Homo sapiens

26 known processes

NUMBL

numb homolog (Drosophila)-like

(Aliases: NUMBR,NUMB-R,TNRC23,NBL,CTG3a,CAG3A,NUMBLIKE)

NUMBL biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
female gamete generation GO:0007292 2 0.544
mating GO:0007618 1 0.479
activation of immune response GO:0002253 114 0.381
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 0.376
hypothalamus development GO:0021854 1 0.314
positive regulation of developmental process GO:0051094 314 0.306
Mouse Rat
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.300
activation of protein kinase activity GO:0032147 90 0.299
sex determination GO:0007530 3 0.292
immune response activating signal transduction GO:0002757 90 0.278
regulation of transferase activity GO:0051338 355 0.268
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.267
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.215
i kappab kinase nf kappab signaling GO:0007249 166 0.213
activation of nf kappab inducing kinase activity GO:0007250 9 0.212
regulation of kinase activity GO:0043549 314 0.206
positive regulation of protein phosphorylation GO:0001934 313 0.193
regulation of cellular amino acid metabolic process GO:0006521 6 0.190
rna splicing GO:0008380 131 0.184
cell development GO:0048468 328 0.184
Mouse Rat Fly
morphogenesis of embryonic epithelium GO:0016331 4 0.167
positive regulation of kinase activity GO:0033674 204 0.161
limbic system development GO:0021761 3 0.152
positive regulation of nik nf kappab signaling GO:1901224 10 0.148
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.146
regulation of cellular ketone metabolic process GO:0010565 50 0.144
cdc42 protein signal transduction GO:0032488 4 0.140
positive regulation of transferase activity GO:0051347 227 0.136
signal transduction by phosphorylation GO:0023014 297 0.135
protein modification by small protein conjugation GO:0032446 342 0.133
hindbrain development GO:0030902 3 0.132
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.129
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.129
protein ubiquitination GO:0016567 314 0.127
positive regulation of protein kinase activity GO:0045860 190 0.127
regulation of binding GO:0051098 111 0.121
Human
positive regulation of map kinase activity GO:0043406 80 0.121
adult locomotory behavior GO:0008344 1 0.119
regulation of ion transmembrane transport GO:0034765 132 0.118
regulation of definitive erythrocyte differentiation GO:0010724 2 0.115
cellular amino acid metabolic process GO:0006520 116 0.115
protein oligomerization GO:0051259 173 0.114
positive regulation of immune system process GO:0002684 283 0.113
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.111
regulation of mapk cascade GO:0043408 262 0.111
regulation of protein kinase activity GO:0045859 289 0.102
response to cytokine GO:0034097 232 0.100
oogenesis GO:0048477 2 0.098
protein polyubiquitination GO:0000209 110 0.095
regulation of protein binding GO:0043393 66 0.093
Human
mitotic cell cycle GO:0000278 326 0.093
t cell receptor signaling pathway GO:0050852 21 0.093
regulation of interleukin 2 production GO:0032663 19 0.089
positive regulation of mapk cascade GO:0043410 190 0.088
intracellular receptor signaling pathway GO:0030522 104 0.084
positive regulation of transport GO:0051050 336 0.084
Human Fly
positive regulation of t cell cytokine production GO:0002726 4 0.084
small gtpase mediated signal transduction GO:0007264 78 0.083
intracellular estrogen receptor signaling pathway GO:0030520 23 0.082
regulation of apoptotic signaling pathway GO:2001233 175 0.082
response to lipid GO:0033993 206 0.078
positive regulation of leukocyte differentiation GO:1902107 37 0.077
dosage compensation GO:0007549 3 0.077
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.076
regulation of cell differentiation GO:0045595 393 0.075
Mouse Rat Fly
positive regulation of phosphorylation GO:0042327 394 0.075
regulation of protein serine threonine kinase activity GO:0071900 179 0.072
cellular response to oxygen containing compound GO:1901701 276 0.072
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.071
positive regulation of interleukin 2 production GO:0032743 11 0.070
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.069
myeloid cell differentiation GO:0030099 117 0.068
system process GO:0003008 349 0.067
neuromuscular process controlling balance GO:0050885 7 0.066
regulation of map kinase activity GO:0043405 108 0.065
mapk cascade GO:0000165 288 0.065
negative regulation of cellular protein metabolic process GO:0032269 353 0.064
neural tube formation GO:0001841 3 0.064
nik nf kappab signaling GO:0038061 12 0.064
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.064
cellular response to lipopolysaccharide GO:0071222 57 0.064
antigen receptor mediated signaling pathway GO:0050851 38 0.064
protein homooligomerization GO:0051260 100 0.062
cellular amine metabolic process GO:0044106 41 0.062
enzyme linked receptor protein signaling pathway GO:0007167 303 0.060
cellular response to lipid GO:0071396 127 0.059
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.059
nucleotide catabolic process GO:0009166 408 0.058
locomotory behavior GO:0007626 1 0.058
cellular response to biotic stimulus GO:0071216 71 0.057
negative regulation of apoptotic process GO:0043066 316 0.056
regulation of t cell cytokine production GO:0002724 10 0.056
cytokine mediated signaling pathway GO:0019221 109 0.055
lymphocyte mediated immunity GO:0002449 48 0.054
cellular cation homeostasis GO:0030003 163 0.054
hemopoiesis GO:0030097 180 0.054
glial cell migration GO:0008347 4 0.053
Fly
mrna metabolic process GO:0016071 175 0.053
amine metabolic process GO:0009308 44 0.053
positive regulation of catabolic process GO:0009896 310 0.052
regulation of ion transport GO:0043269 189 0.051
regulation of rna splicing GO:0043484 62 0.051
immunoglobulin secretion GO:0048305 1 0.051
t cell cytokine production GO:0002369 12 0.050
regulation of cellular amine metabolic process GO:0033238 11 0.049
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.048
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.048
negative regulation of programmed cell death GO:0043069 321 0.048
neurological system process GO:0050877 163 0.048
regulation of cytokine production GO:0001817 232 0.047
compound eye development GO:0048749 1 0.047
regulation of cardiac muscle cell proliferation GO:0060043 4 0.047
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.047
central nervous system development GO:0007417 123 0.046
Mouse
positive regulation of osteoclast differentiation GO:0045672 9 0.046
cellular ion homeostasis GO:0006873 168 0.046
peptidyl tyrosine phosphorylation GO:0018108 170 0.046
rho protein signal transduction GO:0007266 26 0.046
primary neural tube formation GO:0014020 3 0.046
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.046
regulation of cytokine production involved in immune response GO:0002718 22 0.045
response to interleukin 1 GO:0070555 47 0.045
negative regulation of phosphorus metabolic process GO:0010563 267 0.044
single organism reproductive process GO:0044702 98 0.044
regulation of secretion GO:0051046 194 0.044
response to external biotic stimulus GO:0043207 261 0.044
regulation of dna binding GO:0051101 37 0.044
metencephalon development GO:0022037 2 0.043
purine nucleotide catabolic process GO:0006195 405 0.043
apoptotic signaling pathway GO:0097190 268 0.043
protein k63 linked ubiquitination GO:0070534 31 0.042
morphogenesis of an epithelium GO:0002009 60 0.042
regulation of adaptive immune response GO:0002819 33 0.042
nuclear export GO:0051168 69 0.042
positive regulation of dna binding GO:0043388 17 0.042
positive regulation of apoptotic signaling pathway GO:2001235 70 0.041
regulation of immune response GO:0050776 201 0.041
cellular response to cytokine stimulus GO:0071345 181 0.041
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.041
mrna processing GO:0006397 133 0.041
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.040
positive regulation of stress activated mapk cascade GO:0032874 60 0.040
negative regulation of kinase activity GO:0033673 106 0.040
protein trimerization GO:0070206 20 0.038
neuromuscular process GO:0050905 15 0.038
negative regulation of protein modification process GO:0031400 200 0.038
regulation of immune effector process GO:0002697 91 0.038
cellular lipid metabolic process GO:0044255 303 0.037
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.037
positive regulation of myeloid cell differentiation GO:0045639 39 0.037
regulation of myeloid cell differentiation GO:0045637 81 0.036
defense response GO:0006952 315 0.036
extrinsic apoptotic signaling pathway GO:0097191 119 0.036
neurogenesis GO:0022008 169 0.036
Mouse Rat Fly
positive regulation of apoptotic process GO:0043065 246 0.035
positive regulation of binding GO:0051099 45 0.035
immune response regulating signaling pathway GO:0002764 97 0.035
positive regulation of cell differentiation GO:0045597 211 0.035
Mouse Rat
regulation of nik nf kappab signaling GO:1901222 11 0.034
metal ion homeostasis GO:0055065 169 0.034
associative learning GO:0008306 1 0.034
myeloid dendritic cell differentiation GO:0043011 3 0.034
negative regulation of multicellular organismal process GO:0051241 317 0.034
negative regulation of transferase activity GO:0051348 124 0.034
regulation of mrna metabolic process GO:1903311 53 0.033
negative regulation of phosphorylation GO:0042326 174 0.033
positive regulation of programmed cell death GO:0043068 249 0.033
cellular component morphogenesis GO:0032989 314 0.033
Mouse Rat
regulation of cellular response to stress GO:0080135 244 0.032
positive regulation of cell death GO:0010942 263 0.032
regulation of transmembrane transport GO:0034762 139 0.032
negative regulation of catalytic activity GO:0043086 335 0.032
immune system development GO:0002520 195 0.031
brain development GO:0007420 97 0.031
Mouse
negative regulation of protein metabolic process GO:0051248 391 0.031
protein autoubiquitination GO:0051865 37 0.031
ubiquitin dependent protein catabolic process GO:0006511 206 0.030
hematopoietic or lymphoid organ development GO:0048534 186 0.030
blood vessel morphogenesis GO:0048514 162 0.030
cation transport GO:0006812 331 0.030
regulation of osteoclast differentiation GO:0045670 18 0.030
immune response GO:0006955 307 0.030
negative regulation of cell death GO:0060548 345 0.030
positive regulation of hydrolase activity GO:0051345 331 0.030
reproductive process GO:0022414 106 0.029
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.029
response to lipopolysaccharide GO:0032496 70 0.029
positive regulation of protein binding GO:0032092 24 0.029
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.029
response to molecule of bacterial origin GO:0002237 82 0.028
tube morphogenesis GO:0035239 95 0.028
regulation of wnt signaling pathway GO:0030111 123 0.028
muscle cell fate commitment GO:0042693 4 0.027
Fly
ribonucleotide catabolic process GO:0009261 405 0.027
leukocyte mediated immunity GO:0002443 59 0.027
regulation of purine nucleotide catabolic process GO:0033121 205 0.027
myeloid dendritic cell activation GO:0001773 4 0.027
cellular ketone metabolic process GO:0042180 80 0.027
syncytium formation by plasma membrane fusion GO:0000768 2 0.027
calcium ion homeostasis GO:0055074 122 0.027
neuromuscular junction development GO:0007528 3 0.027
regulation of response to external stimulus GO:0032101 222 0.027
innate immune response GO:0045087 178 0.026
positive regulation of proteolysis GO:0045862 142 0.026
regulation of protein homodimerization activity GO:0043496 9 0.026
angiogenesis GO:0001525 147 0.026
regulation of cell cycle process GO:0010564 266 0.026
nervous system development GO:0007399 293 0.026
Mouse Rat Fly
cellular metal ion homeostasis GO:0006875 146 0.026
negative regulation of neurological system process GO:0031645 2 0.026
blood circulation GO:0008015 113 0.026
regulation of stress activated mapk cascade GO:0032872 84 0.026
positive regulation of nucleoside metabolic process GO:0045979 186 0.025
positive regulation of t cell mediated immunity GO:0002711 12 0.025
cardiovascular system development GO:0072358 262 0.025
Fly
negative regulation of apoptotic signaling pathway GO:2001234 97 0.025
regulation of transcription regulatory region dna binding GO:2000677 15 0.025
positive regulation of cell cycle GO:0045787 140 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.025
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
Rat
ion homeostasis GO:0050801 230 0.024
cellular response to molecule of bacterial origin GO:0071219 62 0.024
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.024
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.024
regulation of actin filament based process GO:0032970 141 0.024
cell fate determination GO:0001709 3 0.023
negative regulation of transport GO:0051051 176 0.023
cellular protein catabolic process GO:0044257 261 0.023
regulation of t cell mediated immunity GO:0002709 18 0.023
positive regulation of immune response GO:0050778 159 0.023
vasculature development GO:0001944 181 0.023
regulation of myeloid leukocyte differentiation GO:0002761 39 0.023
interleukin 2 production GO:0032623 20 0.023
circulatory system development GO:0072359 262 0.023
Fly
response to other organism GO:0051707 261 0.023
canonical wnt signaling pathway GO:0060070 116 0.023
cation transmembrane transport GO:0098655 238 0.023
response to bacterium GO:0009617 144 0.023
positive regulation of ras gtpase activity GO:0032320 117 0.022
mrna splicing via spliceosome GO:0000398 89 0.022
neuron differentiation GO:0030182 138 0.022
Mouse Rat
embryonic epithelial tube formation GO:0001838 4 0.022
protein catabolic process GO:0030163 325 0.022
purine ribonucleotide catabolic process GO:0009154 404 0.022
divalent inorganic cation homeostasis GO:0072507 136 0.022
negative regulation of cell cycle GO:0045786 193 0.022
positive regulation of transcription regulatory region dna binding GO:2000679 8 0.022
muscle structure development GO:0061061 98 0.021
Fly
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
regulation of nuclear division GO:0051783 65 0.021
regulation of heart contraction GO:0008016 50 0.021
jnk cascade GO:0007254 80 0.021
regulation of protein ubiquitination GO:0031396 95 0.021
protein autophosphorylation GO:0046777 123 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
Human
regulation of secretion by cell GO:1903530 177 0.021
regulation of jnk cascade GO:0046328 73 0.021
regulation of gtp catabolic process GO:0033124 180 0.021
heart process GO:0003015 62 0.020
anatomical structure formation involved in morphogenesis GO:0048646 284 0.020
regulation of gtpase activity GO:0043087 180 0.020
positive regulation of wnt signaling pathway GO:0030177 54 0.020
peripheral nervous system development GO:0007422 2 0.020
epithelial tube morphogenesis GO:0060562 38 0.020
regulation of t cell activation GO:0050863 77 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.020
nucleoside catabolic process GO:0009164 408 0.020
regulation of leukocyte activation GO:0002694 115 0.020
regulation of proteolysis GO:0030162 293 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
Human Rat Fly
positive regulation of cytokine production GO:0001819 167 0.020
regulation of membrane potential GO:0042391 95 0.019
cytokine production involved in immune response GO:0002367 27 0.019
skeletal system development GO:0001501 79 0.019
guanosine containing compound metabolic process GO:1901068 244 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
ion transmembrane transport GO:0034220 338 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
eye photoreceptor cell differentiation GO:0001754 2 0.019
cell projection morphogenesis GO:0048858 129 0.019
Mouse Rat
response to growth factor GO:0070848 205 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
positive regulation of leukocyte mediated immunity GO:0002705 24 0.019
protein secretion GO:0009306 98 0.019
cellular homeostasis GO:0019725 196 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.019
ossification GO:0001503 121 0.019
actin filament based process GO:0030029 224 0.019
regulation of cell division GO:0051302 116 0.019
Fly
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.019
regulation of cell cycle GO:0051726 393 0.018
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.018
carbohydrate metabolic process GO:0005975 207 0.018
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.018
regulation of meiosis GO:0040020 3 0.018
regulation of glial cell proliferation GO:0060251 4 0.018
positive regulation of cellular catabolic process GO:0031331 284 0.018
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.018
leukocyte differentiation GO:0002521 98 0.018
response to oxygen containing compound GO:1901700 369 0.018
cerebellum development GO:0021549 2 0.018
photoreceptor cell differentiation GO:0046530 2 0.018
regulation of protein transport GO:0051223 213 0.018
regulation of ras protein signal transduction GO:0046578 155 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
regulation of cardiac muscle tissue growth GO:0055021 4 0.017
long term memory GO:0007616 2 0.017
positive regulation of immune effector process GO:0002699 40 0.017
immune effector process GO:0002252 159 0.017
regulation of meiotic cell cycle GO:0051445 4 0.017
regulation of neuron migration GO:2001222 3 0.017
regulation of gene expression epigenetic GO:0040029 73 0.017
generation of neurons GO:0048699 152 0.017
Mouse Rat Fly
modification dependent protein catabolic process GO:0019941 209 0.017
positive regulation of adaptive immune response GO:0002821 21 0.017
behavior GO:0007610 112 0.017
endodermal cell fate specification GO:0001714 4 0.017
cellular response to tumor necrosis factor GO:0071356 63 0.017
positive regulation of jnk cascade GO:0046330 52 0.017
endodermal cell fate commitment GO:0001711 4 0.017
negative regulation of developmental process GO:0051093 247 0.017
inorganic ion transmembrane transport GO:0098660 231 0.017
intrinsic apoptotic signaling pathway GO:0097193 127 0.017
regeneration GO:0031099 4 0.017
cell morphogenesis GO:0000902 296 0.017
Mouse Rat
cytokine production GO:0001816 247 0.016
negative regulation of protein phosphorylation GO:0001933 140 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
jak stat cascade GO:0007259 46 0.016
cell part morphogenesis GO:0032990 137 0.016
Mouse Rat
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.016
regulation of nervous system development GO:0051960 88 0.016
Mouse Rat Fly
divalent inorganic cation transport GO:0072511 158 0.016
regulation of cytokine mediated signaling pathway GO:0001959 41 0.016
small molecule biosynthetic process GO:0044283 157 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
tissue morphogenesis GO:0048729 96 0.016
motor neuron axon guidance GO:0008045 2 0.016
negative regulation of protein kinase activity GO:0006469 98 0.016
regulation of heart growth GO:0060420 4 0.016
cell growth GO:0016049 160 0.016
multicellular organismal signaling GO:0035637 34 0.015
muscle cell proliferation GO:0033002 35 0.015
embryonic morphogenesis GO:0048598 85 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
stress activated mapk cascade GO:0051403 93 0.015
tissue regeneration GO:0042246 3 0.015
heart contraction GO:0060047 62 0.015
regulation of defense response GO:0031347 154 0.015
regulation of cell growth GO:0001558 135 0.015
myeloid leukocyte differentiation GO:0002573 60 0.015
phospholipid metabolic process GO:0006644 99 0.015
regulation of canonical wnt signaling pathway GO:0060828 88 0.015
cytoplasmic transport GO:0016482 379 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
multicellular organismal aging GO:0010259 3 0.015
sensory organ development GO:0007423 52 0.015
Fly
segmentation GO:0035282 4 0.015
multicellular organism reproduction GO:0032504 42 0.015
regulation of cytoplasmic transport GO:1903649 149 0.014
erbb signaling pathway GO:0038127 44 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.014
activation of jnkk activity GO:0007256 1 0.014
mrna destabilization GO:0061157 1 0.014
neural crest cell development GO:0014032 3 0.014
t cell mediated immunity GO:0002456 25 0.014
biological adhesion GO:0022610 331 0.014
regulation of ras gtpase activity GO:0032318 128 0.014
regulation of production of molecular mediator of immune response GO:0002700 25 0.014
asymmetric stem cell division GO:0098722 1 0.014
Fly
spermatid development GO:0007286 4 0.014
definitive hemopoiesis GO:0060216 2 0.014
wnt signaling pathway GO:0016055 156 0.014
spermatid differentiation GO:0048515 4 0.014
cell activation GO:0001775 213 0.014
positive regulation of gtpase activity GO:0043547 166 0.014
tumor necrosis factor mediated signaling pathway GO:0033209 27 0.014
transmission of nerve impulse GO:0019226 11 0.014
neurotransmitter secretion GO:0007269 4 0.014
positive regulation of innate immune response GO:0045089 79 0.014
neuron projection regeneration GO:0031102 1 0.013
pituitary gland development GO:0021983 2 0.013
regulation of mrna splicing via spliceosome GO:0048024 32 0.013
positive regulation of ion transport GO:0043270 87 0.013
tube closure GO:0060606 3 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
ameboidal type cell migration GO:0001667 135 0.013
memory GO:0007613 3 0.013
cell junction organization GO:0034330 79 0.013
Mouse
positive regulation of protein catabolic process GO:0045732 75 0.013
regulation of homeostatic process GO:0032844 121 0.013
regulation of growth GO:0040008 165 0.013
regulation of body fluid levels GO:0050878 99 0.013
nuclear transport GO:0051169 179 0.013
chemotaxis GO:0006935 157 0.013
secretion by cell GO:0032940 226 0.013
multicellular organismal reproductive process GO:0048609 40 0.013
respiratory gaseous exchange GO:0007585 3 0.013
visual behavior GO:0007632 2 0.013
neuronal action potential GO:0019228 9 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
positive regulation of locomotion GO:0040017 186 0.013
Human
negative regulation of mitotic cell cycle GO:0045930 102 0.013
neural tube closure GO:0001843 3 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.013
tube development GO:0035295 125 0.012
Fly
kidney development GO:0001822 53 0.012
metal ion transport GO:0030001 272 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
circulatory system process GO:0003013 113 0.012
regulation of jun kinase activity GO:0043506 27 0.012
dephosphorylation GO:0016311 209 0.012
stress activated protein kinase signaling cascade GO:0031098 94 0.012
regulation of immunoglobulin secretion GO:0051023 1 0.012
actin mediated cell contraction GO:0070252 12 0.012
neuron fate commitment GO:0048663 2 0.012
organelle assembly GO:0070925 176 0.012
regulation of leukocyte mediated immunity GO:0002703 38 0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.012
regulation of transporter activity GO:0032409 82 0.012
nucleoside triphosphate catabolic process GO:0009143 394 0.012
epithelium development GO:0060429 227 0.012
Fly
positive regulation of protein homodimerization activity GO:0090073 5 0.012
divalent metal ion transport GO:0070838 152 0.012
lens development in camera type eye GO:0002088 2 0.012
post embryonic development GO:0009791 2 0.012
secretion GO:0046903 254 0.012
positive regulation of lymphocyte activation GO:0051251 73 0.012
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.012
peptidyl lysine modification GO:0018205 144 0.012
protein localization to organelle GO:0033365 280 0.012
positive regulation of intracellular transport GO:0032388 104 0.012
organic acid biosynthetic process GO:0016053 97 0.012
organophosphate catabolic process GO:0046434 430 0.012
positive regulation of organelle organization GO:0010638 195 0.012
protein homotrimerization GO:0070207 9 0.012
internal protein amino acid acetylation GO:0006475 101 0.012
positive regulation of response to external stimulus GO:0032103 88 0.012
regulation of postsynaptic membrane potential GO:0060078 1 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
blood vessel development GO:0001568 172 0.011
negative regulation of map kinase activity GO:0043407 27 0.011
response to inorganic substance GO:0010035 127 0.011
positive regulation of jun kinase activity GO:0043507 23 0.011
muscle contraction GO:0006936 73 0.011
sequestering of calcium ion GO:0051208 17 0.011
regulation of cellular component movement GO:0051270 334 0.011
Human
anterior posterior axis specification GO:0009948 2 0.011
positive regulation of cell motility GO:2000147 177 0.011
Human
myosin filament assembly GO:0031034 2 0.011
activation of mapkk activity GO:0000186 18 0.011
cellular response to dna damage stimulus GO:0006974 379 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
Mouse Rat
regulation of immunoglobulin production GO:0002637 4 0.011
lipid metabolic process GO:0006629 381 0.011
neuron projection development GO:0031175 106 0.011
Mouse Rat
regulation of vasculature development GO:1901342 97 0.011
dna repair GO:0006281 198 0.011
3 utr mediated mrna destabilization GO:0061158 1 0.011
regulation of calcium ion transmembrane transport GO:1903169 28 0.011
chemical homeostasis GO:0048878 306 0.011
Human
oxidation reduction process GO:0055114 396 0.011
striated muscle contraction GO:0006941 52 0.010
response to axon injury GO:0048678 1 0.010
negative regulation of protein processing GO:0010955 142 0.010
myosin filament organization GO:0031033 2 0.010
organophosphate biosynthetic process GO:0090407 163 0.010
regulation of ion homeostasis GO:2000021 73 0.010
heart development GO:0007507 95 0.010
Fly
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.010
purine nucleoside triphosphate metabolic process GO:0009144 412 0.010
nucleoside triphosphate metabolic process GO:0009141 422 0.010
regulation of blood circulation GO:1903522 59 0.010

NUMBL disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.069
nervous system disease DOID:863 431 0.069
neurodegenerative disease DOID:1289 102 0.032
spinocerebellar degeneration DOID:2478 27 0.032
musculoskeletal system disease DOID:17 223 0.030
disease of cellular proliferation DOID:14566 174 0.027
cancer DOID:162 167 0.022
organ system cancer DOID:0050686 164 0.022
meckel syndrome DOID:0050778 11 0.018
sensory system disease DOID:0050155 203 0.017
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.014
myopathy DOID:423 104 0.014
muscular disease DOID:0080000 114 0.014
muscle tissue disease DOID:66 113 0.014
connective tissue disease DOID:65 109 0.013
disease of metabolism DOID:0014667 295 0.013