Homo sapiens

94 known processes

HGS

hepatocyte growth factor-regulated tyrosine kinase substrate

(Aliases: FLJ11421,HRS,FLJ39878)

HGS biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein deubiquitination GO:0016579 79 0.792
vesicle mediated transport GO:0016192 371 0.790
protein catabolic process GO:0030163 325 0.734
cytoplasmic transport GO:0016482 379 0.718
endosomal transport GO:0016197 129 0.683
Fly
cellular macromolecule catabolic process GO:0044265 380 0.630
histone modification GO:0016570 251 0.591
protein modification by small protein conjugation GO:0032446 342 0.588
Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.569
Fly
single organism cellular localization GO:1902580 332 0.531
covalent chromatin modification GO:0016569 254 0.510
protein ubiquitination GO:0016567 314 0.499
Fly
vacuolar transport GO:0007034 34 0.468
positive regulation of catabolic process GO:0009896 310 0.463
actin filament based process GO:0030029 224 0.455
modulation of growth of symbiont involved in interaction with host GO:0044144 2 0.426
chromatin modification GO:0016568 298 0.417
actin cytoskeleton organization GO:0030036 207 0.402
modification dependent protein catabolic process GO:0019941 209 0.400
peptidyl lysine modification GO:0018205 144 0.378
mitotic cell cycle process GO:1903047 286 0.375
golgi vesicle transport GO:0048193 80 0.369
viral budding GO:0046755 9 0.354
epithelial cell differentiation GO:0030855 141 0.351
Fly
locomotory behavior GO:0007626 1 0.350
spermatid development GO:0007286 4 0.331
g protein coupled receptor signaling pathway GO:0007186 207 0.328
regulation of exocytosis GO:0017157 46 0.318
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.302
positive regulation of gtpase activity GO:0043547 166 0.297
mitotic cell cycle GO:0000278 326 0.279
glycosyl compound catabolic process GO:1901658 413 0.255
spermatid differentiation GO:0048515 4 0.254
intracellular protein transport GO:0006886 270 0.219
cell projection organization GO:0030030 252 0.217
positive regulation of phosphorylation GO:0042327 394 0.212
guanosine containing compound metabolic process GO:1901068 244 0.211
single organism membrane organization GO:0044802 268 0.194
positive regulation of proteolysis GO:0045862 142 0.175
ras protein signal transduction GO:0007265 73 0.172
regulation of proteolysis GO:0030162 293 0.171
regulation of chromatin organization GO:1902275 56 0.169
cellular protein catabolic process GO:0044257 261 0.167
establishment of protein localization to membrane GO:0090150 121 0.165
regulation of vesicle mediated transport GO:0060627 130 0.165
regulation of proteasomal protein catabolic process GO:0061136 87 0.162
cell adhesion GO:0007155 325 0.162
ubiquitin dependent protein catabolic process GO:0006511 206 0.158
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.157
regulation of nucleoside metabolic process GO:0009118 209 0.150
circulatory system development GO:0072359 262 0.145
regulation of dna metabolic process GO:0051052 153 0.144
regulation of secretion by cell GO:1903530 177 0.141
small gtpase mediated signal transduction GO:0007264 78 0.140
regulation of peptidase activity GO:0052547 180 0.139
positive regulation of hydrolase activity GO:0051345 331 0.136
maintenance of location GO:0051235 112 0.126
post embryonic development GO:0009791 2 0.126
Worm
defense response GO:0006952 315 0.125
nucleotide catabolic process GO:0009166 408 0.124
innate immune response GO:0045087 178 0.123
regulation of cellular ketone metabolic process GO:0010565 50 0.123
anatomical structure formation involved in morphogenesis GO:0048646 284 0.122
protein polyubiquitination GO:0000209 110 0.119
dna packaging GO:0006323 77 0.117
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.117
actin filament organization GO:0007015 128 0.116
nucleoside triphosphate catabolic process GO:0009143 394 0.114
proteasomal protein catabolic process GO:0010498 176 0.113
organelle fission GO:0048285 149 0.110
positive regulation of cellular component organization GO:0051130 376 0.107
negative regulation of intracellular signal transduction GO:1902532 183 0.105
rab protein signal transduction GO:0032482 4 0.105
biological adhesion GO:0022610 331 0.105
regulation of cell cycle GO:0051726 393 0.101
Fly
endomembrane system organization GO:0010256 196 0.095
cell morphogenesis GO:0000902 296 0.094
purine nucleoside catabolic process GO:0006152 398 0.093
modification dependent macromolecule catabolic process GO:0043632 212 0.093
regulation of growth GO:0040008 165 0.092
establishment of protein localization to organelle GO:0072594 172 0.091
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.091
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.089
regulation of endopeptidase activity GO:0052548 170 0.087
cellular component morphogenesis GO:0032989 314 0.086
ribonucleoside catabolic process GO:0042454 406 0.085
regulation of anatomical structure morphogenesis GO:0022603 286 0.082
inorganic ion transmembrane transport GO:0098660 231 0.079
nucleoside catabolic process GO:0009164 408 0.079
organelle assembly GO:0070925 176 0.078
nervous system development GO:0007399 293 0.078
regulation of kinase activity GO:0043549 314 0.077
regulation of cellular component movement GO:0051270 334 0.076
Fly
cellular potassium ion transport GO:0071804 60 0.074
cell projection morphogenesis GO:0048858 129 0.073
plasma membrane organization GO:0007009 115 0.072
microtubule based process GO:0007017 210 0.072
cellular response to endogenous stimulus GO:0071495 336 0.072
Fly
positive regulation of protein catabolic process GO:0045732 75 0.071
regulation of cell adhesion GO:0030155 166 0.070
i kappab kinase nf kappab signaling GO:0007249 166 0.070
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.070
Fly
regulation of protein catabolic process GO:0042176 155 0.069
protein acetylation GO:0006473 116 0.069
organ morphogenesis GO:0009887 147 0.068
nitrogen compound transport GO:0071705 191 0.068
growth GO:0040007 202 0.068
regulation of cell projection organization GO:0031344 107 0.067
response to hormone GO:0009725 175 0.067
cellular response to oxygen containing compound GO:1901701 276 0.066
response to other organism GO:0051707 261 0.065
regulation of small gtpase mediated signal transduction GO:0051056 156 0.064
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.064
Fly
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.064
protein deacetylation GO:0006476 38 0.063
purine nucleotide catabolic process GO:0006195 405 0.063
embryo development GO:0009790 123 0.062
Worm
mapk cascade GO:0000165 288 0.062
immune response GO:0006955 307 0.061
purine nucleoside triphosphate catabolic process GO:0009146 392 0.061
response to oxygen containing compound GO:1901700 369 0.061
positive regulation of nucleotide metabolic process GO:0045981 230 0.061
peptidyl lysine acetylation GO:0018394 101 0.059
regulation of purine nucleotide catabolic process GO:0033121 205 0.059
negative regulation of camp mediated signaling GO:0043951 4 0.058
protein targeting GO:0006605 187 0.058
negative regulation of cellular protein metabolic process GO:0032269 353 0.058
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.055
cell development GO:0048468 328 0.054
Fly
dna repair GO:0006281 198 0.054
protein oligomerization GO:0051259 173 0.053
ribonucleoside triphosphate metabolic process GO:0009199 412 0.052
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.051
regulation of gtp catabolic process GO:0033124 180 0.051
secretion by cell GO:0032940 226 0.050
membrane organization GO:0061024 292 0.050
protein deacylation GO:0035601 39 0.050
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.050
regulation of ras protein signal transduction GO:0046578 155 0.050
meiosis i GO:0007127 4 0.050
potassium ion transport GO:0006813 62 0.049
positive regulation of nucleotide catabolic process GO:0030813 185 0.049
tube development GO:0035295 125 0.049
hemopoiesis GO:0030097 180 0.049
positive regulation of transferase activity GO:0051347 227 0.048
regulation of transferase activity GO:0051338 355 0.048
negative regulation of apoptotic process GO:0043066 316 0.048
negative regulation of cellular component organization GO:0051129 235 0.047
nucleoside triphosphate metabolic process GO:0009141 422 0.047
negative regulation of protein modification process GO:0031400 200 0.047
Fly
positive regulation of protein kinase activity GO:0045860 190 0.046
chromatin organization GO:0006325 351 0.046
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.046
purine ribonucleoside metabolic process GO:0046128 437 0.046
negative regulation of potassium ion transmembrane transport GO:1901380 5 0.046
positive regulation of nucleoside metabolic process GO:0045979 186 0.045
negative regulation of protein maturation GO:1903318 142 0.044
regulation of protein localization GO:0032880 296 0.044
regulation of secretion GO:0051046 194 0.044
intracellular receptor signaling pathway GO:0030522 104 0.043
negative regulation of cell death GO:0060548 345 0.042
cellular ketone metabolic process GO:0042180 80 0.042
enzyme linked receptor protein signaling pathway GO:0007167 303 0.042
Fly
gene silencing GO:0016458 49 0.042
signal transduction by phosphorylation GO:0023014 297 0.041
regulation of apoptotic signaling pathway GO:2001233 175 0.041
protein localization to organelle GO:0033365 280 0.041
multi organism membrane budding GO:1902592 9 0.041
response to growth factor GO:0070848 205 0.040
Fly
negative regulation of programmed cell death GO:0043069 321 0.040
protein autophosphorylation GO:0046777 123 0.040
apoptotic mitochondrial changes GO:0008637 57 0.040
female gamete generation GO:0007292 2 0.040
Fly
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.039
Fly
ribonucleotide catabolic process GO:0009261 405 0.039
regulation of chromosome organization GO:0033044 103 0.039
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.039
Fly
cellular response to dna damage stimulus GO:0006974 379 0.039
response to abiotic stimulus GO:0009628 336 0.039
viral process GO:0016032 146 0.039
adult locomotory behavior GO:0008344 1 0.038
regulation of chromatin modification GO:1903308 51 0.038
multi organism membrane organization GO:0044803 12 0.038
epithelial cell development GO:0002064 34 0.038
Fly
negative regulation of multi organism process GO:0043901 92 0.037
dna conformation change GO:0071103 113 0.037
purine nucleoside triphosphate metabolic process GO:0009144 412 0.037
regulation of cellular response to stress GO:0080135 244 0.037
cell activation GO:0001775 213 0.037
positive regulation of innate immune response GO:0045089 79 0.037
regulation of multi organism process GO:0043900 157 0.036
purine ribonucleotide catabolic process GO:0009154 404 0.036
protein acylation GO:0043543 138 0.036
receptor metabolic process GO:0043112 81 0.036
gtp catabolic process GO:0006184 237 0.036
regulation of purine nucleotide metabolic process GO:1900542 264 0.036
microtubule cytoskeleton organization GO:0000226 176 0.035
inorganic cation transmembrane transport GO:0098662 194 0.035
regulation of cell differentiation GO:0045595 393 0.035
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.034
positive regulation of secretion GO:0051047 116 0.034
negative regulation of cytokine production GO:0001818 82 0.034
potassium ion transmembrane transport GO:0071805 60 0.034
regulation of nucleotide catabolic process GO:0030811 205 0.033
regulation of protein kinase activity GO:0045859 289 0.033
guanosine containing compound catabolic process GO:1901069 239 0.033
nucleoside phosphate catabolic process GO:1901292 412 0.033
arf protein signal transduction GO:0032011 0 0.032
gtp metabolic process GO:0046039 239 0.032
multicellular organismal aging GO:0010259 3 0.032
exosomal secretion GO:1990182 15 0.032
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.032
defense response to bacterium GO:0042742 63 0.031
organophosphate catabolic process GO:0046434 430 0.031
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.031
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.031
mrna metabolic process GO:0016071 175 0.030
receptor mediated endocytosis GO:0006898 84 0.030
positive regulation of protein phosphorylation GO:0001934 313 0.030
apoptotic signaling pathway GO:0097190 268 0.029
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.029
secretion GO:0046903 254 0.029
endocytosis GO:0006897 159 0.029
Fly
segmentation GO:0035282 4 0.029
negative regulation of organelle organization GO:0010639 126 0.028
regulation of nucleotide metabolic process GO:0006140 269 0.028
response to external biotic stimulus GO:0043207 261 0.028
negative regulation of cell proliferation GO:0008285 228 0.028
rna interference GO:0016246 4 0.028
mitotic nuclear division GO:0007067 119 0.028
regulation of defense response GO:0031347 154 0.027
nucleoside monophosphate metabolic process GO:0009123 191 0.027
cellular response to biotic stimulus GO:0071216 71 0.027
memory GO:0007613 3 0.027
receptor catabolic process GO:0032801 11 0.027
muscle cell differentiation GO:0042692 63 0.027
cell substrate junction assembly GO:0007044 35 0.027
negative regulation of protein transport GO:0051224 75 0.027
positive regulation of transport GO:0051050 336 0.027
spindle organization GO:0007051 53 0.027
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.026
negative regulation of catalytic activity GO:0043086 335 0.026
regulation of establishment of protein localization GO:0070201 242 0.026
single organism reproductive process GO:0044702 98 0.025
Fly
regulation of protein ubiquitination GO:0031396 95 0.025
Fly
protein k48 linked deubiquitination GO:0071108 19 0.025
ncrna metabolic process GO:0034660 108 0.025
regulation of gtpase activity GO:0043087 180 0.024
nuclear division GO:0000280 128 0.024
viral life cycle GO:0019058 132 0.024
neuron projection development GO:0031175 106 0.024
cation transmembrane transport GO:0098655 238 0.024
negative regulation of protein metabolic process GO:0051248 391 0.023
Fly
response to nitrogen compound GO:1901698 184 0.023
cellular homeostasis GO:0019725 196 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
regulation of cell motility GO:2000145 299 0.022
Fly
somitogenesis GO:0001756 2 0.022
multi organism cellular process GO:0044764 156 0.022
regulation of cytokine production GO:0001817 232 0.022
t cell differentiation in thymus GO:0033077 4 0.022
response to decreased oxygen levels GO:0036293 96 0.022
positive regulation of organelle organization GO:0010638 195 0.021
neurogenesis GO:0022008 169 0.021
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.021
cytokinesis GO:0000910 96 0.021
endocytic recycling GO:0032456 12 0.020
regulation of response to external stimulus GO:0032101 222 0.020
plasma membrane to endosome transport GO:0048227 6 0.020
lymphocyte activation GO:0046649 133 0.020
multi organism organelle organization GO:1902590 9 0.020
cell cell signaling GO:0007267 155 0.020
post golgi vesicle mediated transport GO:0006892 36 0.020
cell division GO:0051301 168 0.020
regulation of exosomal secretion GO:1903541 12 0.019
negative regulation of multicellular organismal process GO:0051241 317 0.019
protein maturation GO:0051604 233 0.019
determination of adult lifespan GO:0008340 2 0.019
regulation of ras gtpase activity GO:0032318 128 0.019
brain morphogenesis GO:0048854 1 0.018
cell substrate adherens junction assembly GO:0007045 30 0.018
rna processing GO:0006396 255 0.018
establishment of protein localization to plasma membrane GO:0090002 68 0.018
negative regulation of ion transport GO:0043271 39 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
rna export from nucleus GO:0006405 33 0.018
leukocyte activation GO:0045321 164 0.018
regulation of dna repair GO:0006282 47 0.018
protein localization to plasma membrane GO:0072659 93 0.018
lysosomal transport GO:0007041 33 0.018
negative regulation of kinase activity GO:0033673 106 0.017
positive regulation of cell differentiation GO:0045597 211 0.017
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.017
Fly
positive regulation of protein localization to early endosome GO:1902966 2 0.017
regulation of epithelial cell migration GO:0010632 93 0.017
Fly
cellular response to lipid GO:0071396 127 0.017
protein k63 linked deubiquitination GO:0070536 21 0.017
cell cycle checkpoint GO:0000075 117 0.017
regulation of immune response GO:0050776 201 0.017
positive regulation of intracellular transport GO:0032388 104 0.017
regulation of histone modification GO:0031056 47 0.017
visual learning GO:0008542 1 0.017
negative regulation of phosphorylation GO:0042326 174 0.016
Fly
ribonucleoside triphosphate catabolic process GO:0009203 391 0.016
monovalent inorganic cation transport GO:0015672 128 0.016
spermatogenesis GO:0007283 22 0.016
immune system development GO:0002520 195 0.016
regulation of protein deubiquitination GO:0090085 4 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.016
interspecies interaction between organisms GO:0044419 156 0.016
virion assembly GO:0019068 14 0.016
regulation of response to dna damage stimulus GO:2001020 94 0.016
positive regulation of protein ubiquitination GO:0031398 53 0.016
Fly
regulation of gene expression epigenetic GO:0040029 73 0.016
protein targeting to vacuole GO:0006623 8 0.016
negative regulation of locomotion GO:0040013 118 0.016
adherens junction organization GO:0034332 36 0.016
amine metabolic process GO:0009308 44 0.015
positive regulation of defense response GO:0031349 87 0.015
negative regulation of protein processing GO:0010955 142 0.015
regulation of cysteine type endopeptidase activity GO:2000116 127 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
cell matrix adhesion GO:0007160 85 0.015
positive regulation of rab gtpase activity GO:0032851 39 0.015
cellular response to hormone stimulus GO:0032870 125 0.015
regulation of mapk cascade GO:0043408 262 0.015
regulation of neuron projection development GO:0010975 57 0.015
cellular amino acid metabolic process GO:0006520 116 0.015
metal ion homeostasis GO:0055065 169 0.014
epidermis morphogenesis GO:0048730 3 0.014
protein homooligomerization GO:0051260 100 0.014
rrna metabolic process GO:0016072 40 0.014
response to cytokine GO:0034097 232 0.014
regulation of binding GO:0051098 111 0.014
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
protein processing GO:0016485 226 0.014
multi organism reproductive process GO:0044703 54 0.014
Fly
immune response activating signal transduction GO:0002757 90 0.014
protein k48 linked ubiquitination GO:0070936 38 0.014
chromosome segregation GO:0007059 114 0.014
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.013
protein localization to membrane GO:0072657 160 0.013
positive regulation of secretion by cell GO:1903532 108 0.013
positive regulation of peptidase activity GO:0010952 88 0.013
regulation of ubiquitin protein transferase activity GO:0051438 28 0.013
ncrna processing GO:0034470 83 0.013
steroid metabolic process GO:0008202 94 0.013
cation transport GO:0006812 331 0.013
cell junction assembly GO:0034329 67 0.013
regulation of response to cytokine stimulus GO:0060759 46 0.013
actin cytoskeleton reorganization GO:0031532 37 0.013
negative regulation of transport GO:0051051 176 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
Fly
hematopoietic or lymphoid organ development GO:0048534 186 0.013
neuron projection morphogenesis GO:0048812 50 0.013
lipid localization GO:0010876 106 0.013
negative regulation of growth GO:0045926 97 0.013
cytokine production GO:0001816 247 0.013
generation of neurons GO:0048699 152 0.013
purine containing compound catabolic process GO:0072523 411 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.013
golgi to plasma membrane protein transport GO:0043001 19 0.013
lipid storage GO:0019915 28 0.012
actomyosin structure organization GO:0031032 59 0.012
skin development GO:0043588 76 0.012
muscle structure development GO:0061061 98 0.012
response to organic cyclic compound GO:0014070 204 0.012
early endosome to late endosome transport GO:0045022 21 0.012
regulation of cellular protein catabolic process GO:1903362 96 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
toll signaling pathway GO:0008063 2 0.012
Fly
regulation of pinocytosis GO:0048548 6 0.012
negative regulation of voltage gated calcium channel activity GO:1901386 4 0.012
behavior GO:0007610 112 0.012
multivesicular body assembly GO:0036258 1 0.012
second messenger mediated signaling GO:0019932 78 0.012
developmental process involved in reproduction GO:0003006 66 0.011
Fly
regulation of intracellular transport GO:0032386 195 0.011
cardiovascular system development GO:0072358 262 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
cellular component assembly involved in morphogenesis GO:0010927 73 0.011
single organismal cell cell adhesion GO:0016337 148 0.011
regulation of leukocyte activation GO:0002694 115 0.011
multicellular organismal reproductive process GO:0048609 40 0.011
Fly
camp mediated signaling GO:0019933 23 0.011
male gamete generation GO:0048232 22 0.011
negative regulation of apoptotic signaling pathway GO:2001234 97 0.011
cell part morphogenesis GO:0032990 137 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
regulation of cell growth GO:0001558 135 0.011
cellular chemical homeostasis GO:0055082 180 0.011
canonical wnt signaling pathway GO:0060070 116 0.011
transmembrane transport GO:0055085 399 0.011
cellular response to organic cyclic compound GO:0071407 127 0.011
reproduction GO:0000003 63 0.011
Worm Fly
cellular response to molecule of bacterial origin GO:0071219 62 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
interleukin 8 production GO:0032637 51 0.010
regulation of interleukin 2 secretion GO:1900040 2 0.010
negative regulation of epithelial cell migration GO:0010633 38 0.010
histone acetylation GO:0016573 93 0.010
regulation of protein targeting GO:1903533 91 0.010

HGS disease predictions

Disease DO term ID Size Probability Func Analog Org
urinary system disease DOID:18 40 0.427
kidney disease DOID:557 36 0.419
disease of mental health DOID:150 70 0.074
central nervous system disease DOID:331 186 0.023
nervous system disease DOID:863 431 0.023
disease of cellular proliferation DOID:14566 174 0.022
cancer DOID:162 167 0.017
organ system cancer DOID:0050686 164 0.017
nephritis DOID:10952 6 0.016
glomerulonephritis DOID:2921 6 0.016
focal segmental glomerulosclerosis DOID:1312 6 0.016
glomerulosclerosis DOID:0050851 6 0.016