Homo sapiens

58 known processes

POLE

polymerase (DNA directed), epsilon

(Aliases: FLJ21434,POLE1,DKFZp434F222)

POLE biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.534
dna dependent dna replication GO:0006261 44 0.520
Yeast
dna replication GO:0006260 116 0.452
cellular response to dna damage stimulus GO:0006974 379 0.360
regulation of cell cycle GO:0051726 393 0.288
Yeast
chromatin modification GO:0016568 298 0.256
atp catabolic process GO:0006200 157 0.253
dna repair GO:0006281 198 0.201
determination of adult lifespan GO:0008340 2 0.174
peptidyl lysine modification GO:0018205 144 0.157
dna strand elongation involved in dna replication GO:0006271 3 0.145
Yeast
dna biosynthetic process GO:0071897 40 0.145
peptidyl lysine acetylation GO:0018394 101 0.137
ribonucleotide catabolic process GO:0009261 405 0.129
vesicle mediated transport GO:0016192 371 0.128
ribonucleoside triphosphate catabolic process GO:0009203 391 0.121
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.117
multicellular organismal aging GO:0010259 3 0.116
purine ribonucleotide catabolic process GO:0009154 404 0.113
organophosphate catabolic process GO:0046434 430 0.106
histone exchange GO:0043486 3 0.099
embryo development GO:0009790 123 0.094
Worm
female gamete generation GO:0007292 2 0.094
cellular macromolecular complex assembly GO:0034622 324 0.094
response to abiotic stimulus GO:0009628 336 0.093
chromatin organization GO:0006325 351 0.089
Yeast
histone acetylation GO:0016573 93 0.086
purine ribonucleoside metabolic process GO:0046128 437 0.086
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.086
translesion synthesis GO:0019985 8 0.085
Yeast
mitotic cell cycle process GO:1903047 286 0.085
dna recombination GO:0006310 77 0.085
Yeast
regulation of gene expression epigenetic GO:0040029 73 0.084
Yeast
purine nucleotide catabolic process GO:0006195 405 0.083
regulation of cell cycle process GO:0010564 266 0.080
Yeast
negative regulation of cell cycle GO:0045786 193 0.080
Yeast
internal peptidyl lysine acetylation GO:0018393 97 0.078
cellular amino acid metabolic process GO:0006520 116 0.076
purine nucleoside triphosphate catabolic process GO:0009146 392 0.076
dna geometric change GO:0032392 32 0.075
ribonucleoside monophosphate metabolic process GO:0009161 187 0.073
reproductive process GO:0022414 106 0.070
Worm
single organism reproductive process GO:0044702 98 0.069
Worm
nucleoside triphosphate catabolic process GO:0009143 394 0.068
purine containing compound catabolic process GO:0072523 411 0.067
oogenesis GO:0048477 2 0.067
response to ionizing radiation GO:0010212 65 0.067
cell development GO:0048468 328 0.067
nucleoside catabolic process GO:0009164 408 0.066
response to radiation GO:0009314 151 0.065
nucleus localization GO:0051647 1 0.063
purine nucleoside catabolic process GO:0006152 398 0.062
nuclear migration GO:0007097 1 0.061
purine ribonucleoside catabolic process GO:0046130 398 0.060
regulation of cell cycle phase transition GO:1901987 126 0.060
Yeast
negative regulation of mitotic cell cycle GO:0045930 102 0.060
Yeast
glycosyl compound catabolic process GO:1901658 413 0.059
chromosome segregation GO:0007059 114 0.058
Yeast
meiotic chromosome segregation GO:0045132 4 0.058
nervous system development GO:0007399 293 0.057
covalent chromatin modification GO:0016569 254 0.057
mitotic cell cycle GO:0000278 326 0.057
cell cycle phase transition GO:0044770 173 0.056
nucleoside phosphate catabolic process GO:1901292 412 0.055
atp metabolic process GO:0046034 176 0.055
ribonucleoside triphosphate metabolic process GO:0009199 412 0.053
nucleoside monophosphate catabolic process GO:0009125 159 0.053
nucleotide catabolic process GO:0009166 408 0.052
cellular ketone metabolic process GO:0042180 80 0.051
establishment of nucleus localization GO:0040023 1 0.050
ribonucleoside catabolic process GO:0042454 406 0.047
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
gene silencing GO:0016458 49 0.044
Yeast
meiosis i GO:0007127 4 0.042
regulation of cellular ketone metabolic process GO:0010565 50 0.041
histone modification GO:0016570 251 0.038
mitotic dna damage checkpoint GO:0044773 28 0.038
Yeast
endocytosis GO:0006897 159 0.037
nucleotide excision repair GO:0006289 31 0.037
microtubule based process GO:0007017 210 0.036
internal protein amino acid acetylation GO:0006475 101 0.035
oocyte differentiation GO:0009994 2 0.035
neurogenesis GO:0022008 169 0.034
cellular component morphogenesis GO:0032989 314 0.034
chromatin remodeling GO:0006338 55 0.034
nuclear division GO:0000280 128 0.034
Yeast
lagging strand elongation GO:0006273 3 0.032
regulation of mitotic cell cycle phase transition GO:1901990 118 0.031
Yeast
purine nucleoside monophosphate catabolic process GO:0009128 158 0.031
regulation of cytoskeleton organization GO:0051493 177 0.031
response to inorganic substance GO:0010035 127 0.031
negative regulation of cell cycle process GO:0010948 121 0.031
Yeast
nucleoside monophosphate metabolic process GO:0009123 191 0.031
regulation of cellular amino acid metabolic process GO:0006521 6 0.030
protein acetylation GO:0006473 116 0.030
response to nitrogen compound GO:1901698 184 0.030
protein dna complex subunit organization GO:0071824 80 0.030
positive regulation of cell proliferation GO:0008284 301 0.030
endomembrane system organization GO:0010256 196 0.029
mitotic sister chromatid cohesion GO:0007064 12 0.029
Yeast
double strand break repair GO:0006302 101 0.028
Yeast
purine nucleoside triphosphate metabolic process GO:0009144 412 0.028
regulation of cellular component biogenesis GO:0044087 281 0.027
membrane organization GO:0061024 292 0.027
nucleoside triphosphate metabolic process GO:0009141 422 0.027
multi organism reproductive process GO:0044703 54 0.027
cell morphogenesis GO:0000902 296 0.027
amine metabolic process GO:0009308 44 0.026
primary mirna processing GO:0031053 3 0.026
posttranscriptional regulation of gene expression GO:0010608 213 0.026
protein acylation GO:0043543 138 0.026
chromatin assembly or disassembly GO:0006333 78 0.025
neuron projection development GO:0031175 106 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.025
regulation of multi organism process GO:0043900 157 0.025
negative regulation of cell death GO:0060548 345 0.024
actin filament based process GO:0030029 224 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.022
cell projection organization GO:0030030 252 0.022
cellular amine metabolic process GO:0044106 41 0.021
gtp metabolic process GO:0046039 239 0.021
protein localization to organelle GO:0033365 280 0.021
negative regulation of apoptotic process GO:0043066 316 0.021
negative regulation of developmental process GO:0051093 247 0.021
cell projection morphogenesis GO:0048858 129 0.020
histone methylation GO:0016571 60 0.020
central nervous system development GO:0007417 123 0.020
cell cycle checkpoint GO:0000075 117 0.020
Yeast
mitotic cell cycle phase transition GO:0044772 162 0.020
mitotic nuclear division GO:0007067 119 0.020
Yeast
response to fungus GO:0009620 4 0.020
immune system development GO:0002520 195 0.020
protein dna complex assembly GO:0065004 64 0.020
single organism cellular localization GO:1902580 332 0.019
chemical homeostasis GO:0048878 306 0.019
locomotory behavior GO:0007626 1 0.019
positive regulation of developmental process GO:0051094 314 0.019
regulation of chromosome segregation GO:0051983 44 0.019
rna processing GO:0006396 255 0.019
protein alkylation GO:0008213 74 0.019
regulation of transcription by chromatin organization GO:0034401 1 0.019
organelle fission GO:0048285 149 0.019
Yeast
recombinational repair GO:0000725 50 0.019
regulation of mitotic cell cycle GO:0007346 189 0.019
Yeast
dna packaging GO:0006323 77 0.019
cellular response to nitrogen compound GO:1901699 144 0.018
anatomical structure homeostasis GO:0060249 100 0.018
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
cell part morphogenesis GO:0032990 137 0.018
regulation of protein localization GO:0032880 296 0.018
ion homeostasis GO:0050801 230 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
atp dependent chromatin remodeling GO:0043044 25 0.017
brain development GO:0007420 97 0.017
protein ubiquitination GO:0016567 314 0.017
dna damage checkpoint GO:0000077 68 0.017
Yeast
methylation GO:0032259 106 0.017
epithelium development GO:0060429 227 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.017
Yeast
establishment of protein localization to organelle GO:0072594 172 0.017
dephosphorylation GO:0016311 209 0.017
reproduction GO:0000003 63 0.017
Worm
nucleosome organization GO:0034728 66 0.016
negative regulation of transport GO:0051051 176 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
positive regulation of catabolic process GO:0009896 310 0.016
neuron differentiation GO:0030182 138 0.016
response to organic cyclic compound GO:0014070 204 0.016
response to oxygen containing compound GO:1901700 369 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
intracellular protein transport GO:0006886 270 0.016
gene silencing by mirna GO:0035195 23 0.016
positive regulation of cell death GO:0010942 263 0.016
chromatin silencing GO:0006342 12 0.015
Yeast
protein catabolic process GO:0030163 325 0.015
tube development GO:0035295 125 0.015
head development GO:0060322 108 0.015
oocyte development GO:0048599 1 0.015
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.015
Yeast
mitotic cell cycle checkpoint GO:0007093 68 0.015
Yeast
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.015
mitochondrion organization GO:0007005 156 0.015
positive regulation of cellular amine metabolic process GO:0033240 7 0.015
dna conformation change GO:0071103 113 0.015
macromolecule methylation GO:0043414 97 0.015
mitotic sister chromatid segregation GO:0000070 53 0.014
Yeast
regulation of microtubule cytoskeleton organization GO:0070507 61 0.014
mapk cascade GO:0000165 288 0.014
cell cycle g2 m phase transition GO:0044839 43 0.014
Yeast
regeneration GO:0031099 4 0.014
response to uv GO:0009411 73 0.014
protein modification by small protein conjugation GO:0032446 342 0.014
dna strand elongation GO:0022616 5 0.014
Yeast
regulation of chromosome organization GO:0033044 103 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.014
growth GO:0040007 202 0.014
regulation of microtubule based process GO:0032886 74 0.014
adult locomotory behavior GO:0008344 1 0.013
organelle assembly GO:0070925 176 0.013
regulation of viral genome replication GO:0045069 48 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
tube closure GO:0060606 3 0.013
single organism membrane organization GO:0044802 268 0.013
dna integrity checkpoint GO:0031570 71 0.013
Yeast
regulation of growth GO:0040008 165 0.013
cilium assembly GO:0042384 63 0.013
protein import GO:0017038 130 0.012
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.012
multicellular organismal reproductive process GO:0048609 40 0.012
receptor mediated endocytosis GO:0006898 84 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
cellular response to radiation GO:0071478 65 0.012
neuron development GO:0048666 113 0.012
alpha amino acid metabolic process GO:1901605 72 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
spermatid development GO:0007286 4 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
regulation of dna replication GO:0006275 68 0.012
protein oligomerization GO:0051259 173 0.012
non recombinational repair GO:0000726 14 0.012
Yeast
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
cellular response to organic cyclic compound GO:0071407 127 0.012
microtubule organizing center organization GO:0031023 62 0.012
protein targeting to nucleus GO:0044744 104 0.012
negative regulation of cellular protein metabolic process GO:0032269 353 0.011
base excision repair GO:0006284 21 0.011
hemopoiesis GO:0030097 180 0.011
microtubule cytoskeleton organization GO:0000226 176 0.011
response to other organism GO:0051707 261 0.011
centrosome organization GO:0051297 58 0.011
neuromuscular junction development GO:0007528 3 0.011
cell division GO:0051301 168 0.011
aging GO:0007568 66 0.011
rna interference GO:0016246 4 0.011
regulation of dephosphorylation GO:0035303 96 0.011
posttranscriptional gene silencing GO:0016441 25 0.010
cell projection assembly GO:0030031 126 0.010
myosin filament organization GO:0031033 2 0.010
myosin filament assembly GO:0031034 2 0.010
regulation of cell differentiation GO:0045595 393 0.010
spermatid differentiation GO:0048515 4 0.010
positive regulation of programmed cell death GO:0043068 249 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
negative regulation of cell cycle phase transition GO:1901988 89 0.010
Yeast
hematopoietic or lymphoid organ development GO:0048534 186 0.010
gtp catabolic process GO:0006184 237 0.010
positive regulation of cellular component organization GO:0051130 376 0.010
histone lysine methylation GO:0034968 50 0.010
dna duplex unwinding GO:0032508 30 0.010

POLE disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.185
disease of cellular proliferation DOID:14566 174 0.185
organ system cancer DOID:0050686 164 0.043
musculoskeletal system disease DOID:17 223 0.039
bone development disease DOID:0080006 55 0.021
bone disease DOID:0080001 88 0.021
dysostosis DOID:1934 22 0.021
connective tissue disease DOID:65 109 0.021
gastrointestinal system cancer DOID:3119 52 0.020
integumentary system disease DOID:16 43 0.013
disease of metabolism DOID:0014667 295 0.011
large intestine cancer DOID:5672 29 0.010
intestinal cancer DOID:10155 29 0.010
colorectal cancer DOID:9256 29 0.010