidyl threonine phosphorylation GO:0018107 41 0.019
oocyte development GO:0048599 1 0.019
positive regulation of intracellular transport GO:0032388 104 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
response to abiotic stimulus GO:0009628 336 0.019
regulation of protein complex assembly GO:0043254 147 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.018
protein catabolic process GO:0030163 325 0.018
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.018
regulation of peptidase activity GO:0052547 180 0.018
dna recombination GO:0006310 77 0.018
positive regulation of protein transport GO:0051222 135 0.018
cardiovascular system development GO:0072358 262 0.018
epithelium development GO:0060429 227 0.018
developmental process involved in reproduction GO:0003006 66 0.018
cell projection assembly GO:0030031 126 0.017
anterior posterior axis specification GO:0009948 2 0.017
immune response GO:0006955 307 0.017
positive regulation of chromosome organization GO:2001252 41 0.017
positive regulation of developmental process GO:0051094 314 0.017
cell cycle g1 s phase transition GO:0044843 80 0.017
protein targeting to nucleus GO:0044744 104 0.017
positive regulation of transport GO:0051050 336 0.017
centrosome duplication GO:0051298 28 0.017
cell fate determination GO:0001709 3 0.017
negative regulation of protein phosphorylation GO:0001933 140 0.017
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.017
protein localization to chromosome centromeric region GO:0071459 12 0.016
regulation of phosphatase activity GO:0010921 81 0.016
response to lipid GO:0033993 206 0.016
positive regulation of cytoskeleton organization GO:0051495 83 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
wnt signaling pathway GO:0016055 156 0.016
Fly
regulation of nucleocytoplasmic transport GO:0046822 98 0.016
positive regulation of proteolysis GO:0045862 142 0.016
nuclear migration GO:0007097 1 0.016
tube development GO:0035295 125 0.016
regulation of cysteine type endopeptidase activity GO:2000116 127 0.016
regulation of protein localization GO:0032880 296 0.016
positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 2 0.016
cellular amine metabolic process GO:0044106 41 0.016
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.016
mitotic spindle organization GO:0007052 27 0.016
Mouse
spermatid differentiation GO:0048515 4 0.016
cellular ketone metabolic process GO:0042180 80 0.015
positive regulation of kinase activity GO:0033674 204 0.015
amine metabolic process GO:0009308 44 0.015
cell cycle g2 m phase transition GO:0044839 43 0.015
positive regulation of transferase activity GO:0051347 227 0.015
cell cell signaling GO:0007267 155 0.015
nucleoside catabolic process GO:0009164 408 0.015
growth GO:0040007 202 0.014
positive regulation of chromosome segregation GO:0051984 9 0.014
protein import GO:0017038 130 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
developmental growth GO:0048589 48 0.014
protein autophosphorylation GO:0046777 123 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.014
positive regulation of cytoplasmic transport GO:1903651 82 0.014
regulation of cardiac muscle cell proliferation GO:0060043 4 0.013
neuron development GO:0048666 113 0.013
Zebrafish
negative regulation of catabolic process GO:0009895 104 0.013
membrane organization GO:0061024 292 0.013
response to biotic stimulus GO:0009607 276 0.013
neuronal stem cell division GO:0036445 1 0.013
peptidyl threonine modification GO:0018210 45 0.013
peptidyl tyrosine phosphorylation GO:0018108 170 0.013
negative regulation of chromosome organization GO:2001251 48 0.013
negative regulation of sister chromatid segregation GO:0033046 17 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
blastocyst development GO:0001824 3 0.013
Mouse
regulation of double strand break repair GO:2000779 22 0.013
hemopoiesis GO:0030097 180 0.013
regulation of canonical wnt signaling pathway GO:0060828 88 0.013
apoptotic signaling pathway GO:0097190 268 0.013
negative regulation of methylation dependent chromatin silencing GO:0090310 2 0.013
receptor mediated endocytosis GO:0006898 84 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.012
establishment of chromosome localization GO:0051303 20 0.012
negative regulation of cellular protein catabolic process GO:1903363 38 0.012
response to wounding GO:0009611 168 0.012
double strand break repair via homologous recombination GO:0000724 50 0.012
maintenance of protein location GO:0045185 57 0.012
protein ubiquitination GO:0016567 314 0.012
lysosomal transport GO:0007041 33 0.012
multi organism reproductive process GO:0044703 54 0.011
protein localization to nucleus GO:0034504 136 0.011
purine containing compound catabolic process GO:0072523 411 0.011
mitotic cell cycle checkpoint GO:0007093 68 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
regulation of protein dephosphorylation GO:0035304 18 0.011
response to radiation GO:0009314 151 0.011
response to organic cyclic compound GO:0014070 204 0.011
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 6 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
muscle structure development GO:0061061 98 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
multicellular organismal aging GO:0010259 3 0.011
regulation of protein import into nucleus GO:0042306 78 0.011
regulation of ligase activity GO:0051340 29 0.011
negative regulation of protein complex disassembly GO:0043242 20 0.011
dna packaging GO:0006323 77 0.010
response to oxygen containing compound GO:1901700 369 0.010
reproductive system development GO:0061458 56 0.010
regulation of mitotic spindle organization GO:0060236 6 0.010
neuron differentiation GO:0030182 138 0.010
Zebrafish
intrinsic apoptotic signaling pathway GO:0097193 127 0.010

NEK2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.047
disease of cellular proliferation DOID:14566 174 0.047
gastrointestinal system cancer DOID:3119 52 0.046
organ system cancer DOID:0050686 164 0.046