Homo sapiens

81 known processes

ISG15

ISG15 ubiquitin-like modifier

(Aliases: IFI15,G1P2,IP17,UCRP,hUCRP)

ISG15 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of viral genome replication GO:0045069 48 0.999
viral life cycle GO:0019058 132 0.998
negative regulation of viral process GO:0048525 66 0.989
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.985
defense response to virus GO:0051607 71 0.982
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.972
defense response to other organism GO:0098542 129 0.972
response to other organism GO:0051707 261 0.953
negative regulation of viral genome replication GO:0045071 35 0.938
multi organism cellular process GO:0044764 156 0.929
negative regulation of multi organism process GO:0043901 92 0.916
response to biotic stimulus GO:0009607 276 0.914
cellular response to cytokine stimulus GO:0071345 181 0.838
regulation of defense response to virus GO:0050688 33 0.811
immune effector process GO:0002252 159 0.796
intracellular transport of viral protein in host cell GO:0019060 4 0.731
interspecies interaction between organisms GO:0044419 156 0.677
response to external biotic stimulus GO:0043207 261 0.627
lipoprotein biosynthetic process GO:0042158 33 0.622
response to interferon alpha GO:0035455 11 0.609
defense response GO:0006952 315 0.597
nucleoside phosphate biosynthetic process GO:1901293 109 0.587
viral genome replication GO:0019079 50 0.555
interaction with host GO:0051701 42 0.529
response to cytokine GO:0034097 232 0.524
regulation of viral process GO:0050792 103 0.523
chemical homeostasis GO:0048878 306 0.481
response to virus GO:0009615 126 0.454
positive regulation of cell death GO:0010942 263 0.453
viral process GO:0016032 146 0.433
cellular response to organic cyclic compound GO:0071407 127 0.425
intracellular protein transport in other organism involved in symbiotic interaction GO:0051708 4 0.374
negative regulation of defense response to virus by host GO:0050689 4 0.370
cellular response to dsrna GO:0071359 19 0.366
protein lipidation GO:0006497 33 0.365
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.345
negative regulation of cell death GO:0060548 345 0.341
cellular response to type i interferon GO:0071357 12 0.320
negative regulation of catalytic activity GO:0043086 335 0.310
response to organic cyclic compound GO:0014070 204 0.287
negative regulation of apoptotic process GO:0043066 316 0.275
regulation of multi organism process GO:0043900 157 0.271
regulation of intracellular transport GO:0032386 195 0.249
protein myristoylation GO:0018377 1 0.214
intracellular protein transport GO:0006886 270 0.213
response to dsrna GO:0043331 25 0.209
regulation by virus of viral protein levels in host cell GO:0046719 4 0.207
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.196
negative regulation of programmed cell death GO:0043069 321 0.166
positive regulation of apoptotic process GO:0043065 246 0.163
regulation of intracellular protein transport GO:0033157 123 0.161
nuclear transport GO:0051169 179 0.152
extracellular transport GO:0006858 4 0.146
positive regulation of programmed cell death GO:0043068 249 0.143
negative regulation of immune effector process GO:0002698 38 0.143
response to type i interferon GO:0034340 14 0.136
regulation of apoptotic signaling pathway GO:2001233 175 0.126
regulation of defense response to virus by host GO:0050691 22 0.126
regulation of immune effector process GO:0002697 91 0.126
nucleocytoplasmic transport GO:0006913 176 0.125
negative regulation of apoptotic signaling pathway GO:2001234 97 0.123
regulation of nucleocytoplasmic transport GO:0046822 98 0.110
glucose metabolic process GO:0006006 45 0.107
negative regulation of cell motility GO:2000146 104 0.107
innate immune response GO:0045087 178 0.107
cellular response to interferon alpha GO:0035457 4 0.106
negative regulation of defense response GO:0031348 47 0.095
positive regulation of rig i signaling pathway GO:1900246 4 0.093
multi organism localization GO:1902579 14 0.091
negative regulation of response to external stimulus GO:0032102 83 0.088
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.084
regulation of cell migration GO:0030334 289 0.083
regulation of response to biotic stimulus GO:0002831 55 0.081
symbiont intracellular protein transport in host GO:0030581 4 0.080
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.078
interferon beta production GO:0032608 23 0.077
posttranscriptional gene silencing GO:0016441 25 0.072
mapk cascade GO:0000165 288 0.071
positive regulation of proteolysis GO:0045862 142 0.070
regulation of binding GO:0051098 111 0.069
negative regulation of hydrolase activity GO:0051346 182 0.068
nucleoside phosphate catabolic process GO:1901292 412 0.068
immune response GO:0006955 307 0.068
glycosylation GO:0070085 71 0.065
regulation of protein localization to nucleus GO:1900180 85 0.065
cytoplasmic transport GO:0016482 379 0.065
positive regulation of interferon beta production GO:0032728 17 0.062
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.062
regulation of defense response GO:0031347 154 0.061
cellular macromolecular complex assembly GO:0034622 324 0.060
lipoprotein metabolic process GO:0042157 42 0.059
epinephrine secretion GO:0048242 1 0.057
intracellular receptor signaling pathway GO:0030522 104 0.055
negative regulation of defense response to virus GO:0050687 10 0.055
response to nitrogen compound GO:1901698 184 0.055
cellular macromolecule catabolic process GO:0044265 380 0.053
Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.050
regulation of cell motility GO:2000145 299 0.048
regulation of protein binding GO:0043393 66 0.047
negative regulation of locomotion GO:0040013 118 0.045
intracellular transport of virus GO:0075733 14 0.045
ion homeostasis GO:0050801 230 0.044
regulation of membrane potential GO:0042391 95 0.044
regulation of anatomical structure morphogenesis GO:0022603 286 0.043
positive regulation of multi organism process GO:0043902 56 0.043
regulation of cellular component movement GO:0051270 334 0.041
interferon alpha production GO:0032607 11 0.041
cellular response to exogenous dsrna GO:0071360 5 0.041
multi organism transport GO:0044766 14 0.041
single organism cellular localization GO:1902580 332 0.040
protein localization to organelle GO:0033365 280 0.037
negative regulation of cell migration GO:0030336 102 0.037
rna interference GO:0016246 4 0.037
release of cytochrome c from mitochondria GO:0001836 35 0.037
protein glycosylation GO:0006486 62 0.036
modification dependent protein catabolic process GO:0019941 209 0.036
Mouse
negative regulation of cellular component movement GO:0051271 106 0.036
negative regulation of mitochondrial depolarization GO:0051902 2 0.036
regulation of response to external stimulus GO:0032101 222 0.034
rig i signaling pathway GO:0039529 7 0.033
negative regulation of endopeptidase activity GO:0010951 84 0.033
organophosphate biosynthetic process GO:0090407 163 0.032
carbohydrate derivative biosynthetic process GO:1901137 207 0.032
negative regulation of protein metabolic process GO:0051248 391 0.032
cytidine metabolic process GO:0046087 7 0.031
response to exogenous dsrna GO:0043330 10 0.031
regulation of peptidase activity GO:0052547 180 0.030
protein acylation GO:0043543 138 0.030
positive regulation of intracellular protein transport GO:0090316 76 0.030
protein export from nucleus GO:0006611 29 0.030
mrna metabolic process GO:0016071 175 0.029
ncrna metabolic process GO:0034660 108 0.028
negative regulation of protein binding GO:0032091 35 0.028
negative regulation of immune system process GO:0002683 136 0.028
regulation of body fluid levels GO:0050878 99 0.028
positive regulation of developmental process GO:0051094 314 0.028
Mouse
positive regulation of cellular catabolic process GO:0031331 284 0.027
regulation of nuclease activity GO:0032069 11 0.027
regulation of cytoskeleton organization GO:0051493 177 0.027
mitochondrion organization GO:0007005 156 0.027
regulation of protein transport GO:0051223 213 0.027
purine nucleotide biosynthetic process GO:0006164 84 0.027
single organism nuclear import GO:1902593 104 0.027
transport of virus GO:0046794 14 0.026
response to abiotic stimulus GO:0009628 336 0.026
protein catabolic process GO:0030163 325 0.025
Mouse
chromatin organization GO:0006325 351 0.025
gene silencing by mirna GO:0035195 23 0.025
regulation of protein catabolic process GO:0042176 155 0.024
response to interferon beta GO:0035456 11 0.024
positive regulation of transferase activity GO:0051347 227 0.023
nuclear export GO:0051168 69 0.023
negative regulation of cell proliferation GO:0008285 228 0.023
determination of adult lifespan GO:0008340 2 0.022
negative regulation of kinase activity GO:0033673 106 0.022
negative regulation of transferase activity GO:0051348 124 0.022
posttranscriptional regulation of gene expression GO:0010608 213 0.022
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.022
positive regulation of hydrolase activity GO:0051345 331 0.022
response to phenylpropanoid GO:0080184 1 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.021
organophosphate catabolic process GO:0046434 430 0.021
regulation of transferase activity GO:0051338 355 0.020
regulation of ion homeostasis GO:2000021 73 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
Mouse
regulation of cytoplasmic transport GO:1903649 149 0.019
regulation of locomotion GO:0040012 329 0.019
positive regulation of interleukin 4 production GO:0032753 3 0.019
production of sirna involved in rna interference GO:0030422 3 0.019
atp metabolic process GO:0046034 176 0.019
regulation of cell growth GO:0001558 135 0.019
regulation of protein maturation GO:1903317 150 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
positive regulation of intracellular transport GO:0032388 104 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.017
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.017
cilium organization GO:0044782 68 0.017
dna damage response signal transduction resulting in transcription GO:0042772 12 0.017
negative regulation of protein maturation GO:1903318 142 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
ras protein signal transduction GO:0007265 73 0.016
negative regulation of response to biotic stimulus GO:0002832 18 0.016
response to steroid hormone GO:0048545 80 0.016
negative regulation of binding GO:0051100 57 0.016
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.016
regulation of rig i signaling pathway GO:0039535 6 0.016
protein import GO:0017038 130 0.016
positive regulation of viral process GO:0048524 37 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.015
rna catabolic process GO:0006401 71 0.015
cytokine production GO:0001816 247 0.015
dna catabolic process GO:0006308 49 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
cellular protein catabolic process GO:0044257 261 0.015
Mouse
epinephrine transport GO:0048241 1 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.015
regulation of protein kinase activity GO:0045859 289 0.015
negative regulation of protein processing GO:0010955 142 0.015
rna phosphodiester bond hydrolysis GO:0090501 35 0.014
negative regulation of proteolysis GO:0045861 132 0.014
regulation of kinase activity GO:0043549 314 0.014
cell fate determination GO:0001709 3 0.014
regulation of helicase activity GO:0051095 8 0.014
positive regulation of interferon alpha production GO:0032727 11 0.014
nitrogen compound transport GO:0071705 191 0.014
isg15 protein conjugation GO:0032020 5 0.014
protein targeting to nucleus GO:0044744 104 0.014
embryo development GO:0009790 123 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
atp catabolic process GO:0006200 157 0.013
regulation of cellular response to stress GO:0080135 244 0.013
regulation of growth GO:0040008 165 0.013
protein maturation GO:0051604 233 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.013
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.013
brain morphogenesis GO:0048854 1 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
cellular response to glucocorticoid stimulus GO:0071385 4 0.013
activation of cysteine type endopeptidase activity GO:0097202 57 0.013
ossification GO:0001503 121 0.013
negative regulation of transport GO:0051051 176 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
extrinsic apoptotic signaling pathway GO:0097191 119 0.013
cellular component morphogenesis GO:0032989 314 0.013
regulation of endopeptidase activity GO:0052548 170 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
regulation of interferon beta production GO:0032648 22 0.012
regulation of protein export from nucleus GO:0046825 15 0.012
negative regulation of protein modification process GO:0031400 200 0.012
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
negative regulation of catabolic process GO:0009895 104 0.012
negative regulation of protein transport GO:0051224 75 0.012
response to light stimulus GO:0009416 87 0.012
positive regulation of endopeptidase activity GO:0010950 84 0.012
positive regulation of peptidase activity GO:0010952 88 0.012
purine containing compound catabolic process GO:0072523 411 0.012
nucleotide catabolic process GO:0009166 408 0.012
response to transforming growth factor beta GO:0071559 94 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
maintenance of location GO:0051235 112 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.011
rna processing GO:0006396 255 0.011
ribonucleoside triphosphate metabolic process GO:0009199 412 0.011
glycerolipid metabolic process GO:0046486 107 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
nucleoside catabolic process GO:0009164 408 0.011
response to growth factor GO:0070848 205 0.011
regulation of protein stability GO:0031647 87 0.011
positive regulation of cytokine production GO:0001819 167 0.011
modification dependent macromolecule catabolic process GO:0043632 212 0.011
Mouse
negative regulation of interferon beta production GO:0032688 4 0.011
signal transduction in absence of ligand GO:0038034 22 0.011
positive regulation of interleukin 13 production GO:0032736 4 0.011
cytokine mediated signaling pathway GO:0019221 109 0.010
negative regulation of developmental process GO:0051093 247 0.010
nuclear import GO:0051170 106 0.010
negative regulation of phosphorus metabolic process GO:0010563 267 0.010
cardiovascular system development GO:0072358 262 0.010

ISG15 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.078
aicardi goutieres syndrome DOID:0050629 7 0.058
connective tissue disease DOID:65 109 0.036
bone disease DOID:0080001 88 0.023
diabetes mellitus DOID:9351 31 0.019
disease of metabolism DOID:0014667 295 0.019
carbohydrate metabolism disease DOID:0050013 32 0.019
glucose metabolism disease DOID:4194 32 0.019
acquired metabolic disease DOID:0060158 58 0.019
bone development disease DOID:0080006 55 0.019
disease of cellular proliferation DOID:14566 174 0.017
mitochondrial metabolism disease DOID:700 29 0.013
inherited metabolic disorder DOID:655 242 0.013
cardiovascular system disease DOID:1287 106 0.012