Homo sapiens

22 known processes

SPG20

spastic paraplegia 20 (Troyer syndrome)

(Aliases: SPARTIN,TAHCCP1,KIAA0610)

SPG20 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of icosanoid secretion GO:0032304 2 0.998
cofactor metabolic process GO:0051186 87 0.582
long chain fatty acid metabolic process GO:0001676 30 0.541
determination of adult lifespan GO:0008340 2 0.504
small molecule biosynthetic process GO:0044283 157 0.459
single organism membrane organization GO:0044802 268 0.378
multicellular organismal aging GO:0010259 3 0.368
cytoplasmic transport GO:0016482 379 0.359
protein catabolic process GO:0030163 325 0.290
enzyme linked receptor protein signaling pathway GO:0007167 303 0.288
lipid localization GO:0010876 106 0.286
positive regulation of cellular catabolic process GO:0031331 284 0.284
regulation of cellular amine metabolic process GO:0033238 11 0.279
positive regulation of cytoplasmic transport GO:1903651 82 0.261
intracellular protein transport GO:0006886 270 0.258
protein modification by small protein conjugation GO:0032446 342 0.258
lipid metabolic process GO:0006629 381 0.245
coenzyme metabolic process GO:0006732 65 0.245
protein ubiquitination GO:0016567 314 0.239
membrane organization GO:0061024 292 0.238
positive regulation of lipid metabolic process GO:0045834 50 0.232
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.230
amine metabolic process GO:0009308 44 0.222
regulation of ion transport GO:0043269 189 0.216
negative regulation of ion transport GO:0043271 39 0.215
regulation of icosanoid secretion GO:0032303 4 0.214
sodium ion transmembrane transport GO:0035725 59 0.207
nervous system development GO:0007399 293 0.204
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.199
lipid transport GO:0006869 90 0.190
single organism cellular localization GO:1902580 332 0.187
positive regulation of hydrolase activity GO:0051345 331 0.182
segmentation GO:0035282 4 0.181
positive regulation of cellular amine metabolic process GO:0033240 7 0.180
organic hydroxy compound metabolic process GO:1901615 147 0.179
cellular amine metabolic process GO:0044106 41 0.175
protein localization to membrane GO:0072657 160 0.175
cellular macromolecule catabolic process GO:0044265 380 0.175
fatty acid metabolic process GO:0006631 115 0.168
positive regulation of intracellular protein transport GO:0090316 76 0.162
regulation of cytoplasmic transport GO:1903649 149 0.161
cellular biogenic amine metabolic process GO:0006576 34 0.159
protein localization to plasma membrane GO:0072659 93 0.153
glycerolipid metabolic process GO:0046486 107 0.153
vesicle mediated transport GO:0016192 371 0.153
positive regulation of intracellular transport GO:0032388 104 0.147
establishment of ribosome localization GO:0033753 4 0.147
organic anion transport GO:0015711 103 0.147
post embryonic development GO:0009791 2 0.146
regulation of vesicle mediated transport GO:0060627 130 0.146
notch signaling pathway GO:0007219 31 0.144
establishment of protein localization to organelle GO:0072594 172 0.142
metal ion transport GO:0030001 272 0.142
regulation of cellular component biogenesis GO:0044087 281 0.142
cellular macromolecular complex assembly GO:0034622 324 0.140
response to abiotic stimulus GO:0009628 336 0.139
regulation of protein localization GO:0032880 296 0.138
transmembrane transport GO:0055085 399 0.137
endosomal transport GO:0016197 129 0.136
chromatin organization GO:0006325 351 0.136
regulation of mapk cascade GO:0043408 262 0.135
monocarboxylic acid metabolic process GO:0032787 185 0.134
cellular lipid metabolic process GO:0044255 303 0.132
cell development GO:0048468 328 0.130
isoprenoid metabolic process GO:0006720 39 0.130
regulation of plasma lipoprotein particle levels GO:0097006 32 0.129
carboxylic acid biosynthetic process GO:0046394 97 0.126
positive regulation of lipid biosynthetic process GO:0046889 22 0.124
lipid biosynthetic process GO:0008610 177 0.122
anion transport GO:0006820 161 0.122
cellular protein complex assembly GO:0043623 188 0.122
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.121
ribosomal subunit export from nucleus GO:0000054 4 0.118
glycerophospholipid metabolic process GO:0006650 84 0.116
blastoderm segmentation GO:0007350 2 0.114
cellular response to growth factor stimulus GO:0071363 197 0.112
protein lipid complex subunit organization GO:0071825 24 0.111
organonitrogen compound biosynthetic process GO:1901566 200 0.109
modification dependent protein catabolic process GO:0019941 209 0.108
cellular ketone metabolic process GO:0042180 80 0.106
alcohol biosynthetic process GO:0046165 52 0.105
positive regulation of transport GO:0051050 336 0.104
hard palate development GO:0060022 1 0.103
cellular amino acid metabolic process GO:0006520 116 0.102
alcohol metabolic process GO:0006066 114 0.102
positive regulation of catabolic process GO:0009896 310 0.100
organic hydroxy compound biosynthetic process GO:1901617 71 0.100
immune system development GO:0002520 195 0.099
neuron projection development GO:0031175 106 0.099
regulation of cellular ketone metabolic process GO:0010565 50 0.099
response to biotic stimulus GO:0009607 276 0.098
plasma membrane organization GO:0007009 115 0.093
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.093
negative regulation of cellular amine metabolic process GO:0033239 3 0.093
smad protein complex assembly GO:0007183 12 0.093
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.091
cation transmembrane transport GO:0098655 238 0.090
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.089
protein targeting GO:0006605 187 0.089
regulation of mrna export from nucleus GO:0010793 3 0.087
positive regulation of cellular component organization GO:0051130 376 0.087
regulation of cell differentiation GO:0045595 393 0.086
mapk cascade GO:0000165 288 0.085
aging GO:0007568 66 0.085
protein import GO:0017038 130 0.084
secretion GO:0046903 254 0.084
inorganic cation transmembrane transport GO:0098662 194 0.083
regulation of jnk cascade GO:0046328 73 0.083
negative regulation of developmental process GO:0051093 247 0.081
anterior posterior axis specification GO:0009948 2 0.081
apoptotic signaling pathway GO:0097190 268 0.081
common partner smad protein phosphorylation GO:0007182 3 0.081
protein localization to lysosome GO:0061462 11 0.080
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.079
regulation of cell development GO:0060284 161 0.079
negative regulation of lipid transport GO:0032369 18 0.078
positive regulation of alcohol biosynthetic process GO:1902932 9 0.078
regulation of cellular amino acid metabolic process GO:0006521 6 0.077
glycerolipid biosynthetic process GO:0045017 51 0.077
modification dependent macromolecule catabolic process GO:0043632 212 0.077
fatty acid biosynthetic process GO:0006633 46 0.076
regulation of lipid metabolic process GO:0019216 96 0.076
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.076
cellular protein catabolic process GO:0044257 261 0.076
ubiquitin dependent protein catabolic process GO:0006511 206 0.075
prostaglandin secretion GO:0032310 2 0.075
negative regulation of cellular component organization GO:0051129 235 0.075
phospholipid metabolic process GO:0006644 99 0.074
regulation of protein catabolic process GO:0042176 155 0.073
cellular component morphogenesis GO:0032989 314 0.073
regulation of ketone biosynthetic process GO:0010566 7 0.071
positive regulation of protein transport GO:0051222 135 0.071
female gamete generation GO:0007292 2 0.070
protein localization to organelle GO:0033365 280 0.070
cell projection organization GO:0030030 252 0.069
trna export from nucleus GO:0006409 1 0.068
cell division GO:0051301 168 0.068
positive regulation of bmp signaling pathway GO:0030513 9 0.067
nucleocytoplasmic transport GO:0006913 176 0.067
response to other organism GO:0051707 261 0.066
regulation of stress activated mapk cascade GO:0032872 84 0.066
protein maturation GO:0051604 233 0.065
embryo development GO:0009790 123 0.065
lysosomal transport GO:0007041 33 0.064
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.064
organophosphate biosynthetic process GO:0090407 163 0.064
stem cell division GO:0017145 2 0.064
negative regulation of programmed cell death GO:0043069 321 0.063
regulation of proteolysis GO:0030162 293 0.062
regulation of establishment of protein localization GO:0070201 242 0.061
endomembrane system organization GO:0010256 196 0.061
regulation of intracellular protein transport GO:0033157 123 0.061
ribosomal large subunit export from nucleus GO:0000055 3 0.060
ethanolamine containing compound metabolic process GO:0042439 26 0.060
regulation of protein transport GO:0051223 213 0.060
regulation of metal ion transport GO:0010959 120 0.060
regulation of protein localization to plasma membrane GO:1903076 40 0.060
hemopoiesis GO:0030097 180 0.059
canonical wnt signaling pathway GO:0060070 116 0.059
purine containing compound catabolic process GO:0072523 411 0.058
chemotaxis GO:0006935 157 0.058
negative regulation of cell death GO:0060548 345 0.058
dolichol biosynthetic process GO:0019408 1 0.058
growth GO:0040007 202 0.057
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.057
regulation of cytoskeleton organization GO:0051493 177 0.057
cation transport GO:0006812 331 0.056
regulation of transferase activity GO:0051338 355 0.055
protein import into nucleus GO:0006606 104 0.055
ribonucleotide catabolic process GO:0009261 405 0.055
negative regulation of sodium ion transport GO:0010766 3 0.055
sulfur compound metabolic process GO:0006790 101 0.055
cell fate determination GO:0001709 3 0.054
regulation of immune response GO:0050776 201 0.054
negative regulation of alpha beta t cell proliferation GO:0046642 1 0.054
response to oxidative stress GO:0006979 121 0.053
positive regulation of cell death GO:0010942 263 0.053
response to growth factor GO:0070848 205 0.053
regulation of proteasomal protein catabolic process GO:0061136 87 0.053
regulation of alcohol biosynthetic process GO:1902930 22 0.053
prostaglandin transport GO:0015732 2 0.052
late endosome to vacuole transport GO:0045324 2 0.052
cell growth GO:0016049 160 0.052
nuclear transport GO:0051169 179 0.052
negative regulation of transport GO:0051051 176 0.052
establishment of protein localization to membrane GO:0090150 121 0.052
cellular response to endogenous stimulus GO:0071495 336 0.051
oxidoreduction coenzyme metabolic process GO:0006733 19 0.051
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.050
negative regulation of protein metabolic process GO:0051248 391 0.050
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.049
generation of neurons GO:0048699 152 0.049
protein processing GO:0016485 226 0.049
potassium ion transmembrane transport GO:0071805 60 0.049
photoreceptor cell differentiation GO:0046530 2 0.048
negative regulation of phosphorylation GO:0042326 174 0.048
oxidative stress induced premature senescence GO:0090403 3 0.048
regulation of locomotion GO:0040012 329 0.048
stress activated mapk cascade GO:0051403 93 0.048
negative regulation of apoptotic process GO:0043066 316 0.047
memory GO:0007613 3 0.047
response to cytokine GO:0034097 232 0.047
rho protein signal transduction GO:0007266 26 0.047
regulation of intracellular transport GO:0032386 195 0.047
negative regulation of transferase activity GO:0051348 124 0.047
receptor mediated endocytosis GO:0006898 84 0.047
immune response GO:0006955 307 0.046
positive regulation of proteolysis GO:0045862 142 0.046
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.046
regulation of rrna processing GO:2000232 1 0.046
neurogenesis GO:0022008 169 0.046
negative regulation of protein modification process GO:0031400 200 0.046
positive regulation of protein ubiquitination GO:0031398 53 0.046
positive regulation of sequestering of triglyceride GO:0010890 3 0.045
regulation of anion transport GO:0044070 25 0.045
negative regulation of phosphorus metabolic process GO:0010563 267 0.045
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.045
regulation of pathway restricted smad protein phosphorylation GO:0060393 34 0.044
maintenance of location GO:0051235 112 0.044
ribonucleoprotein complex localization GO:0071166 4 0.043
icosanoid secretion GO:0032309 11 0.043
signal transduction by phosphorylation GO:0023014 297 0.043
phosphatidylcholine metabolic process GO:0046470 19 0.043
receptor catabolic process GO:0032801 11 0.043
negative regulation of cell differentiation GO:0045596 171 0.043
taxis GO:0042330 157 0.042
vacuolar transport GO:0007034 34 0.042
positive regulation of nucleotide metabolic process GO:0045981 230 0.042
endodermal cell fate commitment GO:0001711 4 0.042
receptor internalization GO:0031623 43 0.042
regulation of ion transmembrane transporter activity GO:0032412 72 0.042
neuromuscular junction development GO:0007528 3 0.041
hematopoietic or lymphoid organ development GO:0048534 186 0.041
positive regulation of kinase activity GO:0033674 204 0.041
negative regulation of secretion GO:0051048 58 0.041
metencephalon development GO:0022037 2 0.040
response to host defenses GO:0052200 2 0.040
cell morphogenesis GO:0000902 296 0.040
small gtpase mediated signal transduction GO:0007264 78 0.040
purine nucleoside catabolic process GO:0006152 398 0.039
chemical homeostasis GO:0048878 306 0.039
nucleotide catabolic process GO:0009166 408 0.039
regulation of kinase activity GO:0043549 314 0.039
stress activated protein kinase signaling cascade GO:0031098 94 0.039
positive regulation of transferase activity GO:0051347 227 0.039
regulation of nervous system development GO:0051960 88 0.039
proteasomal protein catabolic process GO:0010498 176 0.038
cellular response to oxidative stress GO:0034599 85 0.038
regulation of wnt signaling pathway GO:0030111 123 0.038
regulation of transmembrane transport GO:0034762 139 0.038
plasma lipoprotein particle organization GO:0071827 22 0.038
receptor metabolic process GO:0043112 81 0.037
purine nucleotide catabolic process GO:0006195 405 0.037
pericardium development GO:0060039 2 0.037
regulation of transporter activity GO:0032409 82 0.036
activation of cysteine type endopeptidase activity GO:0097202 57 0.036
negative regulation of catalytic activity GO:0043086 335 0.036
regulation of bmp signaling pathway GO:0030510 27 0.036
nucleoside catabolic process GO:0009164 408 0.036
quinone metabolic process GO:1901661 18 0.036
lateral mesoderm development GO:0048368 1 0.036
glycosyl compound catabolic process GO:1901658 413 0.036
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.035
regulation of cell growth GO:0001558 135 0.035
regulation of notch signaling pathway GO:0008593 18 0.035
protein lipid complex assembly GO:0065005 12 0.035
actin cytoskeleton organization GO:0030036 207 0.034
purine ribonucleotide catabolic process GO:0009154 404 0.034
nuclear import GO:0051170 106 0.034
extrinsic apoptotic signaling pathway GO:0097191 119 0.034
regulation of lipid biosynthetic process GO:0046890 47 0.034
interaction with host GO:0051701 42 0.034
carbohydrate metabolic process GO:0005975 207 0.034
positive regulation of cell migration GO:0030335 172 0.034
polyprenol metabolic process GO:0016093 3 0.034
regulation of potassium ion transport GO:0043266 24 0.034
positive regulation of programmed cell death GO:0043068 249 0.033
golgi vesicle transport GO:0048193 80 0.033
regulation of receptor mediated endocytosis GO:0048259 32 0.033
neuron differentiation GO:0030182 138 0.033
organic acid biosynthetic process GO:0016053 97 0.033
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.033
positive regulation of cell motility GO:2000147 177 0.033
regulation of prostaglandin secretion GO:0032306 2 0.033
regulation of cellular response to growth factor stimulus GO:0090287 76 0.033
zymogen activation GO:0031638 70 0.033
ion transmembrane transport GO:0034220 338 0.033
heart formation GO:0060914 2 0.032
ribonucleoside triphosphate metabolic process GO:0009199 412 0.032
regulation of cellular component movement GO:0051270 334 0.032
asymmetric stem cell division GO:0098722 1 0.032
establishment of organelle localization GO:0051656 59 0.032
ribonucleoprotein complex biogenesis GO:0022613 116 0.032
polyprenol biosynthetic process GO:0016094 1 0.032
negative regulation of phosphate metabolic process GO:0045936 267 0.032
fatty acid derivative transport GO:1901571 11 0.031
negative regulation of developmental growth GO:0048640 10 0.031
regulation of secretion GO:0051046 194 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
mitochondrion organization GO:0007005 156 0.031
positive regulation of gtpase activity GO:0043547 166 0.031
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.031
regulation of neurotransmitter secretion GO:0046928 3 0.031
cell morphogenesis involved in differentiation GO:0000904 144 0.031
cell part morphogenesis GO:0032990 137 0.031
regulation of purine nucleotide catabolic process GO:0033121 205 0.031
phospholipid translocation GO:0045332 2 0.031
regulation of nucleotide metabolic process GO:0006140 269 0.031
regulation of ribosome biogenesis GO:0090069 1 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
regulation of apoptotic signaling pathway GO:2001233 175 0.030
sodium ion transport GO:0006814 61 0.030
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 2 0.030
locomotory behavior GO:0007626 1 0.030
cytokine production GO:0001816 247 0.029
cellular potassium ion transport GO:0071804 60 0.029
purine ribonucleoside catabolic process GO:0046130 398 0.029
monocarboxylic acid biosynthetic process GO:0072330 67 0.029
eye photoreceptor cell differentiation GO:0001754 2 0.029
regulation of peptidase activity GO:0052547 180 0.029
negative regulation of growth GO:0045926 97 0.029
regulation of lipid transport GO:0032368 44 0.029
regulation of mesoderm development GO:2000380 4 0.029
regeneration GO:0031099 4 0.029
lipid storage GO:0019915 28 0.029
steroid metabolic process GO:0008202 94 0.029
organ morphogenesis GO:0009887 147 0.029
regulation of endopeptidase activity GO:0052548 170 0.028
actin filament based process GO:0030029 224 0.028
lipid translocation GO:0034204 2 0.028
regulation of nucleocytoplasmic transport GO:0046822 98 0.028
positive regulation of protein kinase activity GO:0045860 190 0.028
regulation of ligase activity GO:0051340 29 0.028
spermatid differentiation GO:0048515 4 0.028
response to extracellular stimulus GO:0009991 85 0.028
response to nutrient levels GO:0031667 81 0.028
nerve development GO:0021675 4 0.027
negative regulation of nervous system development GO:0051961 28 0.027
response to wounding GO:0009611 168 0.027
inorganic ion transmembrane transport GO:0098660 231 0.027
regulation of cell migration GO:0030334 289 0.027
regulation of defense response GO:0031347 154 0.027
nucleoside triphosphate catabolic process GO:0009143 394 0.027
development involved in symbiotic interaction GO:0044111 1 0.027
regulation of fatty acid transport GO:2000191 8 0.027
regulation of glial cell differentiation GO:0045685 3 0.027
regulation of purine nucleotide metabolic process GO:1900542 264 0.027
ubiquitin dependent smad protein catabolic process GO:0030579 4 0.027
endodermal cell fate specification GO:0001714 4 0.027
regulation of cell motility GO:2000145 299 0.027
regulation of nucleoside metabolic process GO:0009118 209 0.027
regulation of ion transmembrane transport GO:0034765 132 0.027
regulation of protein kinase activity GO:0045859 289 0.026
regulation of endocytosis GO:0030100 72 0.026
regulation of fatty acid metabolic process GO:0019217 24 0.026
protein targeting to nucleus GO:0044744 104 0.026
nitrogen compound transport GO:0071705 191 0.026
regulation of anatomical structure morphogenesis GO:0022603 286 0.026
cellular response to abiotic stimulus GO:0071214 117 0.026
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.026
hindbrain development GO:0030902 3 0.026
single organism nuclear import GO:1902593 104 0.026
transmission of virus GO:0019089 1 0.026
positive regulation of protein phosphorylation GO:0001934 313 0.026
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.026
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.025
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.025
response to transforming growth factor beta GO:0071559 94 0.025
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.025
positive regulation of developmental process GO:0051094 314 0.025
glycerophospholipid biosynthetic process GO:0046474 40 0.025
purine ribonucleoside metabolic process GO:0046128 437 0.025
positive regulation of ion transport GO:0043270 87 0.025
ras protein signal transduction GO:0007265 73 0.025
transcription from rna polymerase iii promoter GO:0006383 19 0.025
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.025
oxidation reduction process GO:0055114 396 0.025
regulation of gtp catabolic process GO:0033124 180 0.025
nucleoside triphosphate metabolic process GO:0009141 422 0.025
response to tumor cell GO:0002347 10 0.025
single organismal cell cell adhesion GO:0016337 148 0.025
cellular response to radiation GO:0071478 65 0.024
positive regulation of phosphorylation GO:0042327 394 0.024
icosanoid transport GO:0071715 11 0.024
purine nucleoside triphosphate catabolic process GO:0009146 392 0.024
regulation of response to external stimulus GO:0032101 222 0.024
positive regulation of locomotion GO:0040017 186 0.024
maintenance of cell polarity GO:0030011 2 0.024
regulation of neuron differentiation GO:0045664 70 0.024
response to decreased oxygen levels GO:0036293 96 0.024
regulation of cell activation GO:0050865 125 0.024
organophosphate catabolic process GO:0046434 430 0.024
ion homeostasis GO:0050801 230 0.024
adult locomotory behavior GO:0008344 1 0.024
cerebellum development GO:0021549 2 0.024
trna transport GO:0051031 1 0.024
positive regulation of organ growth GO:0046622 2 0.023
negative regulation of ion transmembrane transport GO:0034766 26 0.023
ribonucleoside triphosphate catabolic process GO:0009203 391 0.023
guanosine containing compound catabolic process GO:1901069 239 0.023
neurotransmitter secretion GO:0007269 4 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
peptidyl serine phosphorylation GO:0018105 101 0.023
regulation of epithelial to mesenchymal transition GO:0010717 37 0.023
organelle localization GO:0051640 84 0.023
protein localization to nucleus GO:0034504 136 0.023
regulation of synaptic vesicle transport GO:1902803 3 0.023
regulation of gtpase activity GO:0043087 180 0.023
regulation of peptidyl serine phosphorylation GO:0033135 50 0.023
lymphocyte activation GO:0046649 133 0.023
response to nutrient GO:0007584 20 0.023
covalent chromatin modification GO:0016569 254 0.022
single organism cell adhesion GO:0098602 179 0.022
positive regulation of endopeptidase activity GO:0010950 84 0.022
organ formation GO:0048645 3 0.022
regulation of t cell activation GO:0050863 77 0.022
positive regulation of apoptotic process GO:0043065 246 0.022
protein oligomerization GO:0051259 173 0.022
regulation of protein localization to cell surface GO:2000008 15 0.022
dissemination or transmission of symbiont from host GO:0044007 1 0.022
ribosome localization GO:0033750 4 0.022
response to endoplasmic reticulum stress GO:0034976 49 0.022
avoidance of defenses of other organism involved in symbiotic interaction GO:0051832 2 0.022
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.022
negative regulation of bmp signaling pathway GO:0030514 17 0.021
regulation of nucleotide catabolic process GO:0030811 205 0.021
evasion or tolerance of host defenses by virus GO:0019049 2 0.021
regulation of immune effector process GO:0002697 91 0.021
cellular response to cytokine stimulus GO:0071345 181 0.021
carbohydrate derivative biosynthetic process GO:1901137 207 0.021
negative regulation of jun kinase activity GO:0043508 4 0.021
positive regulation of protein oligomerization GO:0032461 17 0.021
positive regulation of cellular component movement GO:0051272 181 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
kidney development GO:0001822 53 0.021
anterior posterior axis specification embryo GO:0008595 2 0.021
microtubule based process GO:0007017 210 0.021
positive regulation of fatty acid biosynthetic process GO:0045723 5 0.021
regulation of cardiac muscle tissue growth GO:0055021 4 0.021
protein import into mitochondrial matrix GO:0030150 1 0.021
gtp metabolic process GO:0046039 239 0.021
regulation of growth GO:0040008 165 0.021
regulation of sodium ion transmembrane transporter activity GO:2000649 17 0.021
regulation of body fluid levels GO:0050878 99 0.020
neuron development GO:0048666 113 0.020
fatty acid transport GO:0015908 25 0.020
intracellular mrna localization GO:0008298 1 0.020
positive regulation of apoptotic signaling pathway GO:2001235 70 0.020
ribonucleoside catabolic process GO:0042454 406 0.020
response to hypoxia GO:0001666 96 0.020
cell adhesion GO:0007155 325 0.020
ribosome biogenesis GO:0042254 48 0.020
mating GO:0007618 1 0.020
regulation of hormone levels GO:0010817 125 0.020
establishment of nucleus localization GO:0040023 1 0.020
head development GO:0060322 108 0.020
establishment of rna localization GO:0051236 39 0.020
regulation of dna metabolic process GO:0051052 153 0.020
regulation of ubiquitin protein transferase activity GO:0051438 28 0.020
regulation of canonical wnt signaling pathway GO:0060828 88 0.020
brain development GO:0007420 97 0.020
posttranscriptional regulation of gene expression GO:0010608 213 0.020
defense response GO:0006952 315 0.020
regulation of protein targeting GO:1903533 91 0.020
multi organism cellular process GO:0044764 156 0.020
monocarboxylic acid transport GO:0015718 32 0.019
negative regulation of alpha beta t cell activation GO:0046636 3 0.019
positive regulation of gtp catabolic process GO:0033126 166 0.019
membrane repolarization GO:0086009 23 0.019
positive regulation of immune system process GO:0002684 283 0.019
regulation of sodium ion transport GO:0002028 24 0.019
cardiac muscle contraction GO:0060048 34 0.019
spermatid development GO:0007286 4 0.019
endocytosis GO:0006897 159 0.019
regulation of cell cycle process GO:0010564 266 0.019
mitotic cell cycle GO:0000278 326 0.019
pathway restricted smad protein phosphorylation GO:0060389 38 0.019
long chain fatty acid transport GO:0015909 18 0.019
steroid biosynthetic process GO:0006694 46 0.019
regulation of cell morphogenesis GO:0022604 153 0.019
regulation of multivesicular body size GO:0010796 1 0.019
negative regulation of protein phosphorylation GO:0001933 140 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.019
activation of immune response GO:0002253 114 0.019
regulation of lymphocyte activation GO:0051249 103 0.019
dorsal ventral pattern formation GO:0009953 15 0.019
negative regulation of wnt signaling pathway GO:0030178 69 0.019

SPG20 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.039
nervous system disease DOID:863 431 0.039
disease of mental health DOID:150 70 0.028
sensory system disease DOID:0050155 203 0.022
eye and adnexa disease DOID:1492 150 0.022
eye disease DOID:5614 149 0.022
cardiovascular system disease DOID:1287 106 0.021