Homo sapiens

22 known processes

SIX2

SIX homeobox 2

SIX2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extraocular skeletal muscle development GO:0002074 1 0.882
organ morphogenesis GO:0009887 147 0.496
Mouse Fly
organ formation GO:0048645 3 0.440
anatomical structure formation involved in morphogenesis GO:0048646 284 0.425
Mouse Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.368
neuron fate commitment GO:0048663 2 0.349
regulation of cell differentiation GO:0045595 393 0.321
Mouse
epithelium development GO:0060429 227 0.320
Mouse
cardiovascular system development GO:0072358 262 0.287
tube development GO:0035295 125 0.273
Mouse
cardiac cell fate determination GO:0060913 3 0.270
circulatory system development GO:0072359 262 0.265
embryonic morphogenesis GO:0048598 85 0.263
Mouse Fly
specification of organ identity GO:0010092 3 0.260
regulation of locomotion GO:0040012 329 0.226
system process GO:0003008 349 0.207
muscle structure development GO:0061061 98 0.196
nervous system development GO:0007399 293 0.191
Human Fly
negative regulation of developmental process GO:0051093 247 0.188
Mouse
cellular component morphogenesis GO:0032989 314 0.184
Mouse
forelimb morphogenesis GO:0035136 4 0.181
cell development GO:0048468 328 0.180
Mouse
tube morphogenesis GO:0035239 95 0.173
Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.172
vasculature development GO:0001944 181 0.171
regulation of anatomical structure morphogenesis GO:0022603 286 0.146
Mouse
epithelial cell differentiation GO:0030855 141 0.145
Mouse
mesenchyme development GO:0060485 59 0.144
Mouse
endocrine system development GO:0035270 26 0.143
Fly
cellular ketone metabolic process GO:0042180 80 0.140
post embryonic development GO:0009791 2 0.135
regulation of cellular ketone metabolic process GO:0010565 50 0.131
positive regulation of developmental process GO:0051094 314 0.130
negative regulation of cell differentiation GO:0045596 171 0.129
Mouse
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.128
cell morphogenesis GO:0000902 296 0.126
Mouse
forebrain regionalization GO:0021871 3 0.125
Human
cellular response to endogenous stimulus GO:0071495 336 0.124
cell fate determination GO:0001709 3 0.124
positive regulation of phosphorylation GO:0042327 394 0.121
regulation of cellular component movement GO:0051270 334 0.120
embryonic forelimb morphogenesis GO:0035115 4 0.118
negative regulation of cell death GO:0060548 345 0.118
positive regulation of cell proliferation GO:0008284 301 0.116
Mouse
negative regulation of apoptotic process GO:0043066 316 0.112
cranial nerve development GO:0021545 4 0.111
stem cell differentiation GO:0048863 93 0.111
Mouse
segmentation GO:0035282 4 0.110
regulation of cellular amino acid metabolic process GO:0006521 6 0.110
regulation of cell motility GO:2000145 299 0.108
regulation of cellular amine metabolic process GO:0033238 11 0.108
canonical wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044338 2 0.106
amine metabolic process GO:0009308 44 0.105
neuron differentiation GO:0030182 138 0.104
positive regulation of cardioblast differentiation GO:0051891 2 0.104
negative regulation of programmed cell death GO:0043069 321 0.103
regulation of cell migration GO:0030334 289 0.102
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.101
digestive tract development GO:0048565 75 0.100
Mouse
skeletal system development GO:0001501 79 0.100
Mouse
cell morphogenesis involved in differentiation GO:0000904 144 0.100
Mouse
generation of neurons GO:0048699 152 0.099
canonical wnt signaling pathway involved in osteoblast differentiation GO:0044339 2 0.099
digestive system development GO:0055123 75 0.098
Mouse
positive regulation of cellular amine metabolic process GO:0033240 7 0.098
blood vessel development GO:0001568 172 0.098
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.097
negative regulation of cell proliferation GO:0008285 228 0.097
morphogenesis of an epithelium GO:0002009 60 0.096
Mouse
positive regulation of protein phosphorylation GO:0001934 313 0.096
enzyme linked receptor protein signaling pathway GO:0007167 303 0.095
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.095
regulation of cell cycle GO:0051726 393 0.095
pituitary gland development GO:0021983 2 0.094
central nervous system development GO:0007417 123 0.093
Human
locomotory behavior GO:0007626 1 0.092
positive regulation of cell differentiation GO:0045597 211 0.091
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 1 0.090
tissue morphogenesis GO:0048729 96 0.089
Mouse
cellular amine metabolic process GO:0044106 41 0.089
heart development GO:0007507 95 0.086
striated muscle tissue development GO:0014706 59 0.085
mesenchymal cell development GO:0014031 50 0.085
nerve development GO:0021675 4 0.083
head development GO:0060322 108 0.082
Human
canonical wnt signaling pathway GO:0060070 116 0.082
regulation of cell development GO:0060284 161 0.081
muscle tissue development GO:0060537 62 0.080
cartilage condensation GO:0001502 1 0.080
pulmonary vein morphogenesis GO:0060577 1 0.080
pattern specification process GO:0007389 43 0.079
Human Mouse
cellular amino acid metabolic process GO:0006520 116 0.079
brain development GO:0007420 97 0.078
Human
regionalization GO:0003002 29 0.077
Human Mouse
embryo development GO:0009790 123 0.076
Mouse Fly
hematopoietic or lymphoid organ development GO:0048534 186 0.075
gland development GO:0048732 48 0.075
Fly
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.075
immune system development GO:0002520 195 0.074
inner ear morphogenesis GO:0042472 4 0.072
regulation of transferase activity GO:0051338 355 0.072
cell projection organization GO:0030030 252 0.071
signal transduction by phosphorylation GO:0023014 297 0.071
skin development GO:0043588 76 0.071
epithelial tube morphogenesis GO:0060562 38 0.070
Mouse
kidney development GO:0001822 53 0.068
neurogenesis GO:0022008 169 0.068
Fly
morphogenesis of embryonic epithelium GO:0016331 4 0.068
stem cell development GO:0048864 69 0.068
Mouse
hindbrain development GO:0030902 3 0.067
wnt signaling pathway GO:0016055 156 0.066
spinal cord development GO:0021510 4 0.065
cell differentiation in spinal cord GO:0021515 1 0.065
negative regulation of protein metabolic process GO:0051248 391 0.064
cell cell signaling GO:0007267 155 0.064
mapk cascade GO:0000165 288 0.064
growth GO:0040007 202 0.062
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.062
positive regulation of programmed cell death GO:0043068 249 0.062
regulation of kinase activity GO:0043549 314 0.061
soft palate development GO:0060023 3 0.061
regulation of protein kinase activity GO:0045859 289 0.060
cardiac muscle tissue development GO:0048738 39 0.060
heart morphogenesis GO:0003007 48 0.059
pharynx development GO:0060465 1 0.059
negative regulation of cell migration GO:0030336 102 0.058
mitotic cell cycle GO:0000278 326 0.058
positive regulation of apoptotic process GO:0043065 246 0.057
globus pallidus development GO:0021759 1 0.057
cellular response to dna damage stimulus GO:0006974 379 0.056
response to abiotic stimulus GO:0009628 336 0.056
negative regulation of cell cycle GO:0045786 193 0.055
blood vessel morphogenesis GO:0048514 162 0.055
skeletal system morphogenesis GO:0048705 24 0.054
Mouse
positive regulation of cell death GO:0010942 263 0.054
response to organic cyclic compound GO:0014070 204 0.054
negative regulation of locomotion GO:0040013 118 0.054
positive regulation of aldosterone metabolic process GO:0032346 2 0.053
regulation of male gonad development GO:2000018 4 0.053
outflow tract septum morphogenesis GO:0003148 4 0.052
actin filament based process GO:0030029 224 0.052
positive regulation of transferase activity GO:0051347 227 0.052
muscle contraction GO:0006936 73 0.051
positive regulation of tooth mineralization GO:0070172 2 0.051
muscle system process GO:0003012 81 0.050
urogenital system development GO:0001655 65 0.050
regulation of mapk cascade GO:0043408 262 0.050
positive regulation of hydrolase activity GO:0051345 331 0.050
regulation of canonical wnt signaling pathway GO:0060828 88 0.049
positive regulation of cellular component organization GO:0051130 376 0.049
neuromuscular junction development GO:0007528 3 0.049
purine nucleoside triphosphate catabolic process GO:0009146 392 0.048
cell aggregation GO:0098743 1 0.048
anterior posterior axis specification GO:0009948 2 0.048
Mouse
response to wounding GO:0009611 168 0.048
small gtpase mediated signal transduction GO:0007264 78 0.047
striated muscle contraction GO:0006941 52 0.047
endodermal cell fate commitment GO:0001711 4 0.047
ribonucleotide catabolic process GO:0009261 405 0.047
sensory organ development GO:0007423 52 0.047
Human Mouse Fly
biological adhesion GO:0022610 331 0.047
cell adhesion GO:0007155 325 0.046
adult locomotory behavior GO:0008344 1 0.046
regulation of mitotic cell cycle GO:0007346 189 0.046
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.046
cellular response to growth factor stimulus GO:0071363 197 0.045
regulation of response to external stimulus GO:0032101 222 0.045
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 1 0.045
regulation of protein serine threonine kinase activity GO:0071900 179 0.045
muscle cell differentiation GO:0042692 63 0.045
cell fate commitment GO:0045165 27 0.045
Mouse
right ventricular cardiac muscle tissue morphogenesis GO:0003221 2 0.045
single organism cellular localization GO:1902580 332 0.044
Mouse
regulation of hormone levels GO:0010817 125 0.044
nucleoside phosphate catabolic process GO:1901292 412 0.044
response to lipid GO:0033993 206 0.044
hindlimb morphogenesis GO:0035137 2 0.044
regulation of stem cell differentiation GO:2000736 56 0.044
regulation of growth GO:0040008 165 0.044
cation transport GO:0006812 331 0.044
immune response GO:0006955 307 0.043
regulation of nervous system development GO:0051960 88 0.043
menstrual cycle phase GO:0022601 2 0.043
thymus development GO:0048538 3 0.043
hair follicle morphogenesis GO:0031069 2 0.043
chemical homeostasis GO:0048878 306 0.043
positive regulation of protein kinase activity GO:0045860 190 0.043
positive regulation of kinase activity GO:0033674 204 0.042
positive regulation of odontogenesis GO:0042482 3 0.042
purine ribonucleoside metabolic process GO:0046128 437 0.042
nucleoside triphosphate metabolic process GO:0009141 422 0.042
negative regulation of cell motility GO:2000146 104 0.042
oxidative stress induced premature senescence GO:0090403 3 0.042
blastoderm segmentation GO:0007350 2 0.042
embryonic epithelial tube formation GO:0001838 4 0.042
peripheral nervous system development GO:0007422 2 0.042
positive regulation of cell cycle GO:0045787 140 0.041
organophosphate catabolic process GO:0046434 430 0.041
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.041
negative regulation of cellular protein metabolic process GO:0032269 353 0.041
mesenchymal cell differentiation GO:0048762 52 0.041
Mouse
regulation of cell cycle process GO:0010564 266 0.041
multicellular organismal aging GO:0010259 3 0.041
embryonic organ development GO:0048568 36 0.041
Mouse
tongue development GO:0043586 1 0.040
positive regulation of mapk cascade GO:0043410 190 0.040
limbic system development GO:0021761 3 0.040
cardiac right ventricle morphogenesis GO:0003215 3 0.040
ureter development GO:0072189 3 0.039
response to growth factor GO:0070848 205 0.039
neuron development GO:0048666 113 0.039
determination of adult lifespan GO:0008340 2 0.039
hemopoiesis GO:0030097 180 0.039
purine nucleoside catabolic process GO:0006152 398 0.038
somatic stem cell maintenance GO:0035019 4 0.038
Mouse
bmp signaling pathway involved in heart development GO:0061312 3 0.038
cellular response to oxygen containing compound GO:1901701 276 0.038
negative regulation of phosphate metabolic process GO:0045936 267 0.038
renal system development GO:0072001 63 0.038
regulation of body fluid levels GO:0050878 99 0.038
mesonephric tubule formation GO:0072172 1 0.038
endodermal cell fate specification GO:0001714 4 0.038
striated muscle cell differentiation GO:0051146 43 0.038
embryonic camera type eye development GO:0031076 2 0.038
negative regulation of cellular component movement GO:0051271 106 0.038
neuron projection development GO:0031175 106 0.038
nucleoside triphosphate catabolic process GO:0009143 394 0.038
purine nucleotide catabolic process GO:0006195 405 0.038
regulation of cellular response to stress GO:0080135 244 0.037
secretion by cell GO:0032940 226 0.037
blood circulation GO:0008015 113 0.037
purine ribonucleotide catabolic process GO:0009154 404 0.037
ossification GO:0001503 121 0.037
Mouse
intracellular protein transport GO:0006886 270 0.037
Mouse
negative regulation of testosterone biosynthetic process GO:2000225 1 0.036
positive regulation of hormone biosynthetic process GO:0046886 4 0.036
cell proliferation in forebrain GO:0021846 1 0.036
chromatin organization GO:0006325 351 0.036
positive regulation of glucocorticoid biosynthetic process GO:0031948 1 0.036
regulation of testosterone biosynthetic process GO:2000224 2 0.036
cation transmembrane transport GO:0098655 238 0.036
forebrain generation of neurons GO:0021872 3 0.036
inorganic cation transmembrane transport GO:0098662 194 0.036
purine containing compound catabolic process GO:0072523 411 0.035
ras protein signal transduction GO:0007265 73 0.035
regulation of protein localization GO:0032880 296 0.035
cell projection morphogenesis GO:0048858 129 0.035
regulation of endopeptidase activity GO:0052548 170 0.035
cytokine production GO:0001816 247 0.035
negative regulation of cellular component organization GO:0051129 235 0.035
compound eye development GO:0048749 1 0.035
Fly
nucleotide catabolic process GO:0009166 408 0.035
testosterone biosynthetic process GO:0061370 2 0.035
negative regulation of catalytic activity GO:0043086 335 0.035
glycosyl compound catabolic process GO:1901658 413 0.035
negative regulation of phosphorus metabolic process GO:0010563 267 0.035
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.035
wound healing GO:0042060 115 0.035
female gamete generation GO:0007292 2 0.035
regulation of wnt signaling pathway GO:0030111 123 0.034
regulation of intracellular transport GO:0032386 195 0.034
regulation of epithelial cell proliferation GO:0050678 113 0.034
negative regulation of testicular blood vessel morphogenesis GO:0061369 1 0.034
positive regulation of cell development GO:0010720 92 0.034
cellular response to cytokine stimulus GO:0071345 181 0.034
motor neuron axon guidance GO:0008045 2 0.034
protein localization to organelle GO:0033365 280 0.034
Human Mouse
chordate embryonic development GO:0043009 34 0.034
Mouse
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.033
positive regulation of catabolic process GO:0009896 310 0.033
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.033
ribonucleoside triphosphate metabolic process GO:0009199 412 0.033
response to oxygen containing compound GO:1901700 369 0.033
cell part morphogenesis GO:0032990 137 0.033
regulation of cellular component biogenesis GO:0044087 281 0.033
ribonucleoside catabolic process GO:0042454 406 0.033
epithelial cell proliferation GO:0050673 128 0.033
regulation of dermatome development GO:0061183 3 0.033
neural crest cell development GO:0014032 3 0.033
embryonic organ morphogenesis GO:0048562 24 0.033
Mouse
regulation of cardiac muscle tissue growth GO:0055021 4 0.033
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 4 0.033
Mouse
behavior GO:0007610 112 0.033
negative regulation of androgen biosynthetic process GO:2000180 1 0.032
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.032
oogenesis GO:0048477 2 0.032
circulatory system process GO:0003013 113 0.032
purine nucleoside triphosphate metabolic process GO:0009144 412 0.032
foramen ovale closure GO:0035922 1 0.032
cell cycle phase transition GO:0044770 173 0.032
cytoplasmic transport GO:0016482 379 0.031
Mouse
reproductive process GO:0022414 106 0.031
Fly
regulation of cardiac muscle cell proliferation GO:0060043 4 0.031
regulation of system process GO:0044057 101 0.031
chromatin modification GO:0016568 298 0.031
sex determination GO:0007530 3 0.031
apoptotic signaling pathway GO:0097190 268 0.031
taxis GO:0042330 157 0.031
regulation of peptidase activity GO:0052547 180 0.031
regulation of cell growth GO:0001558 135 0.031
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.031
ion homeostasis GO:0050801 230 0.031
response to hormone GO:0009725 175 0.031
response to cytokine GO:0034097 232 0.030
epidermis morphogenesis GO:0048730 3 0.030
small molecule biosynthetic process GO:0044283 157 0.030
negative regulation of protein modification process GO:0031400 200 0.030
embryonic skeletal system development GO:0048706 13 0.030
Mouse
connective tissue development GO:0061448 39 0.030
Mouse
inorganic ion transmembrane transport GO:0098660 231 0.030
follicle stimulating hormone secretion GO:0046884 3 0.030
regulation of cytokine production GO:0001817 232 0.030
positive regulation of cellular catabolic process GO:0031331 284 0.030
cell growth GO:0016049 160 0.030
cell type specific apoptotic process GO:0097285 125 0.030
regulation of organ formation GO:0003156 4 0.029
response to decreased oxygen levels GO:0036293 96 0.029
regulation of multi organism process GO:0043900 157 0.029
metal ion transport GO:0030001 272 0.029
covalent chromatin modification GO:0016569 254 0.029
osteoblast differentiation GO:0001649 92 0.029
dermatome development GO:0061054 3 0.029
single organism membrane organization GO:0044802 268 0.029
regulation of proteolysis GO:0030162 293 0.029
ameboidal type cell migration GO:0001667 135 0.029
nucleoside catabolic process GO:0009164 408 0.029
digestive tract morphogenesis GO:0048546 56 0.028
Mouse
monovalent inorganic cation transport GO:0015672 128 0.028
histone modification GO:0016570 251 0.028
embryonic hindlimb morphogenesis GO:0035116 2 0.028
actin filament based movement GO:0030048 17 0.028
negative regulation of cell growth GO:0030308 83 0.028
positive regulation of transport GO:0051050 336 0.028
angiogenesis GO:0001525 147 0.028
negative regulation of kidney development GO:0090185 2 0.028
regulation of vasculature development GO:1901342 97 0.028
cellular response to hormone stimulus GO:0032870 125 0.028
organelle assembly GO:0070925 176 0.028
regulation of heart growth GO:0060420 4 0.028
response to hypoxia GO:0001666 96 0.028
cardiac muscle contraction GO:0060048 34 0.027
morphogenesis of a branching structure GO:0001763 21 0.027
Mouse
somitogenesis GO:0001756 2 0.027
positive regulation of cortisol biosynthetic process GO:2000066 1 0.027
salivary gland morphogenesis GO:0007435 4 0.027
negative regulation of male gonad development GO:2000019 1 0.027
forebrain development GO:0030900 26 0.027
Human
regulation of purine nucleotide metabolic process GO:1900542 264 0.027
organ induction GO:0001759 4 0.027
negative regulation of cell adhesion GO:0007162 64 0.027
positive regulation of proteolysis GO:0045862 142 0.027
secretion GO:0046903 254 0.027
mesonephros development GO:0001823 17 0.027
Mouse
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.027
cardiocyte differentiation GO:0035051 23 0.027
cell activation GO:0001775 213 0.027
regulation of establishment of protein localization GO:0070201 242 0.027
transmembrane transport GO:0055085 399 0.026
cardiac muscle cell contraction GO:0086003 4 0.026
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
micturition GO:0060073 3 0.026
limb bud formation GO:0060174 1 0.026
appendage morphogenesis GO:0035107 16 0.026
lipid metabolic process GO:0006629 381 0.026
regeneration GO:0031099 4 0.026
regulation of protein transport GO:0051223 213 0.026
response to oxygen levels GO:0070482 100 0.026
mesonephric duct development GO:0072177 3 0.026
regulation of cysteine type endopeptidase activity GO:2000116 127 0.026
muscle organ development GO:0007517 56 0.026
protein acylation GO:0043543 138 0.026
carbohydrate metabolic process GO:0005975 207 0.026
anterior posterior axis specification embryo GO:0008595 2 0.026
cellular macromolecule catabolic process GO:0044265 380 0.026
purine ribonucleoside catabolic process GO:0046130 398 0.026
positive regulation of immune system process GO:0002684 283 0.026
memory GO:0007613 3 0.025
negative regulation of wnt signaling pathway GO:0030178 69 0.025
negative regulation of phosphorylation GO:0042326 174 0.025
intracellular receptor signaling pathway GO:0030522 104 0.025
protein modification by small protein conjugation GO:0032446 342 0.025
bmp signaling pathway GO:0030509 49 0.025
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.025
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.025
regulation of ureteric bud formation GO:0072106 1 0.025
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.025
single organism reproductive process GO:0044702 98 0.025
Fly
endocrine process GO:0050886 25 0.025
regulation of nucleotide catabolic process GO:0030811 205 0.025
appendage development GO:0048736 23 0.025
vesicle mediated transport GO:0016192 371 0.025
mitotic cell cycle phase transition GO:0044772 162 0.025
regulation of odontogenesis GO:0042481 4 0.024
regulation of apoptotic signaling pathway GO:2001233 175 0.024
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.024
mitotic cell cycle process GO:1903047 286 0.024
sensory perception GO:0007600 103 0.024
response to nitrogen compound GO:1901698 184 0.024
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.024
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.024
negative regulation of transport GO:0051051 176 0.024
negative regulation of mitotic cell cycle GO:0045930 102 0.024
response to organonitrogen compound GO:0010243 156 0.024
tissue migration GO:0090130 119 0.023
single organismal cell cell adhesion GO:0016337 148 0.023
cell division GO:0051301 168 0.023
positive regulation of nucleotide metabolic process GO:0045981 230 0.023
regulation of nucleotide metabolic process GO:0006140 269 0.023
positive regulation of epithelial cell proliferation GO:0050679 65 0.023
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.023
response to biotic stimulus GO:0009607 276 0.023
negative regulation of growth GO:0045926 97 0.023
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.023
alcohol metabolic process GO:0006066 114 0.023
dephosphorylation GO:0016311 209 0.023
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 2 0.023
nephron epithelium morphogenesis GO:0072088 15 0.023
Mouse
dna repair GO:0006281 198 0.023
mesonephric tubule development GO:0072164 14 0.023
Mouse
hormone transport GO:0009914 68 0.023
positive regulation of neural precursor cell proliferation GO:2000179 2 0.023
negative regulation of intracellular signal transduction GO:1902532 183 0.023
membrane organization GO:0061024 292 0.023
tripartite regional subdivision GO:0007351 2 0.023
regulation of secretion GO:0051046 194 0.022
regulation of neurogenesis GO:0050767 82 0.022
nucleocytoplasmic transport GO:0006913 176 0.022
Mouse
forebrain neuron differentiation GO:0021879 3 0.022
somatic muscle development GO:0007525 1 0.022
ectodermal placode development GO:0071696 1 0.022
Fly
regulation of purine nucleotide catabolic process GO:0033121 205 0.022
positive regulation of dermatome development GO:0061184 3 0.022
posttranscriptional regulation of gene expression GO:0010608 213 0.022
protein ubiquitination GO:0016567 314 0.022
regulation of cell morphogenesis GO:0022604 153 0.022
heart formation GO:0060914 2 0.022
cellular ion homeostasis GO:0006873 168 0.022
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.022
regulation of neural precursor cell proliferation GO:2000177 4 0.022
cellular cation homeostasis GO:0030003 163 0.022
guanosine containing compound catabolic process GO:1901069 239 0.022
hair cycle GO:0042633 28 0.022
regulation of cell adhesion GO:0030155 166 0.022
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.022
axis elongation GO:0003401 4 0.022
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.022
retinal ganglion cell axon guidance GO:0031290 2 0.022
neuroendocrine cell differentiation GO:0061101 2 0.022
luteinizing hormone secretion GO:0032275 1 0.021
hormone secretion GO:0046879 65 0.021
male genitalia development GO:0030539 1 0.021
cloacal septation GO:0060197 1 0.021
positive regulation of secretion by cell GO:1903532 108 0.021
nuclear transport GO:0051169 179 0.021
Mouse
myeloid cell differentiation GO:0030099 117 0.021
muscle cell fate commitment GO:0042693 4 0.021
guanosine containing compound metabolic process GO:1901068 244 0.021
negative regulation of cellular amine metabolic process GO:0033239 3 0.021
neuron projection morphogenesis GO:0048812 50 0.021
protein catabolic process GO:0030163 325 0.021
cellular homeostasis GO:0019725 196 0.021
potassium ion transmembrane transport GO:0071805 60 0.021
regulation of cardioblast differentiation GO:0051890 4 0.021
eye development GO:0001654 42 0.021
Human Fly
heart field specification GO:0003128 2 0.021
ventral spinal cord development GO:0021517 1 0.021
regulation of heart morphogenesis GO:2000826 4 0.021
response to radiation GO:0009314 151 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.021
receptor metabolic process GO:0043112 81 0.021
cellular component assembly involved in morphogenesis GO:0010927 73 0.020
hormone metabolic process GO:0042445 61 0.020
cellular macromolecular complex assembly GO:0034622 324 0.020
positive regulation of nucleoside metabolic process GO:0045979 186 0.020
regulation of ossification GO:0030278 58 0.020
Mouse
regulation of nucleoside metabolic process GO:0009118 209 0.020
cardiac chamber morphogenesis GO:0003206 26 0.020
embryonic eye morphogenesis GO:0048048 2 0.020

SIX2 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.081
sensory system disease DOID:0050155 203 0.046
Human
nervous system disease DOID:863 431 0.046
Human
cardiovascular system disease DOID:1287 106 0.042
eye and adnexa disease DOID:1492 150 0.032
eye disease DOID:5614 149 0.032
bone disease DOID:0080001 88 0.027
connective tissue disease DOID:65 109 0.027
heart disease DOID:114 68 0.026
disease of cellular proliferation DOID:14566 174 0.026
cancer DOID:162 167 0.025
organ system cancer DOID:0050686 164 0.025
muscular disease DOID:0080000 114 0.024
muscle tissue disease DOID:66 113 0.024
disease of metabolism DOID:0014667 295 0.021