Homo sapiens

539 known processes

PARK7

Parkinson disease (autosomal recessive, early onset) 7

(Aliases: DJ-1,DJ1,FLJ27376,FLJ34360,FLJ92274)

PARK7 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to superoxide GO:0071451 6 0.842
cellular response to oxygen radical GO:0071450 6 0.712
positive regulation of cytokine production GO:0001819 167 0.466
removal of superoxide radicals GO:0019430 6 0.423
posttranscriptional regulation of gene expression GO:0010608 213 0.415
cellular response to oxygen containing compound GO:1901701 276 0.373
regulation of defense response GO:0031347 154 0.347
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 127 0.318
hydrogen peroxide metabolic process GO:0042743 20 0.308
cellular response to reactive oxygen species GO:0034614 50 0.239
cytokine production GO:0001816 247 0.237
positive regulation of apoptotic process GO:0043065 246 0.237
Mouse
multicellular organismal aging GO:0010259 3 0.229
determination of adult lifespan GO:0008340 2 0.214
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.202
cellular response to hydrogen peroxide GO:0070301 37 0.194
nucleoside phosphate catabolic process GO:1901292 412 0.191
protein processing GO:0016485 226 0.186
hydrogen peroxide catabolic process GO:0042744 13 0.186
negative regulation of endopeptidase activity GO:0010951 84 0.185
cellular response to oxidative stress GO:0034599 85 0.182
protein oxidation GO:0018158 5 0.182
Mouse
regulation of cellular response to stress GO:0080135 244 0.170
purine ribonucleotide catabolic process GO:0009154 404 0.169
nucleotide catabolic process GO:0009166 408 0.166
peptidyl cysteine oxidation GO:0018171 1 0.165
Mouse
purine ribonucleoside metabolic process GO:0046128 437 0.165
positive regulation of oxidative stress induced cell death GO:1903209 5 0.159
Mouse
myeloid cell differentiation GO:0030099 117 0.158
protein maturation GO:0051604 233 0.152
nucleoside catabolic process GO:0009164 408 0.134
post embryonic development GO:0009791 2 0.134
purine containing compound catabolic process GO:0072523 411 0.134
regulation of membrane potential GO:0042391 95 0.130
purine nucleotide catabolic process GO:0006195 405 0.126
response to oxygen radical GO:0000305 6 0.123
regulation of cellular amine metabolic process GO:0033238 11 0.122
purine ribonucleoside catabolic process GO:0046130 398 0.119
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.115
heat acclimation GO:0010286 3 0.112
response to abiotic stimulus GO:0009628 336 0.111
regulation of purine nucleotide metabolic process GO:1900542 264 0.108
purine nucleoside triphosphate metabolic process GO:0009144 412 0.108
regeneration GO:0031099 4 0.107
response to oxygen containing compound GO:1901700 369 0.107
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.105
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.104
negative regulation of immune system process GO:0002683 136 0.104
negative regulation of peptidase activity GO:0010466 91 0.100
cell development GO:0048468 328 0.097
positive regulation of developmental process GO:0051094 314 0.096
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.093
Mouse
organic hydroxy compound biosynthetic process GO:1901617 71 0.093
ribonucleotide catabolic process GO:0009261 405 0.090
apoptotic signaling pathway GO:0097190 268 0.089
ribonucleoside triphosphate catabolic process GO:0009203 391 0.087
response to inorganic substance GO:0010035 127 0.087
positive regulation of programmed cell death GO:0043068 249 0.087
Mouse
positive regulation of response to oxidative stress GO:1902884 7 0.086
negative regulation of apoptotic process GO:0043066 316 0.084
regulation of endopeptidase activity GO:0052548 170 0.082
anatomical structure homeostasis GO:0060249 100 0.082
lipid metabolic process GO:0006629 381 0.080
reactive oxygen species biosynthetic process GO:1903409 4 0.079
Mouse
nucleoside triphosphate catabolic process GO:0009143 394 0.076
regulation of apoptotic signaling pathway GO:2001233 175 0.076
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.074
rna interference GO:0016246 4 0.074
response to lipid GO:0033993 206 0.070
negative regulation of programmed cell death GO:0043069 321 0.070
regulation of nucleotide metabolic process GO:0006140 269 0.070
ribonucleoside catabolic process GO:0042454 406 0.068
retina homeostasis GO:0001895 42 0.068
positive regulation of apoptotic signaling pathway GO:2001235 70 0.068
Mouse
regulation of gtpase activity GO:0043087 180 0.067
response to hydrogen peroxide GO:0042542 40 0.067
fatty acid metabolic process GO:0006631 115 0.066
positive regulation of cell proliferation GO:0008284 301 0.065
cellular response to dna damage stimulus GO:0006974 379 0.064
monocarboxylic acid metabolic process GO:0032787 185 0.064
superoxide metabolic process GO:0006801 20 0.063
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.063
glycosyl compound catabolic process GO:1901658 413 0.063
cellular amine metabolic process GO:0044106 41 0.062
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.059
reactive oxygen species metabolic process GO:0072593 75 0.059
response to oxidative stress GO:0006979 121 0.059
ribonucleoside triphosphate metabolic process GO:0009199 412 0.059
female gamete generation GO:0007292 2 0.056
regulation of kinase activity GO:0043549 314 0.054
negative regulation of cell death GO:0060548 345 0.053
protein localization to organelle GO:0033365 280 0.053
negative regulation of cellular protein metabolic process GO:0032269 353 0.053
peptidyl cysteine modification GO:0018198 9 0.053
Mouse
cellular lipid metabolic process GO:0044255 303 0.052
proton transport GO:0015992 22 0.051
Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.051
organophosphate catabolic process GO:0046434 430 0.051
guanosine containing compound metabolic process GO:1901068 244 0.050
tissue regeneration GO:0042246 3 0.049
regulation of cell cycle GO:0051726 393 0.049
purine nucleoside triphosphate catabolic process GO:0009146 392 0.046
negative regulation of protein metabolic process GO:0051248 391 0.046
response to other organism GO:0051707 261 0.042
immune system development GO:0002520 195 0.042
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.042
negative regulation of catalytic activity GO:0043086 335 0.042
gtp metabolic process GO:0046039 239 0.042
response to bacterium GO:0009617 144 0.041
regulation of gtp catabolic process GO:0033124 180 0.041
regulation of multi organism process GO:0043900 157 0.041
hemopoiesis GO:0030097 180 0.041
positive regulation of cell death GO:0010942 263 0.041
Mouse
ras protein signal transduction GO:0007265 73 0.040
chromatin organization GO:0006325 351 0.039
inflammatory response GO:0006954 79 0.039
Mouse
nucleoside monophosphate catabolic process GO:0009125 159 0.039
positive regulation of protein phosphorylation GO:0001934 313 0.038
cellular homeostasis GO:0019725 196 0.037
lipid biosynthetic process GO:0008610 177 0.037
positive regulation of superoxide anion generation GO:0032930 4 0.037
response to metal ion GO:0010038 84 0.036
regulation of lipid metabolic process GO:0019216 96 0.036
small gtpase mediated signal transduction GO:0007264 78 0.036
cell death in response to oxidative stress GO:0036473 29 0.035
positive regulation of nucleotide metabolic process GO:0045981 230 0.034
regulation of nucleotide catabolic process GO:0030811 205 0.033
gtp catabolic process GO:0006184 237 0.033
response to reactive oxygen species GO:0000302 61 0.032
endocytosis GO:0006897 159 0.031
regulation of peptidase activity GO:0052547 180 0.031
regulation of transferase activity GO:0051338 355 0.031
nitrogen compound transport GO:0071705 191 0.031
Mouse
steroid metabolic process GO:0008202 94 0.030
mrna metabolic process GO:0016071 175 0.030
cell type specific apoptotic process GO:0097285 125 0.030
immune response GO:0006955 307 0.030
regulation of small gtpase mediated signal transduction GO:0051056 156 0.029
regulation of response to wounding GO:1903034 101 0.029
Mouse
alcohol metabolic process GO:0006066 114 0.029
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.029
protein acetylation GO:0006473 116 0.028
response to external biotic stimulus GO:0043207 261 0.028
carbohydrate derivative biosynthetic process GO:1901137 207 0.028
nucleoside monophosphate metabolic process GO:0009123 191 0.028
response to wounding GO:0009611 168 0.028
Mouse
muscle structure development GO:0061061 98 0.028
response to superoxide GO:0000303 6 0.028
regulation of ras protein signal transduction GO:0046578 155 0.027
regulation of protein processing GO:0070613 150 0.027
hematopoietic or lymphoid organ development GO:0048534 186 0.026
internal protein amino acid acetylation GO:0006475 101 0.026
innate immune response GO:0045087 178 0.026
regulation of protein maturation GO:1903317 150 0.026
oogenesis GO:0048477 2 0.026
positive regulation of cellular response to oxidative stress GO:1900409 7 0.026
thymus development GO:0048538 3 0.025
bleb assembly GO:0032060 6 0.025
regulation of nucleoside metabolic process GO:0009118 209 0.024
defense response GO:0006952 315 0.024
Mouse
receptor mediated endocytosis GO:0006898 84 0.024
heart process GO:0003015 62 0.023
embryo development GO:0009790 123 0.023
cell aging GO:0007569 52 0.023
regulation of protein kinase activity GO:0045859 289 0.023
chromatin modification GO:0016568 298 0.023
gene silencing GO:0016458 49 0.023
protein modification by small protein conjugation GO:0032446 342 0.023
negative regulation of response to external stimulus GO:0032102 83 0.023
regulation of cell cycle process GO:0010564 266 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
nucleotide biosynthetic process GO:0009165 109 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
response to xenobiotic stimulus GO:0009410 30 0.022
covalent chromatin modification GO:0016569 254 0.022
negative regulation of protein maturation GO:1903318 142 0.022
guanosine containing compound catabolic process GO:1901069 239 0.022
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.021
ribonucleotide biosynthetic process GO:0009260 81 0.021
amine metabolic process GO:0009308 44 0.021
negative regulation of multicellular organismal process GO:0051241 317 0.021
regulation of purine nucleotide catabolic process GO:0033121 205 0.021
amide transport GO:0042886 76 0.021
response to biotic stimulus GO:0009607 276 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
growth GO:0040007 202 0.020
organic hydroxy compound metabolic process GO:1901615 147 0.019
cell division GO:0051301 168 0.019
regulation of mitochondrial membrane potential GO:0051881 23 0.019
cofactor metabolic process GO:0051186 87 0.019
atp metabolic process GO:0046034 176 0.018
reproductive process GO:0022414 106 0.018
regulation of cell growth GO:0001558 135 0.018
regulation of response to external stimulus GO:0032101 222 0.018
Mouse
immune effector process GO:0002252 159 0.018
negative regulation of protein processing GO:0010955 142 0.018
regulation of leukocyte differentiation GO:1902105 61 0.018
nervous system development GO:0007399 293 0.018
nucleoside triphosphate metabolic process GO:0009141 422 0.018
reproduction GO:0000003 63 0.017
system process GO:0003008 349 0.017
regulation of proteolysis GO:0030162 293 0.017
gene silencing by rna GO:0031047 26 0.016
single organism reproductive process GO:0044702 98 0.016
cytoplasmic transport GO:0016482 379 0.016
glucose homeostasis GO:0042593 31 0.016
regulation of innate immune response GO:0045088 97 0.016
cellular amino acid metabolic process GO:0006520 116 0.016
negative regulation of cell growth GO:0030308 83 0.016
regulation of neurogenesis GO:0050767 82 0.015
negative regulation of apoptotic signaling pathway GO:2001234 97 0.015
methylation GO:0032259 106 0.015
regulation of cell development GO:0060284 161 0.015
positive regulation of cellular amine metabolic process GO:0033240 7 0.015
wound healing GO:0042060 115 0.015
tissue homeostasis GO:0001894 63 0.015
aging GO:0007568 66 0.014
steroid biosynthetic process GO:0006694 46 0.014
cell fate commitment GO:0045165 27 0.014
regulation of secretion by cell GO:1903530 177 0.014
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.014
heart contraction GO:0060047 62 0.014
multicellular organismal homeostasis GO:0048871 67 0.014
regulation of inflammatory response GO:0050727 46 0.014
Mouse
protein oligomerization GO:0051259 173 0.014
regulation of epithelial cell proliferation GO:0050678 113 0.014
neuron differentiation GO:0030182 138 0.014
regulation of gene expression epigenetic GO:0040029 73 0.014
ribonucleoside monophosphate catabolic process GO:0009158 158 0.014
response to alcohol GO:0097305 64 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
developmental process involved in reproduction GO:0003006 66 0.013
cell activation GO:0001775 213 0.013
leukocyte activation GO:0045321 164 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
coenzyme metabolic process GO:0006732 65 0.013
histone methylation GO:0016571 60 0.013
dna repair GO:0006281 198 0.013
positive regulation of peptidase activity GO:0010952 88 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.013
protein methylation GO:0006479 74 0.013
regulation of neuron death GO:1901214 56 0.013
segmentation GO:0035282 4 0.013
neuron cellular homeostasis GO:0070050 3 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.013
rho protein signal transduction GO:0007266 26 0.013
neuron death GO:0070997 65 0.013
mrna processing GO:0006397 133 0.012
response to hormone GO:0009725 175 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
mitotic cell cycle GO:0000278 326 0.012
cell projection morphogenesis GO:0048858 129 0.012
regulation of immune response GO:0050776 201 0.012
protein homooligomerization GO:0051260 100 0.012
positive regulation of cell migration GO:0030335 172 0.012
erythrocyte homeostasis GO:0034101 31 0.012
regulation of growth GO:0040008 165 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
cellular component morphogenesis GO:0032989 314 0.012
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902177 4 0.012
Mouse
epithelial cell proliferation GO:0050673 128 0.012
small molecule biosynthetic process GO:0044283 157 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
neuron development GO:0048666 113 0.012
cellular macromolecule catabolic process GO:0044265 380 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
regulation of ras gtpase activity GO:0032318 128 0.012
inorganic ion transmembrane transport GO:0098660 231 0.012
posttranscriptional gene silencing GO:0016441 25 0.012
regulation of superoxide metabolic process GO:0090322 6 0.011
leukocyte proliferation GO:0070661 74 0.011
cellular response to lipid GO:0071396 127 0.011
lymphocyte activation GO:0046649 133 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.011
regulation of cholesterol metabolic process GO:0090181 4 0.011
organelle fission GO:0048285 149 0.011
single organism cellular localization GO:1902580 332 0.011
posttranscriptional gene silencing by rna GO:0035194 25 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
rna splicing via transesterification reactions GO:0000375 90 0.011
response to drug GO:0042493 81 0.011
protein alkylation GO:0008213 74 0.011
response to monosaccharide GO:0034284 20 0.011
sterol metabolic process GO:0016125 28 0.010
sulfur compound metabolic process GO:0006790 101 0.010
regulation of rac gtpase activity GO:0032314 4 0.010
response to acid chemical GO:0001101 66 0.010
regulation of protein localization GO:0032880 296 0.010
response to temperature stimulus GO:0009266 22 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010

PARK7 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.054
disease of cellular proliferation DOID:14566 174 0.054
central nervous system disease DOID:331 186 0.031
nervous system disease DOID:863 431 0.031
organ system cancer DOID:0050686 164 0.019
neurodegenerative disease DOID:1289 102 0.004
synucleinopathy DOID:0050890 22 0.000
parkinson s disease DOID:14330 18 0.000