Homo sapiens

27 known processes

POLK

polymerase (DNA directed) kappa

(Aliases: DINP,POLQ,DINB1)

POLK biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ribonucleotide catabolic process GO:0009261 405 0.124
dna repair GO:0006281 198 0.121
cellular response to dna damage stimulus GO:0006974 379 0.096
nucleoside triphosphate catabolic process GO:0009143 394 0.096
organophosphate catabolic process GO:0046434 430 0.092
purine nucleoside triphosphate catabolic process GO:0009146 392 0.089
purine nucleoside catabolic process GO:0006152 398 0.089
double strand break repair via homologous recombination GO:0000724 50 0.086
regulation of dna metabolic process GO:0051052 153 0.086
nucleoside triphosphate metabolic process GO:0009141 422 0.079
purine nucleotide catabolic process GO:0006195 405 0.078
ribonucleoside triphosphate metabolic process GO:0009199 412 0.073
nucleoside catabolic process GO:0009164 408 0.071
purine ribonucleoside metabolic process GO:0046128 437 0.071
double strand break repair GO:0006302 101 0.071
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.067
response to abiotic stimulus GO:0009628 336 0.066
positive regulation of hydrolase activity GO:0051345 331 0.063
recombinational repair GO:0000725 50 0.063
purine ribonucleotide catabolic process GO:0009154 404 0.062
nucleoside phosphate catabolic process GO:1901292 412 0.062
purine containing compound catabolic process GO:0072523 411 0.061
gtp metabolic process GO:0046039 239 0.058
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.056
guanosine containing compound catabolic process GO:1901069 239 0.056
ribonucleoside triphosphate catabolic process GO:0009203 391 0.056
regulation of nucleotide catabolic process GO:0030811 205 0.054
glycosyl compound catabolic process GO:1901658 413 0.054
regulation of cellular response to stress GO:0080135 244 0.053
vesicle mediated transport GO:0016192 371 0.052
regulation of purine nucleotide catabolic process GO:0033121 205 0.052
cellular macromolecule catabolic process GO:0044265 380 0.051
regulation of gtpase activity GO:0043087 180 0.050
postreplication repair GO:0006301 12 0.049
purine ribonucleoside catabolic process GO:0046130 398 0.048
purine nucleoside triphosphate metabolic process GO:0009144 412 0.046
guanosine containing compound metabolic process GO:1901068 244 0.045
nucleotide catabolic process GO:0009166 408 0.045
positive regulation of nucleotide catabolic process GO:0030813 185 0.044
response to uv GO:0009411 73 0.044
regulation of gtp catabolic process GO:0033124 180 0.044
translesion synthesis GO:0019985 8 0.043
gtp catabolic process GO:0006184 237 0.043
dna recombination GO:0006310 77 0.043
regulation of purine nucleotide metabolic process GO:1900542 264 0.043
regulation of nucleotide metabolic process GO:0006140 269 0.041
positive regulation of cellular catabolic process GO:0031331 284 0.039
positive regulation of catabolic process GO:0009896 310 0.039
response to radiation GO:0009314 151 0.039
positive regulation of gtpase activity GO:0043547 166 0.038
positive regulation of nucleoside metabolic process GO:0045979 186 0.038
negative regulation of cell death GO:0060548 345 0.038
cellular amino acid metabolic process GO:0006520 116 0.036
regulation of nucleoside metabolic process GO:0009118 209 0.035
amine metabolic process GO:0009308 44 0.035
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.033
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.033
dna biosynthetic process GO:0071897 40 0.033
negative regulation of programmed cell death GO:0043069 321 0.033
post embryonic development GO:0009791 2 0.032
cytoplasmic transport GO:0016482 379 0.031
ribonucleoside catabolic process GO:0042454 406 0.029
intracellular protein transport GO:0006886 270 0.028
response to light stimulus GO:0009416 87 0.028
regulation of pathway restricted smad protein phosphorylation GO:0060393 34 0.028
negative regulation of phosphorus metabolic process GO:0010563 267 0.027
regulation of double strand break repair via homologous recombination GO:0010569 11 0.027
positive regulation of gtp catabolic process GO:0033126 166 0.027
cellular ketone metabolic process GO:0042180 80 0.026
positive regulation of nucleotide metabolic process GO:0045981 230 0.025
negative regulation of apoptotic process GO:0043066 316 0.025
immune response GO:0006955 307 0.025
multicellular organismal aging GO:0010259 3 0.025
regulation of cell cycle process GO:0010564 266 0.023
hematopoietic or lymphoid organ development GO:0048534 186 0.023
determination of adult lifespan GO:0008340 2 0.023
negative regulation of catalytic activity GO:0043086 335 0.022
single organism membrane organization GO:0044802 268 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.022
protein ubiquitination GO:0016567 314 0.022
regulation of cell differentiation GO:0045595 393 0.021
intrinsic apoptotic signaling pathway GO:0097193 127 0.021
membrane organization GO:0061024 292 0.021
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.021
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.021
apoptotic signaling pathway GO:0097190 268 0.020
regulation of cell motility GO:2000145 299 0.020
regulation of locomotion GO:0040012 329 0.020
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
negative regulation of phosphate metabolic process GO:0045936 267 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
sex determination GO:0007530 3 0.020
regulation of dna recombination GO:0000018 23 0.020
regulation of cellular component movement GO:0051270 334 0.020
regulation of response to dna damage stimulus GO:2001020 94 0.019
anatomical structure homeostasis GO:0060249 100 0.019
ion homeostasis GO:0050801 230 0.019
immune system development GO:0002520 195 0.019
regulation of cellular component biogenesis GO:0044087 281 0.018
female gamete generation GO:0007292 2 0.018
cellular protein catabolic process GO:0044257 261 0.018
metal ion transport GO:0030001 272 0.018
chemical homeostasis GO:0048878 306 0.018
regulation of protein localization GO:0032880 296 0.018
nuclear transport GO:0051169 179 0.018
protein localization to organelle GO:0033365 280 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
regulation of proteolysis GO:0030162 293 0.017
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.017
regulation of cellular ketone metabolic process GO:0010565 50 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
actin cytoskeleton organization GO:0030036 207 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
regulation of establishment of protein localization GO:0070201 242 0.017
regulation of dna repair GO:0006282 47 0.016
cellular amine metabolic process GO:0044106 41 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
endocytosis GO:0006897 159 0.016
cellular lipid metabolic process GO:0044255 303 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
protein catabolic process GO:0030163 325 0.016
negative regulation of cellular protein metabolic process GO:0032269 353 0.016
positive regulation of cell motility GO:2000147 177 0.016
mitotic cell cycle GO:0000278 326 0.016
single organism cellular localization GO:1902580 332 0.016
atp metabolic process GO:0046034 176 0.016
maintenance of location GO:0051235 112 0.015
nitrogen compound transport GO:0071705 191 0.015
negative regulation of protein metabolic process GO:0051248 391 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.015
oogenesis GO:0048477 2 0.015
meiosis i GO:0007127 4 0.015
organelle assembly GO:0070925 176 0.015
cell adhesion GO:0007155 325 0.015
mitochondrion organization GO:0007005 156 0.015
regulation of cytokine production GO:0001817 232 0.015
rab protein signal transduction GO:0032482 4 0.015
regulation of cellular amine metabolic process GO:0033238 11 0.015
positive regulation of cellular component biogenesis GO:0044089 158 0.015
positive regulation of transport GO:0051050 336 0.015
ras protein signal transduction GO:0007265 73 0.015
regulation of double strand break repair GO:2000779 22 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
cellular macromolecular complex assembly GO:0034622 324 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
protein modification by small protein conjugation GO:0032446 342 0.014
mitotic cell cycle process GO:1903047 286 0.014
modification dependent macromolecule catabolic process GO:0043632 212 0.014
regulation of protein complex assembly GO:0043254 147 0.014
negative regulation of protein modification process GO:0031400 200 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
regulation of transferase activity GO:0051338 355 0.014
chromatin organization GO:0006325 351 0.014
chromatin modification GO:0016568 298 0.014
lipid metabolic process GO:0006629 381 0.013
divalent inorganic cation transport GO:0072511 158 0.013
regeneration GO:0031099 4 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
lung alveolus development GO:0048286 4 0.013
positive regulation of ras gtpase activity GO:0032320 117 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
regulation of cell migration GO:0030334 289 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
sequestering of metal ion GO:0051238 24 0.013
locomotory behavior GO:0007626 1 0.013
memory GO:0007613 3 0.013
negative regulation of cell cycle GO:0045786 193 0.013
cellular homeostasis GO:0019725 196 0.013
regulation of protein transport GO:0051223 213 0.013
positive regulation of immune system process GO:0002684 283 0.013
histone modification GO:0016570 251 0.013
cation transport GO:0006812 331 0.013
inner ear morphogenesis GO:0042472 4 0.013
blastoderm segmentation GO:0007350 2 0.013
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.013
regulation of kinase activity GO:0043549 314 0.012
embryo development GO:0009790 123 0.012
positive regulation of proteolysis GO:0045862 142 0.012
actin filament based process GO:0030029 224 0.012
regulation of protein catabolic process GO:0042176 155 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
hemopoiesis GO:0030097 180 0.012
organelle fission GO:0048285 149 0.012
protein localization to membrane GO:0072657 160 0.012
cellular cation homeostasis GO:0030003 163 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
pathway restricted smad protein phosphorylation GO:0060389 38 0.012
receptor mediated endocytosis GO:0006898 84 0.012
response to growth factor GO:0070848 205 0.012
rna interference GO:0016246 4 0.012
regulation of intracellular transport GO:0032386 195 0.012
biological adhesion GO:0022610 331 0.011
endosomal transport GO:0016197 129 0.011
positive regulation of rab gtpase activity GO:0032851 39 0.011
rho protein signal transduction GO:0007266 26 0.011
hindbrain development GO:0030902 3 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
segmentation GO:0035282 4 0.011
regulation of dephosphorylation GO:0035303 96 0.011
regulation of secretion GO:0051046 194 0.011
innate immune response GO:0045087 178 0.011
cellular component morphogenesis GO:0032989 314 0.011
endomembrane system organization GO:0010256 196 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
cell part morphogenesis GO:0032990 137 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
response to metal ion GO:0010038 84 0.011
cell morphogenesis GO:0000902 296 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
amide transport GO:0042886 76 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
positive regulation of cell migration GO:0030335 172 0.011
negative regulation of transport GO:0051051 176 0.011
autophagy GO:0006914 88 0.011
regulation of cell cycle GO:0051726 393 0.011
cation transmembrane transport GO:0098655 238 0.011
cell projection organization GO:0030030 252 0.011
system process GO:0003008 349 0.011
regulation of protein kinase activity GO:0045859 289 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
protein import into nucleus GO:0006606 104 0.011
negative regulation of cellular component organization GO:0051129 235 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
t cell differentiation in thymus GO:0033077 4 0.010
sequestering of calcium ion GO:0051208 17 0.010
nucleocytoplasmic transport GO:0006913 176 0.010
adult locomotory behavior GO:0008344 1 0.010
response to wounding GO:0009611 168 0.010
regulation of cell morphogenesis GO:0022604 153 0.010
modification dependent protein catabolic process GO:0019941 209 0.010
cellular metal ion homeostasis GO:0006875 146 0.010
protein autophosphorylation GO:0046777 123 0.010
defense response GO:0006952 315 0.010

POLK disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.021
musculoskeletal system disease DOID:17 223 0.018
cancer DOID:162 167 0.015
sensory system disease DOID:0050155 203 0.015
eye and adnexa disease DOID:1492 150 0.015
nervous system disease DOID:863 431 0.015
eye disease DOID:5614 149 0.015
organ system cancer DOID:0050686 164 0.014
central nervous system disease DOID:331 186 0.013
immune system disease DOID:2914 155 0.012
retinal disease DOID:5679 118 0.011
connective tissue disease DOID:65 109 0.011
muscular disease DOID:0080000 114 0.011