Homo sapiens

0 known processes

KLHDC4

kelch domain containing 4

(Aliases: DKFZp434G0522,FLJ00104)

KLHDC4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
defense response to fungus GO:0050832 4 0.078
positive regulation of transcription during mitosis GO:0045897 2 0.074
regulation of transcription from rna polymerase ii promoter mitotic GO:0046021 1 0.062
regulation of cell cycle GO:0051726 393 0.054
post embryonic development GO:0009791 2 0.052
cellular response to dna damage stimulus GO:0006974 379 0.047
chromatin modification GO:0016568 298 0.047
response to fungus GO:0009620 4 0.046
regulation of transcription during mitosis GO:0045896 2 0.046
chromatin organization GO:0006325 351 0.043
defense response GO:0006952 315 0.042
covalent chromatin modification GO:0016569 254 0.041
negative regulation of cell death GO:0060548 345 0.041
positive regulation of transcription from rna polymerase ii promoter during mitosis GO:0046022 1 0.038
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.038
negative regulation of apoptotic process GO:0043066 316 0.037
negative regulation of cellular protein metabolic process GO:0032269 353 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.034
lipid metabolic process GO:0006629 381 0.034
negative regulation of protein metabolic process GO:0051248 391 0.034
protein catabolic process GO:0030163 325 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.032
response to oxygen containing compound GO:1901700 369 0.032
purine nucleoside catabolic process GO:0006152 398 0.032
regulation of cell cycle process GO:0010564 266 0.032
negative regulation of programmed cell death GO:0043069 321 0.031
cellular amine metabolic process GO:0044106 41 0.031
regulation of cellular amine metabolic process GO:0033238 11 0.031
regulation of locomotion GO:0040012 329 0.031
purine containing compound catabolic process GO:0072523 411 0.031
locomotory behavior GO:0007626 1 0.031
negative regulation of cellular component organization GO:0051129 235 0.030
nervous system development GO:0007399 293 0.029
regeneration GO:0031099 4 0.028
positive regulation of organelle organization GO:0010638 195 0.028
peptidyl lysine dimethylation GO:0018027 3 0.028
forebrain generation of neurons GO:0021872 3 0.027
regulation of protein catabolic process GO:0042176 155 0.027
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.027
cellular macromolecule catabolic process GO:0044265 380 0.027
positive regulation of hydrolase activity GO:0051345 331 0.027
neuromuscular junction development GO:0007528 3 0.026
histone modification GO:0016570 251 0.026
regulation of synaptic plasticity GO:0048167 3 0.026
segmentation GO:0035282 4 0.026
organophosphate catabolic process GO:0046434 430 0.026
regulation of cellular ketone metabolic process GO:0010565 50 0.026
regulation of cell differentiation GO:0045595 393 0.026
cytoplasmic transport GO:0016482 379 0.026
methylation GO:0032259 106 0.026
response to abiotic stimulus GO:0009628 336 0.026
regulation of cellular component movement GO:0051270 334 0.026
nucleoside catabolic process GO:0009164 408 0.025
positive regulation of neural precursor cell proliferation GO:2000179 2 0.025
positive regulation of catabolic process GO:0009896 310 0.025
cellular ketone metabolic process GO:0042180 80 0.025
negative regulation of protein modification process GO:0031400 200 0.025
macromolecule methylation GO:0043414 97 0.025
positive regulation of cellular component organization GO:0051130 376 0.025
response to external biotic stimulus GO:0043207 261 0.025
regulation of cellular amino acid metabolic process GO:0006521 6 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.025
positive regulation of hormone biosynthetic process GO:0046886 4 0.025
female gamete generation GO:0007292 2 0.025
histone methylation GO:0016571 60 0.025
ribonucleotide catabolic process GO:0009261 405 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
purine ribonucleoside metabolic process GO:0046128 437 0.024
positive regulation of phosphorylation GO:0042327 394 0.024
positive regulation of cell motility GO:2000147 177 0.024
cellular protein catabolic process GO:0044257 261 0.024
regulation of proteolysis GO:0030162 293 0.024
protein alkylation GO:0008213 74 0.024
cellular amino acid metabolic process GO:0006520 116 0.024
multicellular organismal aging GO:0010259 3 0.023
maintenance of location GO:0051235 112 0.023
positive regulation of cell proliferation GO:0008284 301 0.023
regulation of histone h3 k27 methylation GO:0061085 4 0.023
small gtpase mediated signal transduction GO:0007264 78 0.023
secretion GO:0046903 254 0.023
membrane organization GO:0061024 292 0.023
protein methylation GO:0006479 74 0.022
metencephalon development GO:0022037 2 0.022
positive regulation of cell differentiation GO:0045597 211 0.022
negative regulation of transport GO:0051051 176 0.022
ribonucleoside catabolic process GO:0042454 406 0.022
double strand break repair GO:0006302 101 0.022
determination of adult lifespan GO:0008340 2 0.022
positive regulation of cellular amine metabolic process GO:0033240 7 0.022
lipid biosynthetic process GO:0008610 177 0.022
protein localization to organelle GO:0033365 280 0.021
small molecule biosynthetic process GO:0044283 157 0.021
positive regulation of cell migration GO:0030335 172 0.021
regulation of protein localization GO:0032880 296 0.021
positive regulation of synaptic transmission GO:0050806 4 0.021
cellular lipid metabolic process GO:0044255 303 0.021
purine nucleoside triphosphate metabolic process GO:0009144 412 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
regulation of protein transport GO:0051223 213 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
biological adhesion GO:0022610 331 0.021
negative regulation of multicellular organismal process GO:0051241 317 0.021
posttranscriptional regulation of gene expression GO:0010608 213 0.021
thymus development GO:0048538 3 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
positive regulation of immune system process GO:0002684 283 0.020
protein maturation GO:0051604 233 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
histone lysine methylation GO:0034968 50 0.020
single organism cellular localization GO:1902580 332 0.020
positive regulation of locomotion GO:0040017 186 0.020
amine metabolic process GO:0009308 44 0.019
regulation of homeostatic process GO:0032844 121 0.019
neuron fate commitment GO:0048663 2 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
proteasomal protein catabolic process GO:0010498 176 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
chromatin silencing at rdna GO:0000183 5 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
vesicle mediated transport GO:0016192 371 0.019
negative regulation of organelle organization GO:0010639 126 0.019
regulation of transferase activity GO:0051338 355 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
compound eye development GO:0048749 1 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
response to other organism GO:0051707 261 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
blastoderm segmentation GO:0007350 2 0.018
nitrogen compound transport GO:0071705 191 0.018
regulation of chromatin organization GO:1902275 56 0.018
positive regulation of transport GO:0051050 336 0.018
hindbrain development GO:0030902 3 0.018
negative regulation of protein transport GO:0051224 75 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
nucleoside triphosphate metabolic process GO:0009141 422 0.018
oxidation reduction process GO:0055114 396 0.018
nucleotide catabolic process GO:0009166 408 0.018
mitotic cell cycle GO:0000278 326 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
response to biotic stimulus GO:0009607 276 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
post embryonic organ development GO:0048569 1 0.018
regulation of cell motility GO:2000145 299 0.018
protein processing GO:0016485 226 0.018
positive regulation of developmental process GO:0051094 314 0.017
forebrain neuron differentiation GO:0021879 3 0.017
regulation of chromosome organization GO:0033044 103 0.017
oogenesis GO:0048477 2 0.017
protein localization to membrane GO:0072657 160 0.017
epidermis development GO:0008544 59 0.017
innate immune response GO:0045087 178 0.017
positive regulation of cell cycle process GO:0090068 106 0.017
cellular response to lipid GO:0071396 127 0.017
regulation of cell migration GO:0030334 289 0.017
negative regulation of cell cycle GO:0045786 193 0.017
system process GO:0003008 349 0.017
ras protein signal transduction GO:0007265 73 0.017
mitotic cell cycle process GO:1903047 286 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.017
regulation of secretion by cell GO:1903530 177 0.017
spermatid differentiation GO:0048515 4 0.017
protein ubiquitination GO:0016567 314 0.017
regulation of kinase activity GO:0043549 314 0.016
growth GO:0040007 202 0.016
hair follicle morphogenesis GO:0031069 2 0.016
regulation of response to external stimulus GO:0032101 222 0.016
regulation of neural precursor cell proliferation GO:2000177 4 0.016
nucleoside phosphate catabolic process GO:1901292 412 0.016
protein modification by small protein conjugation GO:0032446 342 0.016
regulation of protein kinase activity GO:0045859 289 0.016
negative regulation of developmental process GO:0051093 247 0.016
secretion by cell GO:0032940 226 0.016
immune response GO:0006955 307 0.016
memory GO:0007613 3 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
glycosyl compound catabolic process GO:1901658 413 0.016
positive regulation of transferase activity GO:0051347 227 0.016
positive regulation of cell death GO:0010942 263 0.016
negative regulation of catalytic activity GO:0043086 335 0.016
peptidyl lysine modification GO:0018205 144 0.016
translation GO:0006412 132 0.016
dephosphorylation GO:0016311 209 0.016
epithelial cell proliferation GO:0050673 128 0.015
cell cycle phase transition GO:0044770 173 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
positive regulation of protein catabolic process GO:0045732 75 0.015
modification dependent macromolecule catabolic process GO:0043632 212 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
chemical homeostasis GO:0048878 306 0.015
epidermis morphogenesis GO:0048730 3 0.015
cell morphogenesis GO:0000902 296 0.015
carboxylic acid biosynthetic process GO:0046394 97 0.015
response to lipid GO:0033993 206 0.015
rna interference GO:0016246 4 0.015
inner ear morphogenesis GO:0042472 4 0.015
negative regulation of protein maturation GO:1903318 142 0.015
neural crest cell development GO:0014032 3 0.015
actin filament based process GO:0030029 224 0.015
regulation of protein maturation GO:1903317 150 0.015
regulation of cell cycle arrest GO:0071156 36 0.015
ribonucleoside triphosphate catabolic process GO:0009203 391 0.015
regulation of cell growth GO:0001558 135 0.015
long term synaptic potentiation GO:0060291 1 0.015
defense response to other organism GO:0098542 129 0.015
stem cell division GO:0017145 2 0.015
positive regulation of secretion GO:0051047 116 0.015
rab protein signal transduction GO:0032482 4 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
gtp metabolic process GO:0046039 239 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
response to cytokine GO:0034097 232 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.014
cardiovascular system development GO:0072358 262 0.014
mitotic cell cycle phase transition GO:0044772 162 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.014
single organism membrane organization GO:0044802 268 0.014
pituitary gland development GO:0021983 2 0.014
apoptotic signaling pathway GO:0097190 268 0.014
tongue development GO:0043586 1 0.014
cell development GO:0048468 328 0.014
oocyte development GO:0048599 1 0.014
cellular response to external stimulus GO:0071496 111 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
regulation of secretion GO:0051046 194 0.013
regulation of growth GO:0040008 165 0.013
hippocampus development GO:0021766 1 0.013
endomembrane system organization GO:0010256 196 0.013
protein secretion GO:0009306 98 0.013
gtp catabolic process GO:0006184 237 0.013
protein targeting GO:0006605 187 0.013
regulation of cell development GO:0060284 161 0.013
neurogenesis GO:0022008 169 0.013
regulation of cellular response to stress GO:0080135 244 0.013
positive regulation of kinase activity GO:0033674 204 0.013
intracellular protein transport GO:0006886 270 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
nuclear transport GO:0051169 179 0.013
regulation of innate immune response GO:0045088 97 0.013
cell fate determination GO:0001709 3 0.013
positive regulation of cell development GO:0010720 92 0.013
regulation of immune response GO:0050776 201 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
epithelial cell differentiation GO:0030855 141 0.013
photoreceptor cell differentiation GO:0046530 2 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
motor neuron axon guidance GO:0008045 2 0.013
hemopoiesis GO:0030097 180 0.013
regulation of intracellular transport GO:0032386 195 0.013
nerve development GO:0021675 4 0.013
cellular homeostasis GO:0019725 196 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
negative regulation of chromatin modification GO:1903309 21 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.013
cell adhesion GO:0007155 325 0.013
cardiac muscle cell contraction GO:0086003 4 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
anterior posterior axis specification GO:0009948 2 0.012
negative regulation of circadian rhythm GO:0042754 1 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
neurological system process GO:0050877 163 0.012
transmembrane transport GO:0055085 399 0.012
regulation of epithelial cell proliferation GO:0050678 113 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
cerebellum development GO:0021549 2 0.012
immune system development GO:0002520 195 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
rhythmic behavior GO:0007622 2 0.012
neurotransmitter secretion GO:0007269 4 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
cell projection organization GO:0030030 252 0.012
cell growth GO:0016049 160 0.012
regulation of protein processing GO:0070613 150 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
spermatid development GO:0007286 4 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
positive regulation of secretion by cell GO:1903532 108 0.012
regulation of glial cell differentiation GO:0045685 3 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
regulation of dna metabolic process GO:0051052 153 0.012
regulation of defense response GO:0031347 154 0.012
mitochondrion organization GO:0007005 156 0.012
lipid localization GO:0010876 106 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
positive regulation of collateral sprouting GO:0048672 2 0.012
response to organonitrogen compound GO:0010243 156 0.012
startle response GO:0001964 3 0.012
tissue regeneration GO:0042246 3 0.012
response to inorganic substance GO:0010035 127 0.012
negative regulation of proteolysis GO:0045861 132 0.012
receptor metabolic process GO:0043112 81 0.012
organ formation GO:0048645 3 0.012
rho protein signal transduction GO:0007266 26 0.012
negative regulation of protein processing GO:0010955 142 0.012
regulation of cytokine production GO:0001817 232 0.012
reactive nitrogen species metabolic process GO:2001057 3 0.012
positive regulation of proteolysis GO:0045862 142 0.012
carbohydrate metabolic process GO:0005975 207 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
tripartite regional subdivision GO:0007351 2 0.011
positive regulation of protein transport GO:0051222 135 0.011
plasma membrane organization GO:0007009 115 0.011
alcohol metabolic process GO:0006066 114 0.011
actin filament based movement GO:0030048 17 0.011
peptidyl tyrosine modification GO:0018212 170 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
limbic system development GO:0021761 3 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
cation transport GO:0006812 331 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
response to organic cyclic compound GO:0014070 204 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
cellular component morphogenesis GO:0032989 314 0.011
metal ion transport GO:0030001 272 0.011
oocyte differentiation GO:0009994 2 0.011
response to nitrogen compound GO:1901698 184 0.011
single organism nuclear import GO:1902593 104 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
monocarboxylic acid metabolic process GO:0032787 185 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
ion homeostasis GO:0050801 230 0.011
visual behavior GO:0007632 2 0.011
regulation of peptide transport GO:0090087 62 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
ion transmembrane transport GO:0034220 338 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
fatty acid metabolic process GO:0006631 115 0.011
glycerolipid metabolic process GO:0046486 107 0.011
negative regulation of chromosome organization GO:2001251 48 0.011
protein oligomerization GO:0051259 173 0.011
cellular response to nutrient levels GO:0031669 69 0.011
nuclear division GO:0000280 128 0.011
positive regulation of gtp catabolic process GO:0033126 166 0.011
regulation of cell adhesion GO:0030155 166 0.011
cytokine production GO:0001816 247 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
regulation of nucleocytoplasmic transport GO:0046822 98 0.011
regulation of gtpase activity GO:0043087 180 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
negative regulation of growth GO:0045926 97 0.011
positive regulation of gtpase activity GO:0043547 166 0.011
positive regulation of chromosome organization GO:2001252 41 0.010
positive regulation of cell cycle GO:0045787 140 0.010
head development GO:0060322 108 0.010
regulation of mapk cascade GO:0043408 262 0.010
cell projection assembly GO:0030031 126 0.010
positive regulation of response to external stimulus GO:0032103 88 0.010
response to wounding GO:0009611 168 0.010
peptidyl lysine methylation GO:0018022 37 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.010
ectodermal placode development GO:0071696 1 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010
purine nucleoside monophosphate catabolic process GO:0009128 158 0.010
regulation of cellular component biogenesis GO:0044087 281 0.010
monocarboxylic acid biosynthetic process GO:0072330 67 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
amide transport GO:0042886 76 0.010
establishment of protein localization to membrane GO:0090150 121 0.010
negative regulation of axonogenesis GO:0050771 4 0.010
positive regulation of cytokine production GO:0001819 167 0.010
circadian behavior GO:0048512 2 0.010
sequestering of metal ion GO:0051238 24 0.010
signal transduction by phosphorylation GO:0023014 297 0.010
syncytium formation by plasma membrane fusion GO:0000768 2 0.010
positive regulation of ras gtpase activity GO:0032320 117 0.010
regulation of binding GO:0051098 111 0.010
glycoprotein metabolic process GO:0009100 110 0.010
regulation of mitotic cell cycle GO:0007346 189 0.010
regulation of protein stability GO:0031647 87 0.010
adult locomotory behavior GO:0008344 1 0.010
cellular response to extracellular stimulus GO:0031668 72 0.010
mitotic sister chromatid segregation GO:0000070 53 0.010
cell activation GO:0001775 213 0.010
chemotaxis GO:0006935 157 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.010

KLHDC4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.023
central nervous system disease DOID:331 186 0.021
nervous system disease DOID:863 431 0.021
musculoskeletal system disease DOID:17 223 0.018
inherited metabolic disorder DOID:655 242 0.018
sensory system disease DOID:0050155 203 0.013
cancer DOID:162 167 0.012
disease of cellular proliferation DOID:14566 174 0.012
organ system cancer DOID:0050686 164 0.012
brain disease DOID:936 73 0.012
connective tissue disease DOID:65 109 0.012
muscular disease DOID:0080000 114 0.011
retinal disease DOID:5679 118 0.011
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011
muscle tissue disease DOID:66 113 0.011
neurodegenerative disease DOID:1289 102 0.010