|
|
negative regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014067 |
4 |
0.925
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.803
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.721
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.694
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.667
|
|
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.584
|
|
|
|
positive regulation of fibroblast growth factor receptor signaling pathway
|
GO:0045743 |
3 |
0.545
|
Fly |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.536
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.523
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.390
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.357
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.315
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.312
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.311
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.293
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.268
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.266
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.247
|
|
|
|
positive regulation of exosomal secretion
|
GO:1903543 |
12 |
0.228
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.228
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.225
|
Worm Fly |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.219
|
|
|
|
endosome to lysosome transport
|
GO:0008333 |
21 |
0.213
|
Worm |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.207
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.202
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.202
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.199
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.198
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.195
|
Worm |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.186
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.173
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.172
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.166
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.164
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.155
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.152
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.151
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.140
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.139
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.138
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.136
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.136
|
Worm Fly |
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.136
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.135
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.129
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.125
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.125
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.123
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.121
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.121
|
Worm |
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.121
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.120
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.118
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.116
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.116
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.112
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.110
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.110
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.109
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.108
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.106
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.106
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.104
|
|
|
|
multi organism organelle organization
|
GO:1902590 |
9 |
0.104
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.103
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.103
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.102
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.102
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.102
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.101
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.099
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.099
|
|
|
|
vesicle organization
|
GO:0016050 |
62 |
0.098
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.098
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.097
|
Worm |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.094
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.093
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.092
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.092
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.092
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.091
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.086
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.085
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.083
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.082
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.082
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.081
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.081
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.081
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.081
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.081
|
Worm |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.080
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.079
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.079
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.079
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.078
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.078
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.077
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.077
|
Fly |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.076
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.076
|
|
|
|
viral budding
|
GO:0046755 |
9 |
0.075
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.073
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.073
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.073
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.072
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.072
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.072
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.072
|
Fly |
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.071
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.070
|
Worm |
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.068
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.066
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.065
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.065
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.065
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.064
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.064
|
Worm |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.063
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.063
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.063
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.062
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.061
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.061
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.061
|
Fly |
|
|
protein complex disassembly
|
GO:0043241 |
52 |
0.061
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.061
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.060
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.059
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.059
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.059
|
Fly |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.059
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.059
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.058
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.058
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.057
|
|
|
|
growth
|
GO:0040007 |
202 |
0.057
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.056
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.056
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.055
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.055
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.055
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.054
|
|
|
|
protein k48 linked deubiquitination
|
GO:0071108 |
19 |
0.054
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.054
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.054
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.053
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.053
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.053
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.053
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.052
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.052
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.051
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.051
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.051
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.051
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.051
|
|
|
|
negative regulation of jak stat cascade
|
GO:0046426 |
4 |
0.050
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.050
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.050
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.049
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.049
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.048
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.048
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.047
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.047
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.047
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.047
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.047
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.046
|
|
|
|
protein k63 linked deubiquitination
|
GO:0070536 |
21 |
0.046
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.046
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.046
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.046
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.045
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.044
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.044
|
|
|
|
regulation of symbiosis encompassing mutualism through parasitism
|
GO:0043903 |
109 |
0.044
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.044
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.044
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.044
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.044
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.044
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.043
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.042
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.042
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.042
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.041
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.041
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.041
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.040
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.040
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.040
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.040
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.040
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.039
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.039
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.039
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.039
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.039
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.039
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.038
|
|
|
|
receptor metabolic process
|
GO:0043112 |
81 |
0.038
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.038
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.038
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.038
|
|
|
|
potassium ion transmembrane transport
|
GO:0071805 |
60 |
0.038
|
|
|
|
memory
|
GO:0007613 |
3 |
0.038
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.038
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.037
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.037
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.037
|
|
|
|
regulation of viral process
|
GO:0050792 |
103 |
0.037
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.037
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.037
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.037
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.036
|
|
|
|
exosomal secretion
|
GO:1990182 |
15 |
0.036
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.035
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.035
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.035
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.035
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.035
|
|
|
|
alcohol biosynthetic process
|
GO:0046165 |
52 |
0.034
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.034
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.034
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.034
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.034
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.034
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.034
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.034
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.034
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.034
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.034
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.033
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.033
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.033
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.032
|
Fly |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.032
|
|
|
|
positive regulation of viral process
|
GO:0048524 |
37 |
0.032
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.032
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.032
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.032
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.032
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.031
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.031
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.031
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.031
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.031
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.031
|
|
|
|
response to starvation
|
GO:0042594 |
59 |
0.031
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.031
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.031
|
|
|
|
mitotic cytokinesis
|
GO:0000281 |
19 |
0.030
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.030
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.030
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.030
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.030
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.030
|
|
|
|
protein depolymerization
|
GO:0051261 |
30 |
0.030
|
|
|
|
system process
|
GO:0003008 |
349 |
0.030
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.030
|
Fly |
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.030
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.029
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.029
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.029
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.029
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.029
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.029
|
Fly |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.029
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.029
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.028
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.028
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.028
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
44 |
0.028
|
Fly |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.028
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.028
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.028
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.028
|
Worm |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.028
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.027
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.027
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.027
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.027
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.027
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.027
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.027
|
|
|
|
endosome organization
|
GO:0007032 |
20 |
0.027
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.026
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.026
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.026
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.026
|
Fly |
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.026
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.026
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.025
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.025
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.025
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.025
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.025
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.025
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.025
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.025
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.025
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.025
|
Fly |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.025
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.025
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.025
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.025
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.024
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.024
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.024
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.024
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.024
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.024
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.024
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.023
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.023
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.023
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.023
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.023
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.023
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.023
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.023
|
|
|
|
exocytosis
|
GO:0006887 |
71 |
0.023
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.022
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.022
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.022
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.022
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.022
|
|
|
|
regulation of rab protein signal transduction
|
GO:0032483 |
39 |
0.022
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.022
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.022
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.022
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.022
|
Worm |
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.021
|
|
|
|
viral life cycle
|
GO:0019058 |
132 |
0.021
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.021
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.021
|
|
|
|
metencephalon development
|
GO:0022037 |
2 |
0.021
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.021
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.021
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.021
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.021
|
|
|
|
ribonucleoprotein complex biogenesis
|
GO:0022613 |
116 |
0.021
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.021
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.021
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.021
|
Worm Fly |
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.021
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.020
|
|
|
|
early endosome to late endosome transport
|
GO:0045022 |
21 |
0.020
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.020
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.020
|
|
|
|
endodermal cell fate commitment
|
GO:0001711 |
4 |
0.020
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.020
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.020
|
|
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
32 |
0.020
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.020
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.020
|
|
|
|
nucleus localization
|
GO:0051647 |
1 |
0.020
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.020
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.020
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.019
|
|
|
|
organic acid biosynthetic process
|
GO:0016053 |
97 |
0.019
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
51 |
0.019
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.019
|
Fly |
|
|
nuclear division
|
GO:0000280 |
128 |
0.019
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.019
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.019
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.019
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.018
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.018
|
|
|
|
cytoskeleton dependent cytokinesis
|
GO:0061640 |
22 |
0.018
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.018
|
|
|
|
endosome transport via multivesicular body sorting pathway
|
GO:0032509 |
3 |
0.018
|
|
|
|
regulation of exosomal secretion
|
GO:1903541 |
12 |
0.018
|
|
|
|
ncrna processing
|
GO:0034470 |
83 |
0.018
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.018
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.018
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.018
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.018
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.018
|
|
|
|
regulation of potassium ion transmembrane transport
|
GO:1901379 |
20 |
0.018
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.018
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.017
|
|
|
|
lysosomal transport
|
GO:0007041 |
33 |
0.017
|
Worm |
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.017
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.017
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.017
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.017
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.017
|
|
|
|
negative regulation of small gtpase mediated signal transduction
|
GO:0051058 |
12 |
0.017
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.017
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.017
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.017
|
|
|
|
maintenance of cell polarity
|
GO:0030011 |
2 |
0.017
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.017
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.017
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.016
|
|
|
|
response to salt stress
|
GO:0009651 |
3 |
0.016
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.016
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.016
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.016
|
|
|
|
rab protein signal transduction
|
GO:0032482 |
4 |
0.016
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.016
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.016
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.016
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.016
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.016
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.016
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.016
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.016
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.015
|
|
|
|
establishment of ribosome localization
|
GO:0033753 |
4 |
0.015
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.015
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.015
|
|
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
31 |
0.015
|
|
|
|
mitochondrion distribution
|
GO:0048311 |
3 |
0.015
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.015
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.015
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
56 |
0.015
|
|
|
|
negative regulation of cell cell adhesion
|
GO:0022408 |
27 |
0.015
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.015
|
|
|
|
virion assembly
|
GO:0019068 |
14 |
0.015
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.015
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.015
|
|
|
|
multi organism membrane organization
|
GO:0044803 |
12 |
0.015
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.015
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.015
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.015
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.014
|
|
|
|
carboxylic acid biosynthetic process
|
GO:0046394 |
97 |
0.014
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.014
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.014
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.014
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.014
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.014
|
|
|
|
cellular potassium ion transport
|
GO:0071804 |
60 |
0.014
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.014
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.014
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.014
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.014
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.014
|
|
|
|
establishment of nucleus localization
|
GO:0040023 |
1 |
0.014
|
|
|
|
late endosome to vacuole transport
|
GO:0045324 |
2 |
0.014
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.014
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.014
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.014
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.014
|
|
|
|
ribonucleoprotein complex localization
|
GO:0071166 |
4 |
0.014
|
|
|
|
hemostasis
|
GO:0007599 |
76 |
0.014
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.014
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.014
|
|
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.013
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.013
|
|
|
|
multi organism membrane budding
|
GO:1902592 |
9 |
0.013
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.013
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.013
|
|
|
|
positive regulation of exocytosis
|
GO:0045921 |
35 |
0.013
|
|
|
|
vacuole organization
|
GO:0007033 |
44 |
0.013
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.013
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.013
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.013
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.013
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.013
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.013
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.013
|
|
|
|
transition metal ion homeostasis
|
GO:0055076 |
31 |
0.013
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.013
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.013
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.013
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.013
|
|
|
|
establishment or maintenance of epithelial cell apical basal polarity
|
GO:0045197 |
1 |
0.013
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
44 |
0.013
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.013
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
92 |
0.013
|
|
|
|
establishment of planar polarity
|
GO:0001736 |
3 |
0.013
|
|
|
|
er associated ubiquitin dependent protein catabolic process
|
GO:0030433 |
31 |
0.013
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.013
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.013
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.012
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.012
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.012
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.012
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.012
|
|
|
|
nuclear migration
|
GO:0007097 |
1 |
0.012
|
|
|
|
rrna metabolic process
|
GO:0016072 |
40 |
0.012
|
|
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.012
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.012
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.012
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.012
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.012
|
|
