Homo sapiens

189 known processes

NKX2-1

NK2 homeobox 1

(Aliases: TITF1,NKX2.1,BCH,BHC,NKX2A,TEBP,TTF-1,TTF1,NK-2)

NKX2-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pattern specification involved in kidney development GO:0061004 1 1.000
regulation of metanephros size GO:0035566 1 1.000
renal system pattern specification GO:0072048 1 1.000
regulation of thyroid hormone generation GO:2000609 2 1.000
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 4 0.999
specification of organ identity GO:0010092 3 0.992
neuron fate commitment GO:0048663 2 0.988
Mouse
organ formation GO:0048645 3 0.957
regulation of thyroid stimulating hormone secretion GO:2000612 1 0.886
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.877
somatic stem cell maintenance GO:0035019 4 0.873
negative regulation of kidney development GO:0090185 2 0.850
nephron tubule formation GO:0072079 1 0.755
forebrain regionalization GO:0021871 3 0.753
Mouse
cellular response to endogenous stimulus GO:0071495 336 0.695
thyroid hormone generation GO:0006590 2 0.664
regulation of kidney size GO:0035564 2 0.627
regulation of cellular ketone metabolic process GO:0010565 50 0.618
metanephric nephron tubule morphogenesis GO:0072282 1 0.599
negative regulation of stem cell differentiation GO:2000737 22 0.593
negative regulation of cytolysis GO:0045918 3 0.568
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.564
endocrine system development GO:0035270 26 0.564
inner ear morphogenesis GO:0042472 4 0.560
cellular ketone metabolic process GO:0042180 80 0.540
cellular amine metabolic process GO:0044106 41 0.507
stem cell differentiation GO:0048863 93 0.499
regulation of mesonephros development GO:0061217 3 0.494
negative regulation of developmental process GO:0051093 247 0.490
morphogenesis of embryonic epithelium GO:0016331 4 0.489
s shaped body morphogenesis GO:0072050 4 0.488
amine metabolic process GO:0009308 44 0.458
regulation of cell differentiation GO:0045595 393 0.455
nephron epithelium morphogenesis GO:0072088 15 0.448
anatomical structure formation involved in morphogenesis GO:0048646 284 0.447
Mouse
positive regulation of cellular amine metabolic process GO:0033240 7 0.444
cell cell signaling GO:0007267 155 0.444
Mouse
regulation of cellular amine metabolic process GO:0033238 11 0.440
mesonephros development GO:0001823 17 0.436
organ morphogenesis GO:0009887 147 0.418
tube morphogenesis GO:0035239 95 0.418
branching involved in ureteric bud morphogenesis GO:0001658 9 0.404
tube development GO:0035295 125 0.397
ureteric bud morphogenesis GO:0060675 10 0.396
kidney morphogenesis GO:0060993 19 0.396
regulation of locomotion GO:0040012 329 0.389
cellular amino acid metabolic process GO:0006520 116 0.385
negative regulation of cell development GO:0010721 48 0.384
urogenital system development GO:0001655 65 0.380
negative regulation of multicellular organismal process GO:0051241 317 0.376
regulation of anatomical structure morphogenesis GO:0022603 286 0.375
kidney epithelium development GO:0072073 25 0.374
embryonic epithelial tube formation GO:0001838 4 0.371
thyroid hormone metabolic process GO:0042403 4 0.371
branching morphogenesis of an epithelial tube GO:0048754 19 0.361
mesonephric tubule morphogenesis GO:0072171 10 0.360
positive regulation of cell differentiation GO:0045597 211 0.349
Human
regulation of epithelial cell differentiation involved in kidney development GO:2000696 4 0.348
epithelium development GO:0060429 227 0.343
circulatory system development GO:0072359 262 0.341
Human
nephron morphogenesis GO:0072028 15 0.340
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.338
cell development GO:0048468 328 0.334
neuron differentiation GO:0030182 138 0.333
Human Mouse Fly
cell morphogenesis GO:0000902 296 0.332
positive regulation of cell proliferation GO:0008284 301 0.328
metanephric s shaped body morphogenesis GO:0072284 4 0.327
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.326
Human Mouse
metanephros development GO:0001656 16 0.325
cell projection organization GO:0030030 252 0.322
Mouse Fly
mesonephric tubule development GO:0072164 14 0.316
mesonephric epithelium development GO:0072163 14 0.312
secretion GO:0046903 254 0.311
post embryonic development GO:0009791 2 0.309
negative regulation of cell death GO:0060548 345 0.302
Human
cellular response to gonadotropin stimulus GO:0071371 4 0.301
secretion by cell GO:0032940 226 0.300
negative regulation of cell differentiation GO:0045596 171 0.298
nephron tubule morphogenesis GO:0072078 13 0.292
kidney development GO:0001822 53 0.291
positive regulation of epithelial cell proliferation GO:0050679 65 0.290
peripheral nervous system development GO:0007422 2 0.278
distal tubule development GO:0072017 4 0.275
regulation of secretion GO:0051046 194 0.272
positive regulation of mesonephros development GO:0061213 2 0.270
response to oxygen containing compound GO:1901700 369 0.269
Rat
positive regulation of developmental process GO:0051094 314 0.268
Human
metanephric tubule development GO:0072170 3 0.267
regulation of hormone levels GO:0010817 125 0.251
renal tubule development GO:0061326 19 0.251
metanephric collecting duct development GO:0072205 2 0.249
renal vesicle morphogenesis GO:0072077 4 0.248
regulation of secretion by cell GO:1903530 177 0.248
regulation of epithelial cell proliferation GO:0050678 113 0.246
metanephric nephron morphogenesis GO:0072273 7 0.243
hormone secretion GO:0046879 65 0.242
nephron epithelium development GO:0072009 23 0.241
neurogenesis GO:0022008 169 0.235
Human Mouse Fly
organic hydroxy compound metabolic process GO:1901615 147 0.235
peptide secretion GO:0002790 51 0.233
amide transport GO:0042886 76 0.232
regulation of hormone secretion GO:0046883 57 0.228
developmental programmed cell death GO:0010623 3 0.220
negative regulation of apoptotic process GO:0043066 316 0.216
Human
central nervous system development GO:0007417 123 0.213
morphogenesis of a branching epithelium GO:0061138 20 0.213
regulation of cell fate specification GO:0042659 5 0.209
negative regulation of programmed cell death GO:0043069 321 0.206
Human
nervous system development GO:0007399 293 0.205
peptide transport GO:0015833 74 0.205
generation of neurons GO:0048699 152 0.204
Human Mouse Fly
epithelial cell differentiation GO:0030855 141 0.204
Mouse
hormone metabolic process GO:0042445 61 0.200
tissue morphogenesis GO:0048729 96 0.199
extraocular skeletal muscle development GO:0002074 1 0.196
peptide hormone secretion GO:0030072 50 0.196
cellular component morphogenesis GO:0032989 314 0.196
epithelial cell proliferation GO:0050673 128 0.196
regulation of cell development GO:0060284 161 0.195
hormone transport GO:0009914 68 0.194
cell morphogenesis involved in differentiation GO:0000904 144 0.190
regulation of cellular component movement GO:0051270 334 0.188
cellular response to hormone stimulus GO:0032870 125 0.188
signal release GO:0023061 70 0.187
neuron projection development GO:0031175 106 0.186
Mouse Fly
response to hormone GO:0009725 175 0.186
hindbrain development GO:0030902 3 0.186
positive regulation of hormone metabolic process GO:0032352 6 0.186
embryonic morphogenesis GO:0048598 85 0.185
regulation of cell migration GO:0030334 289 0.183
photoreceptor cell differentiation GO:0046530 2 0.182
locomotory behavior GO:0007626 1 0.179
Mouse
renal system development GO:0072001 63 0.177
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 1 0.174
regulation of neuron differentiation GO:0045664 70 0.173
Human
stem cell development GO:0048864 69 0.170
metanephric nephron development GO:0072210 9 0.169
forebrain generation of neurons GO:0021872 3 0.168
Mouse
metanephric nephron epithelium development GO:0072243 4 0.168
cranial nerve development GO:0021545 4 0.164
renal tubule morphogenesis GO:0061333 14 0.158
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 2 0.157
regulation of cell morphogenesis GO:0022604 153 0.154
regulation of endopeptidase activity GO:0052548 170 0.152
ectodermal placode development GO:0071696 1 0.151
cardiac cell fate determination GO:0060913 3 0.151
positive regulation of metanephros development GO:0072216 3 0.149
negative regulation of protein metabolic process GO:0051248 391 0.147
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.146
metanephric nephron tubule development GO:0072234 3 0.144
regulation of organ morphogenesis GO:2000027 24 0.143
apoptotic process involved in morphogenesis GO:0060561 3 0.143
spinal cord development GO:0021510 4 0.138
bmp signaling pathway involved in heart development GO:0061312 3 0.136
ectodermal placode formation GO:0060788 1 0.136
cellular modified amino acid metabolic process GO:0006575 64 0.136
system process GO:0003008 349 0.134
Rat
brain development GO:0007420 97 0.133
cardiac right ventricle morphogenesis GO:0003215 3 0.132
Human
nitrogen compound transport GO:0071705 191 0.129
immune system development GO:0002520 195 0.128
Human
chemotaxis GO:0006935 157 0.127
Mouse
cell projection morphogenesis GO:0048858 129 0.126
Mouse Fly
cell type specific apoptotic process GO:0097285 125 0.125
Human
nephron tubule development GO:0072080 17 0.125
regulation of reactive oxygen species metabolic process GO:2000377 41 0.124
ureteric bud development GO:0001657 13 0.123
mesonephric duct development GO:0072177 3 0.122
eye photoreceptor cell differentiation GO:0001754 2 0.120
regulation of nephron tubule epithelial cell differentiation GO:0072182 3 0.116
cell differentiation in spinal cord GO:0021515 1 0.116
otic vesicle development GO:0071599 1 0.115
reactive oxygen species metabolic process GO:0072593 75 0.115
response to abiotic stimulus GO:0009628 336 0.114
Rat
metanephric comma shaped body morphogenesis GO:0072278 2 0.114
regulation of cellular amino acid metabolic process GO:0006521 6 0.113
nephron tubule epithelial cell differentiation GO:0072160 3 0.113
metanephric renal vesicle morphogenesis GO:0072283 4 0.113
thyroid gland development GO:0030878 5 0.112
metanephric distal tubule development GO:0072235 2 0.112
negative regulation of catalytic activity GO:0043086 335 0.112
outflow tract septum morphogenesis GO:0003148 4 0.110
Human
regulation of neurogenesis GO:0050767 82 0.109
Human
cell differentiation involved in metanephros development GO:0072202 3 0.108
negative regulation of protein processing GO:0010955 142 0.107
cell fate determination GO:0001709 3 0.107
muscle organ development GO:0007517 56 0.107
Human
regulation of proteolysis GO:0030162 293 0.104
regulation of cell motility GO:2000145 299 0.104
heart formation GO:0060914 2 0.103
cell part morphogenesis GO:0032990 137 0.103
Mouse Fly
enzyme linked receptor protein signaling pathway GO:0007167 303 0.102
regulation of nervous system development GO:0051960 88 0.099
Human
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.098
forebrain dorsal ventral pattern formation GO:0021798 1 0.097
Mouse
hematopoietic or lymphoid organ development GO:0048534 186 0.096
Human
ectodermal placode morphogenesis GO:0071697 1 0.096
organonitrogen compound biosynthetic process GO:1901566 200 0.096
response to lipid GO:0033993 206 0.095
Rat
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.094
cell fate commitment GO:0045165 27 0.094
Mouse
digestive system development GO:0055123 75 0.094
nephron development GO:0072006 30 0.093
morphogenesis of an epithelium GO:0002009 60 0.093
regulation of cell fate commitment GO:0010453 7 0.093
regionalization GO:0003002 29 0.093
Mouse
metanephric tubule morphogenesis GO:0072173 1 0.093
cardiovascular system development GO:0072358 262 0.092
Human
regulation of metanephros development GO:0072215 4 0.091
regulation of peptide secretion GO:0002791 42 0.090
behavior GO:0007610 112 0.088
Mouse Rat
metanephric epithelium development GO:0072207 7 0.087
positive regulation of thyroid hormone generation GO:2000611 2 0.086
negative regulation of cellular protein metabolic process GO:0032269 353 0.084
regulation of peptide hormone secretion GO:0090276 41 0.084
neuron projection morphogenesis GO:0048812 50 0.084
Mouse Fly
mapk cascade GO:0000165 288 0.084
nerve development GO:0021675 4 0.083
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.082
ear morphogenesis GO:0042471 7 0.080
camera type eye photoreceptor cell differentiation GO:0060219 1 0.079
positive regulation of phosphorylation GO:0042327 394 0.079
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.078
Mouse Fly
positive regulation of transport GO:0051050 336 0.076
sulfur compound metabolic process GO:0006790 101 0.075
response to growth factor GO:0070848 205 0.075
response to organic cyclic compound GO:0014070 204 0.074
epithelial tube morphogenesis GO:0060562 38 0.074
regulation of nucleotide metabolic process GO:0006140 269 0.074
negative regulation of peptidase activity GO:0010466 91 0.073
forebrain development GO:0030900 26 0.073
negative regulation of metanephros development GO:0072217 1 0.073
ras protein signal transduction GO:0007265 73 0.073
negative regulation of protein maturation GO:1903318 142 0.072
regulation of anatomical structure size GO:0090066 101 0.072
cyclic nucleotide metabolic process GO:0009187 82 0.071
collecting duct development GO:0072044 2 0.071
regulation of stem cell maintenance GO:2000036 4 0.071
camera type eye development GO:0043010 25 0.071
paramesonephric duct development GO:0061205 2 0.070
regulation of cell cycle GO:0051726 393 0.070
regulation of hormone metabolic process GO:0032350 14 0.069
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.067
protein maturation GO:0051604 233 0.067
mesenchymal cell development GO:0014031 50 0.067
regulation of peptide transport GO:0090087 62 0.067
mesenchymal to epithelial transition GO:0060231 6 0.067
positive regulation of nucleotide metabolic process GO:0045981 230 0.066
protein catabolic process GO:0030163 325 0.066
eye development GO:0001654 42 0.065
negative regulation of hydrolase activity GO:0051346 182 0.065
regulation of protein processing GO:0070613 150 0.064
embryonic organ development GO:0048568 36 0.064
Human
vasculature development GO:0001944 181 0.063
embryonic organ morphogenesis GO:0048562 24 0.063
taxis GO:0042330 157 0.063
Mouse
muscle structure development GO:0061061 98 0.063
Human
regulation of methylation dependent chromatin silencing GO:0090308 3 0.063
positive regulation of hydrolase activity GO:0051345 331 0.062
gland development GO:0048732 48 0.062
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.062
negative regulation of cell migration GO:0030336 102 0.062
positive regulation of cellular catabolic process GO:0031331 284 0.062
epithelial cell development GO:0002064 34 0.061
regulation of purine nucleotide metabolic process GO:1900542 264 0.061
sensory organ morphogenesis GO:0090596 21 0.061
regulation of cysteine type endopeptidase activity GO:2000116 127 0.060
negative regulation of phosphate metabolic process GO:0045936 267 0.059
sensory organ development GO:0007423 52 0.059
positive regulation of protein phosphorylation GO:0001934 313 0.059
cerebellum development GO:0021549 2 0.058
purine ribonucleotide catabolic process GO:0009154 404 0.058
thymus development GO:0048538 3 0.057
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.057
leukocyte migration GO:0050900 107 0.056
negative regulation of phosphorus metabolic process GO:0010563 267 0.056
positive regulation of cell motility GO:2000147 177 0.056
regulation of epithelial cell differentiation GO:0030856 24 0.056
regeneration GO:0031099 4 0.055
regulation of camp metabolic process GO:0030814 52 0.055
blood vessel development GO:0001568 172 0.055
lipid metabolic process GO:0006629 381 0.055
Mouse
regulation of response to external stimulus GO:0032101 222 0.055
response to wounding GO:0009611 168 0.055
vesicle mediated transport GO:0016192 371 0.054
fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 1 0.053
regulation of protein maturation GO:1903317 150 0.053
cell adhesion GO:0007155 325 0.053
muscle system process GO:0003012 81 0.052
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.052
nucleoside triphosphate metabolic process GO:0009141 422 0.051
metencephalon development GO:0022037 2 0.051
response to nitrogen compound GO:1901698 184 0.051
cellular response to oxygen containing compound GO:1901701 276 0.050
negative regulation of proteolysis GO:0045861 132 0.050
negative regulation of cellular component organization GO:0051129 235 0.049
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.049
endodermal mesodermal cell signaling GO:0003133 3 0.049
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.048
negative regulation of cell motility GO:2000146 104 0.048
cartilage condensation GO:0001502 1 0.047
positive regulation of cortisol biosynthetic process GO:2000066 1 0.047
regulation of transferase activity GO:0051338 355 0.046
purine nucleotide biosynthetic process GO:0006164 84 0.045
luteinizing hormone secretion GO:0032275 1 0.045
carbohydrate derivative biosynthetic process GO:1901137 207 0.045
positive regulation of tooth mineralization GO:0070172 2 0.045
endodermal cell fate commitment GO:0001711 4 0.045
camp biosynthetic process GO:0006171 47 0.044
negative regulation of cell proliferation GO:0008285 228 0.044
segmentation GO:0035282 4 0.044
ribonucleoside catabolic process GO:0042454 406 0.044
purine ribonucleoside metabolic process GO:0046128 437 0.044
neuron development GO:0048666 113 0.043
Mouse Fly
neurological system process GO:0050877 163 0.043
regulation of protein kinase activity GO:0045859 289 0.043
retina development in camera type eye GO:0060041 15 0.043
purine ribonucleotide biosynthetic process GO:0009152 79 0.043
neuroendocrine cell differentiation GO:0061101 2 0.043
synaptic transmission GO:0007268 61 0.043
transmembrane transport GO:0055085 399 0.043
ribonucleoside triphosphate metabolic process GO:0009199 412 0.043
nucleoside phosphate biosynthetic process GO:1901293 109 0.043
response to organonitrogen compound GO:0010243 156 0.042
regulation of mapk cascade GO:0043408 262 0.042
positive regulation of cellular component organization GO:0051130 376 0.041
purine nucleoside catabolic process GO:0006152 398 0.041
positive regulation of secretion by cell GO:1903532 108 0.041
purine containing compound biosynthetic process GO:0072522 88 0.041
positive regulation of epithelial cell differentiation GO:0030858 14 0.041
regulation of cyclase activity GO:0031279 19 0.041
positive regulation of cell development GO:0010720 92 0.041
Human
regulation of cytokine production GO:0001817 232 0.041
limb bud formation GO:0060174 1 0.040
ion homeostasis GO:0050801 230 0.040
metanephros morphogenesis GO:0003338 9 0.040
ribonucleoside triphosphate catabolic process GO:0009203 391 0.040
calcium ion homeostasis GO:0055074 122 0.039
regulation of adenylate cyclase activity GO:0045761 17 0.039
reproductive process GO:0022414 106 0.039
Mouse Rat
purine nucleoside triphosphate metabolic process GO:0009144 412 0.039
inner ear development GO:0048839 8 0.039
endodermal cell fate specification GO:0001714 4 0.039
morphogenesis of a branching structure GO:0001763 21 0.039
skin development GO:0043588 76 0.039
ventral spinal cord development GO:0021517 1 0.038
positive regulation of odontogenesis GO:0042482 3 0.038
regulation of intracellular transport GO:0032386 195 0.038
purine nucleoside triphosphate catabolic process GO:0009146 392 0.038
cellular response to organonitrogen compound GO:0071417 124 0.038
dermatome development GO:0061054 3 0.038
peptidyl tyrosine phosphorylation GO:0018108 170 0.038
ear development GO:0043583 14 0.038
posttranscriptional regulation of gene expression GO:0010608 213 0.037
multicellular organismal aging GO:0010259 3 0.037
growth GO:0040007 202 0.037
chromatin modification GO:0016568 298 0.037
cell proliferation in forebrain GO:0021846 1 0.037
globus pallidus development GO:0021759 1 0.037
cyclic nucleotide biosynthetic process GO:0009190 61 0.037
reproductive system development GO:0061458 56 0.037
Mouse
comma shaped body morphogenesis GO:0072049 2 0.037
right ventricular cardiac muscle tissue morphogenesis GO:0003221 2 0.036
Human
positive regulation of transferase activity GO:0051347 227 0.036
head development GO:0060322 108 0.036
hair follicle morphogenesis GO:0031069 2 0.036
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.035
positive regulation of immune system process GO:0002684 283 0.035
positive regulation of synaptic transmission GO:0050806 4 0.035
protein localization to nucleus GO:0034504 136 0.035
determination of adult lifespan GO:0008340 2 0.035
regulation of nucleotide catabolic process GO:0030811 205 0.035
positive regulation of cell death GO:0010942 263 0.035
organophosphate catabolic process GO:0046434 430 0.034
positive regulation of dermatome development GO:0061184 3 0.034
motor neuron axon guidance GO:0008045 2 0.034
single organism reproductive process GO:0044702 98 0.034
Mouse
regulation of kinase activity GO:0043549 314 0.034
hemopoiesis GO:0030097 180 0.034
positive regulation of camp biosynthetic process GO:0030819 35 0.034
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.034
pharynx development GO:0060465 1 0.033
regulation of establishment of protein localization GO:0070201 242 0.033
response to biotic stimulus GO:0009607 276 0.033
Rat
regulation of synaptic plasticity GO:0048167 3 0.032
regulation of protein serine threonine kinase activity GO:0071900 179 0.032
cellular response to dna damage stimulus GO:0006974 379 0.032
cellular response to nitrogen compound GO:1901699 144 0.032
forebrain neuron differentiation GO:0021879 3 0.032
Mouse
cellular response to cytokine stimulus GO:0071345 181 0.032
regulation of camp biosynthetic process GO:0030817 45 0.032
regulation of cellular response to stress GO:0080135 244 0.032
regulation of peptidase activity GO:0052547 180 0.032
receptor metabolic process GO:0043112 81 0.032
embryonic camera type eye development GO:0031076 2 0.032
membrane organization GO:0061024 292 0.031
menstrual cycle phase GO:0022601 2 0.031
Mouse
positive regulation of nucleotide catabolic process GO:0030813 185 0.031
metal ion homeostasis GO:0055065 169 0.031
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.031
regulation of wnt signaling pathway GO:0030111 123 0.031
reproductive structure development GO:0048608 55 0.030
Mouse
actin cytoskeleton organization GO:0030036 207 0.030
regulation of purine nucleotide catabolic process GO:0033121 205 0.030
chromatin organization GO:0006325 351 0.030
regulation of protein transport GO:0051223 213 0.030
cellular response to organic cyclic compound GO:0071407 127 0.030
epithelial to mesenchymal transition GO:0001837 48 0.030
positive regulation of cytokine production GO:0001819 167 0.030
viral process GO:0016032 146 0.030
positive regulation of programmed cell death GO:0043068 249 0.030
negative regulation of gene silencing by rna GO:0060967 3 0.030
reactive oxygen species biosynthetic process GO:1903409 4 0.030
embryo development GO:0009790 123 0.030
Human Worm
reactive nitrogen species metabolic process GO:2001057 3 0.030
glycosyl compound catabolic process GO:1901658 413 0.030
regulation of protein localization GO:0032880 296 0.029
eye morphogenesis GO:0048592 16 0.029
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.029
mesodermal cell fate specification GO:0007501 2 0.029
positive regulation of apoptotic process GO:0043065 246 0.029
ribonucleotide catabolic process GO:0009261 405 0.029
cellular cation homeostasis GO:0030003 163 0.029
cell differentiation involved in kidney development GO:0061005 9 0.029
multi organism cellular process GO:0044764 156 0.029
response to cytokine GO:0034097 232 0.029
regulation of growth GO:0040008 165 0.029
nucleotide biosynthetic process GO:0009165 109 0.029
metal ion transport GO:0030001 272 0.029
cytosolic calcium ion homeostasis GO:0051480 89 0.029
ribonucleotide biosynthetic process GO:0009260 81 0.029
response to estrogen GO:0043627 47 0.029
negative regulation of locomotion GO:0040013 118 0.029
positive regulation of kinase activity GO:0033674 204 0.028
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.028
pattern specification process GO:0007389 43 0.028
Mouse
cytokine production GO:0001816 247 0.028
cellular chemical homeostasis GO:0055082 180 0.028
limbic system development GO:0021761 3 0.028
Mouse
negative regulation of cell cycle GO:0045786 193 0.028
somitogenesis GO:0001756 2 0.028
erk1 and erk2 cascade GO:0070371 104 0.028
cation homeostasis GO:0055080 189 0.028
axis elongation GO:0003401 4 0.027
defense response GO:0006952 315 0.027
sensory perception GO:0007600 103 0.027
positive regulation of organelle organization GO:0010638 195 0.027
multicellular organismal response to stress GO:0033555 1 0.027
cytoplasmic transport GO:0016482 379 0.027
organ induction GO:0001759 4 0.027
compound eye development GO:0048749 1 0.027
inorganic cation transmembrane transport GO:0098662 194 0.027
adult locomotory behavior GO:0008344 1 0.027
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.027
regulation of organ formation GO:0003156 4 0.027
protein localization to organelle GO:0033365 280 0.027
regulation of nucleotide biosynthetic process GO:0030808 50 0.026
positive regulation of secretion GO:0051047 116 0.026
muscle tissue development GO:0060537 62 0.026
Human
regulation of kidney development GO:0090183 10 0.026
regulation of heart induction GO:0090381 2 0.026
positive regulation of nucleoside metabolic process GO:0045979 186 0.026
muscle contraction GO:0006936 73 0.026
interspecies interaction between organisms GO:0044419 156 0.026
immune response GO:0006955 307 0.026
forelimb morphogenesis GO:0035136 4 0.026
response to other organism GO:0051707 261 0.026
Rat
ventral spinal cord interneuron differentiation GO:0021514 1 0.026
negative regulation of testosterone biosynthetic process GO:2000225 1 0.026
regulation of small gtpase mediated signal transduction GO:0051056 156 0.026
neural tube formation GO:0001841 3 0.026
camp metabolic process GO:0046058 61 0.026
regulation of dna metabolic process GO:0051052 153 0.025
lipid biosynthetic process GO:0008610 177 0.025
nephric duct development GO:0072176 4 0.025
response to decreased oxygen levels GO:0036293 96 0.025
follicle stimulating hormone secretion GO:0046884 3 0.025
signal transduction by phosphorylation GO:0023014 297 0.025
soft palate development GO:0060023 3 0.025
mesodermal cell fate commitment GO:0001710 2 0.024
cellular calcium ion homeostasis GO:0006874 117 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.024
small gtpase mediated signal transduction GO:0007264 78 0.024
mitotic cell cycle GO:0000278 326 0.024

NKX2-1 disease predictions

Disease DO term ID Size Probability Func Analog Org
thyroid gland disease DOID:50 11 0.138
Human
hypothyroidism DOID:1459 10 0.138
Human
congenital hypothyroidism DOID:0050328 8 0.138
Human
endocrine system disease DOID:28 26 0.138
Human
kidney disease DOID:557 36 0.035
urinary system disease DOID:18 40 0.035
disease of cellular proliferation DOID:14566 174 0.033
renal tubular transport disease DOID:447 11 0.030
musculoskeletal system disease DOID:17 223 0.030
cancer DOID:162 167 0.029
organ system cancer DOID:0050686 164 0.029
disease of metabolism DOID:0014667 295 0.024