Homo sapiens

0 known processes

EIF4A1

eukaryotic translation initiation factor 4A1

(Aliases: eIF4A-I,DDX2A,EIF4A,EIF-4A,eIF-4A-I)

EIF4A1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
translation GO:0006412 132 0.994
Yeast
translational initiation GO:0006413 48 0.980
Yeast
regulation of translation GO:0006417 89 0.976
posttranscriptional regulation of gene expression GO:0010608 213 0.808
regulation of translational initiation GO:0006446 24 0.763
post embryonic development GO:0009791 2 0.728
Worm
rna splicing via transesterification reactions GO:0000375 90 0.681
Fly
mrna processing GO:0006397 133 0.660
Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.580
Yeast
determination of adult lifespan GO:0008340 2 0.565
Worm
lipid localization GO:0010876 106 0.502
Worm
mrna metabolic process GO:0016071 175 0.501
Fly
stem cell development GO:0048864 69 0.500
Fly
female gamete generation GO:0007292 2 0.490
Fly
microtubule cytoskeleton organization GO:0000226 176 0.478
Fly
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.389
Yeast
rna catabolic process GO:0006401 71 0.357
nucleoside triphosphate metabolic process GO:0009141 422 0.333
Yeast
cellular homeostasis GO:0019725 196 0.329
growth GO:0040007 202 0.326
ribonucleotide biosynthetic process GO:0009260 81 0.268
rna splicing GO:0008380 131 0.265
Fly
protein secretion GO:0009306 98 0.255
mrna catabolic process GO:0006402 56 0.255
nucleoside catabolic process GO:0009164 408 0.224
Yeast
lipid storage GO:0019915 28 0.217
Worm
cellular response to oxidative stress GO:0034599 85 0.207
positive regulation of developmental process GO:0051094 314 0.199
oogenesis GO:0048477 2 0.195
Fly
response to other organism GO:0051707 261 0.187
embryo development GO:0009790 123 0.186
Worm
ribonucleoprotein complex biogenesis GO:0022613 116 0.185
cellular macromolecular complex assembly GO:0034622 324 0.182
ribonucleoside triphosphate metabolic process GO:0009199 412 0.177
Yeast
apoptotic signaling pathway GO:0097190 268 0.177
cytoplasmic transport GO:0016482 379 0.173
organelle assembly GO:0070925 176 0.172
cellular amine metabolic process GO:0044106 41 0.171
glomerular mesangial cell development GO:0072144 1 0.169
cell activation GO:0001775 213 0.167
multicellular organismal aging GO:0010259 3 0.166
Worm
mrna splicing via spliceosome GO:0000398 89 0.166
Fly
negative regulation of cell death GO:0060548 345 0.165
ribonucleoside catabolic process GO:0042454 406 0.164
Yeast
organonitrogen compound biosynthetic process GO:1901566 200 0.164
circulatory system development GO:0072359 262 0.164
reproduction GO:0000003 63 0.152
Worm Fly
nucleoside phosphate catabolic process GO:1901292 412 0.150
Yeast
cytoplasmic translational initiation GO:0002183 6 0.149
atp metabolic process GO:0046034 176 0.147
Yeast
purine ribonucleoside catabolic process GO:0046130 398 0.143
Yeast
microtubule organizing center organization GO:0031023 62 0.140
Fly
maintenance of location GO:0051235 112 0.135
Worm
anatomical structure formation involved in morphogenesis GO:0048646 284 0.134
Fly
cellular macromolecule catabolic process GO:0044265 380 0.131
purine nucleoside catabolic process GO:0006152 398 0.126
Yeast
response to virus GO:0009615 126 0.125
negative regulation of programmed cell death GO:0043069 321 0.124
rna processing GO:0006396 255 0.122
Fly
mitotic spindle elongation GO:0000022 4 0.121
Fly
regulation of oxidative phosphorylation GO:0002082 3 0.120
oocyte development GO:0048599 1 0.119
negative regulation of cellular component organization GO:0051129 235 0.117
cell development GO:0048468 328 0.116
Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.115
Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.114
Yeast
cellular response to cytokine stimulus GO:0071345 181 0.113
purine ribonucleoside metabolic process GO:0046128 437 0.111
Yeast
oocyte differentiation GO:0009994 2 0.110
reproductive process GO:0022414 106 0.106
Fly
cellular chemical homeostasis GO:0055082 180 0.105
nucleoside triphosphate catabolic process GO:0009143 394 0.099
Yeast
amine metabolic process GO:0009308 44 0.097
tube development GO:0035295 125 0.097
toxin transport GO:1901998 4 0.096
cell growth GO:0016049 160 0.094
putrescine metabolic process GO:0009445 2 0.094
nucleotide biosynthetic process GO:0009165 109 0.092
multi organism cellular process GO:0044764 156 0.092
positive regulation of cell proliferation GO:0008284 301 0.091
purine containing compound catabolic process GO:0072523 411 0.090
Yeast
t cell activation GO:0042110 99 0.088
blastoderm segmentation GO:0007350 2 0.087
cardiovascular system development GO:0072358 262 0.084
regulation of transporter activity GO:0032409 82 0.084
cellular hyperosmotic response GO:0071474 4 0.082
nucleotide catabolic process GO:0009166 408 0.081
Yeast
locomotory behavior GO:0007626 1 0.079
carbohydrate derivative biosynthetic process GO:1901137 207 0.077
glycosyl compound catabolic process GO:1901658 413 0.076
Yeast
lymphocyte activation GO:0046649 133 0.075
transmembrane transport GO:0055085 399 0.073
secretion by cell GO:0032940 226 0.073
negative regulation of apoptotic signaling pathway GO:2001234 97 0.072
developmental growth GO:0048589 48 0.070
single organism carbohydrate metabolic process GO:0044723 193 0.069
muscle cell cellular homeostasis GO:0046716 3 0.069
intracellular protein transport GO:0006886 270 0.068
gtp metabolic process GO:0046039 239 0.067
ribose phosphate biosynthetic process GO:0046390 82 0.067
regeneration GO:0031099 4 0.066
Rat
cofactor metabolic process GO:0051186 87 0.065
nuclear transcribed mrna catabolic process GO:0000956 48 0.064
cation homeostasis GO:0055080 189 0.063
positive regulation of transferase activity GO:0051347 227 0.063
regulation of protein complex assembly GO:0043254 147 0.063
mitochondrion organization GO:0007005 156 0.061
regulation of translational initiation in response to stress GO:0043558 1 0.060
regulation of multi organism process GO:0043900 157 0.059
microtubule based process GO:0007017 210 0.059
Fly
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.058
negative regulation of apoptotic process GO:0043066 316 0.057
adult locomotory behavior GO:0008344 1 0.056
chordate embryonic development GO:0043009 34 0.056
ribonucleoside monophosphate catabolic process GO:0009158 158 0.055
Yeast
chemical homeostasis GO:0048878 306 0.054
secretion GO:0046903 254 0.054
carbohydrate metabolic process GO:0005975 207 0.053
negative regulation of cell growth GO:0030308 83 0.052
cellular ion homeostasis GO:0006873 168 0.052
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.051
nucleoside phosphate biosynthetic process GO:1901293 109 0.051
sex differentiation GO:0007548 45 0.051
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.049
Yeast
single organism reproductive process GO:0044702 98 0.047
Fly
regulation of growth GO:0040008 165 0.046
inflammatory response GO:0006954 79 0.046
purine nucleoside triphosphate catabolic process GO:0009146 392 0.045
Yeast
positive regulation of transport GO:0051050 336 0.045
single organism cell adhesion GO:0098602 179 0.045
protein localization to organelle GO:0033365 280 0.045
response to tumor cell GO:0002347 10 0.045
negative regulation of cellular protein metabolic process GO:0032269 353 0.044
oxidation reduction process GO:0055114 396 0.044
membrane organization GO:0061024 292 0.044
reproductive structure development GO:0048608 55 0.043
viral life cycle GO:0019058 132 0.043
nucleoside monophosphate catabolic process GO:0009125 159 0.043
Yeast
response to nitrogen compound GO:1901698 184 0.043
regulation of anatomical structure morphogenesis GO:0022603 286 0.042
response to organonitrogen compound GO:0010243 156 0.041
purine nucleotide catabolic process GO:0006195 405 0.041
Yeast
positive regulation of immune system process GO:0002684 283 0.041
negative regulation of protein metabolic process GO:0051248 391 0.041
negative regulation of mrna catabolic process GO:1902373 4 0.040
reproductive system development GO:0061458 56 0.040
mesenchymal cell development GO:0014031 50 0.040
single organism membrane organization GO:0044802 268 0.040
neuron differentiation GO:0030182 138 0.040
response to abiotic stimulus GO:0009628 336 0.039
ribonucleoside triphosphate catabolic process GO:0009203 391 0.039
Yeast
nucleic acid transport GO:0050657 39 0.039
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.038
positive regulation of cellular amine metabolic process GO:0033240 7 0.038
purine nucleoside monophosphate catabolic process GO:0009128 158 0.038
Yeast
immune effector process GO:0002252 159 0.038
renal system development GO:0072001 63 0.038
ribosome biogenesis GO:0042254 48 0.038
leukocyte proliferation GO:0070661 74 0.038
negative regulation of catalytic activity GO:0043086 335 0.037
response to external biotic stimulus GO:0043207 261 0.037
response to hormone GO:0009725 175 0.037
regulation of t cell activation GO:0050863 77 0.036
regulation of nucleotide metabolic process GO:0006140 269 0.036
renal interstitial fibroblast development GO:0072141 1 0.035
lipid metabolic process GO:0006629 381 0.035
mitotic cell cycle phase transition GO:0044772 162 0.035
positive regulation of apoptotic process GO:0043065 246 0.035
response to oxidative stress GO:0006979 121 0.035
nitrogen compound transport GO:0071705 191 0.035
cell adhesion GO:0007155 325 0.035
leukocyte activation GO:0045321 164 0.035
single organism cellular localization GO:1902580 332 0.035
regulation of cell activation GO:0050865 125 0.035
regulation of cell cycle process GO:0010564 266 0.034
system process GO:0003008 349 0.034
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.034
spindle elongation GO:0051231 4 0.033
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
cellular cation homeostasis GO:0030003 163 0.032
positive regulation of nucleotide metabolic process GO:0045981 230 0.031
cellular metal ion homeostasis GO:0006875 146 0.030
regulation of purine nucleotide metabolic process GO:1900542 264 0.030
g1 s transition of mitotic cell cycle GO:0000082 78 0.030
ribonucleoprotein complex localization GO:0071166 4 0.030
ribonucleoside monophosphate metabolic process GO:0009161 187 0.030
Yeast
response to acid chemical GO:0001101 66 0.030
protein autophosphorylation GO:0046777 123 0.029
negative regulation of neuron death GO:1901215 32 0.029
purine ribonucleotide catabolic process GO:0009154 404 0.029
Yeast
organophosphate biosynthetic process GO:0090407 163 0.029
cellular response to oxygen containing compound GO:1901701 276 0.029
mononuclear cell proliferation GO:0032943 71 0.029
cell morphogenesis GO:0000902 296 0.029
protein targeting GO:0006605 187 0.028
developmental process involved in reproduction GO:0003006 66 0.028
Fly
interspecies interaction between organisms GO:0044419 156 0.027
maturation of ssu rrna GO:0030490 3 0.027
cellular component morphogenesis GO:0032989 314 0.027
regulation of mitochondrion organization GO:0010821 54 0.027
regulation of cell adhesion GO:0030155 166 0.027
negative regulation of growth GO:0045926 97 0.027
negative regulation of organelle organization GO:0010639 126 0.027
ribonucleotide catabolic process GO:0009261 405 0.026
Yeast
regulation of mrna metabolic process GO:1903311 53 0.026
Fly
regulation of cell migration GO:0030334 289 0.026
regionalization GO:0003002 29 0.026
Fly
intrinsic apoptotic signaling pathway GO:0097193 127 0.026
mitotic cell cycle process GO:1903047 286 0.026
Fly
regulation of rna splicing GO:0043484 62 0.026
Fly
ion transmembrane transport GO:0034220 338 0.025
taxis GO:0042330 157 0.025
nucleoside triphosphate biosynthetic process GO:0009142 20 0.025
purine nucleoside triphosphate biosynthetic process GO:0009145 11 0.025
spindle organization GO:0007051 53 0.025
Fly
positive regulation of hydrolase activity GO:0051345 331 0.024
positive regulation of multi organism process GO:0043902 56 0.024
ribosomal subunit export from nucleus GO:0000054 4 0.024
regulation of apoptotic signaling pathway GO:2001233 175 0.024
regulation of developmental growth GO:0048638 30 0.024
ribonucleoside biosynthetic process GO:0042455 25 0.024
positive regulation of translation GO:0045727 35 0.024
response to wounding GO:0009611 168 0.023
regulation of atp metabolic process GO:1903578 29 0.023
aging GO:0007568 66 0.023
Worm
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.023
cellular response to dna damage stimulus GO:0006974 379 0.023
Fly
regulation of cellular amine metabolic process GO:0033238 11 0.023
regulation of peptidase activity GO:0052547 180 0.023
sexual reproduction GO:0019953 37 0.022
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.022
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 23 0.022
establishment of ribosome localization GO:0033753 4 0.022
establishment or maintenance of cell polarity GO:0007163 31 0.022
nucleocytoplasmic transport GO:0006913 176 0.022
pigment biosynthetic process GO:0046148 10 0.022
embryonic eye morphogenesis GO:0048048 2 0.021
regulation of lymphocyte activation GO:0051249 103 0.021
negative regulation of translation GO:0017148 37 0.021
positive regulation of developmental growth GO:0048639 16 0.021
ribonucleoprotein complex assembly GO:0022618 78 0.021
tripartite regional subdivision GO:0007351 2 0.021
guanosine containing compound catabolic process GO:1901069 239 0.021
cellular component assembly involved in morphogenesis GO:0010927 73 0.021
positive regulation of cell death GO:0010942 263 0.021
cellular amino acid metabolic process GO:0006520 116 0.020
cytokine production GO:0001816 247 0.020
generation of neurons GO:0048699 152 0.020
multicellular organism reproduction GO:0032504 42 0.020
Fly
response to oxygen containing compound GO:1901700 369 0.020
metal ion homeostasis GO:0055065 169 0.020
regulation of cell projection organization GO:0031344 107 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.019
regulation of cell growth GO:0001558 135 0.019
protein localization to membrane GO:0072657 160 0.019
protein oligomerization GO:0051259 173 0.019
cell type specific apoptotic process GO:0097285 125 0.019
positive regulation of organelle organization GO:0010638 195 0.019
response to metal ion GO:0010038 84 0.019
establishment of protein localization to organelle GO:0072594 172 0.019
protein import GO:0017038 130 0.019
positive regulation of cell cycle process GO:0090068 106 0.019
epithelial cell differentiation GO:0030855 141 0.019
innate immune response activating signal transduction GO:0002758 48 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
cytoplasmic translation GO:0002181 8 0.019
anterior posterior axis specification GO:0009948 2 0.019
purine ribonucleotide biosynthetic process GO:0009152 79 0.018
biological adhesion GO:0022610 331 0.018
neuron death GO:0070997 65 0.018
regulation of cytokine production GO:0001817 232 0.018
photoreceptor cell differentiation GO:0046530 2 0.018
cell morphogenesis involved in differentiation GO:0000904 144 0.018
hematopoietic or lymphoid organ development GO:0048534 186 0.018
multicellular organismal reproductive process GO:0048609 40 0.018
Fly
pyrimidine ribonucleoside triphosphate metabolic process GO:0009208 2 0.017
coenzyme metabolic process GO:0006732 65 0.017
negative regulation of viral process GO:0048525 66 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
peptidyl serine phosphorylation GO:0018105 101 0.017
cellular protein complex assembly GO:0043623 188 0.017
negative regulation of developmental process GO:0051093 247 0.017
Fly
ribonucleoprotein complex subunit organization GO:0071826 81 0.017
response to calcium ion GO:0051592 46 0.017
heart development GO:0007507 95 0.017
negative regulation of multi organism process GO:0043901 92 0.017
regulation of response to wounding GO:1903034 101 0.017
response to biotic stimulus GO:0009607 276 0.017
response to cytokine GO:0034097 232 0.017
programmed necrotic cell death GO:0097300 18 0.017
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.017
peptidyl serine modification GO:0018209 106 0.017
regulation of ion transport GO:0043269 189 0.016
regulation of neurogenesis GO:0050767 82 0.016
necroptotic process GO:0070266 16 0.016
embryonic morphogenesis GO:0048598 85 0.016
purine nucleotide biosynthetic process GO:0006164 84 0.016
regulation of membrane potential GO:0042391 95 0.016
negative regulation of necroptotic process GO:0060546 2 0.016
positive regulation of cell differentiation GO:0045597 211 0.016
lymphocyte proliferation GO:0046651 70 0.015
cellular biogenic amine metabolic process GO:0006576 34 0.015
neurogenesis GO:0022008 169 0.015
anterior posterior axis specification embryo GO:0008595 2 0.015
tube morphogenesis GO:0035239 95 0.015
positive regulation of protein secretion GO:0050714 60 0.015
spermatid differentiation GO:0048515 4 0.015
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.015
developmental maturation GO:0021700 28 0.015
regulation of mrna processing GO:0050684 48 0.015
Fly
development of primary sexual characteristics GO:0045137 35 0.015
ossification GO:0001503 121 0.015
mitochondrial membrane organization GO:0007006 40 0.014
peptidyl tyrosine modification GO:0018212 170 0.014
regulation of meiotic cell cycle GO:0051445 4 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
regulation of homeostatic process GO:0032844 121 0.014
neurological system process GO:0050877 163 0.014
inorganic anion transmembrane transport GO:0098661 47 0.014
negative regulation of cellular catabolic process GO:0031330 83 0.014
activation of immune response GO:0002253 114 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
tissue regeneration GO:0042246 3 0.013
regulation of cell development GO:0060284 161 0.013
cation transport GO:0006812 331 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
innate immune response GO:0045087 178 0.013
positive regulation of cellular component organization GO:0051130 376 0.013
divalent inorganic cation homeostasis GO:0072507 136 0.013
cellular response to extracellular stimulus GO:0031668 72 0.013
protein homooligomerization GO:0051260 100 0.013
segmentation GO:0035282 4 0.013
regulation of cell cycle GO:0051726 393 0.013
cellular lipid metabolic process GO:0044255 303 0.013
negative regulation of cell cycle process GO:0010948 121 0.012
pattern recognition receptor signaling pathway GO:0002221 48 0.012
lymphocyte apoptotic process GO:0070227 20 0.012
rrna processing GO:0006364 35 0.012
neural crest cell development GO:0014032 3 0.012
cellular response to nitrogen compound GO:1901699 144 0.012
myoblast fusion GO:0007520 1 0.012
positive regulation of response to external stimulus GO:0032103 88 0.012
pyrimidine ribonucleoside metabolic process GO:0046131 11 0.012
positive regulation of binding GO:0051099 45 0.012
regulation of camp metabolic process GO:0030814 52 0.012
cell projection organization GO:0030030 252 0.012
protein catabolic process GO:0030163 325 0.012
vesicle mediated transport GO:0016192 371 0.012
wound healing GO:0042060 115 0.012
regulation of mitochondrial membrane potential GO:0051881 23 0.012
rhythmic process GO:0048511 31 0.012
blastocyst development GO:0001824 3 0.012
regulation of cellular component movement GO:0051270 334 0.012
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.012
actin mediated cell contraction GO:0070252 12 0.012
central nervous system development GO:0007417 123 0.012
cofactor biosynthetic process GO:0051188 31 0.012
regulation of epithelial cell proliferation GO:0050678 113 0.012
cell cycle g1 s phase transition GO:0044843 80 0.011
polyamine metabolic process GO:0006595 4 0.011
regulation of protein transport GO:0051223 213 0.011
protein maturation GO:0051604 233 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
organelle inheritance GO:0048308 2 0.011
positive regulation of growth GO:0045927 58 0.011
blood vessel development GO:0001568 172 0.011
response to inorganic substance GO:0010035 127 0.011
response to oxygen levels GO:0070482 100 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
srp dependent cotranslational protein targeting to membrane GO:0006614 2 0.011
cellular response to oxygen levels GO:0071453 55 0.011
regulation of mrna splicing via spliceosome GO:0048024 32 0.011
Fly
rrna metabolic process GO:0016072 40 0.011
nuclear division GO:0000280 128 0.011
Fly
male gamete generation GO:0048232 22 0.011
cellular divalent inorganic cation homeostasis GO:0072503 128 0.011
regulation of leukocyte activation GO:0002694 115 0.011
positive regulation of catabolic process GO:0009896 310 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
response to decreased oxygen levels GO:0036293 96 0.011
pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 1 0.011
cellular calcium ion homeostasis GO:0006874 117 0.010
regulation of transmembrane transport GO:0034762 139 0.010
regulation of endopeptidase activity GO:0052548 170 0.010
eye photoreceptor cell differentiation GO:0001754 2 0.010
negative regulation of rna catabolic process GO:1902369 4 0.010
pyrimidine ribonucleotide metabolic process GO:0009218 4 0.010
cation transmembrane transport GO:0098655 238 0.010
rna export from nucleus GO:0006405 33 0.010
regulation of inflammatory response GO:0050727 46 0.010
negative regulation of transport GO:0051051 176 0.010
axonogenesis GO:0007409 31 0.010
cellular ketone metabolic process GO:0042180 80 0.010
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.010
Fly
gtp catabolic process GO:0006184 237 0.010

EIF4A1 disease predictions

Disease DO term ID Size Probability Func Analog Org
parkinson s disease DOID:14330 18 0.081
synucleinopathy DOID:0050890 22 0.081
central nervous system disease DOID:331 186 0.081
neurodegenerative disease DOID:1289 102 0.081
nervous system disease DOID:863 431 0.081
disease of cellular proliferation DOID:14566 174 0.075
cancer DOID:162 167 0.025
organ system cancer DOID:0050686 164 0.025
sensory system disease DOID:0050155 203 0.018
disease of mental health DOID:150 70 0.017
developmental disorder of mental health DOID:0060037 29 0.013