Homo sapiens

8 known processes

FUS

fused in sarcoma

(Aliases: ALS6,TLS,HNRNPP2,POMP75,FUS1)

FUS biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
compound eye development GO:0048749 1 0.940
Fly
positive regulation of cellular component organization GO:0051130 376 0.804
Fly
positive regulation of cellular component biogenesis GO:0044089 158 0.784
Fly
regulation of cellular component biogenesis GO:0044087 281 0.722
Fly
positive regulation of developmental process GO:0051094 314 0.661
Fly
growth GO:0040007 202 0.552
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.490
nervous system development GO:0007399 293 0.481
Fly
sensory perception of light stimulus GO:0050953 35 0.463
sensory organ development GO:0007423 52 0.454
Fly
behavior GO:0007610 112 0.452
Fly
adult behavior GO:0030534 18 0.433
Fly
histone arginine methylation GO:0034969 6 0.428
regulation of mrna splicing via spliceosome GO:0048024 32 0.403
adult locomotory behavior GO:0008344 1 0.386
Fly
rna splicing GO:0008380 131 0.376
regeneration GO:0031099 4 0.372
neuromuscular junction development GO:0007528 3 0.349
Fly
determination of adult lifespan GO:0008340 2 0.341
negative regulation of epidermal cell differentiation GO:0045605 4 0.331
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902177 4 0.305
mitotic cell cycle GO:0000278 326 0.294
multicellular organismal aging GO:0010259 3 0.284
locomotory behavior GO:0007626 1 0.277
Fly
post embryonic development GO:0009791 2 0.271
regulation of meiosis GO:0040020 3 0.247
regulation of meiotic cell cycle GO:0051445 4 0.226
translation GO:0006412 132 0.226
regulation of alternative mrna splicing via spliceosome GO:0000381 22 0.179
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.178
eye development GO:0001654 42 0.168
Fly
mitotic cell cycle process GO:1903047 286 0.165
posttranscriptional gene silencing by rna GO:0035194 25 0.155
innate immune response GO:0045087 178 0.153
positive regulation of growth GO:0045927 58 0.151
Fly
posttranscriptional regulation of gene expression GO:0010608 213 0.148
neuron death in response to oxidative stress GO:0036475 9 0.141
defense response GO:0006952 315 0.139
mrna splicing via spliceosome GO:0000398 89 0.138
regulation of nervous system development GO:0051960 88 0.125
Fly
developmental growth GO:0048589 48 0.125
Fly
rna processing GO:0006396 255 0.125
regulation of neuron projection regeneration GO:0070570 1 0.119
regulation of apoptotic signaling pathway GO:2001233 175 0.110
negative regulation of response to oxidative stress GO:1902883 18 0.108
ncrna metabolic process GO:0034660 108 0.107
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.085
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.083
embryo development GO:0009790 123 0.081
regulation of reactive oxygen species metabolic process GO:2000377 41 0.079
positive regulation of developmental growth GO:0048639 16 0.078
Fly
cell type specific apoptotic process GO:0097285 125 0.078
positive regulation of chromatin assembly or disassembly GO:0045799 2 0.077
gene silencing by mirna GO:0035195 23 0.075
positive regulation of nervous system development GO:0051962 54 0.075
Fly
negative regulation of programmed cell death GO:0043069 321 0.073
negative regulation of protein metabolic process GO:0051248 391 0.072
central nervous system development GO:0007417 123 0.071
rna splicing via transesterification reactions GO:0000375 90 0.071
oogenesis GO:0048477 2 0.071
regulation of cell cycle GO:0051726 393 0.070
intracellular receptor signaling pathway GO:0030522 104 0.067
interspecies interaction between organisms GO:0044419 156 0.066
purine ribonucleotide catabolic process GO:0009154 404 0.066
cellular response to nitrogen compound GO:1901699 144 0.065
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 7 0.065
cell development GO:0048468 328 0.064
rna interference GO:0016246 4 0.063
response to wounding GO:0009611 168 0.063
intrinsic apoptotic signaling pathway GO:0097193 127 0.063
rna stabilization GO:0043489 18 0.062
response to nitrogen compound GO:1901698 184 0.061
actin filament based process GO:0030029 224 0.060
protein oligomerization GO:0051259 173 0.060
coenzyme metabolic process GO:0006732 65 0.059
mrna metabolic process GO:0016071 175 0.058
sensory perception GO:0007600 103 0.058
regulation of synapse assembly GO:0051963 5 0.058
Fly
production of mirnas involved in gene silencing by mirna GO:0035196 12 0.057
vesicle mediated transport GO:0016192 371 0.057
positive regulation of organelle organization GO:0010638 195 0.056
positive regulation of dna metabolic process GO:0051054 73 0.055
positive regulation of apoptotic signaling pathway GO:2001235 70 0.054
positive regulation of oxidative stress induced cell death GO:1903209 5 0.054
positive regulation of synapse assembly GO:0051965 5 0.054
Fly
positive regulation of mrna processing GO:0050685 17 0.053
negative regulation of apoptotic process GO:0043066 316 0.053
regulation of cellular response to stress GO:0080135 244 0.053
circadian rhythm GO:0007623 21 0.052
regulation of cellular response to oxidative stress GO:1900407 26 0.052
negative regulation of cell death GO:0060548 345 0.051
mrna stabilization GO:0048255 18 0.050
visual perception GO:0007601 27 0.050
neuron differentiation GO:0030182 138 0.050
rna export from nucleus GO:0006405 33 0.048
positive regulation of mrna metabolic process GO:1903313 19 0.048
negative regulation of cell differentiation GO:0045596 171 0.047
epithelial cell differentiation GO:0030855 141 0.046
hemopoiesis GO:0030097 180 0.046
protein stabilization GO:0050821 64 0.045
ribonucleoside catabolic process GO:0042454 406 0.043
regulation of cell morphogenesis GO:0022604 153 0.042
mitotic cell cycle phase transition GO:0044772 162 0.041
tissue homeostasis GO:0001894 63 0.041
female gamete generation GO:0007292 2 0.040
negative regulation of oxidative stress induced neuron death GO:1903204 7 0.039
membrane organization GO:0061024 292 0.039
negative regulation of intracellular signal transduction GO:1902532 183 0.039
ras protein signal transduction GO:0007265 73 0.038
cell projection organization GO:0030030 252 0.038
striated muscle myosin thick filament assembly GO:0071688 2 0.037
positive regulation of apoptotic process GO:0043065 246 0.036
cellular response to oxidative stress GO:0034599 85 0.036
single organism membrane organization GO:0044802 268 0.035
maintenance of location GO:0051235 112 0.035
regulation of response to wounding GO:1903034 101 0.035
synapse assembly GO:0007416 8 0.034
Fly
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.034
positive regulation of programmed cell death GO:0043068 249 0.034
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 7 0.034
myeloid cell differentiation GO:0030099 117 0.034
generation of neurons GO:0048699 152 0.032
tissue regeneration GO:0042246 3 0.031
regulation of synapse organization GO:0050807 7 0.031
Fly
response to axon injury GO:0048678 1 0.031
single organism behavior GO:0044708 28 0.030
Fly
positive regulation of protein complex assembly GO:0031334 86 0.030
regulation of developmental growth GO:0048638 30 0.030
Fly
positive regulation of isotype switching to iga isotypes GO:0048298 2 0.030
cellular component morphogenesis GO:0032989 314 0.029
response to abiotic stimulus GO:0009628 336 0.029
negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903377 5 0.028
negative regulation of developmental process GO:0051093 247 0.028
dsrna fragmentation GO:0031050 13 0.028
myeloid leukocyte differentiation GO:0002573 60 0.028
striated muscle cell differentiation GO:0051146 43 0.028
synapse organization GO:0050808 14 0.028
Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.028
ribonucleoprotein complex biogenesis GO:0022613 116 0.027
ossification GO:0001503 121 0.027
regulation of multi organism process GO:0043900 157 0.027
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.027
negative regulation of epidermis development GO:0045683 5 0.026
negative regulation of cellular response to oxidative stress GO:1900408 18 0.026
posttranscriptional gene silencing GO:0016441 25 0.026
regulation of rna stability GO:0043487 23 0.026
reactive oxygen species metabolic process GO:0072593 75 0.026
peptidyl arginine methylation to asymmetrical dimethyl arginine GO:0019919 2 0.026
covalent chromatin modification GO:0016569 254 0.026
purine nucleoside catabolic process GO:0006152 398 0.026
response to dsrna GO:0043331 25 0.026
regulation of cell cycle phase transition GO:1901987 126 0.025
somatic stem cell maintenance GO:0035019 4 0.025
cell growth GO:0016049 160 0.025
reproductive structure development GO:0048608 55 0.025
sex determination GO:0007530 3 0.024
organelle fission GO:0048285 149 0.024
cardiovascular system development GO:0072358 262 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
nucleotide catabolic process GO:0009166 408 0.024
cellular response to interferon gamma GO:0071346 24 0.024
regulation of cellular amine metabolic process GO:0033238 11 0.024
regulation of circadian rhythm GO:0042752 11 0.024
cellular response to dsrna GO:0071359 19 0.024
small gtpase mediated signal transduction GO:0007264 78 0.024
regulation of axon regeneration GO:0048679 1 0.024
negative regulation of multi organism process GO:0043901 92 0.024
central nervous system neuron differentiation GO:0021953 9 0.023
oocyte differentiation GO:0009994 2 0.023
cellular amino acid metabolic process GO:0006520 116 0.023
lipid storage GO:0019915 28 0.023
regulation of cell cycle process GO:0010564 266 0.023
positive regulation of keratinocyte proliferation GO:0010838 4 0.023
regulation of cell differentiation GO:0045595 393 0.022
immune effector process GO:0002252 159 0.022
myosin filament organization GO:0031033 2 0.022
glycosyl compound catabolic process GO:1901658 413 0.022
positive regulation of cell death GO:0010942 263 0.022
muscle cell development GO:0055001 29 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
osteoblast differentiation GO:0001649 92 0.022
reactive oxygen species biosynthetic process GO:1903409 4 0.022
immune system development GO:0002520 195 0.022
central nervous system neuron development GO:0021954 7 0.022
reproduction GO:0000003 63 0.022
Worm
positive regulation of immune system process GO:0002684 283 0.021
neuron projection regeneration GO:0031102 1 0.021
neurogenesis GO:0022008 169 0.021
system process GO:0003008 349 0.021
regulation of mrna metabolic process GO:1903311 53 0.021
binding of sperm to zona pellucida GO:0007339 3 0.021
negative regulation of apoptotic signaling pathway GO:2001234 97 0.021
regulation of mrna processing GO:0050684 48 0.020
protein methylation GO:0006479 74 0.020
regulation of growth GO:0040008 165 0.020
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
sperm egg recognition GO:0035036 3 0.020
mitotic spindle organization GO:0007052 27 0.020
hematopoietic progenitor cell differentiation GO:0002244 38 0.020
apoptotic signaling pathway GO:0097190 268 0.019
amine metabolic process GO:0009308 44 0.019
chromatin assembly or disassembly GO:0006333 78 0.019
cellular response to cytokine stimulus GO:0071345 181 0.019
neuron development GO:0048666 113 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
immune response GO:0006955 307 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.019
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.019
response to organic cyclic compound GO:0014070 204 0.019
chromatin silencing at rdna GO:0000183 5 0.019
muscle cell differentiation GO:0042692 63 0.019
actin cytoskeleton organization GO:0030036 207 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.018
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.018
regulation of leukocyte differentiation GO:1902105 61 0.018
cloaca development GO:0035844 1 0.018
organelle assembly GO:0070925 176 0.018
cellular response to nutrient levels GO:0031669 69 0.018
cloacal septation GO:0060197 1 0.018
negative regulation of epithelial cell differentiation GO:0030857 6 0.018
nucleoside catabolic process GO:0009164 408 0.018
epidermal cell differentiation GO:0009913 45 0.018
gtp catabolic process GO:0006184 237 0.018
regulation of myeloid cell differentiation GO:0045637 81 0.018
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.017
nucleoside triphosphate metabolic process GO:0009141 422 0.017
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.017
chemical homeostasis GO:0048878 306 0.017
regulation of protein stability GO:0031647 87 0.017
histone modification GO:0016570 251 0.017
purine nucleoside monophosphate metabolic process GO:0009126 186 0.017
methylation GO:0032259 106 0.017
mitochondrion organization GO:0007005 156 0.017
chordate embryonic development GO:0043009 34 0.017
negative regulation of cell cycle process GO:0010948 121 0.017
ventricular septum morphogenesis GO:0060412 3 0.017
cellular macromolecule catabolic process GO:0044265 380 0.016
cerebellum development GO:0021549 2 0.016
positive regulation of mitochondrion organization GO:0010822 30 0.016
protein catabolic process GO:0030163 325 0.016
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.016
gene silencing GO:0016458 49 0.016
cell activation GO:0001775 213 0.016
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
neurological system process GO:0050877 163 0.015
cellular macromolecular complex assembly GO:0034622 324 0.015
axon regeneration GO:0031103 1 0.015
nuclear division GO:0000280 128 0.015
lipid localization GO:0010876 106 0.015
response to extracellular stimulus GO:0009991 85 0.015
nucleoside monophosphate catabolic process GO:0009125 159 0.015
spindle organization GO:0007051 53 0.015
neuron apoptotic process GO:0051402 39 0.015
cellular component disassembly GO:0022411 92 0.015
cofactor metabolic process GO:0051186 87 0.015
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.015
cellular response to organic cyclic compound GO:0071407 127 0.015
myosin filament assembly GO:0031034 2 0.015
ribosome biogenesis GO:0042254 48 0.015
ribonucleoprotein complex assembly GO:0022618 78 0.015
protein localization to membrane GO:0072657 160 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.015
atp metabolic process GO:0046034 176 0.015
response to fungus GO:0009620 4 0.014
viral life cycle GO:0019058 132 0.014
modification dependent macromolecule catabolic process GO:0043632 212 0.014
head development GO:0060322 108 0.014
defense response to other organism GO:0098542 129 0.014
macromolecular complex disassembly GO:0032984 60 0.014
regulation of response to oxidative stress GO:1902882 26 0.014
receptor metabolic process GO:0043112 81 0.014
organic acid biosynthetic process GO:0016053 97 0.014
response to starvation GO:0042594 59 0.014
regulation of viral process GO:0050792 103 0.014
positive regulation of lymphocyte activation GO:0051251 73 0.014
regulation of nuclear division GO:0051783 65 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.014
cellular component assembly involved in morphogenesis GO:0010927 73 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.014
macromolecule methylation GO:0043414 97 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
endomembrane system organization GO:0010256 196 0.013
microtubule based process GO:0007017 210 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
female sex determination GO:0030237 1 0.013
response to nutrient levels GO:0031667 81 0.013
cytokinesis GO:0000910 96 0.013
positive regulation of cell differentiation GO:0045597 211 0.013
peptidyl arginine n methylation GO:0035246 6 0.013
cellular amine metabolic process GO:0044106 41 0.013
negative regulation of myeloid cell differentiation GO:0045638 42 0.013
negative regulation of immune system process GO:0002683 136 0.013
reproductive process GO:0022414 106 0.013
gene silencing by rna GO:0031047 26 0.013
regulation of cell development GO:0060284 161 0.013
ncrna processing GO:0034470 83 0.013
cellular response to external stimulus GO:0071496 111 0.013
multi organism reproductive process GO:0044703 54 0.013
negative regulation of multicellular organismal process GO:0051241 317 0.013
regulation of glial cell differentiation GO:0045685 3 0.013
protein complex disassembly GO:0043241 52 0.013
sulfur compound metabolic process GO:0006790 101 0.013
protein deacylation GO:0035601 39 0.013
mrna export from nucleus GO:0006406 29 0.013
purine containing compound catabolic process GO:0072523 411 0.012
cell morphogenesis GO:0000902 296 0.012
cell death in response to oxidative stress GO:0036473 29 0.012
spermatid differentiation GO:0048515 4 0.012
negative regulation of cell cycle GO:0045786 193 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
multi organism cellular process GO:0044764 156 0.012
regulation of mrna stability GO:0043488 23 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
negative regulation of organelle organization GO:0010639 126 0.012
negative regulation of oxidative stress induced cell death GO:1903202 17 0.012
regulation of protein complex disassembly GO:0043244 28 0.012
response to hypoxia GO:0001666 96 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
epithelial cell proliferation GO:0050673 128 0.012
dna replication GO:0006260 116 0.012
response to radiation GO:0009314 151 0.011
regulation of gene expression epigenetic GO:0040029 73 0.011
cellular protein catabolic process GO:0044257 261 0.011
negative regulation of response to external stimulus GO:0032102 83 0.011
morphogenesis of a polarized epithelium GO:0001738 3 0.011
response to oxidative stress GO:0006979 121 0.011
response to interferon gamma GO:0034341 39 0.011
divalent inorganic cation homeostasis GO:0072507 136 0.011
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
negative regulation of circadian rhythm GO:0042754 1 0.011
response to biotic stimulus GO:0009607 276 0.011
spermatid development GO:0007286 4 0.011
dna packaging GO:0006323 77 0.011
lipid metabolic process GO:0006629 381 0.011
organophosphate catabolic process GO:0046434 430 0.011
neuron death GO:0070997 65 0.011
negative regulation of cytoskeleton organization GO:0051494 45 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.011
release of cytochrome c from mitochondria GO:0001836 35 0.011
regulation of cellular amino acid metabolic process GO:0006521 6 0.011
cellular cation homeostasis GO:0030003 163 0.011
nucleoside phosphate catabolic process GO:1901292 412 0.011
brain development GO:0007420 97 0.011
modification of morphology or physiology of other organism GO:0035821 43 0.011
alpha amino acid metabolic process GO:1901605 72 0.011
ameboidal type cell migration GO:0001667 135 0.011
regulation of myeloid leukocyte differentiation GO:0002761 39 0.011
regulation of cell substrate adhesion GO:0010810 68 0.010
regulation of lymphocyte activation GO:0051249 103 0.010
atrial septum primum morphogenesis GO:0003289 1 0.010
regulation of ras gtpase activity GO:0032318 128 0.010
muscle contraction GO:0006936 73 0.010
modulation by host of viral transcription GO:0043921 20 0.010
regulation of cellular component movement GO:0051270 334 0.010
morphogenesis of embryonic epithelium GO:0016331 4 0.010
positive regulation of cell cycle GO:0045787 140 0.010
cardiac muscle tissue development GO:0048738 39 0.010
nucleoside triphosphate catabolic process GO:0009143 394 0.010
macromolecule deacylation GO:0098732 41 0.010
negative regulation of neuron death GO:1901215 32 0.010
defense response to virus GO:0051607 71 0.010
regulation of translation GO:0006417 89 0.010
cation transport GO:0006812 331 0.010
skeletal system development GO:0001501 79 0.010

FUS disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.125
Human
disease of cellular proliferation DOID:14566 174 0.125
Human
organ system cancer DOID:0050686 164 0.120
Human
musculoskeletal system cancer DOID:0060100 11 0.110
Human
sensory system disease DOID:0050155 203 0.033
nervous system disease DOID:863 431 0.033
central nervous system disease DOID:331 186 0.013
musculoskeletal system disease DOID:17 223 0.013
muscular disease DOID:0080000 114 0.013
eye and adnexa disease DOID:1492 150 0.011
neurodegenerative disease DOID:1289 102 0.010
disease of metabolism DOID:0014667 295 0.010
carbohydrate metabolism disease DOID:0050013 32 0.010
acquired metabolic disease DOID:0060158 58 0.010
motor neuron disease DOID:231 27 0.003
amyotrophic lateral sclerosis DOID:332 20 0.002