Homo sapiens

35 known processes

CPSF6

cleavage and polyadenylation specific factor 6, 68kDa

(Aliases: CFIM68,HPBRII-7,CFIM,HPBRII-4)

CPSF6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of meiotic cell cycle GO:0051445 4 0.900
Worm
rna polyadenylation GO:0043631 14 0.757
vesicle targeting rough er to cis golgi GO:0048207 2 0.567
renal sodium ion absorption GO:0070294 2 0.562
post embryonic development GO:0009791 2 0.536
protein ubiquitination GO:0016567 314 0.460
rna processing GO:0006396 255 0.428
cell development GO:0048468 328 0.412
Worm
ribonucleoprotein complex biogenesis GO:0022613 116 0.390
rna splicing GO:0008380 131 0.378
Fly
negative regulation of programmed cell death GO:0043069 321 0.353
multicellular organismal aging GO:0010259 3 0.306
determination of adult lifespan GO:0008340 2 0.302
rna splicing via transesterification reactions GO:0000375 90 0.291
Fly
mrna processing GO:0006397 133 0.283
mrna metabolic process GO:0016071 175 0.275
negative regulation of apoptotic process GO:0043066 316 0.251
protein k33 linked ubiquitination GO:1990390 1 0.250
renal sodium ion transport GO:0003096 2 0.229
protein modification by small protein conjugation GO:0032446 342 0.219
response to biotic stimulus GO:0009607 276 0.202
cellular macromolecule catabolic process GO:0044265 380 0.197
negative regulation of cell death GO:0060548 345 0.189
trna processing GO:0008033 23 0.169
actin filament based process GO:0030029 224 0.159
rna transport GO:0050658 39 0.149
viral process GO:0016032 146 0.148
purine ribonucleoside metabolic process GO:0046128 437 0.140
regulation of cell cycle process GO:0010564 266 0.132
Worm
mrna splicing via spliceosome GO:0000398 89 0.129
Fly
cell division GO:0051301 168 0.127
Worm
copii vesicle coating GO:0048208 2 0.121
ras protein signal transduction GO:0007265 73 0.120
translation GO:0006412 132 0.119
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.113
nucleic acid transport GO:0050657 39 0.113
lipid localization GO:0010876 106 0.113
negative regulation of protein metabolic process GO:0051248 391 0.112
mrna 3 end processing GO:0031124 24 0.112
ribosome biogenesis GO:0042254 48 0.110
vesicle mediated transport GO:0016192 371 0.104
regulation of translation GO:0006417 89 0.098
nucleocytoplasmic transport GO:0006913 176 0.097
rna export from nucleus GO:0006405 33 0.097
rna 3 end processing GO:0031123 35 0.096
defense response to other organism GO:0098542 129 0.096
posttranscriptional regulation of gene expression GO:0010608 213 0.094
regulation of mrna metabolic process GO:1903311 53 0.092
Fly
nucleobase containing compound transport GO:0015931 51 0.089
regulation of cell differentiation GO:0045595 393 0.089
chromatin organization GO:0006325 351 0.086
protein monoubiquitination GO:0006513 39 0.085
covalent chromatin modification GO:0016569 254 0.082
positive regulation of catabolic process GO:0009896 310 0.082
ubiquitin dependent endocytosis GO:0070086 1 0.080
nervous system development GO:0007399 293 0.079
regulation of anatomical structure morphogenesis GO:0022603 286 0.079
protein catabolic process GO:0030163 325 0.079
multi organism cellular process GO:0044764 156 0.077
cytoplasmic transport GO:0016482 379 0.075
cellular amino acid metabolic process GO:0006520 116 0.072
purine ribonucleotide catabolic process GO:0009154 404 0.071
embryo development GO:0009790 123 0.071
Worm
positive regulation of cellular component organization GO:0051130 376 0.070
ribonucleoside catabolic process GO:0042454 406 0.070
defense response GO:0006952 315 0.069
metal ion transport GO:0030001 272 0.068
ncrna processing GO:0034470 83 0.067
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.067
establishment of rna localization GO:0051236 39 0.065
modification dependent macromolecule catabolic process GO:0043632 212 0.065
chemical homeostasis GO:0048878 306 0.064
negative regulation of potassium ion transmembrane transporter activity GO:1901017 3 0.064
positive regulation of cell death GO:0010942 263 0.064
negative regulation of sodium ion transmembrane transporter activity GO:2000650 2 0.062
response to external biotic stimulus GO:0043207 261 0.060
growth GO:0040007 202 0.060
purine ribonucleoside catabolic process GO:0046130 398 0.060
hemopoiesis GO:0030097 180 0.059
rna interference GO:0016246 4 0.059
regulation of gene expression epigenetic GO:0040029 73 0.057
sodium ion transport GO:0006814 61 0.056
female gamete generation GO:0007292 2 0.056
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.055
protein localization to organelle GO:0033365 280 0.054
ion homeostasis GO:0050801 230 0.054
protein polyubiquitination GO:0000209 110 0.053
ncrna metabolic process GO:0034660 108 0.051
small gtpase mediated signal transduction GO:0007264 78 0.051
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.051
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.050
ubiquitin dependent protein catabolic process GO:0006511 206 0.050
ribonucleoprotein complex localization GO:0071166 4 0.050
rna localization GO:0006403 41 0.049
regulation of cell cycle GO:0051726 393 0.049
Worm
establishment of ribosome localization GO:0033753 4 0.048
nuclear transport GO:0051169 179 0.047
purine nucleoside triphosphate catabolic process GO:0009146 392 0.047
cellular macromolecular complex assembly GO:0034622 324 0.044
cell cycle phase transition GO:0044770 173 0.044
negative regulation of catalytic activity GO:0043086 335 0.044
regulation of cell division GO:0051302 116 0.044
Worm
embryo development ending in birth or egg hatching GO:0009792 34 0.043
Worm
lipid metabolic process GO:0006629 381 0.043
nucleoside triphosphate metabolic process GO:0009141 422 0.042
regulation of metal ion transport GO:0010959 120 0.041
actin cytoskeleton organization GO:0030036 207 0.041
cation transport GO:0006812 331 0.041
negative regulation of multi organism process GO:0043901 92 0.040
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.039
regulation of apoptotic signaling pathway GO:2001233 175 0.039
response to decreased oxygen levels GO:0036293 96 0.039
cellular response to oxidative stress GO:0034599 85 0.038
intracellular receptor signaling pathway GO:0030522 104 0.038
regulation of protein catabolic process GO:0042176 155 0.038
regulation of meiosis GO:0040020 3 0.038
Worm
positive regulation of developmental process GO:0051094 314 0.037
cell type specific apoptotic process GO:0097285 125 0.037
compound eye development GO:0048749 1 0.037
interspecies interaction between organisms GO:0044419 156 0.037
system process GO:0003008 349 0.035
negative regulation of viral process GO:0048525 66 0.035
cellular component morphogenesis GO:0032989 314 0.035
cellular protein complex assembly GO:0043623 188 0.033
regulation of histone h3 k27 methylation GO:0061085 4 0.033
lipid biosynthetic process GO:0008610 177 0.033
organelle fission GO:0048285 149 0.032
Worm
ribosomal large subunit export from nucleus GO:0000055 3 0.032
response to bacterium GO:0009617 144 0.031
tissue morphogenesis GO:0048729 96 0.031
wnt signaling pathway GO:0016055 156 0.031
developmental growth GO:0048589 48 0.031
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.030
Fly
regulation of ras protein signal transduction GO:0046578 155 0.030
histone modification GO:0016570 251 0.030
cofactor metabolic process GO:0051186 87 0.030
spermatid development GO:0007286 4 0.030
modification dependent protein catabolic process GO:0019941 209 0.029
positive regulation of cellular component biogenesis GO:0044089 158 0.029
negative regulation of cell differentiation GO:0045596 171 0.029
regulation of nucleotide catabolic process GO:0030811 205 0.029
ribonucleotide catabolic process GO:0009261 405 0.029
regulation of cytoskeleton organization GO:0051493 177 0.028
neuron development GO:0048666 113 0.027
regulation of viral process GO:0050792 103 0.027
regulation of transferase activity GO:0051338 355 0.027
rna phosphodiester bond hydrolysis GO:0090501 35 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
response to abiotic stimulus GO:0009628 336 0.026
organelle localization GO:0051640 84 0.026
neuron projection development GO:0031175 106 0.026
regulation of cellular ketone metabolic process GO:0010565 50 0.026
rrna processing GO:0006364 35 0.025
maintenance of location GO:0051235 112 0.025
negative regulation of response to external stimulus GO:0032102 83 0.025
mrna export from nucleus GO:0006406 29 0.025
regulation of cell development GO:0060284 161 0.025
nucleoside catabolic process GO:0009164 408 0.024
myeloid cell differentiation GO:0030099 117 0.024
ribonucleoside monophosphate catabolic process GO:0009158 158 0.024
purine nucleoside catabolic process GO:0006152 398 0.024
mitotic cell cycle process GO:1903047 286 0.024
purine nucleoside triphosphate metabolic process GO:0009144 412 0.023
ion transmembrane transport GO:0034220 338 0.023
protein acylation GO:0043543 138 0.023
regulation of multi organism process GO:0043900 157 0.023
generation of neurons GO:0048699 152 0.023
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.023
cellular response to endogenous stimulus GO:0071495 336 0.023
mitotic cell cycle phase transition GO:0044772 162 0.022
oogenesis GO:0048477 2 0.022
cell adhesion GO:0007155 325 0.022
regulation of actin filament based process GO:0032970 141 0.022
posttranscriptional gene silencing by rna GO:0035194 25 0.022
ribosome localization GO:0033750 4 0.022
positive regulation of apoptotic process GO:0043065 246 0.022
response to inorganic substance GO:0010035 127 0.022
multi organism reproductive process GO:0044703 54 0.022
Worm
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.022
positive regulation of cell differentiation GO:0045597 211 0.022
epithelial tube morphogenesis GO:0060562 38 0.022
membrane organization GO:0061024 292 0.022
cell cycle g1 s phase transition GO:0044843 80 0.021
cellular response to abiotic stimulus GO:0071214 117 0.021
chromatin modification GO:0016568 298 0.021
epithelium development GO:0060429 227 0.021
cardiovascular system development GO:0072358 262 0.021
regeneration GO:0031099 4 0.021
sulfur compound metabolic process GO:0006790 101 0.021
internal protein amino acid acetylation GO:0006475 101 0.021
regulation of cell growth GO:0001558 135 0.021
positive regulation of growth GO:0045927 58 0.020
regulation of cellular amine metabolic process GO:0033238 11 0.020
methylation GO:0032259 106 0.020
organic acid biosynthetic process GO:0016053 97 0.020
oocyte differentiation GO:0009994 2 0.020
distal tubule morphogenesis GO:0072156 3 0.020
coenzyme metabolic process GO:0006732 65 0.019
amine metabolic process GO:0009308 44 0.019
response to oxidative stress GO:0006979 121 0.019
ribonucleoprotein complex export from nucleus GO:0071426 4 0.019
endomembrane system organization GO:0010256 196 0.019
regulation of potassium ion transmembrane transport GO:1901379 20 0.019
regulation of cellular response to stress GO:0080135 244 0.019
cellular protein catabolic process GO:0044257 261 0.018
regulation of growth GO:0040008 165 0.018
positive regulation of immune system process GO:0002684 283 0.018
regulation of cellular component biogenesis GO:0044087 281 0.018
regulation of sodium ion transmembrane transport GO:1902305 23 0.018
establishment of organelle localization GO:0051656 59 0.018
multicellular organism reproduction GO:0032504 42 0.018
Worm
enzyme linked receptor protein signaling pathway GO:0007167 303 0.018
chromatin assembly or disassembly GO:0006333 78 0.018
regulation of purine nucleotide metabolic process GO:1900542 264 0.018
gene silencing by rna GO:0031047 26 0.018
regulation of cell adhesion GO:0030155 166 0.018
regulation of anatomical structure size GO:0090066 101 0.018
proteasomal protein catabolic process GO:0010498 176 0.018
regulation of developmental growth GO:0048638 30 0.018
cell projection organization GO:0030030 252 0.017
blastocyst development GO:0001824 3 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.017
regulation of establishment of protein localization GO:0070201 242 0.017
regulation of nuclear division GO:0051783 65 0.017
Worm
single organism membrane organization GO:0044802 268 0.017
apoptotic signaling pathway GO:0097190 268 0.017
positive regulation of intracellular transport GO:0032388 104 0.017
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
response to hypoxia GO:0001666 96 0.016
multicellular organismal reproductive process GO:0048609 40 0.016
Worm
biological adhesion GO:0022610 331 0.016
nucleoside phosphate catabolic process GO:1901292 412 0.016
cellular lipid metabolic process GO:0044255 303 0.016
purine containing compound catabolic process GO:0072523 411 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
reproductive process GO:0022414 106 0.016
Worm
endocytosis GO:0006897 159 0.016
regulation of cellular amino acid metabolic process GO:0006521 6 0.016
spermatid differentiation GO:0048515 4 0.016
vesicle targeting to from or within golgi GO:0048199 6 0.016
alternative mrna splicing via spliceosome GO:0000380 27 0.016
Fly
circulatory system process GO:0003013 113 0.016
trna metabolic process GO:0006399 35 0.016
protein localization to cytoskeleton GO:0044380 11 0.015
response to other organism GO:0051707 261 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
muscle system process GO:0003012 81 0.015
immune effector process GO:0002252 159 0.015
negative regulation of apoptotic signaling pathway GO:2001234 97 0.015
protein oligomerization GO:0051259 173 0.015
ribonucleoside triphosphate catabolic process GO:0009203 391 0.015
distal tubule development GO:0072017 4 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
regulation of response to external stimulus GO:0032101 222 0.014
cellular response to oxygen containing compound GO:1901701 276 0.014
response to virus GO:0009615 126 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
regulation of protein localization GO:0032880 296 0.014
immune system development GO:0002520 195 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.014
regulation of response to biotic stimulus GO:0002831 55 0.014
aging GO:0007568 66 0.013
ribonucleoside triphosphate metabolic process GO:0009199 412 0.013
neurogenesis GO:0022008 169 0.013
posttranscriptional gene silencing GO:0016441 25 0.013
ribonucleoprotein complex assembly GO:0022618 78 0.013
negative regulation of mrna processing GO:0050686 12 0.013
negative regulation of protein modification process GO:0031400 200 0.013
sensory organ development GO:0007423 52 0.013
regulation of immune effector process GO:0002697 91 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
single organism reproductive process GO:0044702 98 0.012
Worm
negative regulation of immune system process GO:0002683 136 0.012
nucleoside triphosphate catabolic process GO:0009143 394 0.012
protein alkylation GO:0008213 74 0.012
monovalent inorganic cation transport GO:0015672 128 0.012
negative regulation of defense response GO:0031348 47 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.012
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.012
small molecule biosynthetic process GO:0044283 157 0.012
mitochondrion organization GO:0007005 156 0.012
cellular ketone metabolic process GO:0042180 80 0.012
regulation of protein complex assembly GO:0043254 147 0.012
establishment of nucleus localization GO:0040023 1 0.012
negative regulation of developmental process GO:0051093 247 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
regulation of cell cycle g1 s phase transition GO:1902806 42 0.012
dendritic spine organization GO:0097061 4 0.011
convergent extension GO:0060026 1 0.011
positive regulation of cytoplasmic transport GO:1903651 82 0.011
regulation of nervous system development GO:0051960 88 0.011
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.011
regulation of circadian rhythm GO:0042752 11 0.011
reproduction GO:0000003 63 0.011
Worm
notch signaling pathway GO:0007219 31 0.011
response to radiation GO:0009314 151 0.011
cellular potassium ion transport GO:0071804 60 0.011
regulation of intracellular transport GO:0032386 195 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 22 0.011
Fly
regulation of protein processing GO:0070613 150 0.011
receptor mediated endocytosis GO:0006898 84 0.011
viral life cycle GO:0019058 132 0.011
nuclear export GO:0051168 69 0.011
cell growth GO:0016049 160 0.011
cardiac muscle contraction GO:0060048 34 0.011
negative regulation of locomotion GO:0040013 118 0.010
organonitrogen compound biosynthetic process GO:1901566 200 0.010
mrna catabolic process GO:0006402 56 0.010
mrna transport GO:0051028 30 0.010
regulation of purine nucleotide catabolic process GO:0033121 205 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010

CPSF6 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.013
neurodegenerative disease DOID:1289 102 0.013
nervous system disease DOID:863 431 0.013