Homo sapiens

111 known processes

TLR8

toll-like receptor 8

(Aliases: CD288,MGC119599,MGC119600)

TLR8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of immune system process GO:0002684 283 0.240
cell activation GO:0001775 213 0.227
Human
immune response activating signal transduction GO:0002757 90 0.176
Human
regulation of immune response GO:0050776 201 0.153
immune response GO:0006955 307 0.147
regulation of cytokine production GO:0001817 232 0.131
positive regulation of immune response GO:0050778 159 0.130
immune response regulating signaling pathway GO:0002764 97 0.129
Human
regulation of leukocyte activation GO:0002694 115 0.125
leukocyte activation GO:0045321 164 0.121
Human
regulation of innate immune response GO:0045088 97 0.111
response to other organism GO:0051707 261 0.111
activation of immune response GO:0002253 114 0.110
Human
response to external biotic stimulus GO:0043207 261 0.099
positive regulation of phosphorylation GO:0042327 394 0.097
Human
biological adhesion GO:0022610 331 0.090
signal transduction by phosphorylation GO:0023014 297 0.088
Human
g protein coupled receptor signaling pathway GO:0007186 207 0.086
interleukin 12 secretion GO:0072610 1 0.085
negative regulation of tumor necrosis factor biosynthetic process GO:0042536 3 0.082
defense response GO:0006952 315 0.078
regulation of defense response GO:0031347 154 0.077
negative regulation of interferon beta production GO:0032688 4 0.074
lymphocyte activation GO:0046649 133 0.073
detection of muramyl dipeptide GO:0032498 1 0.073
secretion GO:0046903 254 0.070
immune system development GO:0002520 195 0.068
response to biotic stimulus GO:0009607 276 0.067
cellular response to oxygen containing compound GO:1901701 276 0.066
Human
positive regulation of transport GO:0051050 336 0.066
Human
regulation of mapk cascade GO:0043408 262 0.065
Human
type i interferon secretion GO:0072641 1 0.065
negative regulation of immune system process GO:0002683 136 0.064
cytokine production GO:0001816 247 0.064
regulation of protein transport GO:0051223 213 0.062
Human
positive regulation of cell proliferation GO:0008284 301 0.062
negative regulation of protein metabolic process GO:0051248 391 0.060
regulation of cellular ketone metabolic process GO:0010565 50 0.060
innate immune response GO:0045087 178 0.060
regulation of lymphocyte activation GO:0051249 103 0.060
response to oxygen containing compound GO:1901700 369 0.059
Human
cell adhesion GO:0007155 325 0.058
regulation of dendritic cell apoptotic process GO:2000668 4 0.058
cation transport GO:0006812 331 0.057
hematopoietic or lymphoid organ development GO:0048534 186 0.057
mapk cascade GO:0000165 288 0.056
Human
regulation of cell activation GO:0050865 125 0.055
negative regulation of alpha beta t cell activation GO:0046636 3 0.054
negative regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:2001189 1 0.054
calcium ion transport GO:0006816 147 0.051
positive regulation of developmental process GO:0051094 314 0.050
cellular amine metabolic process GO:0044106 41 0.049
secretion by cell GO:0032940 226 0.049
regulation of cellular amine metabolic process GO:0033238 11 0.048
cellular amino acid metabolic process GO:0006520 116 0.048
serotonin transport GO:0006837 3 0.048
positive regulation of mapk cascade GO:0043410 190 0.048
Human
regulation of secretion by cell GO:1903530 177 0.048
response to virus GO:0009615 126 0.048
immune effector process GO:0002252 159 0.048
negative regulation of serotonin secretion GO:0014063 1 0.047
regulation of protein localization GO:0032880 296 0.047
Human
post embryonic development GO:0009791 2 0.047
myeloid cell differentiation GO:0030099 117 0.046
amine metabolic process GO:0009308 44 0.046
positive regulation of apoptotic process GO:0043065 246 0.046
vesicle mediated transport GO:0016192 371 0.046
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.046
Human
hemopoiesis GO:0030097 180 0.046
cellular ketone metabolic process GO:0042180 80 0.045
positive regulation of cell differentiation GO:0045597 211 0.044
response to lipid GO:0033993 206 0.043
Human
metal ion transport GO:0030001 272 0.043
negative regulation of cell death GO:0060548 345 0.043
positive regulation of lymphocyte activation GO:0051251 73 0.043
negative regulation of multicellular organismal process GO:0051241 317 0.043
positive regulation of innate immune response GO:0045089 79 0.042
positive regulation of leukocyte activation GO:0002696 80 0.041
regulation of cellular component movement GO:0051270 334 0.041
regulation of cell differentiation GO:0045595 393 0.041
cellular response to lipid GO:0071396 127 0.041
Human
negative regulation of apoptotic process GO:0043066 316 0.040
negative regulation of cell proliferation GO:0008285 228 0.040
negative regulation of programmed cell death GO:0043069 321 0.040
regulation of cell cycle GO:0051726 393 0.039
leukocyte proliferation GO:0070661 74 0.039
response to cytokine GO:0034097 232 0.039
positive regulation of lymphocyte proliferation GO:0050671 46 0.038
determination of adult lifespan GO:0008340 2 0.038
positive regulation of cell death GO:0010942 263 0.038
negative regulation of dendritic cell apoptotic process GO:2000669 3 0.038
cytoplasmic transport GO:0016482 379 0.037
Human
regulation of proteolysis GO:0030162 293 0.036
regulation of response to external stimulus GO:0032101 222 0.036
Human
positive regulation of cell activation GO:0050867 81 0.036
negative regulation of cellular protein metabolic process GO:0032269 353 0.036
purine containing compound catabolic process GO:0072523 411 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
defense response to other organism GO:0098542 129 0.036
multicellular organismal aging GO:0010259 3 0.035
regulation of cellular amino acid metabolic process GO:0006521 6 0.035
purine nucleoside triphosphate metabolic process GO:0009144 412 0.035
positive regulation of hydrolase activity GO:0051345 331 0.035
cd8 positive alpha beta t cell activation GO:0036037 3 0.035
regulation of protein secretion GO:0050708 86 0.034
purine ribonucleoside metabolic process GO:0046128 437 0.034
pattern recognition receptor signaling pathway GO:0002221 48 0.034
Human
regulation of gamma delta t cell activation involved in immune response GO:2001191 1 0.034
nucleotide catabolic process GO:0009166 408 0.034
protein secretion GO:0009306 98 0.034
organophosphate catabolic process GO:0046434 430 0.033
fc receptor mediated inhibitory signaling pathway GO:0002774 2 0.033
regulation of multi organism process GO:0043900 157 0.033
Human
single organismal cell cell adhesion GO:0016337 148 0.033
regulation of metal ion transport GO:0010959 120 0.033
leukocyte migration GO:0050900 107 0.033
regulation of calcium ion transport GO:0051924 79 0.032
ribonucleoside catabolic process GO:0042454 406 0.032
cellular homeostasis GO:0019725 196 0.032
nucleoside triphosphate metabolic process GO:0009141 422 0.032
cytokine secretion GO:0050663 64 0.032
regulation of transferase activity GO:0051338 355 0.032
Human
glycosyl compound catabolic process GO:1901658 413 0.032
cellular metal ion homeostasis GO:0006875 146 0.032
response to bacterium GO:0009617 144 0.032
Human
negative regulation of catalytic activity GO:0043086 335 0.032
regulation of interferon beta secretion GO:0035547 1 0.031
negative regulation of phosphorus metabolic process GO:0010563 267 0.031
regulation of locomotion GO:0040012 329 0.031
regulation of erk1 and erk2 cascade GO:0070372 99 0.031
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.031
Human
defense response to virus GO:0051607 71 0.031
leukocyte differentiation GO:0002521 98 0.031
protein maturation GO:0051604 233 0.031
nucleoside catabolic process GO:0009164 408 0.031
regulation of vesicle mediated transport GO:0060627 130 0.031
cellular response to molecule of bacterial origin GO:0071219 62 0.030
Human
regulation of secretion GO:0051046 194 0.030
taxis GO:0042330 157 0.030
activation of innate immune response GO:0002218 55 0.029
Human
ras protein signal transduction GO:0007265 73 0.029
regulation of peptidase activity GO:0052547 180 0.029
divalent metal ion transport GO:0070838 152 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.029
regulation of cytokine secretion GO:0050707 57 0.028
nitrogen compound transport GO:0071705 191 0.028
Human
negative regulation of developmental process GO:0051093 247 0.028
negative regulation of defense response GO:0031348 47 0.028
dendritic cell apoptotic process GO:0097048 4 0.028
positive regulation of secretion GO:0051047 116 0.028
regulation of mononuclear cell proliferation GO:0032944 65 0.028
t cell activation GO:0042110 99 0.028
purinergic nucleotide receptor signaling pathway GO:0035590 4 0.028
innate immune response activating signal transduction GO:0002758 48 0.027
Human
purine nucleotide catabolic process GO:0006195 405 0.027
positive regulation of cytokine production GO:0001819 167 0.027
purine nucleoside triphosphate catabolic process GO:0009146 392 0.027
oogenesis GO:0048477 2 0.027
regulation of establishment of protein localization GO:0070201 242 0.027
Human
female gamete generation GO:0007292 2 0.027
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.027
Human
negative regulation of transport GO:0051051 176 0.026
regulation of protein kinase activity GO:0045859 289 0.026
Human
regulation of purine nucleotide metabolic process GO:1900542 264 0.026
positive regulation of programmed cell death GO:0043068 249 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.026
purine ribonucleotide catabolic process GO:0009154 404 0.026
purine ribonucleoside catabolic process GO:0046130 398 0.026
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
protein processing GO:0016485 226 0.026
interferon gamma production GO:0032609 39 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
divalent inorganic cation transport GO:0072511 158 0.026
apoptotic signaling pathway GO:0097190 268 0.026
negative regulation of cell cycle GO:0045786 193 0.026
purine nucleoside catabolic process GO:0006152 398 0.025
response to lipopolysaccharide GO:0032496 70 0.025
Human
positive regulation of secretion by cell GO:1903532 108 0.025
regulation of endopeptidase activity GO:0052548 170 0.025
complement receptor mediated signaling pathway GO:0002430 3 0.025
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.025
segmentation GO:0035282 4 0.025
regulation of cell migration GO:0030334 289 0.025
cellular response to cytokine stimulus GO:0071345 181 0.025
regulation of kinase activity GO:0043549 314 0.025
Human
negative regulation of cellular amine metabolic process GO:0033239 3 0.025
ion homeostasis GO:0050801 230 0.024
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 0.024
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.024
negative regulation of phosphate metabolic process GO:0045936 267 0.024
regulation of nucleotide metabolic process GO:0006140 269 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
protein localization to organelle GO:0033365 280 0.024
Human
cellular chemical homeostasis GO:0055082 180 0.023
maintenance of location GO:0051235 112 0.023
regulation of leukocyte proliferation GO:0070663 67 0.023
cellular response to dna damage stimulus GO:0006974 379 0.023
divalent inorganic cation homeostasis GO:0072507 136 0.023
positive regulation of cellular component organization GO:0051130 376 0.023
regulation of lymphocyte proliferation GO:0050670 64 0.023
nucleoside phosphate catabolic process GO:1901292 412 0.023
lipid metabolic process GO:0006629 381 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.023
regulation of gamma delta t cell activation GO:0046643 1 0.023
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.023
sequestering of metal ion GO:0051238 24 0.023
small gtpase mediated signal transduction GO:0007264 78 0.023
myeloid leukocyte differentiation GO:0002573 60 0.023
cellular ion homeostasis GO:0006873 168 0.023
regulation of intracellular transport GO:0032386 195 0.022
Human
response to molecule of bacterial origin GO:0002237 82 0.022
Human
ribonucleotide catabolic process GO:0009261 405 0.022
positive regulation of cellular amine metabolic process GO:0033240 7 0.022
chemical homeostasis GO:0048878 306 0.022
regulation of endocytosis GO:0030100 72 0.022
nucleoside triphosphate catabolic process GO:0009143 394 0.022
cellular response to lipopolysaccharide GO:0071222 57 0.022
Human
cellular response to endogenous stimulus GO:0071495 336 0.022
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
protein modification by small protein conjugation GO:0032446 342 0.022
interferon gamma biosynthetic process GO:0042095 8 0.022
regulation of interferon beta production GO:0032648 22 0.022
regulation of cell cycle process GO:0010564 266 0.022
interferon beta secretion GO:0035546 1 0.022
positive regulation of mononuclear cell proliferation GO:0032946 47 0.022
regulation of cell motility GO:2000145 299 0.022
positive regulation of cellular component movement GO:0051272 181 0.022
negative regulation of secretion by cell GO:1903531 52 0.022
actin filament based process GO:0030029 224 0.022
blood coagulation GO:0007596 76 0.021
regulation of t cell activation GO:0050863 77 0.021
locomotory behavior GO:0007626 1 0.021
regulation of cytoplasmic transport GO:1903649 149 0.021
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.021
Human
i kappab kinase nf kappab signaling GO:0007249 166 0.021
endocytosis GO:0006897 159 0.021
response to fungus GO:0009620 4 0.021
single organism cellular localization GO:1902580 332 0.021
Human
negative regulation of protein modification process GO:0031400 200 0.021
mononuclear cell proliferation GO:0032943 71 0.021
negative regulation of hydrolase activity GO:0051346 182 0.021
anatomical structure formation involved in morphogenesis GO:0048646 284 0.021
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.021
Human
negative regulation of phosphorylation GO:0042326 174 0.021
guanosine containing compound catabolic process GO:1901069 239 0.021
gamma delta t cell activation GO:0046629 3 0.021
negative regulation of intracellular signal transduction GO:1902532 183 0.020
regulation of homeostatic process GO:0032844 121 0.020
erk1 and erk2 cascade GO:0070371 104 0.020
positive regulation of protein transport GO:0051222 135 0.020
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
cellular macromolecule catabolic process GO:0044265 380 0.020
neuromuscular junction development GO:0007528 3 0.020
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:0002291 4 0.020
cellular cation homeostasis GO:0030003 163 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
positive regulation of defense response GO:0031349 87 0.020
regulation of transforming growth factor beta secretion GO:2001201 1 0.020
single organism cell adhesion GO:0098602 179 0.019
regulation of interleukin 10 secretion GO:2001179 4 0.019
response to abiotic stimulus GO:0009628 336 0.019
system process GO:0003008 349 0.019
negative regulation of dendritic cell differentiation GO:2001199 2 0.019
lymphocyte proliferation GO:0046651 70 0.019
negative regulation of immune response GO:0050777 40 0.019
negative regulation of protein processing GO:0010955 142 0.019
positive regulation of transferase activity GO:0051347 227 0.019
Human
cellular macromolecular complex assembly GO:0034622 324 0.019
regulation of protein processing GO:0070613 150 0.019
lymphocyte mediated immunity GO:0002449 48 0.019
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
dephosphorylation GO:0016311 209 0.019
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
cellular lipid metabolic process GO:0044255 303 0.019
negative regulation of interleukin 12 secretion GO:2001183 1 0.019
positive regulation of catabolic process GO:0009896 310 0.018
regulation of cysteine type endopeptidase activity GO:2000116 127 0.018
negative regulation of protein maturation GO:1903318 142 0.018
type i interferon production GO:0032606 27 0.018
hindbrain development GO:0030902 3 0.018
regulation of immune effector process GO:0002697 91 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.018
regulation of ion transport GO:0043269 189 0.018
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.018
Human
cation homeostasis GO:0055080 189 0.018
regulation of cytokine biosynthetic process GO:0042035 35 0.018
negative regulation of interferon gamma biosynthetic process GO:0045077 1 0.018
membrane organization GO:0061024 292 0.018
intracellular protein transport GO:0006886 270 0.018
Human
nucleocytoplasmic transport GO:0006913 176 0.018
Human
positive regulation of protein phosphorylation GO:0001934 313 0.018
Human
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.018
cellular response to biotic stimulus GO:0071216 71 0.018
Human
positive regulation of cytoplasmic transport GO:1903651 82 0.018
Human
cytokine mediated signaling pathway GO:0019221 109 0.018
positive regulation of leukocyte proliferation GO:0070665 48 0.018
metal ion homeostasis GO:0055065 169 0.018
regulation of cellular response to stress GO:0080135 244 0.018
Human
calcium ion homeostasis GO:0055074 122 0.018
cardiovascular system development GO:0072358 262 0.017
cellular protein catabolic process GO:0044257 261 0.017
mitotic cell cycle process GO:1903047 286 0.017
regulation of tumor necrosis factor production GO:0032680 43 0.017
Human
organophosphate biosynthetic process GO:0090407 163 0.017
regulation of interferon gamma biosynthetic process GO:0045072 8 0.017
cardiac muscle cell contraction GO:0086003 4 0.017
regulation of protein maturation GO:1903317 150 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
positive regulation of kinase activity GO:0033674 204 0.017
Human
serotonin secretion GO:0001820 1 0.017
regulation of osteoclast development GO:2001204 1 0.017
rho protein signal transduction GO:0007266 26 0.017
nervous system development GO:0007399 293 0.017
positive regulation of regulatory t cell differentiation GO:0045591 3 0.017
protein catabolic process GO:0030163 325 0.017
blood vessel morphogenesis GO:0048514 162 0.017
guanosine containing compound metabolic process GO:1901068 244 0.017
regulation of tolerance induction GO:0002643 4 0.017
negative regulation of protein transport GO:0051224 75 0.017
memory GO:0007613 3 0.017
cellular divalent inorganic cation homeostasis GO:0072503 128 0.017
intrinsic apoptotic signaling pathway GO:0097193 127 0.017
azole transport GO:0045117 4 0.016
t cell tolerance induction GO:0002517 4 0.016
establishment of protein localization to organelle GO:0072594 172 0.016
Human
protein ubiquitination GO:0016567 314 0.016
regulation of cell development GO:0060284 161 0.016
regulation of regulatory t cell differentiation GO:0045589 4 0.016
peptidyl tyrosine modification GO:0018212 170 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
alcohol metabolic process GO:0006066 114 0.016
regulation of response to biotic stimulus GO:0002831 55 0.016
Human
regulation of chemotaxis GO:0050920 74 0.016
negative regulation of protein phosphorylation GO:0001933 140 0.016
gtp metabolic process GO:0046039 239 0.016
response to wounding GO:0009611 168 0.016
positive regulation of proteolysis GO:0045862 142 0.016
positive regulation of locomotion GO:0040017 186 0.016
regulation of body fluid levels GO:0050878 99 0.016
regulation of interferon gamma production GO:0032649 36 0.015
wound healing GO:0042060 115 0.015
cell type specific apoptotic process GO:0097285 125 0.015
hemostasis GO:0007599 76 0.015
leukocyte mediated cytotoxicity GO:0001909 27 0.015
sequestering of calcium ion GO:0051208 17 0.015
gamma delta t cell activation involved in immune response GO:0002290 1 0.015
positive regulation of cell motility GO:2000147 177 0.015
negative regulation of protein secretion GO:0050709 29 0.015
regulation of angiogenesis GO:0045765 92 0.015
osteoclast development GO:0036035 2 0.015
cell development GO:0048468 328 0.015
single organism membrane organization GO:0044802 268 0.015
peripheral nervous system development GO:0007422 2 0.015
negative regulation of transforming growth factor beta secretion GO:2001202 1 0.015
epithelial cell proliferation GO:0050673 128 0.015
small molecule biosynthetic process GO:0044283 157 0.015
spermatid differentiation GO:0048515 4 0.015
positive regulation of t cell tolerance induction GO:0002666 2 0.015
organonitrogen compound biosynthetic process GO:1901566 200 0.015
stress activated protein kinase signaling cascade GO:0031098 94 0.015
Human
regulation of leukocyte migration GO:0002685 63 0.015
positive regulation of gamma delta t cell activation GO:0046645 1 0.015
gtp catabolic process GO:0006184 237 0.015
positive regulation of protein kinase activity GO:0045860 190 0.014
Human
response to organic cyclic compound GO:0014070 204 0.014
interferon beta production GO:0032608 23 0.014
positive regulation of t cell proliferation GO:0042102 33 0.014
positive regulation of t cell activation GO:0050870 54 0.014
protein oligomerization GO:0051259 173 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
negative regulation of proteolysis GO:0045861 132 0.014
protein import GO:0017038 130 0.014
Human
circulatory system development GO:0072359 262 0.014
carbohydrate metabolic process GO:0005975 207 0.014
single organism carbohydrate metabolic process GO:0044723 193 0.014
negative regulation of interleukin 10 production GO:0032693 7 0.014
positive regulation of peptidase activity GO:0010952 88 0.014
regulation of t cell tolerance induction GO:0002664 4 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
positive regulation of protein secretion GO:0050714 60 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
cellular component morphogenesis GO:0032989 314 0.014
associative learning GO:0008306 1 0.014
blastoderm segmentation GO:0007350 2 0.014
cell projection organization GO:0030030 252 0.014
positive regulation of leukocyte differentiation GO:1902107 37 0.014
cytokine metabolic process GO:0042107 38 0.014
actin filament based movement GO:0030048 17 0.014
actin cytoskeleton organization GO:0030036 207 0.014
inner ear morphogenesis GO:0042472 4 0.014
regulation of leukocyte differentiation GO:1902105 61 0.014
inorganic ion transmembrane transport GO:0098660 231 0.014
inflammatory response GO:0006954 79 0.014
spermatid development GO:0007286 4 0.014
regulation of membrane potential GO:0042391 95 0.014
adult locomotory behavior GO:0008344 1 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
atp metabolic process GO:0046034 176 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
organic hydroxy compound transport GO:0015850 63 0.014
b cell activation GO:0042113 33 0.014
salivary gland morphogenesis GO:0007435 4 0.014
chemotaxis GO:0006935 157 0.013
cell morphogenesis GO:0000902 296 0.013
positive regulation of cell migration GO:0030335 172 0.013
mitotic cell cycle GO:0000278 326 0.013
negative regulation of osteoclast development GO:2001205 1 0.013
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.013
negative regulation of t cell mediated cytotoxicity GO:0001915 1 0.013
regulation of t cell proliferation GO:0042129 42 0.013
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 1 0.013
protein targeting GO:0006605 187 0.013
Human
cellular response to abiotic stimulus GO:0071214 117 0.013
protein autophosphorylation GO:0046777 123 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
natural killer cell mediated cytotoxicity GO:0042267 23 0.013
rna interference GO:0016246 4 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
organelle assembly GO:0070925 176 0.013
regulation of dna metabolic process GO:0051052 153 0.013
leukocyte chemotaxis GO:0030595 76 0.013
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:2001188 2 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
oxidation reduction process GO:0055114 396 0.013
chromatin organization GO:0006325 351 0.013
positive regulation of cytolysis GO:0045919 3 0.013
regulation of peptide transport GO:0090087 62 0.013
Human
negative regulation of transferase activity GO:0051348 124 0.013
actin mediated cell contraction GO:0070252 12 0.013
long term memory GO:0007616 2 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
negative regulation of cell activation GO:0050866 33 0.013
regulation of serotonin secretion GO:0014062 1 0.013
negative regulation of endopeptidase activity GO:0010951 84 0.013
regeneration GO:0031099 4 0.013
antigen receptor mediated signaling pathway GO:0050851 38 0.013
phosphatidylinositol mediated signaling GO:0048015 55 0.013
positive regulation of endopeptidase activity GO:0010950 84 0.012
negative regulation of phagocytosis GO:0050765 4 0.012
positive regulation of immune effector process GO:0002699 40 0.012
chromatin modification GO:0016568 298 0.012
regulation of epithelial cell proliferation GO:0050678 113 0.012
neurotransmitter secretion GO:0007269 4 0.012
cation transmembrane transport GO:0098655 238 0.012
oocyte differentiation GO:0009994 2 0.012
complement component c5a signaling pathway GO:0038178 1 0.012
myeloid dendritic cell activation GO:0001773 4 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
ossification GO:0001503 121 0.012
cell fate determination GO:0001709 3 0.012
angiogenesis GO:0001525 147 0.012
nuclear transport GO:0051169 179 0.012
Human
thymus development GO:0048538 3 0.012
positive regulation of cell cycle GO:0045787 140 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
anterior posterior axis specification GO:0009948 2 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.012
response to growth factor GO:0070848 205 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
positive regulation of cytokine secretion GO:0050715 42 0.012
adaptive immune response GO:0002250 49 0.012
regulation of hormone levels GO:0010817 125 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.012
negative regulation of cytokine production GO:0001818 82 0.012
regulation of growth GO:0040008 165 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.012
protein localization to nucleus GO:0034504 136 0.012
Human
lipid biosynthetic process GO:0008610 177 0.012
cell substrate adhesion GO:0031589 132 0.012
positive regulation of gtpase activity GO:0043547 166 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
regulation of leukocyte mediated immunity GO:0002703 38 0.012
microtubule based process GO:0007017 210 0.012

TLR8 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.021
sensory system disease DOID:0050155 203 0.019
Human
nervous system disease DOID:863 431 0.019
Human
cancer DOID:162 167 0.018
Human
disease of cellular proliferation DOID:14566 174 0.018
Human
eye and adnexa disease DOID:1492 150 0.017
Human
organ system cancer DOID:0050686 164 0.016
Human
musculoskeletal system disease DOID:17 223 0.016
Human
eye disease DOID:5614 149 0.015
Human
inherited metabolic disorder DOID:655 242 0.015
connective tissue disease DOID:65 109 0.013
Human