Homo sapiens

0 known processes

NKX2-2

NK2 homeobox 2

(Aliases: NKX2.2,NKX2B)

NKX2-2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
pancreatic a cell differentiation GO:0003310 1 0.928
Mouse
neuron fate commitment GO:0048663 2 0.734
Mouse
organ morphogenesis GO:0009887 147 0.256
Human
cell development GO:0048468 328 0.240
Human Zebrafish Mouse
hindbrain development GO:0030902 3 0.233
regulation of locomotion GO:0040012 329 0.207
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.206
Human
endocrine system development GO:0035270 26 0.197
Human Zebrafish Mouse
generation of neurons GO:0048699 152 0.197
Human Zebrafish Mouse
nervous system development GO:0007399 293 0.189
Human Zebrafish Mouse Rat
regulation of cell differentiation GO:0045595 393 0.181
Human Mouse
forebrain generation of neurons GO:0021872 3 0.181
neuron differentiation GO:0030182 138 0.169
Human Zebrafish Mouse
cell differentiation in spinal cord GO:0021515 1 0.163
Zebrafish Mouse
secretion GO:0046903 254 0.156
cell fate determination GO:0001709 3 0.154
Mouse
cellular amine metabolic process GO:0044106 41 0.152
anatomical structure formation involved in morphogenesis GO:0048646 284 0.148
Zebrafish
epithelial cell differentiation GO:0030855 141 0.147
Mouse
regulation of cellular component movement GO:0051270 334 0.142
Human
enzyme linked receptor protein signaling pathway GO:0007167 303 0.139
Human
regulation of secretion GO:0051046 194 0.137
circulatory system development GO:0072359 262 0.136
Human
epithelium development GO:0060429 227 0.133
Human Zebrafish Mouse
amine metabolic process GO:0009308 44 0.132
cellular amino acid metabolic process GO:0006520 116 0.132
regulation of hormone levels GO:0010817 125 0.131
cell projection organization GO:0030030 252 0.128
Zebrafish
regulation of cellular amino acid metabolic process GO:0006521 6 0.126
peripheral nervous system development GO:0007422 2 0.124
Zebrafish
locomotory behavior GO:0007626 1 0.122
cellular ketone metabolic process GO:0042180 80 0.121
morphogenesis of embryonic epithelium GO:0016331 4 0.119
post embryonic development GO:0009791 2 0.119
regulation of cellular ketone metabolic process GO:0010565 50 0.116
cell cell signaling GO:0007267 155 0.114
embryonic camera type eye development GO:0031076 2 0.112
negative regulation of multicellular organismal process GO:0051241 317 0.109
Human Mouse
cell morphogenesis GO:0000902 296 0.109
Human Zebrafish
neurogenesis GO:0022008 169 0.108
Human Zebrafish Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.108
positive regulation of developmental process GO:0051094 314 0.105
Human Mouse
positive regulation of cell proliferation GO:0008284 301 0.104
system process GO:0003008 349 0.103
cardiovascular system development GO:0072358 262 0.103
Human
secretion by cell GO:0032940 226 0.101
regulation of secretion by cell GO:1903530 177 0.101
vasculature development GO:0001944 181 0.100
positive regulation of cellular amine metabolic process GO:0033240 7 0.098
cellular component morphogenesis GO:0032989 314 0.098
Human Zebrafish
nerve development GO:0021675 4 0.097
Rat
pituitary gland development GO:0021983 2 0.096
cerebral cortex gabaergic interneuron differentiation GO:0021892 1 0.096
stem cell development GO:0048864 69 0.092
Human
regulation of cell migration GO:0030334 289 0.091
Human
regulation of cellular amine metabolic process GO:0033238 11 0.091
neuron projection development GO:0031175 106 0.089
Zebrafish
anion transport GO:0006820 161 0.089
forebrain regionalization GO:0021871 3 0.087
forebrain neuron differentiation GO:0021879 3 0.086
cardiac cell fate determination GO:0060913 3 0.086
positive regulation of transport GO:0051050 336 0.084
regulation of neuron differentiation GO:0045664 70 0.084
Human Mouse
regulation of cell motility GO:2000145 299 0.083
Human
negative regulation of developmental process GO:0051093 247 0.083
Human Mouse
regulation of cell development GO:0060284 161 0.082
Human Mouse
cellular response to endogenous stimulus GO:0071495 336 0.082
Human
brain development GO:0007420 97 0.080
Human
positive regulation of cell development GO:0010720 92 0.080
Human Mouse
negative regulation of cell differentiation GO:0045596 171 0.080
Human Mouse
spinal cord development GO:0021510 4 0.077
Zebrafish Mouse
response to oxygen containing compound GO:1901700 369 0.074
Rat
hormone secretion GO:0046879 65 0.074
regulation of nervous system development GO:0051960 88 0.071
Human Mouse
organ formation GO:0048645 3 0.071
negative regulation of apoptotic process GO:0043066 316 0.069
Human
negative regulation of programmed cell death GO:0043069 321 0.069
Human
head development GO:0060322 108 0.069
Human
limbic system development GO:0021761 3 0.069
negative regulation of cell proliferation GO:0008285 228 0.069
embryonic morphogenesis GO:0048598 85 0.068
Zebrafish
neuron development GO:0048666 113 0.067
Zebrafish
skeletal system development GO:0001501 79 0.066
segmentation GO:0035282 4 0.065
positive regulation of cell differentiation GO:0045597 211 0.065
Human Mouse
cell adhesion GO:0007155 325 0.064
digestive system development GO:0055123 75 0.064
Mouse Worm
somatic stem cell maintenance GO:0035019 4 0.064
cell morphogenesis involved in differentiation GO:0000904 144 0.064
Human Zebrafish
mesenchymal cell development GO:0014031 50 0.063
Human
central nervous system development GO:0007417 123 0.062
Human Zebrafish Mouse
metencephalon development GO:0022037 2 0.062
hormone transport GO:0009914 68 0.061
tissue morphogenesis GO:0048729 96 0.060
Human Zebrafish
positive regulation of phosphorylation GO:0042327 394 0.060
regulation of neurogenesis GO:0050767 82 0.059
Human Mouse
blood vessel development GO:0001568 172 0.059
stem cell differentiation GO:0048863 93 0.059
Human
ventral spinal cord interneuron differentiation GO:0021514 1 0.059
Zebrafish Mouse
ventral spinal cord development GO:0021517 1 0.059
Zebrafish Mouse
negative regulation of protein metabolic process GO:0051248 391 0.059
negative regulation of phosphorus metabolic process GO:0010563 267 0.058
negative regulation of cell death GO:0060548 345 0.057
Human
single organism cellular localization GO:1902580 332 0.057
regulation of protein localization GO:0032880 296 0.057
regulation of kinase activity GO:0043549 314 0.056
mesenchyme development GO:0060485 59 0.056
Human
negative regulation of transport GO:0051051 176 0.055
positive regulation of neural precursor cell proliferation GO:2000179 2 0.055
cytoplasmic transport GO:0016482 379 0.055
mesenchymal cell differentiation GO:0048762 52 0.054
Human
ion transmembrane transport GO:0034220 338 0.054
chemical homeostasis GO:0048878 306 0.054
regulation of cell cycle GO:0051726 393 0.053
positive regulation of secretion GO:0051047 116 0.053
nitrogen compound transport GO:0071705 191 0.052
endocrine pancreas development GO:0031018 11 0.052
Zebrafish Mouse
tube development GO:0035295 125 0.052
Human Zebrafish Mouse Worm
negative regulation of gliogenesis GO:0014014 3 0.049
lipid metabolic process GO:0006629 381 0.049
mitotic cell cycle GO:0000278 326 0.049
positive regulation of secretion by cell GO:1903532 108 0.049
negative regulation of cellular protein metabolic process GO:0032269 353 0.048
regulation of hormone secretion GO:0046883 57 0.047
regulation of anatomical structure morphogenesis GO:0022603 286 0.047
Human
cation transport GO:0006812 331 0.047
adult locomotory behavior GO:0008344 1 0.047
gabaergic neuron differentiation GO:0097154 1 0.046
pancreas development GO:0031016 19 0.046
Zebrafish Mouse
regulation of establishment of protein localization GO:0070201 242 0.046
inner ear morphogenesis GO:0042472 4 0.046
biological adhesion GO:0022610 331 0.045
cell proliferation in forebrain GO:0021846 1 0.045
neural crest cell development GO:0014032 3 0.045
female gamete generation GO:0007292 2 0.045
growth GO:0040007 202 0.045
regulation of protein transport GO:0051223 213 0.044
protein localization to organelle GO:0033365 280 0.044
negative regulation of cellular component organization GO:0051129 235 0.044
Human
organonitrogen compound biosynthetic process GO:1901566 200 0.044
neuroblast proliferation GO:0007405 4 0.044
inorganic cation transmembrane transport GO:0098662 194 0.043
digestive tract development GO:0048565 75 0.043
Mouse Worm
vesicle mediated transport GO:0016192 371 0.042
Worm
regulation of neural precursor cell proliferation GO:2000177 4 0.042
taxis GO:0042330 157 0.042
Zebrafish
negative regulation of cell development GO:0010721 48 0.041
Human Mouse
transmembrane transport GO:0055085 399 0.041
wnt signaling pathway GO:0016055 156 0.041
pattern specification process GO:0007389 43 0.041
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.040
Mouse
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.040
Human
intracellular protein transport GO:0006886 270 0.040
small gtpase mediated signal transduction GO:0007264 78 0.040
regeneration GO:0031099 4 0.040
motor neuron axon guidance GO:0008045 2 0.040
Zebrafish
signal release GO:0023061 70 0.040
amide transport GO:0042886 76 0.039
purine ribonucleoside metabolic process GO:0046128 437 0.039
positive regulation of programmed cell death GO:0043068 249 0.039
positive regulation of protein phosphorylation GO:0001934 313 0.039
forebrain dorsal ventral pattern formation GO:0021798 1 0.038
ras protein signal transduction GO:0007265 73 0.038
cation transmembrane transport GO:0098655 238 0.038
purine nucleoside triphosphate metabolic process GO:0009144 412 0.038
regulation of synaptic plasticity GO:0048167 3 0.038
positive regulation of cellular component organization GO:0051130 376 0.038
regulation of wnt signaling pathway GO:0030111 123 0.038
regionalization GO:0003002 29 0.037
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.037
photoreceptor cell differentiation GO:0046530 2 0.037
negative regulation of phosphate metabolic process GO:0045936 267 0.037
chromatin organization GO:0006325 351 0.037
forebrain development GO:0030900 26 0.037
Human
regulation of cell cycle process GO:0010564 266 0.037
embryo development GO:0009790 123 0.036
Human Zebrafish
regulation of cell projection organization GO:0031344 107 0.036
peptide secretion GO:0002790 51 0.036
cell part morphogenesis GO:0032990 137 0.036
Zebrafish
positive regulation of neurogenesis GO:0050769 49 0.036
Human Mouse
glial cell migration GO:0008347 4 0.036
Zebrafish
embryonic camera type eye morphogenesis GO:0048596 2 0.036
regulation of intracellular transport GO:0032386 195 0.036
canonical wnt signaling pathway GO:0060070 116 0.036
chromatin modification GO:0016568 298 0.036
nucleoside triphosphate metabolic process GO:0009141 422 0.035
response to organic cyclic compound GO:0014070 204 0.035
Rat
neuroendocrine cell differentiation GO:0061101 2 0.035
negative regulation of protein modification process GO:0031400 200 0.035
regulation of purine nucleotide metabolic process GO:1900542 264 0.035
neurological system process GO:0050877 163 0.035
cellular lipid metabolic process GO:0044255 303 0.035
positive regulation of locomotion GO:0040017 186 0.035
oogenesis GO:0048477 2 0.035
immune response GO:0006955 307 0.034
regulation of cell morphogenesis GO:0022604 153 0.034
Human
metal ion transport GO:0030001 272 0.034
endodermal cell fate commitment GO:0001711 4 0.034
response to wounding GO:0009611 168 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.034
signal transduction by phosphorylation GO:0023014 297 0.034
cranial nerve development GO:0021545 4 0.033
Rat
extraocular skeletal muscle development GO:0002074 1 0.033
positive regulation of catabolic process GO:0009896 310 0.033
actin filament based process GO:0030029 224 0.033
negative regulation of catalytic activity GO:0043086 335 0.033
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.033
Human
regulation of growth GO:0040008 165 0.033
cellular response to oxygen containing compound GO:1901701 276 0.033
cardiac muscle cell contraction GO:0086003 4 0.033
ribonucleoside triphosphate metabolic process GO:0009199 412 0.033
organophosphate catabolic process GO:0046434 430 0.033
peptide hormone secretion GO:0030072 50 0.033
single organism membrane organization GO:0044802 268 0.032
regulation of transferase activity GO:0051338 355 0.032
nucleotide catabolic process GO:0009166 408 0.032
cell type specific apoptotic process GO:0097285 125 0.032
Human
determination of adult lifespan GO:0008340 2 0.032
positive regulation of apoptotic process GO:0043065 246 0.032
cellular homeostasis GO:0019725 196 0.031
mapk cascade GO:0000165 288 0.031
peptide transport GO:0015833 74 0.031
regulation of mitotic cell cycle GO:0007346 189 0.031
regulation of cellular response to stress GO:0080135 244 0.031
sex determination GO:0007530 3 0.031
apoptotic signaling pathway GO:0097190 268 0.031
multicellular organismal aging GO:0010259 3 0.031
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 1 0.031
regulation of protein kinase activity GO:0045859 289 0.031
regulation of nucleotide metabolic process GO:0006140 269 0.031
urogenital system development GO:0001655 65 0.031
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.031
purine nucleoside triphosphate catabolic process GO:0009146 392 0.031
neuron projection regeneration GO:0031102 1 0.031
nucleocytoplasmic transport GO:0006913 176 0.031
regulation of ion transport GO:0043269 189 0.031
response to abiotic stimulus GO:0009628 336 0.030
cell fate commitment GO:0045165 27 0.030
Zebrafish Mouse
positive regulation of cell death GO:0010942 263 0.030
response to hormone GO:0009725 175 0.030
Human Rat
ribonucleoside catabolic process GO:0042454 406 0.030
regulation of proteolysis GO:0030162 293 0.030
negative regulation of cell cycle GO:0045786 193 0.030
ameboidal type cell migration GO:0001667 135 0.030
glycosyl compound catabolic process GO:1901658 413 0.029
membrane organization GO:0061024 292 0.029
positive regulation of cellular component movement GO:0051272 181 0.029
nucleoside catabolic process GO:0009164 408 0.029
negative regulation of neurogenesis GO:0050768 26 0.029
Mouse
ribonucleotide catabolic process GO:0009261 405 0.029
ribonucleoside triphosphate catabolic process GO:0009203 391 0.029
cell projection morphogenesis GO:0048858 129 0.029
Zebrafish
purine containing compound catabolic process GO:0072523 411 0.029
cerebellum development GO:0021549 2 0.029
regulation of cell growth GO:0001558 135 0.029
regulation of glial cell differentiation GO:0045685 3 0.029
Mouse
regulation of membrane potential GO:0042391 95 0.029
astrocyte differentiation GO:0048708 4 0.028
Mouse
negative regulation of phosphorylation GO:0042326 174 0.028
neuromuscular junction development GO:0007528 3 0.028
cell growth GO:0016049 160 0.028
gtp metabolic process GO:0046039 239 0.028
positive regulation of nervous system development GO:0051962 54 0.028
Human Mouse
salivary gland morphogenesis GO:0007435 4 0.028
reproductive process GO:0022414 106 0.028
embryonic eye morphogenesis GO:0048048 2 0.028
cellular response to dna damage stimulus GO:0006974 379 0.028
neuron projection morphogenesis GO:0048812 50 0.028
Zebrafish
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.028
Human
behavior GO:0007610 112 0.027
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.027
Zebrafish
mitotic cell cycle process GO:1903047 286 0.027
regulation of neuron projection development GO:0010975 57 0.027
endodermal cell fate specification GO:0001714 4 0.027
neural tube patterning GO:0021532 2 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
regulation of cytokine production GO:0001817 232 0.027
negative regulation of protein phosphorylation GO:0001933 140 0.027
nuclear transport GO:0051169 179 0.027
regulation of canonical wnt signaling pathway GO:0060828 88 0.027
immune system development GO:0002520 195 0.027
Human
positive regulation of immune system process GO:0002684 283 0.027
sensory organ development GO:0007423 52 0.026
positive regulation of transferase activity GO:0051347 227 0.026
regulation of male gonad development GO:2000018 4 0.026
anterior posterior axis specification GO:0009948 2 0.026
positive regulation of protein kinase activity GO:0045860 190 0.026
nucleoside phosphate catabolic process GO:1901292 412 0.026
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.026
Mouse
protein catabolic process GO:0030163 325 0.026
striated muscle tissue development GO:0014706 59 0.026
Human
blastoderm segmentation GO:0007350 2 0.026
positive regulation of synaptic transmission GO:0050806 4 0.026
embryonic camera type eye formation GO:0060900 2 0.026
regulation of cell adhesion GO:0030155 166 0.026
regulation of apoptotic signaling pathway GO:2001233 175 0.026
protein localization to membrane GO:0072657 160 0.026
enteroendocrine cell differentiation GO:0035883 6 0.026
Mouse
regulation of homeostatic process GO:0032844 121 0.025
muscle structure development GO:0061061 98 0.025
Human Worm
endomembrane system organization GO:0010256 196 0.025
negative regulation of wnt signaling pathway GO:0030178 69 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
regulation of mapk cascade GO:0043408 262 0.025
establishment of protein localization to organelle GO:0072594 172 0.025
positive regulation of neuron differentiation GO:0045666 40 0.025
Human Mouse
purine nucleoside catabolic process GO:0006152 398 0.025
positive regulation of monocyte chemotactic protein 1 production GO:0071639 3 0.025
purine ribonucleoside catabolic process GO:0046130 398 0.025
forelimb morphogenesis GO:0035136 4 0.024
bmp signaling pathway involved in heart development GO:0061312 3 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
purine ribonucleotide catabolic process GO:0009154 404 0.024
positive regulation of cytokine production GO:0001819 167 0.024
embryonic epithelial tube formation GO:0001838 4 0.024
cellular response to nitrogen compound GO:1901699 144 0.024
kidney development GO:0001822 53 0.024
cell division GO:0051301 168 0.024
positive regulation of kinase activity GO:0033674 204 0.024
cytokine production GO:0001816 247 0.023
prostate gland development GO:0030850 3 0.023
response to lipid GO:0033993 206 0.023
Rat
regulation of peptide hormone secretion GO:0090276 41 0.023
guanosine containing compound catabolic process GO:1901069 239 0.023
cellular macromolecule catabolic process GO:0044265 380 0.023
hippocampus development GO:0021766 1 0.023
positive regulation of nucleotide metabolic process GO:0045981 230 0.023
regulation of peptidase activity GO:0052547 180 0.022
renal system development GO:0072001 63 0.022
g protein coupled receptor signaling pathway GO:0007186 207 0.022
heart morphogenesis GO:0003007 48 0.022
Human
response to nitrogen compound GO:1901698 184 0.022
regulation of response to external stimulus GO:0032101 222 0.022
small molecule biosynthetic process GO:0044283 157 0.022
regulation of nucleoside metabolic process GO:0009118 209 0.022
posttranscriptional regulation of gene expression GO:0010608 213 0.022
gtp catabolic process GO:0006184 237 0.022
guanosine containing compound metabolic process GO:1901068 244 0.022
chemotaxis GO:0006935 157 0.022
Zebrafish
regulation of system process GO:0044057 101 0.022
response to growth factor GO:0070848 205 0.022
Human
epithelial cell development GO:0002064 34 0.022
Mouse
positive regulation of dermatome development GO:0061184 3 0.022
rho protein signal transduction GO:0007266 26 0.022
positive regulation of organelle organization GO:0010638 195 0.022
regulation of endopeptidase activity GO:0052548 170 0.022
regulation of peptide transport GO:0090087 62 0.022
cerebral cortex cell migration GO:0021795 3 0.022
protein localization to nucleus GO:0034504 136 0.021
regulation of peptide secretion GO:0002791 42 0.021
negative regulation of nervous system development GO:0051961 28 0.021
Mouse
positive regulation of cell migration GO:0030335 172 0.021
eye development GO:0001654 42 0.021
positive regulation of gliogenesis GO:0014015 4 0.021
Mouse
monovalent inorganic cation transport GO:0015672 128 0.021
synaptic transmission GO:0007268 61 0.021
osteoblast differentiation GO:0001649 92 0.021
lipid biosynthetic process GO:0008610 177 0.021
protein targeting GO:0006605 187 0.021
regulation of cytoplasmic transport GO:1903649 149 0.021
cellular macromolecular complex assembly GO:0034622 324 0.021
oxidation reduction process GO:0055114 396 0.021
compound eye development GO:0048749 1 0.021
blood vessel morphogenesis GO:0048514 162 0.021
positive regulation of cell cycle GO:0045787 140 0.021
sensory organ morphogenesis GO:0090596 21 0.021
organophosphate biosynthetic process GO:0090407 163 0.021
negative regulation of locomotion GO:0040013 118 0.021
Human
positive regulation of cell motility GO:2000147 177 0.021
carbohydrate metabolic process GO:0005975 207 0.021
regulation of gtpase activity GO:0043087 180 0.021
regulation of intracellular protein transport GO:0033157 123 0.021
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
hair cell differentiation GO:0035315 2 0.020
positive regulation of aldosterone metabolic process GO:0032346 2 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
positive regulation of nucleoside metabolic process GO:0045979 186 0.020
muscle tissue development GO:0060537 62 0.020
Human
maintenance of location GO:0051235 112 0.020
regulation of cell division GO:0051302 116 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
Human
response to axon injury GO:0048678 1 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
eye photoreceptor cell differentiation GO:0001754 2 0.020
limb bud formation GO:0060174 1 0.020
positive regulation of gtpase activity GO:0043547 166 0.020
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.020
positive regulation of protein transport GO:0051222 135 0.020
regulation of immune response GO:0050776 201 0.020
regulation of neuroblast proliferation GO:1902692 3 0.020
single organism carbohydrate metabolic process GO:0044723 193 0.020
cell activation GO:0001775 213 0.020
cellular chemical homeostasis GO:0055082 180 0.020
protein ubiquitination GO:0016567 314 0.020
action potential GO:0001508 34 0.020
organic hydroxy compound metabolic process GO:1901615 147 0.020
lens development in camera type eye GO:0002088 2 0.020
response to organonitrogen compound GO:0010243 156 0.020
heart formation GO:0060914 2 0.020
tube morphogenesis GO:0035239 95 0.019
Human
single organism reproductive process GO:0044702 98 0.019
response to drug GO:0042493 81 0.019
specification of organ identity GO:0010092 3 0.019
cellular response to organonitrogen compound GO:0071417 124 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
neural crest cell migration GO:0001755 2 0.019
oocyte differentiation GO:0009994 2 0.019
somitogenesis GO:0001756 2 0.019
heart development GO:0007507 95 0.019
Human
right ventricular cardiac muscle tissue morphogenesis GO:0003221 2 0.019
Human
memory GO:0007613 3 0.019
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
histone modification GO:0016570 251 0.019
organic anion transport GO:0015711 103 0.019
pharynx development GO:0060465 1 0.019
Worm
negative regulation of intracellular signal transduction GO:1902532 183 0.019
regulation of gtp catabolic process GO:0033124 180 0.019
positive regulation of mapk cascade GO:0043410 190 0.018
single organism cell adhesion GO:0098602 179 0.018
embryonic forelimb morphogenesis GO:0035115 4 0.018
regulation of protein serine threonine kinase activity GO:0071900 179 0.018
negative regulation of cell motility GO:2000146 104 0.018
Human
plasma membrane organization GO:0007009 115 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
ossification GO:0001503 121 0.018
cardiac muscle contraction GO:0060048 34 0.018
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.018
organic acid biosynthetic process GO:0016053 97 0.018
regulation of cellular component biogenesis GO:0044087 281 0.018
signal transduction involved in regulation of gene expression GO:0023019 1 0.018
regulation of protein complex assembly GO:0043254 147 0.018
oocyte development GO:0048599 1 0.018
axon regeneration GO:0031103 1 0.018
innate immune response GO:0045087 178 0.018
covalent chromatin modification GO:0016569 254 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.018
rhythmic behavior GO:0007622 2 0.018
regulation of metal ion transport GO:0010959 120 0.018
spinal cord dorsal ventral patterning GO:0021513 2 0.018
Mouse
positive regulation of proteolysis GO:0045862 142 0.018
positive regulation of gtp catabolic process GO:0033126 166 0.018
regulation of ras protein signal transduction GO:0046578 155 0.017
regulation of nucleocytoplasmic transport GO:0046822 98 0.017
regulation of small gtpase mediated signal transduction GO:0051056 156 0.017
positive regulation of cellular component biogenesis GO:0044089 158 0.017
sequestering of metal ion GO:0051238 24 0.017
positive regulation of ras gtpase activity GO:0032320 117 0.017
negative regulation of cell migration GO:0030336 102 0.017
Human
regulation of multi organism process GO:0043900 157 0.017
regulation of nucleotide catabolic process GO:0030811 205 0.017
regulation of leukocyte activation GO:0002694 115 0.017
canonical wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044338 2 0.017
actin cytoskeleton organization GO:0030036 207 0.017
second messenger mediated signaling GO:0019932 78 0.017
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.017
Human
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.017
axonogenesis GO:0007409 31 0.017
Zebrafish
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.017
canonical wnt signaling pathway involved in osteoblast differentiation GO:0044339 2 0.017
tripartite regional subdivision GO:0007351 2 0.017
tissue regeneration GO:0042246 3 0.017
defense response GO:0006952 315 0.017
protein targeting to nucleus GO:0044744 104 0.017
nucleoside phosphate biosynthetic process GO:1901293 109 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
gland development GO:0048732 48 0.017
Human
cell cycle phase transition GO:0044770 173 0.017
regulation of epithelial cell proliferation GO:0050678 113 0.016
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.016
cartilage condensation GO:0001502 1 0.016
cellular protein catabolic process GO:0044257 261 0.016
telencephalon development GO:0021537 17 0.016
regulation of dna metabolic process GO:0051052 153 0.016
regulation of actin filament based process GO:0032970 141 0.016
circadian behavior GO:0048512 2 0.016
neural tube formation GO:0001841 3 0.016
positive regulation of neuroblast proliferation GO:0002052 2 0.016
dephosphorylation GO:0016311 209 0.016

NKX2-2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.071
central nervous system disease DOID:331 186 0.031
nervous system disease DOID:863 431 0.031
sensory system disease DOID:0050155 203 0.028
musculoskeletal system disease DOID:17 223 0.024
cancer DOID:162 167 0.023
disease of cellular proliferation DOID:14566 174 0.023
acquired metabolic disease DOID:0060158 58 0.023
bone disease DOID:0080001 88 0.022
connective tissue disease DOID:65 109 0.022
organ system cancer DOID:0050686 164 0.021
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.017
brain disease DOID:936 73 0.016