|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
1.000
|
Human |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.993
|
Human |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.988
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.984
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.981
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.979
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.969
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.965
|
Human |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.960
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.921
|
Human |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.918
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.914
|
Human |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.908
|
Human |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.900
|
Human |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.899
|
Human |
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.888
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.881
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.880
|
Human |
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.875
|
Human |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.874
|
Human |
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.874
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.863
|
Human |
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.852
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.849
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.841
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.841
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.827
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.827
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.815
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.796
|
Human |
|
|
dna repair
|
GO:0006281 |
198 |
0.774
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.763
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.753
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.746
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.742
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.734
|
Human |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.718
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.698
|
|
|
|
negative regulation of transcription initiation from rna polymerase ii promoter
|
GO:0060633 |
3 |
0.696
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.692
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.681
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.678
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.671
|
Human |
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.662
|
Human |
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
35 |
0.658
|
Human |
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.641
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.641
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.640
|
Human |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.639
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.627
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.623
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.607
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.600
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.589
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.570
|
Human |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.567
|
Human |
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.563
|
Human |
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.557
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.543
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.540
|
|
|
|
mitotic dna damage checkpoint
|
GO:0044773 |
28 |
0.534
|
Human |
|
|
mitotic dna integrity checkpoint
|
GO:0044774 |
30 |
0.527
|
Human |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.524
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.515
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.509
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.508
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.500
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.497
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.495
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.494
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.494
|
Human |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.492
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.470
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.469
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.467
|
Human |
|
|
positive regulation of cell cycle arrest
|
GO:0071158 |
23 |
0.460
|
Human |
|
|
immune response
|
GO:0006955 |
307 |
0.447
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.446
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.443
|
Human |
|
|
histone deubiquitination
|
GO:0016578 |
16 |
0.443
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.441
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.425
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.419
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.417
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.416
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.412
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.405
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.396
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.396
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.391
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.388
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.384
|
Human |
|
|
regulation of signal transduction by p53 class mediator
|
GO:1901796 |
26 |
0.377
|
Human |
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.374
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.367
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.366
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.363
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.363
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.354
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.353
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.350
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.348
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.341
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.337
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.336
|
Human |
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
50 |
0.330
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.330
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.330
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.323
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.322
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.316
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.313
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.313
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.313
|
|
|
|
response to caffeine
|
GO:0031000 |
3 |
0.309
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.296
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.295
|
Human |
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.293
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.293
|
Human |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.289
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.276
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.276
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.274
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.270
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.268
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.266
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.265
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.259
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.257
|
Human |
|
|
smoothened signaling pathway
|
GO:0007224 |
14 |
0.255
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.254
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.251
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.245
|
|
|
|
protein deacylation
|
GO:0035601 |
39 |
0.242
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.242
|
Human |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.242
|
|
|
|
positive regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032436 |
30 |
0.240
|
Human |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.239
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.239
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.238
|
Human |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.237
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.235
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.233
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.232
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.230
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.227
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.227
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.226
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.226
|
|
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
33 |
0.225
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.224
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.223
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.221
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.218
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.217
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.214
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.211
|
|
|
|
limbic system development
|
GO:0021761 |
3 |
0.210
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.210
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.208
|
Human |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.208
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.208
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.206
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.205
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.205
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.203
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.203
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.201
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.200
|
|
|
|
mitotic cytokinesis
|
GO:0000281 |
19 |
0.197
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.197
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.196
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.194
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.192
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.192
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.192
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.191
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.187
|
Human |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.187
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.184
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.182
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.177
|
Human |
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.175
|
Human |
|
|
chemotaxis
|
GO:0006935 |
157 |
0.175
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.175
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.172
|
Human |
|
|
negative regulation of smoothened signaling pathway
|
GO:0045879 |
3 |
0.170
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.169
|
|
|
|
regulation of dna repair
|
GO:0006282 |
47 |
0.166
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.165
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.160
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.159
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.158
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.156
|
|
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.155
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.155
|
|
|
|
negative regulation of transcription involved in g1 s transition of mitotic cell cycle
|
GO:0071930 |
2 |
0.155
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.151
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.150
|
|
|
|
regulation of microtubule based process
|
GO:0032886 |
74 |
0.150
|
|
|
|
protein k48 linked deubiquitination
|
GO:0071108 |
19 |
0.149
|
|
|
|
regulation of mitochondrion organization
|
GO:0010821 |
54 |
0.149
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.147
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.147
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.146
|
Human |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.146
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.146
|
|
|
|
growth
|
GO:0040007 |
202 |
0.146
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.145
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.144
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.144
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.144
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.143
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.143
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.142
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.141
|
Human |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.139
|
|
|
|
trna modification
|
GO:0006400 |
10 |
0.138
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.137
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.135
|
|
|
|
regulation of transcription involved in g1 s transition of mitotic cell cycle
|
GO:0000083 |
8 |
0.132
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.131
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.130
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.128
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.127
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.127
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.126
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.126
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.125
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.125
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.124
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.123
|
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
36 |
0.123
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.123
|
|
|
|
mitotic centrosome separation
|
GO:0007100 |
1 |
0.123
|
|
|
|
trna wobble uridine modification
|
GO:0002098 |
3 |
0.123
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.122
|
|
|
|
dna damage induced protein phosphorylation
|
GO:0006975 |
5 |
0.122
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.122
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.122
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.121
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.121
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.121
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.120
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.120
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.119
|
|
|
|
negative regulation of dna replication
|
GO:0008156 |
29 |
0.116
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.116
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.115
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.114
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.114
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.113
|
|
|
|
regulation of microtubule cytoskeleton organization
|
GO:0070507 |
61 |
0.113
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.112
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.112
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.111
|
Human |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.109
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.108
|
Mouse |
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.108
|
|
|
|
glucan metabolic process
|
GO:0044042 |
22 |
0.107
|
|
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.106
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.106
|
|
|
|
establishment or maintenance of microtubule cytoskeleton polarity
|
GO:0030951 |
2 |
0.106
|
|
|
|
regulation of histone modification
|
GO:0031056 |
47 |
0.105
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.105
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.104
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.103
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.103
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.102
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.102
|
|
|
|
histone acetylation
|
GO:0016573 |
93 |
0.101
|
|
|
|
negative regulation of myotube differentiation
|
GO:0010832 |
4 |
0.101
|
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.101
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.100
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.099
|
|
|
|
nucleus organization
|
GO:0006997 |
28 |
0.099
|
|
|
|
peptidyl lysine acetylation
|
GO:0018394 |
101 |
0.099
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.098
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.098
|
|
|
|
ribosome biogenesis
|
GO:0042254 |
48 |
0.097
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.097
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.096
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.096
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.095
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
92 |
0.095
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.095
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.094
|
|
|
|
substrate adhesion dependent cell spreading
|
GO:0034446 |
41 |
0.094
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.093
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.093
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.092
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.092
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.090
|
|
|
|
ncrna processing
|
GO:0034470 |
83 |
0.090
|
|
|
|
positive regulation of nuclease activity
|
GO:0032075 |
5 |
0.090
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902042 |
15 |
0.089
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.088
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.087
|
|
|
|
interleukin 1 production
|
GO:0032612 |
26 |
0.086
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.086
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.085
|
Human |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.084
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.084
|
|
|
|
maintenance of protein location
|
GO:0045185 |
57 |
0.084
|
|
|
|
negative regulation of cell cycle g1 s phase transition
|
GO:1902807 |
29 |
0.084
|
Human |
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.083
|
|
|
|
histone threonine phosphorylation
|
GO:0035405 |
7 |
0.083
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.082
|
|
|
|
positive regulation of apoptotic process involved in mammary gland involution
|
GO:0060058 |
1 |
0.082
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.080
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.080
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.079
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.079
|
|
|
|
regulation of dna templated transcription in response to stress
|
GO:0043620 |
18 |
0.079
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.079
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.078
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.077
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.077
|
|
|
|
regulation of chromatin modification
|
GO:1903308 |
51 |
0.076
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.076
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.075
|
|
|
|
oxidative stress induced premature senescence
|
GO:0090403 |
3 |
0.075
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.074
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.074
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.074
|
|
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
3 |
0.074
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.073
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.073
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.072
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.072
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.072
|
|
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
37 |
0.072
|
|
|
|
response to gamma radiation
|
GO:0010332 |
14 |
0.072
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.072
|
Human |
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.070
|
|
|
|
positive regulation of apoptotic process involved in morphogenesis
|
GO:1902339 |
1 |
0.070
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.070
|
|
|
|
histone h2a ubiquitination
|
GO:0033522 |
17 |
0.070
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.070
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.070
|
|
|
|
male meiosis
|
GO:0007140 |
1 |
0.070
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.069
|
|
|
|
er to golgi vesicle mediated transport
|
GO:0006888 |
19 |
0.069
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.068
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.068
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.068
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.068
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.067
|
|
|
|
spindle assembly
|
GO:0051225 |
29 |
0.067
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.067
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.066
|
|
|
|
androgen receptor signaling pathway
|
GO:0030521 |
34 |
0.065
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.065
|
|
|
|
substantia nigra development
|
GO:0021762 |
45 |
0.065
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.064
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.064
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.064
|
|
|
|
positive regulation of growth
|
GO:0045927 |
58 |
0.063
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.063
|
|
|
|
ribonucleoprotein complex biogenesis
|
GO:0022613 |
116 |
0.062
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
2 |
0.062
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.061
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.061
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.061
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.061
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.059
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.058
|
|
|
|
positive regulation of erythrocyte differentiation
|
GO:0045648 |
11 |
0.058
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.058
|
|
|
|
specification of organ identity
|
GO:0010092 |
3 |
0.058
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.057
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.057
|
Human |
|
|
regulation of carbohydrate metabolic process
|
GO:0006109 |
54 |
0.057
|
|
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
38 |
0.057
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.057
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.057
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.057
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.057
|
|
|
|
positive regulation of dendrite morphogenesis
|
GO:0050775 |
3 |
0.056
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.056
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.056
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.055
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.055
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.055
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.055
|
|
|
|
hormone transport
|
GO:0009914 |
68 |
0.054
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.054
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.053
|
|
|
|
male gonad development
|
GO:0008584 |
23 |
0.053
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.053
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.052
|
|
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.052
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.052
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.052
|
|
|
|
mitotic sister chromatid segregation
|
GO:0000070 |
53 |
0.052
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.051
|
|
|
|
regulation of release of cytochrome c from mitochondria
|
GO:0090199 |
29 |
0.051
|
|
|
|
energy reserve metabolic process
|
GO:0006112 |
22 |
0.051
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.051
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.051
|
|
|
|
regulation of transcription from rna polymerase ii promoter in response to stress
|
GO:0043618 |
17 |
0.051
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.051
|
|
|
|
golgi vesicle transport
|
GO:0048193 |
80 |
0.051
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.051
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.050
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.050
|
|
|
|
meiotic nuclear division
|
GO:0007126 |
10 |
0.050
|
|
|
|
morphogenesis of a branching epithelium
|
GO:0061138 |
20 |
0.050
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.050
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.050
|
|
|
|
ncrna metabolic process
|
GO:0034660 |
108 |
0.049
|
|
|
|
internal protein amino acid acetylation
|
GO:0006475 |
101 |
0.049
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.049
|
|
|
|
regulation of dendrite morphogenesis
|
GO:0048814 |
11 |
0.048
|
|
|
|
regulation of generation of precursor metabolites and energy
|
GO:0043467 |
27 |
0.048
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.047
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.047
|
Human |
|
|
regulation of binding
|
GO:0051098 |
111 |
0.047
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.047
|
|
|
|
positive regulation of response to interferon gamma
|
GO:0060332 |
2 |
0.047
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.047
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.046
|
Human |
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.046
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.046
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.046
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.046
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.046
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.046
|
|
|
|
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest
|
GO:0006977 |
9 |
0.046
|
Human |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.045
|
|
|
|
regulation of cytokinesis
|
GO:0032465 |
45 |
0.045
|
|
|
|
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly
|
GO:0017055 |
2 |
0.045
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.045
|
|
|
|
negative regulation of endothelial cell apoptotic process
|
GO:2000352 |
16 |
0.045
|
|
|
|
female sex differentiation
|
GO:0046660 |
12 |
0.045
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.044
|
|
|
|
histone h3 acetylation
|
GO:0043966 |
45 |
0.044
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.043
|
|
|
|
vesicle organization
|
GO:0016050 |
62 |
0.043
|
|
|
|
macromolecule deacylation
|
GO:0098732 |
41 |
0.043
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.043
|
|
|
|
cellular response to purine containing compound
|
GO:0071415 |
3 |
0.043
|
|
|
|
response to purine containing compound
|
GO:0014074 |
40 |
0.043
|
|
|
|
trna processing
|
GO:0008033 |
23 |
0.042
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.042
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.042
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.042
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.042
|
|
|
|
histone deacetylation
|
GO:0016575 |
32 |
0.041
|
|
|
|
positive regulation of interferon gamma mediated signaling pathway
|
GO:0060335 |
2 |
0.041
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
51 |
0.041
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.041
|
|
|
|
apoptotic process involved in morphogenesis
|
GO:0060561 |
3 |
0.041
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.041
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.040
|
|
|
|
rna polymerase ii transcriptional preinitiation complex assembly
|
GO:0051123 |
4 |
0.040
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.040
|
|
|
|
transcription initiation from rna polymerase ii promoter
|
GO:0006367 |
27 |
0.040
|
|
|
|
retina layer formation
|
GO:0010842 |
3 |
0.040
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.040
|
|
|
|
ribosomal large subunit biogenesis
|
GO:0042273 |
10 |
0.040
|
|
|
|
response to alkaloid
|
GO:0043279 |
20 |
0.040
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.039
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.039
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.039
|
|
|
|
peptidyl serine dephosphorylation
|
GO:0070262 |
2 |
0.039
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.039
|
|
|
|
glucocorticoid catabolic process
|
GO:0006713 |
1 |
0.039
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.039
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.038
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.038
|
|
|
|
potassium ion transmembrane transport
|
GO:0071805 |
60 |
0.038
|
|
|
|
negative regulation of innate immune response
|
GO:0045824 |
18 |
0.038
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.038
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.038
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
76 |
0.038
|
|
|
|
intra s dna damage checkpoint
|
GO:0031573 |
4 |
0.037
|
|
|
|
cellular response to caffeine
|
GO:0071313 |
3 |
0.037
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.037
|
|
|
|
prostate gland development
|
GO:0030850 |
3 |
0.037
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.037
|
Human |
|
|
patterning of blood vessels
|
GO:0001569 |
2 |
0.037
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.037
|
|
|
|
positive regulation of cell division
|
GO:0051781 |
59 |
0.037
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.036
|
|
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.036
|
|
|
|
positive regulation of leukocyte migration
|
GO:0002687 |
46 |
0.036
|
|
|
|
regulation of glycogen biosynthetic process
|
GO:0005979 |
14 |
0.035
|
|
|
|
positive regulation of mitochondrion organization
|
GO:0010822 |
30 |
0.035
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.035
|
|
